Article
Microbiology
Dokyun Kim, Eun-Jeong Yoon, Jun Sung Hong, Min Hyuk Choi, Hyun Soo Kim, Young Ree Kim, Young Ah Kim, Young Uh, Kyeong Seob Shin, Jeong Hwan Shin, Jeong Su Park, Kyoung Un Park, Eun Jeong Won, Soo Hyun Kim, Jong Hee Shin, Jung Wook Kim, SungYoung Lee, Seok Hoon Jeong
Summary: To monitor national antimicrobial resistance, the Korea Global AMR Surveillance System (Kor-GLASS) was established. This study analyzed bloodstream infection cases from Kor-GLASS phase I from January 2017 to December 2019. The results showed the presence of antimicrobial resistance in various pathogens isolated from blood specimens.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Immunology
Yuan Li, Samuel Dominguez, Srinivas A. Nanduri, Joy Rivers, Saundra Mathis, Zhongya Li, Lesley McGee, Sopio Chochua, Benjamin J. Metcalf, Chris A. Van Beneden, Bernard Beall, Lisa Miller
Summary: The study revealed that in the Denver metropolitan area, closely related Group A Streptococcus isolates commonly showed mixed invasive and pharyngitis infections, indicating overlapping transmission networks. Antibiotic resistance and covS gene inactivation were disproportionately associated with invasive disease.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Medical Laboratory Technology
Si Hyun Kim, Gyung-Hye Sung, Eun Hee Park, In Yeong Hwang, Gyu Ri Kim, Sae Am Song, Hae Kyung Lee, Young Uh, Young Ah Kim, Seok Hoon Jeong, Jong Hee Shin, Kyeong Seob Shin, Jaehyeon Lee, Joseph Jeong, Young Ree Kim, Dongeun Yong, Miae Lee, Yu Kyung Kim, Nam Hee Ryoo, Seungok Lee, Jayoung Kim, Sunjoo Kim, Hyun Soo Kim, Jeong Hwan Shin
Summary: This study investigated the distribution and antimicrobial resistance of Salmonella isolates collected in Korea from 2016 to 2017. The results showed that the most prevalent serogroups were C and B, and there were multiple serotypes of Salmonella with many strains showing resistance to antibiotics. Periodic investigations of Salmonella serotypes and antimicrobial resistance are necessary.
ANNALS OF LABORATORY MEDICINE
(2022)
Review
Public, Environmental & Occupational Health
Sultan Ali, Abdullah F. F. Alsayeqh
Summary: The importance of meat-borne pathogens to global disease transmission and food safety is significant, with bacteria being the main pathogens. Consuming contaminated meat or meat products can lead to various diseases.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Infectious Diseases
Mario R. Felicio, Gislaine G. O. S. Silveira, Karen G. N. Oshiro, Beatriz T. Meneguetti, Octavio L. Franco, Nuno C. Santos, Sonia Goncalves
Summary: This study evaluated the applicability and mechanisms of action of two synthetic AMPs against a clinically isolated multidrug-resistant Escherichia coli strain. The results showed that both peptides have potential antimicrobial activity, but with different mechanisms of action, with Pa-MAP 1.9 being more effective than Pa-MAP 2. These findings highlight the potential use of these AMPs as antimicrobial agents against MDR bacteria.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2021)
Article
Public, Environmental & Occupational Health
Tien Viet Dung Vu, Marc Choisy, Thi Thuy Nga Do, Van Minh Hoang Nguyen, James Campbell, Thi Hoi Le, Vu Trung Nguyen, Heiman F. L. Wertheim, Ngoc Thach Pham, Van Kinh Nguyen, H. Rogier van Doorn
Summary: The study analyzed antimicrobial resistance surveillance data from 13 hospitals in Vietnam from 2016-17, showing alarmingly high and increasing resistant proportions among important organisms. Resistance proportions varied across hospital types and caution should be taken in interpretation.
ANTIMICROBIAL RESISTANCE AND INFECTION CONTROL
(2021)
Article
Immunology
Katherine E. Goodman, Sara E. Cosgrove, Lisa Pineles, Laurence S. Magder, Deverick J. Anderson, Elizabeth Dodds Ashley, Ronald E. Polk, Hude Quan, William E. Trick, Keith F. Woeltje, Surbhi Leekha, Anthony D. Harris
Summary: The study found that adult inpatient antibiotic use remains high, mainly driven by broad-spectrum agents. Teaching hospitals had lower rates of antibiotic use compared to nonteaching hospitals, and regional and teaching status differences persisted in adjusted models for antibiotic use. Understanding these factors can help inform efforts to reduce inappropriate antibiotic prescribing.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Infectious Diseases
Dania Khalid Saeed, Joveria Farooqi, Sadia Shakoor, Rumina Hasan
Summary: The study conducted a situational analysis of antimicrobial resistance rates in Pakistan aligned with the Global Antimicrobial Surveillance System (GLASS). The results showed high rates of resistance, particularly amongst certain organisms to specific antimicrobials. Antibiograms were found to be a valuable tool in capturing the evolution of resistance over time and could supplement national AMR surveillance efforts in areas where national surveillance may be limited.
