Article
Immunology
Olivier Paccoud, Nizar Mahlaoui, Despina Moshous, Claire Aguilar, Benedicte Neven, Fanny Lanternier, Felipe Suarez, Capucine Picard, Alain Fischer, Stephane Blanche, Marc Lecuit, Olivier Hermine, Olivier Lortholary
Summary: The outcome of patients with X-linked agammaglobulinemia has improved with the use of IgRT therapy, despite the persistence of infection issues. Infections mainly occur in the lungs and gastrointestinal tract, even with adequate IgG trough levels. Immunosuppressive therapies and chronic inflammatory manifestations may contribute to infections in adulthood.
JOURNAL OF CLINICAL IMMUNOLOGY
(2021)
Review
Clinical Neurology
Julia Kraemer, Amit Bar-Or, Timothy J. Turner, Heinz Wiendl
Summary: Bruton tyrosine kinase inhibitors are a promising emerging treatment for multiple sclerosis, as they can target both peripheral immune cells and compartmentalized inflammation. Current therapies for multiple sclerosis are effective in reducing relapses and relapse-associated worsening of disability, but they are less effective in slowing disability accumulation associated with CNS-compartmentalized inflammation. By targeting the B cells and microglia in the CNS, CNS-penetrant BTK inhibitors have the potential to curtail disease progression.
NATURE REVIEWS NEUROLOGY
(2023)
Article
Infectious Diseases
Rong-Guang Lu, Shuang-Shuang Li, Bo Hu, Hong-Ye Li, Hong Tian, Wei-Quan Liu, Xi-Jun Yan, Hao Liu, Xue Bai
Summary: This study reports SMS-AstV-associated encephalitis in farmed minks in China and provides preliminary findings on the pathogenicity of the virus.
TRANSBOUNDARY AND EMERGING DISEASES
(2022)
Review
Infectious Diseases
Sakshi Bami, Jennifer Hidinger, Arshia Madni, Virginia Hargest, Stacey Schultz-Cherry, Valerie Cortez, Shane J. Cross, Deborah A. Ward, Randall T. Hayden, Jeffrey Rubnitz, Ching-Hon Pui, Raja B. Khan, Diego R. Hijano
Summary: HAstV-VA1 detected by metagenomic next-generation sequencing can cause encephalitis with poor prognosis in immunocompromised children.
JOURNAL OF THE PEDIATRIC INFECTIOUS DISEASES SOCIETY
(2022)
Article
Allergy
Manuela Olaya-Hernandez, Carolina Aristizabal-Henao, Paola Perez-Camacho, Jaime Patino-Nino, Diego Medina-Valencia, Veronica Botero-Osorio, Harry Pachajoa
Summary: This article reports a rare case of a 14-year-old patient from Colombia who presented with both Bruton agammaglobulinemia and Wilson disease, a combination that has not been reported in the literature.
ALLERGOLOGIA ET IMMUNOPATHOLOGIA
(2023)
Article
Oncology
Jeong-Mi Kim, Jinny Park, Eun-Mi Noh, Hyun-Kyung Song, Sang Yull Kang, Sung Hoo Jung, Jong-Suk Kim, Byung-Hyun Park, Young-Rae Lee, Hyun Jo Youn
Summary: The study found that BTK inhibitors can attenuate TPA-induced cell invasion and migration in MCF-7 cells, and suppress MMP-9 expression by activating the MAPK or IκB kinase/NF-κB/activator protein-1 pathway.
Article
Virology
Su-Beom Chae, Chang-Gi Jeong, Jun-Soo Park, Eun-Jee Na, Jae-Ku Oem
Summary: A novel AstV associated with neurological symptoms has been detected in the intestines and brains of wild raccoon dogs in South Korea. These AstVs showed a high similarity to canine AstVs, suggesting possible interspecies transmission between raccoon dogs and dogs. Further research and surveillance are needed to understand the pathogenicity and transmission routes of these AstVs in raccoon dogs.
