期刊
FOOD CHEMISTRY
卷 270, 期 -, 页码 305-314出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.foodchem.2018.07.117
关键词
Myricanol; AMP-activated protein kinase; Adipogenesis; Lipid accumulation; Insulin sensitivity; Zebrafish
资金
- Science and Technology Development Fund, Macao S.A.R [FDCT 109/2017/A]
- Research Fund of University of Macau [MYRG2015-00153-ICMS-QRCM, MYRG2017-00109-ICMS]
Myricanol is a diarylheptanoid isolated from Chinese bayberry. Through virtual docking strategy, myricanol was discovered as an AMP-activated protein kinase (AMPK) activator among a series of structural analogs, with high affinity for the. subunit of AMPK. Myricanol was also evaluated for regulatory effects on lipid accumulation and insulin sensitivity in 3T3-L1 adipocytes and adiposity in high-fat diet-fed zebrafish. Myricanol suppressed lipid accumulation in 3T3-L1 cells in the initial stage (days 0-2) by suppressing adipogenesis and in the terminal stage (days 4-7) by inducing lipolysis and lipid combustion through activating AMPK. Moreover, myricanol enhanced insulin-stimulated glucose uptake by activating the insulin signaling pathway. In high-fat diet-fed zebrafish, myricanol inhibited lipid accumulation by suppressing adipogenic factors including peroxisome proliferatoractivated receptor gamma (PPAR gamma) and CCAAT/enhancer binding protein alpha (C/EBP alpha). In summary, the results indicate that myricanol could be a potential therapeutic agent against obesity by activating the AMPK signaling pathway.
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