BMC INFECTIOUS DISEASES
(2021)
Article
Infectious Diseases
Yue Qiu, Junwen Yang, Yiping Chen, Jinhong Yang, Qingxiong Zhu, Chunhui Zhu, Shuangjie Li, Jing Liu, Chaomin Wan, Yu Zhu, Minxia Chen, Yi Xu, Jianning Tong, Rui Li, Qingwen Shan, Daojiong Lin, Shouye Wu, Zhiqiang Zhuo, Caihong Wang, Shiyong Zhao, Zhenghong Qi, Xiaofeng Sun, Bieerding Maihebuba, Chunmei Jia, Huiling Gao, Yibing Cheng, Mei Zeng
Summary: The study investigated the microbiological profiles and antimicrobial resistance patterns of bloodstream pathogens in Chinese children. The results showed that the major bacterial pathogens differ in different age groups, ward types, and regions, with Escherichia coli being the most common pathogen, especially in neonates and infants. The high prevalence of important resistant phenotypes is a serious concern.
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
(2021)
Article
Infectious Diseases
Zhen Zhang, Ziyong Sun, Lei Tian
Summary: Bloodstream infections are a common consequence of infectious diseases, and appropriate antibiotic use is crucial for patient treatment. This retrospective study analyzed trends in antimicrobial resistance in common bloodstream infection-associated pathogens in Hubei Province, China.
INFECTION AND DRUG RESISTANCE
(2022)
Article
Chemistry, Medicinal
Daniela Visaggio, Emanuela Frangipani, Sarah Hijazi, Mattia Pirolo, Livia Leoni, Giordano Rampioni, Francesco Imperi, Lawrence Bernstein, Raffaella Sorrentino, Francesca Ungaro, Paolo Visca
Summary: Iron uptake and metabolism are vital for bacterial growth, making gallium (III) a potential therapeutic agent that disrupts these processes and inhibits bacterial growth. Different CF pathogens showed varying susceptibility to gallium (III) compounds, with some being sensitive to all compounds while others were only susceptible to specific ones. The results support the development of gallium (III)-based therapy as a broad-spectrum strategy to treat CF lung infections.
ACS INFECTIOUS DISEASES
(2022)
Article
Engineering, Geological
Giovanni Forte, Luca Verrucci, Anita Di Giulio, Melania De Falco, Paolo Tommasi, Giuseppe Lanzo, Kevin W. Franke, Antonio Santo
Summary: The 2016 Italian seismic sequence was characterized by three main shocks, with the strongest being a Mw 6.5 event triggering numerous seismic events and observed landslides.
ENGINEERING GEOLOGY
(2021)
Article
Microbiology
Moses B. Ayoola, Nisha Pillai, Bindu Nanduri, Michael J. Rothrock, Mahalingam Ramkumar
Summary: The demand for antibiotic-free pastured poultry chicken continues to rise due to its nutritional benefits and perceived humane treatment. However, antibiotic resistance is still reported in zoonotic poultry pathogens despite the non-usage of antibiotics in pastured poultry broiler production. This study uses machine learning and deep learning approaches to predict the factors that drive multidrug resistance in poultry pathogens, providing insights into the management practices and environmental variables that contribute to antibiotic resistance in broiler production systems.
Article
Infectious Diseases
Jun-Sik Lim, Ricardo J. Soares Magalhaes, Shovon Chakma, Dae-Sung You, Kwang-Nyeong Lee, Son-Il Pak, Eutteum Kim
Summary: This study describes the spatial epidemiology of the H5N6 avian influenza outbreak in Gyeonggi Province, South Korea in 2016-2017. It identifies poultry density as a risk factor for all species and rice paddy as a risk factor for chicken and duck farms. The findings suggest a more geographically focused outbreak response when considering these risk factors.
TRANSBOUNDARY AND EMERGING DISEASES
(2022)
Review
Biochemistry & Molecular Biology
Manuel F. Varela, Jerusha Stephen, Deeksha Bharti, Manjusha Lekshmi, Sanath Kumar
Summary: Bacterial pathogens resistant to multiple antimicrobial agents through active efflux pose a serious threat to public health. This review discusses recent molecular studies focused on modulating the antimicrobial efflux transporters to restore the clinical efficacy of infectious disease chemotherapy.
