期刊
FITOTERAPIA
卷 132, 期 -, 页码 75-81出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.fitote.2018.11.017
关键词
Paralactonic acids; Antimicrobial activity; Ca2+-signaling; Paraconiothyrium sp.; Chondrus ocellatus Holmes
Five polyketides, paralactonic acids A-E (1-5) were isolated from Paraconiothyrium sp. SW-B-1, an endophytic fungus isolated from the seaweed, Chondrus ocellatus Holmes. Their structures were determined by various spectroscopic methods, predominantly by 2D NMR spectroscopic analyses. The absolute configurations of compounds 1-5 were determined by comparison of the experimental and calculated ECD spectra. Compound 5 showed moderate antibacterial activity and restored the growth of a mutant yeast strain inhibited by hyper-activated Ca2+-signaling.
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