Review
Allergy
Fahad Khan, Hannibal Person, Fumiko Dekio, Makoto Ogawa, Hsi-en Ho, David Dunkin, Elizabeth Secord, Charlotte Cunningham-Rundles, Stephen C. Ward
Summary: X-linked agammaglobulinemia (XLA) is an inherited immunodeficiency disease that can manifest with gastrointestinal symptoms, including Crohn disease (CD)-like enteritis. Although clinically similar to CD, XLA-associated enteritis presents with unique histological features and requires a multidisciplinary evaluation for proper diagnosis and management.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2021)
Article
Microbiology
Olga A. Maximova, Melodie L. Weller, Tammy Krogmann, Daniel E. Sturdevant, Stacy Ricklefs, Kimmo Virtaneva, Craig Martens, Kurt Wollenberg, Mahnaz Minai, Ian N. Moore, Craig S. Sauter, Juliet N. Barker, W. Ian Lipkin, Danielle Seilhean, Avindra Nath, Jeffrey I. Cohen
Summary: In this study, it was found that Astroviruses (AstVs) can cause severe infection of the central nervous system (CNS) in immunocompromised individuals. The research showed that AstV primarily targets neurons in the brain, with the cerebellum and brainstem being the most affected areas. Furthermore, it was observed that the innate immune response was the main defense mechanism against AstV infection in the brain of immunocompromised patients. These findings are important for improving the outcomes of viral CNS infections in immunocompromised individuals.
Article
Microbiology
Hongyu Wei, Kattareeya Kumthip, Pattara Khamrin, Arpaporn Yodmeeklin, Nutthawadee Jampanil, Phitchakorn Phengma, Zhenfeng Xie, Nuthapong Ukarapol, Hiroshi Ushijima, Niwat Maneekarn
Summary: This study identified three novel recombinant strains of HAstV, which underwent intergenotype recombination at the ORF1a-ORF1b-ORF2 regions of the HAstV genome. The study also found that recombination hotspots in the HAstV genome frequently occur near the ORF1a-ORF1b and ORF1b-ORF2 junctions. These findings indicate that intergenotype recombination of HAstV occurs frequently in nature. The emergence of a novel recombinant strain allows the new virus to adapt and successfully escape from the host immune system, eventually becoming the predominant genotype infecting populations lacking herd immunity against novel recombinant strains. The virus may cause outbreaks and needs to be continuously monitored.
MICROBIOLOGY SPECTRUM
(2023)
Review
Veterinary Sciences
Abdullahi Abdullahi Raji, Abdul Rahman Omar
Summary: Chicken astrovirus is associated with various diseases in young broiler chicks, but its pathogenesis remains unclear. This review focuses on the understanding of its pathogenesis and the development of in vivo and in vitro models.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Linlin Li, Minhua Sun, Yun Zhang, Ming Liao
Summary: This article reviews the recent discoveries in genetic diversity and variation of avian astroviruses, as well as the pathogenesis and relation to visceral gout in poultry. The aim is to gain insights into the prevention and control of visceral gout diseases in poultry and understand the possible producing process.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Veterinary Sciences
Farzad Beikpour, Francesco Pellegrini, Gianvito Lanave, Michele Camero, Cristiana Catella, Barbara Di Martino, Federica Di Profio, Chiara Masotti, Roberta Battistini, Laura Serracca, Giuseppina La Rosa, Vito Martella, Elisabetta Suffredini
Summary: This study demonstrated the potential of using a commonly used primer set and a nanopore sequencing platform to generate astroviromic data in complex matrices. The study found that astroviruses are widely present in mammals, birds, lower vertebrates, and invertebrates, and are associated with enteric and extra-intestinal diseases. The study also identified avian-origin astrovirus sequences as the predominant type, likely due to contamination of surface water.
