Article
Biochemistry & Molecular Biology
Benjamin X. Wang, Julie Takagi, Abigail McShane, Jin Hwan Park, Kazuhiro Aoki, Catherine Griffin, Jennifer Teschler, Giordan Kitts, Giulietta Minzer, Michael Tiemeyer, Rachel Hevey, Fitnat Yildiz, Katharina Ribbeck
Summary: We found that mucin polymers are potent regulators that block toxigenic conversion and suppress the expression of virulence factors in V. cholerae, mediated by CTX phi. This discovery highlights the novel role of mucins and their associated O-glycan structures in modulating the evolution and pathogenicity of V. cholerae through interfering with the TcpP/ToxR/ToxT virulence pathway.
Article
Immunology
Huihui Sun, Ming Liu, Fenxia Fan, Zhe Li, Yufeng Fan, Jingyun Zhang, Yuanming Huang, Zhenpeng Li, Jie Li, Jialiang Xu, Biao Kan
Summary: This study investigated the infection mechanism of lytic phage VP2 on Vibrio cholerae and found that the type II secretory system plays a significant role in this process.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Environmental Sciences
Eizo Takahashi, Kei Kitahara, Shin-ichi Miyoshi, Goutam Chowdhury, Asish K. Mukhopadhyay, Shanta Dutta, Sadayuki Ochi, Keinosuke Okamoto
Summary: Many cholera patients are found in Kolkata, India every year, indicating the widespread presence of cholera toxin-producing Vibrio cholerae O1. Suitable conditions for the replication of toxigenic V. cholerae O1 are provided in Kolkata. A study showed that the replication rate of toxigenic V. cholerae O1 is low in low ionic aqueous solution. The ion concentration in the environmental water of Kolkata was found to be significantly high, suggesting the suitability of Kolkata's environmental water for the survival of V. cholerae O1.
ENVIRONMENTAL RESEARCH
(2023)
Article
Virology
Fenxia Fan, Zhenpeng Li, Jiazheng Wang, Baowei Diao, Weili Liang, Biao Kan
Summary: This study identified VcpQ as the receptor for bacteriophage VP1 infection of Vibrio cholerae, with the reduction of glutamine residues in VcpQ affecting VP1 adsorption and likely being the main cause of resistance in natural resistant strains. Mutations in the polyQ stretch may provide V. cholerae with phage resistance and enhance survival against VP1 or related phages.
JOURNAL OF VIROLOGY
(2021)
Article
Microbiology
Ranjan Kumar Barman, Alok Kumar Chakrabarti, Shanta Dutta
Summary: Cholera continues to be a major burden for developing nations, and the rise of antimicrobial-resistant strains of Vibrio cholerae highlights the need for alternative therapeutic strategies. Bacteriophage therapy is considered a promising alternative to antibiotics. This study conducted a comprehensive comparative analysis of 86 Vibrio cholerae phages, identifying clusters and singletons based on sequence similarity. Within the clusters, there were high levels of sequence and functional similarities. The study also proposed potential therapeutic phages for cholera based on a system biology approach.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Claire Vit, Egill Richard, Florian Fournes, Clemence Whiteway, Xavier Eyer, Delphine Lapaillerie, Vincent Parissi, Didier Mazel, Celine Loot
Summary: In this study, it was found that cassette recruitment in the Vibrio cholerae chromosomal integron mainly occurs at the attIA site, with newly inserted cassettes being expressed and selected due to the presence of a promoter in the vicinity of this site. The RecA protein plays a critical role in this process, but the V. cholerae integron integrase is not active in other bacteria.
NUCLEIC ACIDS RESEARCH
(2021)
Article
Microbiology
Heidi A. Butz, Alexandra R. Mey, Ashley L. Ciosek, Alexander A. Crofts, Bryan W. Davies, Shelley M. Payne
Summary: CsrA is a critical posttranscriptional global regulator in Vibrio cholerae, controlling 22% of the bacterial transcriptome involving various cellular processes. Through RNA coimmunoprecipitation experiments, it was found that CsrA binds to multiple mRNAs encoding regulatory proteins, including major sigma factors. Additionally, CsrA directly binds to virulence gene transcripts, positively regulating the production of important virulence factors.
