Article
Veterinary Sciences
Woo Keyoung Kim, Yeon Sung Son, Ji-Hey Lim, Wan Hee Kim, Byung-Jae Kang
Summary: This study demonstrates the successful isolation and propagation of NSPCs derived from the canine cervical spinal cord, which have the potential to differentiate into neuronal and glial cells.
BMC VETERINARY RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Seonguk Yang, Seulah Lee, Yujeong Lee, Jung-Hyun Cho, Sou Hyun Kim, Eun-Sol Ha, Young-Suk Jung, Hae Young Chung, Min-Soo Kim, Hyung Sik Kim, Seung-Cheol Chang, Kyung-Jin Min, Jaewon Lee
Summary: This study investigated the neurotoxicity of polystyrene nanoparticles on neural progenitor cells and hippocampal neurogenesis. The results showed that cationic amine-modified polystyrene had cytotoxic effects, while anionic carboxylate-modified polystyrene and neutral nanoparticles did not. Cationic polystyrene nanoparticles caused mitochondrial dysfunction, energy depletion, and cellular senescence. In vivo studies on mice demonstrated impaired hippocampal neurogenesis and memory retention after exposure to cationic polystyrene nanoparticles.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Neurosciences
Yamila Azul Molinari, Agustin Jesus Byrne, Maria Julia Perez, Lucas Silvestroff, Paula Gabriela Franco
Summary: Despite the extensive use of the cuprizone (CPZ) demyelination animal model, there is little evidence regarding the effects of CPZ on a cellular level. Recent studies have demonstrated that CPZ not only damages mature oligodendrocytes (OL), but also reduces neural stem cell and progenitor cell (NSC/NPC) proliferation and activates progenitor migration. These findings shed light on the direct effects of CPZ on NSC proliferation and in vitro differentiation progression.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Cell Biology
Jiabin Pan, Shiyang Sheng, Ling Ye, Xiaonan Xu, Yizhao Ma, Xuanran Feng, Lisha Qiu, Zhaohuan Fan, Yi Wang, Xiaohuan Xia, Jialin C. Zheng
Summary: This study reveals the crucial role of extracellular vesicles (EVs) in intercellular communication within the tumor microenvironment. Inhibition of the tumorigenic EVs-mediated PI3K-Akt-mTOR pathway activation may provide a novel strategy for glioblastoma therapy.
CELL COMMUNICATION AND SIGNALING
(2022)
Article
Cell Biology
Jordis Klose, Lu Li, Melanie Pahl, Farina Bendt, Ulrike Hubenthal, Christian Jungst, Patrick Petzsch, Astrid Schauss, Karl Kohrer, Ping Chung Leung, Chi Chiu Wang, Katharina Koch, Julia Tigges, Xiaohui Fan, Ellen Fritsche
Summary: Adverse Outcome Pathways (AOPs) provide a framework for linking toxicological mechanistic information with adverse health effects. This study combines phenotypic and transcriptomic analyses to assess the developmental neurotoxicity (DNT) hazards of two Chinese herbal medicines and gain insights into their modes-of-action. The results demonstrate the power of this approach in elucidating compounds' MoA and incorporating them into novel or existing AOPs for a better understanding of DNT risk in a regulatory context.
CELL BIOLOGY AND TOXICOLOGY
(2023)
Article
Food Science & Technology
Yan Zhang, Fei-Fei Yang, Huan Chen, Yao-Dong Qi, Jian-Yong Si, Qing Wu, Yong-Hong Liao
Summary: This study aimed to analyze pyrrolizidine alkaloids in E. fortunei herbs and evaluate their effects on neural progenitor cells. Using LC-MS/MS, 8 PAs were identified with potential negative impacts on cell viability and oligodendrogenesis.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Environmental Sciences
Ha-Na Oh, Donggon Yoo, Seungmin Park, Sangwoo Lee, Woo-Keun Kim
Summary: The study found that glutaraldehyde (GA) has potential neurotoxic effects, inhibiting neurite outgrowth and downregulating specific genes in vitro and in vivo experiments. In zebrafish embryos, GA adversely affected neural morphogenesis, leading to decreased survival and irregular hatching, among other effects.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Environmental Sciences
Ha-Na Oh, Donggon Yoo, Seungmin Park, Sangwoo Lee, Woo-Keun Kim
Summary: The potential developmental neurotoxicity (DNT) of glutaraldehyde (GA) has been demonstrated in vitro and in vivo. GA inhibits neurite outgrowth and alters the expression of neurodevelopmental genes in cell models. GA also affects the early development and neural morphogenesis of zebrafish embryos, resulting in decreased survival, irregular hatching, reduced heart rate, decreased brain and spinal cord width, and decreased myelination of Schwann cells and oligodendrocytes.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Ophthalmology
Luciano Fiore, Cindy Lorena Olmos-Carreno, Mara Medori, Gonzalo Spelzini, Viviana Sanchez, Gabriel Scicolone
Summary: The study found that neural progenitor cells (NPCs) in the neurogenic niche CM of the chicken eye have positional values along the radial and tangential axes, and have the potential to differentiate into retinal ganglion cells (RGCs). These RGCs also retain positional values along the tangential axis and respond to the Eph/ephrin axon guidance system. These findings contribute to the understanding of cellular and molecular mechanisms involved in CNS development and regeneration.