Article
Multidisciplinary Sciences
Yong Chan Kim, Heun Choi, Young Ah Kim, Yoon Soo Park, Young Hee Seo, Hyukmin Lee, Kyungwon Lee
Summary: Understanding the risk factors and microbiological features in recurrent E. coli BSI can aid clinicians in their management planning. Data from 2017 to 2018 were collected to assess antimicrobial resistance rates and molecular epidemiology. Risk factors for recurrence included vascular catheterization, ESBL phenotype, and high SOFA score. The highest proportion of ST131 and ESBL genotype was observed in early onset recurrent BSI. Whole genome sequencing revealed the presence of various virulence factors, resistant genes, and plasmid types in all types of BSI. This knowledge is important for clinicians in managing recurrent E. coli BSI.
Article
Medical Laboratory Technology
Ki Ho Hong, Gab Jung Kim, Kyoung Ho Roh, Hyukmin Lee, Ok Kyu Park, Taek Soo Kim, Jae-Seok Kim, Jaehyeon Lee, Moon-Woo Seong, So Yeon Kim, Jae-Sun Park, Younhee Park, Hee Jae Huh, Namhee Ryoo, Hyun Soo Kim, Heungsup Sung, Cheon Kwon Yoo
Summary: Since May 2022, there has been a rapid spread of monkeypox in non-endemic countries during the ongoing COVID-19 pandemic. Guidelines proposed by the Korean Society for Laboratory Medicine and the Korea Disease Prevention and Control Agency provide recommendations for diagnosing monkeypox in clinical laboratories in Korea. These guidelines cover various aspects such as test types, specimen selection and collection, diagnostic methods, interpretation of results, and biosafety. Molecular tests are recommended as confirmatory tests, and different specimens are recommended for testing at different stages of the disease.
ANNALS OF LABORATORY MEDICINE
(2023)
Article
Medical Laboratory Technology
Yu Jeong Choi, Young Ah Kim, Kim Junglim, Seok Hoon Jeong, Jong Hee Shin, Kyeong Seob Shin, Jeong Hwan Shin, Young Ree Kim, Hyun Soo Kim, Young Uh, Nam Hee Ryoo
Summary: IMP-6-producing Pseudomonas aeruginosa sequence type 235 is a dominant clone of carbapenemase-producing P. aeruginosa in Korea. The resistance rate of P. aeruginosa isolates from blood cultures has increased and there has been a shift in the molecular epidemiology of carbapenemase-producing P. aeruginosa.
ANNALS OF LABORATORY MEDICINE
(2023)
Article
Medical Laboratory Technology
Yangsoon Lee, Hye Gyung Bae, Dongju Won, Woobin Yun, Hyukmin Lee, Jong Rak Choi, Young Uh, Kyungwon Lee
Summary: In this study, the distribution of GBS isolates in pregnant Korean women was investigated. CC1 was the dominant lineage, followed by CC19, CC12, and CC17. The low prevalence of CC17 GBS colonization may explain the low frequency of neonatal GBS infections. Whole-genome sequencing is a useful tool for predicting antimicrobial susceptibility and capsular serotypes in GBS isolates.
ANNALS OF LABORATORY MEDICINE
(2023)
Article
Multidisciplinary Sciences
Eun Jeong Won, Seong Hoon Kim, Kyeong Hwan Byeon, Chae-Hyeon Jeon, Seung-Ji Kang, Joo-Heon Park, Seung-Jung Kee, Hyun-Woo Choi
Summary: Due to environmental changes, vector-borne diseases are becoming more common. This study investigated the seroprevalence of four major vector-borne pathogens in patients suspected of having Scrub Typhus. It was found that many patients had antibodies to multiple pathogens, highlighting the importance of considering co-infections in clinical practice and the laboratory.
Article
Medical Laboratory Technology
Jong -Min Park, Mijung Kwon, Ki Ho Hong, Hyukmin Lee, Dongeun Yong
Summary: RAST is effective for early diagnosis and treatment of bloodstream infections caused by Klebsiella pneumoniae and Staphylococcus aureus, but not as accurate for Escherichia coli.
ANNALS OF LABORATORY MEDICINE
(2023)
Article
Immunology
Han Sang Kim, Chang Gon Kim, Won Kyu Kim, Kyung-A Kim, Jinseon Yoo, Byung Soh Min, Soonmyung Paik, Sang Joon Shin, Hyukmin Lee, Kyungwon Lee, Hoguen Kim, Eui-Cheol Shin, Tae-Min Kim, Joong Bae Ahn
Summary: This study found that Fusobacterium nucleatum (FN) in colorectal cancer tissues is associated with immune regulation in the tumor microenvironment, and its infection is correlated with poor prognosis and altered distribution of immune cells.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Infectious Diseases
Soon Young Park, Eun Hwa Lee, Dokyun Kim, Young Goo Song, Su Jin Jeong
Summary: Helicobacter pylori is a major causative agent of various gastrointestinal diseases and its eradication is often hindered by antibiotic resistance. This study aimed to identify clinical strains of H. pylori with amoxicillin resistance and analyze the genetic variations associated with it. Analysis of 368 clinical strains revealed amoxicillin resistance in 8.7% of the strains. Whole-genome sequencing analysis identified specific genetic variations in multiple genes related to amoxicillin resistance. Six specific genetic variations in PBP2 were found to be associated with high amoxicillin resistance. Consideration of amoxicillin resistance is important in the clinical setting for the failure of H. pylori eradication.