VETERINARY SCIENCES
(2023)
Article
Immunology
Jie Chen, Huie Jing, Andrea Martin-Nalda, Paul Bastard, Jacques G. Riviere, Zhiyong Liu, Roger Colobran, Danyel Lee, Wesley Tung, Jeremy Manry, Mary Hasek, Soraya Boucherit, Lazaro Lorenzo, Flore Rozenberg, Melodie Aubart, Laurent Abel, Helen C. Su, Pere Soler Palacin, Jean-Laurent Casanova, Shen-Ying Zhang
Summary: This study reports two children infected with EV30 and EV71, who have TLR3 and IFIH1 gene mutations. The research found that TLR3 and MDA5 play crucial roles in combating EV infection by controlling the production of type I IFNs.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Article
Immunology
Claire P. Mattison, Molly Dunn, Mary E. Wikswo, Anita Kambhampati, Laura Calderwood, Neha Balachandran, Eleanor Burnett, Aron J. Hall
Summary: Between 2009 and 2018, numerous gastroenteritis outbreaks were reported to the US National Outbreak Reporting System, with the majority attributed to person-to-person transmission in long-term care facilities, daycares, and schools. Investigations of norovirus-negative outbreaks should include testing for adenovirus, astrovirus, rotavirus, and sapovirus.
EMERGING INFECTIOUS DISEASES
(2021)
Article
Allergy
Quentin Riller, Jacques Fourgeaud, Julie Bruneau, Suk See De Ravin, Grace Smith, Mathieu Fusaro, Samy Meriem, Aude Magerus, Marine Luka, Ghaith Abdessalem, Ludovic Lhermitte, Anne Jamet, Emmanuelle Six, Alessandra Magnani, Martin Castelle, Romain Levy, Mathilde M. Lecuit, Benjamin Fournier, Sarah Winter, Michaela Semeraro, Graziella Pinto, Hanene Abid, Nizar Mahlaoui, Nathalie Cheikh, Benoit Florkin, Pierre Frange, Eric Jeziorski, Felipe Suarez, Francoise Sarrot-Reynauld, Dalila Nouar, Dominique Debray, Florence Lacaille, Capucine Picard, Philippe Perot, Beatrice Regnault, Nicolas Da Rocha, Camille de Cevins, Laure Delage, Brieuc P. Perot, Angelique Vinit, Francesco Carbone, Camille Brunaud, Manon Marchais, Marie-Claude Stolzenberg, Vahid Asnafi, Thierry Molina, Frederic Rieux-Laucat, Luigi D. Notarangelo, Stefania Pittaluga, Jean Philippe, Despina Moshous, Stephane Blanche, Harry Malech, Marc Eloit, Marina Cavazzana, Alain Fischer, Mickaeeurol M. Menager, Benedicte Neven
Summary: Persistent hepatitis is a common late-onset posttreatment complication in transplanted SCID patients. This study found that it is associated with chronic enteric viral infection and immune dysregulation, and identified risk factors such as myeloablation absence and defective B-cell function. Treatment options such as retransplantation or gene therapy can lead to remission of hepatitis.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Immunology
Carla Palacios-Gorba, Alexandra Moura, Yuval Markovich, Nathalie Tessaud-Rita, Angel Gomez-Martin, Helene Bracq-Dieye, Jesus Gomis, Guillaume Vales, Maria Pastor-Martin, Pierre Thouvenot, Carles Escrig, Alexandre Leclercq, Marc Lecuit, Juan J. Quereda
Summary: Two species of pathogenic Listeria, L. monocytogenes and L. ivanovii, can asymptomatically colonize udders and tonsils of ruminants without fecal shedding. Their whole-genome sequences contain known core virulence and antibiotic resistance genes. This study highlights the importance of udders and tonsils as intra-host sites of Listeria colonization.
MICROBES AND INFECTION
(2023)
Article
Multidisciplinary Sciences
Richard Wheeler, Paulo Andre Dias Bastos, Olivier Disson, Aline Rifflet, Ilana Gabanyi, Julia Spielbauer, Marion Berard, Marc Lecuit, Ivo Gomperts Boneca
Summary: Peptidoglycan, the major component of bacterial cell walls, plays a crucial role in affecting physiological and behavioral changes in mammalian hosts. However, the mechanism and regulation of its translocation from the gut to host tissues have not been fully understood. This study investigated the absorption and dissemination of peptidoglycan across the intestine. The results showed that peptidoglycan has a preference for certain host organs, particularly the brain, when absorbed through the gut. The translocation of peptidoglycan is an active process regulated by the microbiota-induced parasympathetic pathway through muscarinic acetylcholine receptors.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Letter
Rheumatology
Brigitte Bader-Meunier, Sylvain Breton, Darragh Duffy, Cyril Gitiaux, Pierre Quartier, Irene Lemelle, Alain Meyer, Anne Welfringer-Morin, Marie-Louise Fremond, Jean-Luc Charuel, Mathieu P. Rodero, Isabelle Melki
Article
Urology & Nephrology
Clara Pardinhas, Rui Filipe, Paul Vergnaud, Mathilde Grapin, Elsa Ferriere, Anne Jamet, Jacques Fourgeaud, Nicolas Da Rocha, Philippe Perot, Olivia Boyer, Marion Rabant, Jean-Paul Duong Van Huyen, Pierre Isnard
Summary: This study reports five pediatric cases of renal arcuate vein thrombosis (RAVT), a rare condition causing acute kidney injury (AKI) in young adults. The investigation suggests that NSAIDs use and SARS-CoV-2 infection may be crucial contributing factors to the development of renal thrombosis.