EXPERIMENTAL EYE RESEARCH
(2022)
Review
Developmental Biology
Wenlong Xia, Stephen P. J. Fancy
Summary: This article discusses factors influencing the migration of oligodendrocytes, including long-range guidance cues, factors regulating cellular motility, and critical factors determining final positioning. Recent studies have identified the vasculature as the physical substrate used by oligodendrocyte progenitor cells for migration, providing new insights into the relationship between oligodendrocytes and blood vessels in the developing and adult brain.
DEVELOPMENTAL NEUROBIOLOGY
(2021)
Review
Neurosciences
Chiara Ossola, Nereo Kalebic
Summary: The development of the cerebral cortex is a complex process, and disturbances in the characteristics of neural progenitor cells are associated with cortical developmental abnormalities that can lead to neurodevelopmental disorders.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Neurosciences
Juliana Minardi Nascimento, Danielle Gouvea-Junqueira, Giuliana S. Zuccoli, Carolina da Silva Gouveia Pedrosa, Caroline Brandao-Teles, Fernanda Crunfli, Andre S. L. M. Antunes, Juliana S. Cassoli, Karina Karmirian, Jose Alexandre Salerno, Gabriela Fabiano de Souza, Stefanie Primon Muraro, Jose Luiz Proenca-Modena, Luiza M. Higa, Amilcar Tanuri, Patricia P. Garcez, Stevens K. Rehen, Daniel Martins-de-Souza
Summary: This study investigates the proteomic alterations induced by the Brazilian and African strains of Zika virus as well as the molecular responses to dengue virus. The results reveal that both Zika virus and dengue virus lead to biological effects such as cell death, cell cycle dysregulation, and neurogenesis.
MOLECULAR NEUROBIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Britt Mossink, Moritz Negwer, Dirk Schubert, Nael Nadif Kasri
Summary: This review discusses the important role of chromatin remodelers in neurodevelopment, indicating that gene mutations in NDDs are related to epigenetics, which is an important pathogenic pathway between these disorders. Over time, chromatin remodeling defects can result in impaired brain circuit establishment, especially in glutamatergic neurons, GABAergic neurons, and glia cells.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Megan Chesnut, Thomas Hartung, Helena Hogberg, David Pamies
Summary: Neurodevelopment is highly sensitive to toxic insults, and there is a lack of evaluation on the potential developmental neurotoxicity (DNT) of most commonly used chemicals. Using human cell-based in vitro systems for testing DNT chemicals can aid in prioritizing them based on their effects on neurodevelopment, but there is a limited number of in vitro models for myelination, which is a fundamental process in neurodevelopment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Nutrition & Dietetics
Marta Czarnowska-Kujawska, Joanna Klepacka, Olga Zielinska, Maria de Lourdes Samaniego-Vaesken
Summary: The dietary supplements market in Poland has a high number of products containing folic acid, but many of them do not meet the declared values on the labels, raising concerns about inaccurate information. The results indicate the urgent need for improvements in the notification system and monitoring the authenticity of these products to ensure consumers are provided with accurate folic acid supplements.