Article
Cell Biology
Lena O. Jones, Reegan J. Willms, Xinyue Xu, Ralph Derrick Graham, Mckenna Eklund, Minjeong Shin, Edan Foley
Summary: This study uses a natural infection model to characterize the host mucosal responses to Vibrio in adult zebrafish guts. The results show that Vibrio causes a mild mucosal immune response and suppresses host interferon signaling, and the activation of interferon alters the course of infection. The study also reveals similarities between zebrafish and mammalian guts, providing insights into host-pathogen interactions.
Review
Microbiology
Laura Alvarez, Sara B. Hernandez, Felipe Cava
Summary: The cell wall of most bacteria, composed of peptidoglycan, plays a crucial role in protecting them from environmental stressors. Vibrio cholerae has become a major model for studying cell wall genetic determinants, regulatory links, and adaptive mechanisms, shedding light on novel insights. This review provides a comprehensive overview of V. cholerae's cell wall biology and genetics, emphasizing the similarities and differences with Escherichia coli.
ANNUAL REVIEW OF MICROBIOLOGY, VOL 75, 2021
(2021)
Article
Environmental Sciences
Candice A. Thorstenson, Matthias S. Ullrich
Summary: The potential spread of infectious diseases in response to climate change and rising sea surface temperatures in temperate regions has raised concerns over the past few decades. Different species of Vibrio, particularly Vibrio cholerae, Vibrio parahaemolyticus, and Vibrio vulnificus, have been correlated with human health risks in relation to extreme heat waves in the North Atlantic and North Sea regions. Studying the behavior and ecology of both pathogenic and non-pathogenic strains of these bacteria can provide insights into their native microbiome and how they disperse in coastal regions.
FRONTIERS IN MARINE SCIENCE
(2021)
Article
Multidisciplinary Sciences
Moiz Usmani, Kyle D. Brumfield, Bailey M. Magers, Juan Chaves-Gonzalez, Helen Ticehurst, Rosa Barciela, Fergus McBean, Rita R. Colwell, Antarpreet Jutla
Summary: Cholera remains a global public health threat in vulnerable regions, where climate and weather processes intersect with infectious Vibrio cholerae. Predictive abilities for forecasting cholera risk can aid in combating disease outbreaks, as demonstrated by a study in Yemen. The study developed a predictive model that accurately predicted cholera risk at least four weeks in advance for all governorates of Yemen.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Junxiang Yan, Qian Liu, Xinke Xue, Jinghao Li, Yuehua Li, Yingying Su, Boyang Cao
Summary: This study reveals that the VC1795 gene plays a key role in the intestinal colonization and pathogenicity of Vibrio cholerae, and it regulates the expression of its downstream gene, VC1794, and the toxin-coregulated pilus (TCP) cluster. These findings provide insights into the regulatory mechanisms of VC1795 in bacterial pathogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Wilfredo R. Matias, Yodeline Guillaume, Gertrude Cene Augustin, Kenia Vissieres, Ralph Ternier, Richelle C. Charles, Jason B. Harris, Molly F. Franke, Louise C. Ivers
Summary: In 2017, the prevalence of cholera infection was high among adults in two areas of Haiti, indicating the need for improved surveillance programs to guide public health interventions.
EMERGING INFECTIOUS DISEASES
(2023)
Review
Microbiology
Roberto C. Molina-Quiroz, Cecilia A. Silva-Valenzuela
Summary: Bacteriophages are viruses that infect bacteria and have been used as a model system in microbial genetics and molecular biology. Understanding the arms race between bacteria and phages is important for the design of phage-based therapies for bacterial infections. Vibrio species and their phages provide a suitable model to study these interactions in aquatic environments.
CURRENT OPINION IN MICROBIOLOGY
(2023)
Article
Microbiology
Xiaojian Gao, Zirui Zhang, Qieqi Qian, Qiyun Chen, Shuwen Gu, Jie Li, Yingjie Zhang, Congcong Wu, Qun Jiang, Xiaojun Zhang
Summary: Non-O1/O139 Vibrio cholerae can survive under starvation stress for a long period of time and cause disease by altering cell structure, upregulating stress resistance-related genes, and downregulating flagellum assembly-related genes. This knowledge can contribute to the development of intervention strategies for controlling non-O1/O139 V. cholerae infection in aquaculture.
MICROBIOLOGY SPECTRUM
(2022)
