Article
Neurosciences
Robert A. Marino, Pauline Gaprielian, Ron Levy
Summary: This study investigated the effects of systemic dopamine blockade on cognition in healthy monkeys by administering D1 and D2 receptor antagonists. The results showed that D2 receptor antagonist impaired cognitive flexibility, while D1 receptor antagonist had less impact on frontal executive function.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2022)
Article
Biology
Gabriella H. Wolff, Chloe Lahondere, Clement Vinauger, Elizabeth Rylance, Jeffrey A. Riffell
Summary: Mosquitoes can change their feeding behaviours based on past experiences, but the role of dopamine in their primary olfactory centre remains unclear. This study found that different mosquito species learn odours salient to their preferred host, and the innervation patterns in the antennal lobe (AL) by dopaminergic neurons varied among the species. Changes in dopamine expression in the insect AL may allow mosquitoes to adapt to new hosts without altering brain structure.
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Jana Lubec, Ahmed M. Hussein, Predrag Kalaba, Daniel Daba Feyissa, Edgar Arias-Sandoval, Anita Cybulska-Klosowicz, Mekite Bezu, Tamara Stojanovic, Volker Korz, Jovana Malikovic, Nilima Y. Aher, Martin Zehl, Vladimir Dragacevic, Johann Jakob Leban, Claudia Sagheddu, Judith Wackerlig, Marco Pistis, Merce Correa, Thierry Langer, Ernst Urban, Harald Hoeger, Gert Lubec
Summary: The worldwide increase in cognitive decline calls for the search of pharmacological treatment. Current dopamine transporter (DAT) inhibitors have unwanted side effects due to lack of specificity. A highly specific DAT inhibitor, S-CE-123, was synthesized and tested for its potential to enhance cognitive functions in rats. S-CE-123 showed good bioavailability and improved the performance of aged rats.
Article
Biochemistry & Molecular Biology
Bettina Reka Laszlo, Erika Kertes, Tamas Ollmann, Laszlo Peczely, Anita Kovacs, Zoltan Karadi, Laszlo Lenard, Kristof Laszlo
Summary: The neurotransmitter and neuromodulator neurotensin (NT) has been found to facilitate spatial learning and memory through the activation of DA D2 receptors in the central nucleus of amygdala (CeA).
Article
Multidisciplinary Sciences
E. L. Isenstein, T. Waz, A. LoPrete, Y. Hernandez, E. J. Knight, A. Busza, D. Tadin
Summary: Using virtual reality (VR) coupled with hand-tracking provides an efficient and adaptable way to study human perception and action, bridging the gap between conventional perception research and real perceptual experiences.
Article
Clinical Neurology
Wei Luo, Lizhu Luo, Qiang Wang, Yunge Li, Yamin Zhang, Yalan Hu, Yue Yu, Shu Yu, Fengmei Lu, Jiajia Chen, Li Liu, Na Du, Christelle Langley, Barbara J. Sahakian, Zongling He, Tao Li
Summary: The present study aimed to compare the cognitive impairments between patients with generalized anxiety disorder (GAD) and major depressive disorder (MDD). Both GAD and MDD groups showed significant deficits in sustained attention, visual memory, working memory, and learning compared to healthy controls. However, the MDD group had more severe impairment in learning, particularly generalization, while the GAD group had more pronounced deficits in visual memory.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Review
Behavioral Sciences
Mayuri Shukla, Bruno Vincent
Summary: Methamphetamine abuse can have detrimental effects on various parts of the memory system, including the learning process. The structural similarities between this drug and dopamine can lead to cognitive deficits and potentially trigger neurodegenerative disorders.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Psychology, Multidisciplinary
Jefferson Ortega, Chelsea Reichert Plaska, Bernard A. Gomes, Timothy M. Ellmore
Summary: Spontaneous eye blink rate (sEBR) has been found to be related to attention and memory, specifically working memory (WM), and is associated with striatal dopamine (DA) activity in schizophrenia and Parkinson's disease. However, previous studies on sEBR and WM have some limitations. This study aimed to investigate how fluctuations in sEBR during different phases of a visual WM task predict task accuracy. The results showed a positive correlation between sEBR and WM task accuracy during the WM delay period, as well as task-related modulation of sEBR.
