Costimulatory pathway targets for autoimmune and inflammatory conditions: clinical successes, failures, and hope for the future

Randomized, controlled study of bleselumab (ASKP1240) pharmacokinetics and safety in patients with moderate-to-severe plaque psoriasis

(2018) Mysore S. Anil Kumar et al.   BIOPHARMACEUTICS & DRUG DISPOSITION

453 GBR 830 induces progressive and sustained changes in atopic dermatitis biomarkers in patient skin lesions

(2018) E. Guttman-Yassky et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Brief Report: A Randomized, Double-Blind, Parallel-Group, Placebo-Controlled, Multiple-Dose Study to Evaluate AMG 557 in Patients With Systemic Lupus Erythematosus and Active Lupus Arthritis

(2018) Laurence E. Cheng et al.   Arthritis & Rheumatology

An update on chemical pharmacotherapy options for the prevention of kidney transplant rejection with a focus on costimulation blockade

(2017) Florian Kälble et al.   EXPERT OPINION ON PHARMACOTHERAPY

First-in-Human Study in Healthy Subjects with FR104, a Pegylated Monoclonal Antibody Fragment Antagonist of CD28

(2016) Nicolas Poirier et al.   JOURNAL OF IMMUNOLOGY

ACCLAIM: A randomized trial of abatacept (CTLA4-Ig) for relapsing-remitting multiple sclerosis

(2016) Samia J Khoury et al.   Multiple Sclerosis Journal

ACCLAIM: A randomized trial of abatacept (CTLA4-Ig) for relapsing-remitting multiple sclerosis

(2016) Samia J Khoury et al.   Multiple Sclerosis Journal

Belatacept-Based Immunosuppression inDe NovoLiver Transplant Recipients: 1-Year Experience From a Phase II Randomized Study

(2014) G. B. Klintmalm et al.   AMERICAN JOURNAL OF TRANSPLANTATION

A Novel Drug for Treatment of Necrotizing Soft-Tissue Infections

(2014) Eileen M. Bulger et al.   JAMA Surgery

A Randomized Controlled Trial to Evaluate Inhibition of T-Cell Costimulation in Allergen-induced Airway Inflammation

(2013) Amit D. Parulekar et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

A First-in-Disease Trial of in Vivo Costimulation Blockade for GVHD Prevention: The Addition of Abatacept to Standard GVHD Prophylaxis Controls Early CD4+ T Cell Proliferation and is Associated with Low Rates of Severe Acute GVHD

(2013) Divya Tiwari et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Costimulatory Pathways in Kidney Transplantation: Pathogenetic Role, Clinical Significance and New Therapeutic Opportunities

(2013) Pasquale Esposito et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

Abatacept for Crohn's Disease and Ulcerative Colitis

(2012) William J. Sandborn et al.   GASTROENTEROLOGY

B cells in Sjögren's syndrome: From pathophysiology to diagnosis and treatment

(2012) Divi Cornec et al.   JOURNAL OF AUTOIMMUNITY

Treatment of active ankylosing spondylitis with abatacept: an open-label, 24-week pilot study

(2011) I.-H. Song et al.   ANNALS OF THE RHEUMATIC DISEASES

B lymphocytes and lupus nephritis: New insights into pathogenesis and targeted therapies

(2007) P. Bhat et al.   KIDNEY INTERNATIONAL