Article
Biochemistry & Molecular Biology
Adelina Orellana, Pablo Garcia-Gonzalez, Sergi Valero, Laura Montrreal, Itziar de Rojas, Isabel Hernandez, Maitee Rosende-Roca, Liliana Vargas, Juan Pablo Tartari, Ester Esteban-De Antonio, Urszula Bojaryn, Leire Narvaiza, Emilio Alarcon-Martin, Montserrat Alegret, Daniel Alcolea, Alberto Lleo, Lluis Tarraga, Vanesa Pytel, Amanda Cano, Marta Marquie, Merce Boada, Agustin Ruiz
Summary: This study established internal cutoffs for CSF biomarkers to differentiate between Alzheimer's disease patients and amyloid-negative subjective cognitive decline individuals. The results obtained by two different methods showed good agreement but are not interchangeable. CLEIA is a good and faster alternative for providing AT(N) classification. AT(N) classifiers increase the certainty of mild cognitive impairment prognosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Triana Espinosa-Jimenez, Oriol Busquets, Amanda Cano, Elena Sanchez-Lopez, Ester Verdaguer, Antoni Parcerisas, Jordi Olloquequi, Carme Auladell, Jaume Folch, Walter Wahli, Manuel Vazquez-Carrera, Antoni Camins, Miren Ettcheto
Summary: Peroxisome proliferator-activated receptor beta/delta (PPAR beta/delta) plays a key role in microglial homeostasis and metabolism in the central nervous system. However, its contribution to neuronal and memory processes is still not well-understood. This study aimed to evaluate the role of PPAR beta/delta in neuropathological pathways associated with memory impairment and the modulation of these pathways by obesity. The results showed that PPAR beta/delta deficiency affects neuronal and synaptic structure, leading to memory dysfunction.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Medicine, Research & Experimental
Jordi Olloquequi, Amanda Cano, Elena Sanchez-Lopez, Marina Carrasco, Ester Verdaguer, Ana Fortuna, Jaume Folch, Monica Bullo, Carme Auladell, Antoni Camins, Miren Ettcheto
Summary: PTP1B is a potential target for the treatment of neurological diseases, as its activation in brain cells can lead to various neuronal deficits. However, inhibition of PTP1B has shown promising therapeutic effects and potential to improve cognitive processes. Clinical trials evaluating the neurological benefits of PTP1B inhibition are still needed.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Amanda Cano, Miren Ettcheto, Mireia Bernuz, Raquel Puerta, Ester Esteban de Antonio, Elena Sanchez-Lopez, Eliana B. Souto, Antonio Camins, Merce Marti, Maria Isabel Pividori, Merce Boada, Agustin Ruiz
Summary: Extracellular vesicles are secreted by cells and play important roles in intercellular communication, immune responses, human reproduction, and synaptic plasticity. They have potential as biomarkers for diseases due to their biological relevance and easy accessibility. They can also be used as mirrors of brain diseases as they can cross the blood-brain barrier. This review explores their biogenesis, functions, and potential in clinical practice, as well as their role in major human brain diseases.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Marta Marquie, Fernando Garcia-Gutierrez, Adelina Orellana, Laura Montrreal, Itziar de Rojas, Pablo Garcia-Gonzalez, Raquel Puerta, Claudia Olive, Amanda Cano, Isabel Hernandez, Maitee Rosende-Roca, Liliana Vargas, Juan Pablo Tartari, Ester Esteban-De Antonio, Urszula Bojaryn, Mario Ricciardi, Diana M. Ariton, Vanesa Pytel, Montserrat Alegret, Gemma Ortega, Ana Espinosa, Alba Perez-Cordon, Angela Sanabria, Nathalia Munoz, Nuria Lleonart, Nuria Aguilera, Ainhoa Garcia-Sanchez, Emilio Alarcon-Martin, Lluis Tarraga, Agustin Ruiz, Merce Boada, Sergi Valero
Summary: This study found that the association between Alzheimer's disease biomarkers and neuropsychiatric symptoms has a significant impact on the conversion to dementia in patients with mild cognitive impairment. A total of 500 individuals with MCI were followed-up yearly, and it was found that certain AT(N) profiles and the presence of depression and apathy were associated with a higher risk of conversion. The additive combination of AT(N) profile with depression exacerbates the risk of conversion, and a synergic effect of prodromal AD profile with depressive symptoms is evidenced.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Pablo Garcia-Gonzalez, Itziar de Rojas, Sonia Moreno-Grau, Laura Montrreal, Raquel Puerta, Emilio Alarcon-Martin, Ines Quintela, Adela Orellana, Victor Andrade, Pamela V. Martino Adami, Stefanie Heilmann-Heimbach, Pilar Gomez-Garre, Maria Teresa Perinan, Ignacio Alvarez, Monica Diez-Fairen, Raul Nunez Llaves, Claudia Olive Roig, Guillermo Garcia-Ribas, Manuel Menendez-Gonzalez, Carmen Martinez, Miquel Aguilar, Mariateresa Buongiorno, Emilio Franco-Macias, Maria Eugenia Saez, Amanda Cano, Maria J. Bullido, Luis Miguel Real, Eloy Rodriguez-Rodriguez, Jose Luis Royo, Victoria Alvarez, Pau Pastor, Gerard Pinol-Ripoll, Pablo Mir, Miguel Calero Lara, Miguel Medina Padilla, Pascual Sanchez-Juan, Angel Carracedo, Sergi Valero, Isabel Hernandez, Lluis Tarraga, Alfredo Ramirez, Merce Boada, Agustin Ruiz
