Article
Biochemistry & Molecular Biology
Sara E. Lewis, Courtney B. Rosencrance, Evan De Vallance, Andrew Giromini, Xena M. Williams, Joo-Yeun Oh, Heidi Schmidt, Adam C. Straub, Paul D. Chantler, Rakesh P. Patel, Eric E. Kelley
Summary: Research indicates that XOR does not contribute to nitrite reduction in human and rodent erythrocytes, suggesting a need to validate immuno-detectable XOR by demonstrating enzymatic activity.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Chemistry, Multidisciplinary
Balakrishnan S. Anju, Neeraja R. Nair, Subrata Kundu
Summary: This study demonstrates the importance of the interconversion between nitrite and nitric oxide in maintaining optimal NO flux in mammalian physiology. The research also reveals potential applications of copper-based catalysts in nitrite reduction and deepens our understanding of the involvement of red copper proteins in denitrification.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Biochemistry & Molecular Biology
Sonia Eligini, Benedetta Porro, Jose Pablo Werba, Nicolo Capra, Stefano Genovese, Arianna Greco, Viviana Cavalca, Cristina Banfi
Summary: The effects of oral glucose tolerance test (OGTT) on red blood cells (RBCs), particularly oxidative stress and L-arginine/Nitric Oxide (L-Arg/NO) metabolic pathway, were evaluated in patients with prediabetes. The results showed an increase in oxidative stress and a reduction in NO production in RBCs after glucose loading, suggesting the importance of avoiding acute glycemic variations to prevent diabetic complications, even in the early stages of diabetes.
Article
Biochemistry & Molecular Biology
John Ukeri, Michael T. Wilson, Brandon J. Reeder
Summary: Cytoglobin has physiological roles that are not clearly understood, but may include regulation of nitric oxide, oxygen sensing, and protection against oxidative stress. Specific mutations can affect the nitric oxide binding and metabolism activities of cytoglobin, helping to understand its precise role under physiological and pathophysiological conditions.
Article
Biochemistry & Molecular Biology
Nadeem Wajih, Elmira Alipour, Fernando Rigal, Jiqing Zhu, Andreas Perlegas, David L. Caudell, Daniel Kim-Shapiro
Summary: The combination of nitrite and far-red light treatment shows inhibitory effects on platelet activation and blood coagulation, particularly in preventing device-associated thrombosis; mono-treatment with nitrite or far-red light alone has mixed results; the combined treatment may have a positive impact on preventing thrombosis.
NITRIC OXIDE-BIOLOGY AND CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Zhiqiang Shen, Shaoqiu Zheng, Shiyan Xiao, Ruan Shen, Shiyong Liu, Jinming Hu
Summary: This study introduces a coumarin-based NO donor that can be activated under red-light conditions, enabling self-reporting NO release through photoredox catalysis. This NO-releasing platform shows promise in eradicating bacterial biofilms and treating cutaneous abscesses.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Nutrition & Dietetics
Barbora Piknova, Ji Won Park, Samantha M. Thomas, Khalid J. Tunau-Spencer, Alan N. Schechter
Summary: Nitric oxide (NO) (co)regulates physiological processes in the body and its availability is affected by aging. Aging leads to changes in nitrate and nitrite contents in tissues, with higher nitrate levels and lower nitrite levels in old rats compared to young rats. However, the nitrate reduction pathway is not affected by aging. Further investigation is needed to understand the changes in NO accessibility during aging.
Article
Cardiac & Cardiovascular Systems
Francesca Leo, Tatsiana Suvorava, Sophia K. Heuser, Junjie Li, Anthea LoBue, Frederik Barbarino, Eugenia Piragine, Rebekka Schneckmann, Beate Hutzler, Miranda E. Good, Bernadette O. Fernandez, Lukas Vornholz, Stephen Rogers, Allan Doctor, Maria Grandoch, Johannes Stegbauer, Eddie Weitzberg, Martin Feelisch, Jon O. Lundberg, Brant E. Isakson, Malte Kelm, Miriam M. Cortese-Krott
Summary: This study demonstrates that eNOS in ECs and RBCs independently contribute to blood pressure homeostasis. EC eNOS KO mice exhibited significantly impaired aortic dilatory responses to acetylcholine, loss of flow-mediated dilation, and increased blood pressure. On the other hand, RBC eNOS KO mice showed no alterations in acetylcholine-mediated dilation or flow-mediated dilation but were hypertensive.
