Red blood cells as an organ? How deep omics characterization of the most abundant cell in the human body highlights other systemic metabolic functions beyond oxygen transport

Increased erythrophagocytosis induces ferroptosis in red pulp macrophages in a mouse model of transfusion

(2018) Lyla A. Youssef et al.   BLOOD

The Science and Translation of Lactate Shuttle Theory

(2018) George A. Brooks   Cell Metabolism

Macrophage-derived IL-1β/NF-κB signaling mediates parenteral nutrition-associated cholestasis

(2018) Karim C. El Kasmi et al.   Nature Communications

Efficient RNA drug delivery using red blood cell extracellular vesicles

(2018) Waqas Muhammad Usman et al.   Nature Communications

Hypoxia modulates the purine salvage pathway and decreases red blood cell and supernatant levels of hypoxanthine during refrigerated storage

(2017) Travis Nemkov et al.   HAEMATOLOGICA

A Relay Pathway between Arginine and Tryptophan Metabolism Confers Immunosuppressive Properties on Dendritic Cells

(2017) Giada Mondanelli et al.   IMMUNITY

Kynurenine Pathway Metabolites in Alzheimer’s Disease

(2017) Lasse Melvaer Giil et al.   JOURNAL OF ALZHEIMERS DISEASE

Testosterone regulates the expression and functional activity of sphingosine-1-phosphate receptors in the rat corpus cavernosum

(2017) Jing Yin et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Quantitative Analysis of Human Red Blood Cell Proteome

(2017) Agata H. Bryk et al.   JOURNAL OF PROTEOME RESEARCH

Plasma succinate is a predictor of mortality in critically injured patients

(2017) Angelo DʼAlessandro et al.   Journal of Trauma and Acute Care Surgery

Human umbilical cord plasma proteins revitalize hippocampal function in aged mice

(2017) Joseph M. Castellano et al.   NATURE

Interleukin 37 reverses the metabolic cost of inflammation, increases oxidative respiration, and improves exercise tolerance

(2017) Giulio Cavalli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Involvement of the kynurenine pathway in the pathogenesis of Parkinson’s disease

(2017) Chai K. Lim et al.   PROGRESS IN NEUROBIOLOGY

A three-minute method for high-throughput quantitative metabolomics and quantitative tracing experiments of central carbon and nitrogen pathways

(2017) Travis Nemkov et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

Murine red blood cells from genetically distinct donors cross-regulate when stored together

(2017) Ariel Hay et al.   TRANSFUSION

Metabolomics comparison of red cells stored in four additive solutions reveals differences in citrate anticoagulant permeability and metabolism

(2017) Ó. Rolfsson et al.   VOX SANGUINIS

Erythrocyte nanovesicles: Biogenesis, biological roles and therapeutic approach

(2017) Gamaleldin I. Harisa et al.   SAUDI PHARMACEUTICAL JOURNAL

Erythrocytes retain hypoxic adenosine response for faster acclimatization upon re-ascent

(2017) Anren Song et al.   Nature Communications

Hypoxia modulates the purine salvage pathway and decreases red blood cell and supernatant levels of hypoxanthine during refrigerated storage

(2017) Travis Nemkov et al.   HAEMATOLOGICA

Plasma succinate is a predictor of mortality in critically injured patients

(2017) Angelo DʼAlessandro et al.   Journal of Trauma and Acute Care Surgery

Red blood cells release microparticles containing human argonaute 2 and miRNAs to target genes of Plasmodium falciparum

(2017) Zhensheng Wang et al.   Emerging Microbes & Infections

Involvement of acetylcholinesterase and protein kinase C in the protective effect of caffeine against β-amyloid-induced alterations in red blood cells

(2016) Cristiana Carelli-Alinovi et al.   BIOCHIMIE

Reversible binding of hemoglobin to band 3 constitutes the molecular switch that mediates O2 regulation of erythrocyte properties

(2016) H. Chu et al.   BLOOD

Adenosine monophosphate deaminase 3 activation shortens erythrocyte half-life and provides malaria resistance in mice

(2016) E. Hortle et al.   BLOOD

Oxidative modifications of glyceraldehyde 3-phosphate dehydrogenase regulate metabolic reprogramming of stored red blood cells