Summary: Mosaic loss of chromosome Y (mLOY) is a common somatic event associated with Alzheimer's disease (AD) and can be age-confounded in genome-wide association studies. This study used Mendelian randomisation to construct an age-independent mLOY polygenic risk score (mloy-PRS) and found that higher genetic risk for mLOY was associated with faster progression to AD in men with mild cognitive impairment. The study suggests that mLOY is involved in AD pathogenesis and shows associations with cerebrospinal fluid biomarkers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Itziar de Rojas, Laura del Barrio, Isabel Hernandez, Laura Montrreal, Pablo Garcia-Gonzalez, Marta Marquie, Sergi Valero, Amanda Cano, Adelina Orellana, Merce Boada, Santos Manes, Agustin Ruiz
Summary: Cholesterol efflux capacity (CEC), which is closely related to Alzheimer's disease and other clinical conditions, is determined by APOE genotype and plasma metabolome profile. In this study, it was found that plasma 3-hydroxybutyrate and male sex were strongly correlated with CEC. Most NMR particles associated with CEC were not correlated with APOE genotype. The study confirmed the impact of APOE genotype on plasma lipoprotein particles and omega-3 fatty acids independently of plasma cholesterol level.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Chemistry, Multidisciplinary
Gerard Riesco-Llach, Marta Planas, Lidia Feliu, John A. Joule
Summary: Pyrazinones are components of natural substances and are important for the synthesis of bioactive molecules. This review summarizes the strategies developed for the synthesis of pyrazinones from acyclic precursors, particularly alpha-amino acid-derived units, from the earliest examples in 1905 to the latest research in 2021.
Review
Pharmacology & Pharmacy
Amanda Cano, Alvaro Munoz-Morales, Elena Sanchez-Lopez, Miren Ettcheto, Eliana B. Souto, Antonio Camins, Merce Boada, Agustin Ruiz
Summary: Neurodegenerative diseases have unknown etiology in many cases and lack effective treatments. The blood-brain barrier poses a challenge for drug delivery. Exosomes, secreted vesicles, have emerged as promising therapeutic tools due to their natural origin and molecular similarities. They are particularly promising for targeting neurodegenerative diseases due to the difficulty of accessing the brain and the complexity of the diseases.
Article
Multidisciplinary Sciences
Xavier Morato, Marta Marquie, Juan Pablo Tartari, Asuncion Lafuente, Carla Abdelnour, Montserrat Alegret, Sara Jofresa, Mar Buendia, Ana Pancho, Nuria Aguilera, Marta Ibarria, Susana Diego, Rosario Cuevas, Laia Canada, Anna Calvet, Ester Esteban-De Antonio, Alba Perez-Cordon, Angela Sanabria, Itziar de Rojas, Raul Nunez-Llaves, Amanda Cano, Adelina Orellana, Laura Montrreal, Pilar Canabate, Maitee Rosende-Roca, Liliana Vargas, Urszula Bojaryn, Mario Ricciardi, Diana M. Ariton, Ana Espinosa, Gemma Ortega, Nathalia Munoz, Nuria Lleonart, Emilio Alarcon-Martin, Mariola Moreno, Silvia Preckler, Natalia Tantinya, Maribel Ramis, Ana Belen Nogales, Susanna Seguer, Elvira Martin, Vanesa Pytel, Sergi Valero, Miren Gurruchaga, Lluis Tarraga, Agustin Ruiz, Merce Boada
Summary: The pathophysiological mechanisms of cognitive impairment in Alzheimer's disease involve neuroinflammation and oxidative stress. The standardized extract of Ginkgo biloba EGb 761 has been shown to interfere with these mechanisms. This study aims to compare changes in blood markers of inflammation and oxidative stress after treatment with EGb 761 in patients with mild cognitive impairment, and also assess changes in cognitive test scores.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Triana Espinosa-Jimenez, Amanda Cano, Elena Sanchez-Lopez, Jordi Olloquequi, Jaume Folch, Monica Bullo, Ester Verdaguer, Carme Auladell, Caterina Pont, Diego Munoz-Torrero, Antoni Parcerisas, Antoni Camins, Miren Ettcheto
Summary: This study evaluated the effects of a synthesized inhibitor called RHE-HUP on APP/PS1 mice, a familial AD mouse model challenged by high-fat diet to simulate a T2DM-like condition. Results showed that RHE-HUP reduced the main hallmarks of AD, including Tau hyperphosphorylation, A beta(42) peptide levels, and plaque formation. Additionally, it decreased inflammation, increased synaptic proteins and neurotrophic factors, leading to memory improvement. Importantly, these improvements were observed at a central level without peripheral modifications induced by HFD consumption.