CLINICAL KIDNEY JOURNAL
(2023)
Article
Rheumatology
Javier Rodriguez-Carrio, Agata Burska, Philip G. Conaghan, Willem A. Dik, Robert Biesen, Maija-Leena Eloranta, Giulio Cavalli, Marianne Visser, Dimitrios T. Boumpas, George Bertsias, Marie Wahren-Herlenius, Jan Rehwinkel, Marie-Louise Fremond, Mary K. Crow, Lars Ronnblom, Marjan A. Versnel, Edward M. Vital
Summary: This study developed evidence-based points to consider for the measurement and reporting of IFN-I assays in clinical research. The study provides recommendations on terminology, assay characteristics, and reporting practices, as well as explores the clinical applications of IFN-I assays in diagnosis and outcome assessments.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Immunology
Jacques Fourgeaud, Mathilde M. Lecuit, Philippe Perot, Julie Bruneau, Beatrice Regnault, Nicolas Da Rocha, Mael Bessaud, Capucine Picard, Eric Jeziorski, Benjamin Fournier, Romain Levy, Ambroise Marcais, Stephane Blanche, Pierre Frange, Alain Fischer, Marina Cavazzana, Agnes Ferroni, Anne Jamet, Marianne Leruez-Ville, Marc Eloit, Benedicte Neven
Summary: Using metagenomic next-generation sequencing and reverse-transcription polymerase chain reaction, we detected the Aichi virus genome in tissues of patients with primary immune deficiency and unexplained multiorgan inflammatory involvement. We showed evidence supporting the causality of Aichi virus in these cases.
CLINICAL INFECTIOUS DISEASES
(2023)
Letter
Urology & Nephrology
Marina Avramescu, Pierre Isnard, Sarah Temmam, Agnes Chevalier, Paul Bastard, Mikael Attia, Romain Berthaud, Marc Fila, Claire Dossier, Julien Hogan, Tim Ulinski, Damia Leguevaques, Ferielle Louillet, Edouard Martinez Casado, Jean-Michel Halimi, Sylvie Cloarec, Ariane Zaloszyc, Camille Faudeux, Caroline Rousset-Rouviere, Stephanie Clave, Jerome Harambat, Edouard Rollot, Thomas Simon, Megan Nallet-Amate, Bruno Ranchin, Justine Bacchetta, Florence Porcheret, Josselin Bernard, Amelie Ryckewaert, Anne Jamet, Jacques Fourgeaud, Nicolas Da Rocha, Philippe Perot, Nicolas Kuperwasser, Naim Bouazza, Marion Rabant, Jean-Paul Duong Van Huyen, Matthieu P. Robert, Julien Zuber, Jean-Laurent Casanova, Marc Eloit, Isabelle Sermet-Gaudelus, Olivia Boyer
KIDNEY INTERNATIONAL
(2023)
Article
Virology
Julia Kende, Massimiliano Bonomi, Sarah Temmam, Beatrice Regnault, Philippe Perot, Marc Eloit, Thomas Bigot
Summary: The improvement of knowledge about unknown viruses in the virosphere is crucial in virology. However, current evaluation methods for metagenomics tools do not consider their ability to detect novel or distant viruses. Simulating realistic evolutionary directions is essential for benchmarking and improving these tools. The Virus Pop pipeline is introduced here as a tool for simulating realistic protein sequences and expanding databases to better detect distant viruses. It has been demonstrated that Virus Pop is capable of generating simulated sequences that closely resemble real protein sequences and can identify novel pathogenic viruses not included in the databases.