(2016) J. A. Reisz et al.   BLOOD

Lactate Wreaks Havoc on Tumor-Infiltrating T and NK Cells

(2016) Kristen E.N. Scott et al.   Cell Metabolism

Metformin as a Tool to Target Aging

(2016) Nir Barzilai et al.   Cell Metabolism

LDHA-Associated Lactic Acid Production Blunts Tumor Immunosurveillance by T and NK Cells

(2016) Almut Brand et al.   Cell Metabolism

A Comprehensive Review on Eryptosis

(2016) Etheresia Pretorius et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Beneficial Role of Erythrocyte Adenosine A2B Receptor–Mediated AMP-Activated Protein Kinase Activation in High-Altitude HypoxiaClinical Perspective

(2016) Hong Liu et al.   CIRCULATION

Glucose 6-phosphate dehydrogenase deficient subjects may be better “storers” than donors of red blood cells

(2016) Vassilis L. Tzounakas et al.   FREE RADICAL BIOLOGY AND MEDICINE

Metabolic pathways that correlate with post-transfusion circulation of stored murine red blood cells

(2016) K. de Wolski et al.   HAEMATOLOGICA

Prolonged red cell storage before transfusion increases extravascular hemolysis

(2016) Francesca Rapido et al.   JOURNAL OF CLINICAL INVESTIGATION

AltitudeOmics: Red Blood Cell Metabolic Adaptation to High Altitude Hypoxia

(2016) Angelo D’Alessandro et al.   JOURNAL OF PROTEOME RESEARCH

Comparison of the Proteome of Adult and Cord Erythroid Cells, and Changes in the Proteome Following Reticulocyte Maturation

(2016) Marieangela C. Wilson et al.   MOLECULAR & CELLULAR PROTEOMICS

Bioactive lipids accumulate in stored red blood cells despite leukoreduction: a targeted metabolomics study

(2016) Xiaoyun Fu et al.   TRANSFUSION

Citrate metabolism in red blood cells stored in additive solution-3

(2016) Angelo D'Alessandro et al.   TRANSFUSION

Testosterone-dependent sex differences in red blood cell hemolysis in storage, stress, and disease

(2016) Tamir Kanias et al.   TRANSFUSION

Sphingosine-1-phosphate promotes erythrocyte glycolysis and oxygen release for adaptation to high-altitude hypoxia

(2016) Kaiqi Sun et al.   Nature Communications

Revised Estimates for the Number of Human and Bacteria Cells in the Body

(2016) Ron Sender et al.   PLOS BIOLOGY

Metabolic pathways that correlate with post-transfusion circulation of stored murine red blood cells

(2016) K. de Wolski et al.   HAEMATOLOGICA

Hypoxia-mediated impaired erythrocyte Lands’ Cycle is pathogenic for sickle cell disease

(2016) Hongyu Wu et al.   Scientific Reports

Purinergic transmission in blood vessels

(2015) Vera Ralevic et al.   AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL

Macrophages and iron trafficking at the birth and death of red cells

(2015) T. Korolnek et al.   BLOOD

The human microbiome in hematopoiesis and hematologic disorders

(2015) V. E. Manzo et al.   BLOOD

A TDO2-AhR Signaling Axis Facilitates Anoikis Resistance and Metastasis in Triple-Negative Breast Cancer

(2015) Nicholas C. D'Amato et al.   CANCER RESEARCH

Red Blood Cell Dysfunction Induced by High Fat Diet: Potential Implications for Obesity-Related Atherosclerosis

(2015) Dusten Unruh et al.   CIRCULATION

Splenic Dendritic Cells Survey Red Blood Cells for Missing Self-CD47 to Trigger Adaptive Immune Responses

(2015) Tangsheng Yi et al.   IMMUNITY

Amino acid uptake in erythropoiesis

(2015) David G. Nathan   Science Signaling

Uric acid variation among regular blood donors is indicative of red blood cell susceptibility to storage lesion markers: A new hypothesis tested

(2015) Vassilis L. Tzounakas et al.   TRANSFUSION

Metabolomics in transfusion medicine

(2015) Travis Nemkov et al.   TRANSFUSION

Crosstalk between Red Blood Cells and the Immune System and Its Impact on Atherosclerosis

(2015) Brigitta Buttari et al.   Biomed Research International

Amino acid uptake in erythropoiesis

(2015) David G. Nathan   Science Signaling

Cannabidiol: Pharmacology and potential therapeutic role in epilepsy and other neuropsychiatric disorders

(2014) Orrin Devinsky et al.   EPILEPSIA

Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice

(2014) Saul A Villeda et al.   NATURE MEDICINE

Endothelial nitric oxide synthase in red blood cells: Key to a new erythrocrine function?