Article
Peripheral Vascular Disease
Matthew J. Rossman, Rachel A. Gioscia-Ryan, Jessica R. Santos-Parker, Brian P. Ziemba, Kara L. Lubieniecki, Lawrence C. Johnson, Natalie E. Poliektov, Nina Z. Bispham, Kayla A. Woodward, Erzsebet E. Nagy, Nathan S. Bryan, Julie A. Reisz, Angelo D'Alessandro, Michel Chonchol, Amy L. Sindler, Douglas R. Seals
Summary: Inorganic nitrite supplementation improves endothelial function in older adults by increasing NO, decreasing mitochondrial reactive oxygen species/oxidative stress, and increasing mitochondrial stress resistance.
Article
Biochemistry & Molecular Biology
Tijana Suboticki, Olivera Mitrovic Ajtic, Dragoslava Djikic, Marijana Kovacic, Juan F. Santibanez, Milica Tosic, Vladan P. Cokic
Summary: In various systems, hydroxyurea has been shown to stimulate the release of nitric oxide or activate nitric oxide synthase. Through inhibiting nitric oxide metabolites, hydroxyurea is able to inhibit the growth of mature erythroid colonies and impact the presence of iNOS immunoreactive CFU-E.
Article
Chemistry, Multidisciplinary
Cristina Parisi, Mariacristina Failla, Aurore Fraix, Luca Menilli, Francesca Moret, Elena Reddi, Barbara Rolando, Francesca Spyrakis, Loretta Lazzarato, Roberta Fruttero, Alberto Gasco, Salvatore Sortino
Summary: Researchers have developed a molecular hybrid that releases nitric oxide and superoxide anions, generating peroxynitrite upon red light activation. This hybrid shows good tolerance in various cancer cells and induces significant cell death under red light irradiation.
Article
Chemistry, Physical
Namitha Brijit Bejoy, Prahlad Roy Chowdhury, G. Naresh Patwari
Summary: The release of NO upon photodissociation of nitroaromatic compounds is influenced by the interaction between the NO2 group and substituent in the ortho position. Two distinct NO elimination channels are observed with a bimodal translational energy distribution of the NO photofragment. The hydrogen bonding ability of the ortho substituent regulates the ratio of slow-to-fast branching for NO release, with OH and NH2 favoring the roaming mechanism.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2023)
Article
Pharmacology & Pharmacy
Rose I. M. Batista, Renato C. Nogueira, Graziele C. Ferreira, Gustavo H. Oliveira-Paula, Lucas C. Pinheiro, Jose E. Tanus-Santos
Summary: Supplementation with L-arginine has been shown to have beneficial effects in hypertension by increasing nitric oxide formation and enhancing nitrate concentrations, but these effects may be prevented by antiseptic mouthwash. Alteration of the nitrate cycle in the body by mouthwash can impact endothelial dysfunction, antihypertensive effects, and antioxidant effects of L-arginine in hypertensive rats. The findings suggest a new mechanism where antibacterial mouth rinse can affect arterial blood pressure and the development of cardiovascular diseases.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
A. Ledo, C. F. Lourenco, E. Cadenas, R. M. Barbosa, J. Laranjinha
Summary: Nitric oxide is a biological ubiquitous signaling molecule with unique physical chemical properties, playing important roles in brain physiology, aging, and neurodegeneration. Understanding the concentration dynamics of nitric oxide in the brain is crucial for studying neurovascular coupling and bioenergetic metabolism.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Chemistry, Physical
Ning Yang, Xiaojing Tian, Yuehong Du, Yumeng Zhang, Qiuli Wang, Ning Ma, Yafei Zhang, Wenhang Wang
Summary: In this study, sodium nitrite-loaded gelatin microspheres and gels were prepared using microbial transglutaminase and their physicochemical properties and antibacterial effects were compared. The microspheres showed better antibacterial effect, achieving the goal of extending the shelf life of meat products.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2022)