FRONTIERS IN PSYCHOLOGY
(2022)
Review
Neurosciences
Angela Radulescu, Yeon Soon Shin, Yael Niv
Summary: The review explores the dynamic interaction between information selection and learning, highlighting the role of attention and memory in determining what features of experiences are worth learning about. Recent evidence suggests that representations shaped by attention and memory are inferred from experience with each task. This inference process has implications for human decision-making in social environments.
ANNUAL REVIEW OF NEUROSCIENCE, VOL 44, 2021
(2021)
Article
Neurosciences
Sankar Muthukumar, Karnika Mehrotra, Mohammed Fouda, Sarah Hamimi, Lauren L. Jantzie, Shenandoah Robinson
Summary: The use of touchscreen technology in evaluating cognitive deficits in animal models has expanded significantly over the past 20 years, offering researchers the opportunity to explore deficits in various perinatal disorders across critical developmental windows.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Multidisciplinary Sciences
Matthew F. Panichello, Timothy J. Buschman
Summary: Cognitive control guides behavior by controlling what, when, and how information is represented in the brain. Prefrontal cortex acts as a domain-general controller for both selection and attention, while parietal and visual cortex represent attention and selection independently. Selection and attention facilitate behavior by enhancing and transforming the representation of selected memory or attended stimulus.
Article
Multidisciplinary Sciences
Jia Jia, Lei He, Junfei Yang, Yichun Shuai, Jingjing Yang, Yalan Wu, Xin Liu, Tianli Chen, Guaxiu Wang, Xingyu Wang, Xiaoxu Song, Zhaowen Ding, Yan Zhu, Li Zhang, Peng Chen, Hongtao Qin
Summary: Chronic stress can induce severe cognitive impairments in Drosophila melanogaster, with long-lasting learning and memory deficits accompanied by depression-like behaviors. Excessive dopaminergic activity is shown to increase susceptibility to chronic stress-induced learning deficits, with specific dopaminergic neurons and mushroom body output neurons playing key roles in regulating this susceptibility. Imaging studies suggest that dopaminergic activity is essential for the development of maladaptations in the mushroom body network induced by chronic stress, leading to CSLD.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Behavioral Sciences
Logan E. Savidge, Karen L. Bales
Summary: Pair bonding relies on preexisting dopamine connectivity to establish and maintain the bond. Research has linked pair bonding to dopamine-dependent processes such as addiction and social cognition. However, the relationship between pair bonding and non-social cognitive processes has received less attention.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Article
Mathematics
Yingxin Xiang, Chengyuan Zhang, Zhichao Han, Hao Yu, Jiaye Li, Lei Zhu
Summary: Visual question answering (VQA) is a multi-modal fine-grained feature fusion task that requires the construction of multi-level and omnidirectional relations between nodes. This paper proposes a path attention memory network (PAM) to construct a more robust composite attention model. The PAM enhances the learning effect on the whole path by using memoried single-hop attention matrices and guides the attention adjustment with guard gates and conditioning gates. The proposed PAM achieves excellent performance on both VQA2.0 and VQA-CP V2 datasets.
Article
Multidisciplinary Sciences
Ali Ghazizadeh, Okihide Hikosaka
Summary: Ecological fitness depends on maintaining object histories to guide future interactions. Recent evidence shows that value memory changes passive visual responses to objects in ventrolateral prefrontal cortex (vlPFC) and substantia nigra reticulata (SNr). Changes in visual responses across domains happened in the same neural populations and were related to salience rather than valence of objects.
NATURE COMMUNICATIONS
(2022)