(2014) Miriam M. Cortese-Krott et al.   Redox Biology

N-methyl-d-aspartate receptors in human erythroid precursor cells and in circulating red blood cells contribute to the intracellular calcium regulation

(2013) Asya Makhro et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

An estimation of the number of cells in the human body

(2013) Eva Bianconi et al.   ANNALS OF HUMAN BIOLOGY

Contribution made by parabiosis to the understanding of energy balance regulation

(2013) Ruth B.S. Harris   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Testosterone Induces Erythrocytosis via Increased Erythropoietin and Suppressed Hepcidin: Evidence for a New Erythropoietin/Hemoglobin Set Point

(2013) E. Bachman et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Serotonin Is a Key Factor for Mouse Red Blood Cell Survival

(2013) Pascal Amireault et al.   PLoS One

Strain-specific red blood cell storage, metabolism, and eicosanoid generation in a mouse model

(2013) James C. Zimring et al.   TRANSFUSION

Ontogeny of erythroid gene expression

(2012) P. D. Kingsley et al.   BLOOD

Transfusion of human volunteers with older, stored red blood cells produces extravascular hemolysis and circulating non-transferrin-bound iron

(2011) E. A. Hod et al.   BLOOD

iAB-RBC-283: A proteomically derived knowledge-base of erythrocyte metabolism that can be used to simulate its physiological and patho-physiological states

(2011) Aarash Bordbar et al.   BMC Systems Biology

Regulation of Phosphatidylserine Exposure in Red Blood Cells

(2011) Duc Bach Nguyen et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

The Dopaminergic System in Peripheral Blood Lymphocytes: From Physiology to Pharmacology and Potential Applications to Neuropsychiatric Disorders

(2011) Clelia Pellicano et al.   Current Neuropharmacology

Iron and intestinal immunity

(2011) Bobby J. Cherayil et al.   CURRENT OPINION IN GASTROENTEROLOGY

The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression

(2010) Jean-Philippe Coppé et al.   Annual Review of Pathology-Mechanisms of Disease

Transfusion of red blood cells after prolonged storage produces harmful effects that are mediated by iron and inflammation

(2010) E. A. Hod et al.   BLOOD

AMPKα1 Deletion Shortens Erythrocyte Life Span in Mice

(2010) Shaobin Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Markers of Oxidative Stress in Erythrocytes and Plasma During Aging in Humans

(2010) Kanti Bhooshan Pandey et al.   Oxidative Medicine and Cellular Longevity

Differential profiling of human red blood cells during storage for 52 selected microRNAs

(2010) Meganathan Kannan et al.   TRANSFUSION

Perfusion vs. oxygen delivery in transfusion with “fresh” and “old” red blood cells: The experimental evidence

(2010) Amy G. Tsai et al.   TRANSFUSION AND APHERESIS SCIENCE

Sphingosine-1-phosphate and immune regulation: trafficking and beyond

(2010) Hongbo Chi   TRENDS IN PHARMACOLOGICAL SCIENCES

The Red Blood Cell Proteome and Interactome: An Update

(2009) Angelo D’Alessandro et al.   JOURNAL OF PROTEOME RESEARCH

Characterization of glycolytic enzyme interactions with murine erythrocyte membranes in wild-type and membrane protein knockout mice

(2008) M. E. Campanella et al.   BLOOD

Eryptosis, a Window to Systemic Disease

(2008) Florian Lang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Hypoxic Vasodilation by Red Blood Cells

(2008) Diana L. Diesen et al.   CIRCULATION RESEARCH

Dynamics of shear-induced ATP release from red blood cells

(2008) J. Wan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Characterization of the deoxyhemoglobin binding site on human erythrocyte band 3: implications for O2 regulation of erythrocyte properties

(2007) H. Chu et al.   BLOOD

How environmental and genetic factors combine to cause autism: A redox/methylation hypothesis

(2007) Richard Deth et al.   NEUROTOXICOLOGY