Article
Microbiology
Peiqi Yin, Bennett J. Davenport, Judy J. Wan, Arthur S. Kim, Michael S. Diamond, Brian C. Ware, Karen Tong, Therese Couderc, Marc Lecuit, Jonathan R. Lai, Thomas E. Morrison, Margaret Kielian
Summary: The Chikungunya virus (CHIKV) forms long intercellular extensions that connect infected and neighboring cells, facilitating efficient transmission of the virus. These extensions are critical for CHIKV transmission, which occurs through endocytosis and endosomal acidification, rather than the CHIKV receptor MXRA8. In vivo experiments demonstrate that neutralizing antibodies are unable to block infection when the virus is transferred through infected cells. This study suggests that the contact sites of the intercellular extensions shield CHIKV from neutralizing antibodies, promoting efficient virus transmission both in vitro and in vivo.
NATURE MICROBIOLOGY
(2023)
Review
Medicine, General & Internal
Isabelle Melki, Marie-Louise Fremond
Summary: Juvenile idiopathic arthritis (JIA) is a diverse group of diseases with different underlying physiopathology. Treatment options are limited for some patients due to severe disease, drug adverse events, drug allergy, or association with severe comorbidities. Janus Kinase (JAK) inhibitors show promise in providing an alternative treatment for these cases and may also be beneficial for patients with Mendelian disorders resembling JIA. However, more research is needed to evaluate their long-term safety and identify subsets of JIA patients who will benefit from these treatments.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Hematology
Audrey Petit, Benedicte Neven, Victoria Min, Nizar Mahlaoui, Despina Moshous, Martin Castelle, Maya Allouche, Arthur Sterin, Sandrine Visentin, Paul Saultier, Mohamed Boucekine, Alaa Mustafa Shawket, Capucine Picard, Pascal Auquier, Gerard Michel, Alain Fischer, Vincent Barlogis
Summary: The survival rate after hematopoietic stem cell transplantation for inborn errors of immunity has improved considerably, but many patients still experience poor health status and impaired quality of life. Abnormal graft function and chronic graft-versus-host disease are correlated with poor health and very poor health, which in turn directly affect the patients' HRQoL. Further studies are needed to examine the long-term impact of transplant procedure improvements on health status and HRQoL.
TRANSPLANTATION AND CELLULAR THERAPY
(2023)
Article
Immunology
Philippe Perot, Jacques Fourgeaud, Claire Rouzaud, Beatrice Regnault, Nicolas Da Rocha, Helene Fontaine, Jerome Le Pavec, Samuel Dolidon, Margaux Garzaro, Delphine Chretien, Guillaume Morcrette, Thierry Jo Molina, Agnes Ferroni, Marianne Leruez-Ville, Olivier Lortholary, Anne Jamet, Marc Eloit
Summary: In March 2022, a 61-year-old woman in France who had received a heart-lung transplant was diagnosed with chronic hepatitis characterized by increased liver enzymes. Metagenomic next-generation sequencing revealed the presence of an unknown circovirus, named human circovirus 1 (HCirV-1), in a liver biopsy sample. The viral genome was undetectable in blood samples from 2017-2019, but became detectable in September 2020 and reached high titers in January 2022, concurrent with liver damage indicated by elevated liver enzyme levels and high viral copies in the liver and blood.
EMERGING INFECTIOUS DISEASES
(2023)
Article
Hematology
Philippe Perot, Nicolas Da Rocha, Maria R. Farcet, Thomas R. Kreil, Marc Eloit
Summary: The prevalence and titer of Human Circovirus 1 and 2 in plasma pools from healthy donors were investigated, and it was found that high levels of circovirus are not widely prevalent in such donations.
Meeting Abstract
Biochemistry & Molecular Biology
Frouin Arthur, Fabien Laporte, Hafner Lukas, Maury Mylene, Marc Lecuit, Chikhi Rayan, Hugues Aschard
EUROPEAN JOURNAL OF HUMAN GENETICS
(2023)