CELL AND BIOSCIENCE
(2023)
Article
Biotechnology & Applied Microbiology
Amanda Cano, Ester Esteban-de-Antonio, Mireia Bernuz, Raquel Puerta, Pablo Garcia-Gonzalez, Itziar de Rojas, Claudia Olive, Alba Perez-Cordon, Laura Montrreal, Raul Nunez-Llaves, Oscar Sotolongo-Grau, Emilio Alarcon-Martin, Sergi Valero, Montserrat Alegret, Elvira Martin, Pamela V. Martino-Adami, Miren Ettcheto, Antonio Camins, Assumpta Vivas, Marta Gomez-Chiari, Miguel angel Tejero, Adelina Orellana, Lluis Tarraga, Marta Marquie, Alfredo Ramirez, Merce Marti, Maria Isabel Pividori, Merce Boada, Agustin Ruiz
Summary: Alzheimer's disease (AD) is commonly preceded by a prodromal phase characterized by high levels of A beta and p-tau-mediated neuronal injury and mild cognitive impairment (MCI). Differential diagnosis of MCI causes in these prodromal stages is a challenge for clinicians. Blood biomarkers, particularly plasma extracellular vesicles (pEVs), are emerging as potential tools for early AD detection.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Neurosciences
Marta Marquie, Ainhoa Garcia-Sanchez, Emilio Alarcon-Martin, Joan Martinez, Miguel Castilla-Marti, Luis Castilla-Marti, Adelina Orellana, Laura Montrreal, Itziar de Rojas, Pablo Garcia-Gonzalez, Raquel Puerta, Claudia Olive, Amanda Cano, Isabel Hernandez, Maitee Rosende-Roca, Liliana Vargas, Juan Pablo Tartari, Ester Esteban-De Antonio, Urszula Bojaryn, Mario Ricciardi, Diana M. Ariton, Vanesa Pytel, Montserrat Alegret, Gemma Ortega, Ana Espinosa, Alba Perez-Cordon, Angela Sanabria, Nathalia Munoz, Nuria Lleonart, Nuria Aguilera, Lluis Tarraga, Sergi Valero, Agustin Ruiz, Merce Boada
Summary: This study aimed to investigate the association between macular vessel density measured by optical coherence tomography angiography (OCT-A) and the AT(N) classification based on cerebrospinal fluid (CSF) biomarkers in individuals with mild cognitive impairment (MCI). The results showed that there was no association between macular vessel density measures and the AT(N) classification in MCI patients.
FRONTIERS IN NEUROSCIENCE
(2023)
Review
Biochemistry & Molecular Biology
Jordi Olloquequi, Miren Ettcheto, Amanda Cano, Elena Sanchez-Lopez, Marina Carrasco, Triana Espinosa, Carlos Beas-Zarate, Graciela Gudino-Cabrera, Monica E. Urena-Guerrero, Ester Verdaguer, Jaume Folch, Carme Auladell, Antoni Camins
Summary: The increasing population ageing and growth have led to a rise in the number of people living with dementia, with Alzheimer's disease being the most common cause. Although a cure for Alzheimer's disease has not been found yet, there are proposed treatments that may alter disease progression and help manage symptoms. In addition to the traditional hypotheses of Alzheimer's disease etiopathogenesis involving amyloid beta peptide accumulation and tau hyperphosphorylation, there is a trend that emphasizes the role of other molecular mechanisms, prompting the study of different therapeutic targets.
FRONTIERS IN BIOSCIENCE-LANDMARK
(2022)