Article
Medical Laboratory Technology
Min Ji Choi, Yong Jun Kwon, Seung A. Byun, Mi-Na Kim, Wee Gyo Lee, Jaehyeon Lee, Dongeun Yong, Chulhun L. Chang, Eun Jeong Won, Soo Hyun Kim, Seung Yeob Lee, Jong Hee Shin
Summary: We studied the mechanism and clinical features of acquired fluconazole resistance (FR) in 14 fluconazole non-susceptible (FNS) isolates of Candida albicans recovered from bloodstream infections in Korea. Mutations in drug-target gene ERG11 and transcription factor genes TAC1, MRR1, and UPC2 were compared between FNS and fluconazole-susceptible isolates. We found that amino acid substitutions in ERG11 and TAC1 likely contribute to FR in C. albicans bloodstream infections, and most FNS infections occur without azole exposure.
ANNALS OF LABORATORY MEDICINE
(2023)
Article
Microbiology
Seung A. Byun, Yong Jun Kwon, Ga Yeong Lee, Min Ji Choi, Seok Hoon Jeong, Dokyun Kim, Min Hyuk Choi, Seung-Jung Kee, Soo Hyun Kim, Myung Geun Shin, Eun Jeong Won, Jong Hee Shin
Summary: This study analyzed the virulence traits and azole resistance mechanisms of 104 Candida auris isolates collected from Korean hospitals from 1996 to 2022. The results showed a high fluconazole resistance rate among C. auris isolates in Korean hospitals, with two clades identified and clade II isolates exhibiting higher resistance. The isolates from different clades were sensitive to other drugs, and clade II isolates displayed reduced thermotolerance, competitive growth, and virulence.
Article
Infectious Diseases
Hae Suk Cheong, Kyung-Hwa Park, Bongyoung Kim, Byung Wook Eun, Hyung-sook Kim, Yong Chan Kim, Hyukmin Lee, Su Jin Jeong, Chisook Moon, Shin-Woo Kim, Young Kyung Yoon, In Sun Hwang, Choon-Seon Park, Mi Suk Lee, Hong Bin Kim, Ji-Yeon Shin, Ki Tae Kwon
Summary: This study aims to establish a national consensus on the core elements and related checklist items for the implementation of antimicrobial stewardship programs (ASPs) in Korean general hospitals. Through a literature review, online questionnaires, and expert meetings, 6 core elements and 28 checklist items were identified, providing useful indicators for the implementation of ASPs in Korea.
INFECTION AND CHEMOTHERAPY
(2023)
Letter
Medical Laboratory Technology
Seong-Jun Jeon, Joo-Heon Park, Hajin Lim, Eun Jeong Won, HyunWoo Choi, Hyun-Jung Choi, Seung-Jung Kee, Soo Hyun Kim, Jong Hee Shin, Myung-Geun Shin
ANNALS OF LABORATORY MEDICINE
(2023)
Letter
Medical Laboratory Technology
Ki Ho Hong, Jaehyeon Lee, So Yeon Kim, Yeseul Oh, Hae Weon Cho, Hyukmin Lee
ANNALS OF LABORATORY MEDICINE
(2023)
Article
Medical Laboratory Technology
Gyu Ri Kim, Eun-Young Kim, Si Hyun Kim, Hae Kyung Lee, Jaehyeon Lee, Jong Hee Shin, Young Ree Kim, Sae Am Song, Joseph Jeong, Young Uh, Yu Kyung Kim, Dongeun Yong, Hyun Soo Kim, Sunjoo Kim, Young Ah Kim, Kyeong Seob Shin, Seok Hoon Jeong, Namhee Ryoo, Jeong Hwan Shin
Summary: After the introduction of PCV13 in Korea, there have been changes in the serotype distribution and antimicrobial resistance of invasive S. pneumoniae causing IPD. Non-PCV13 serotypes are increasing, and there are differences in antimicrobial resistance according to specific serotypes. Continuous monitoring of serotypes and antimicrobial resistance is crucial for the appropriate management of S. pneumoniae infections.
ANNALS OF LABORATORY MEDICINE
(2023)
Letter
Medical Laboratory Technology
Kyunghee Yu, Junhyup Song, Dokyun Kim, Yongjung Park, Seok Hoon Jeong
ANNALS OF LABORATORY MEDICINE
(2023)
