期刊
EUROPEAN JOURNAL OF NEUROSCIENCE
卷 49, 期 4, 页码 525-532出版社
WILEY
DOI: 10.1111/ejn.14264
关键词
IPSC; mitochondrial dysfunction; oxidative stress; PD; therapeutics
资金
- Cure Parkinson's Trust
Parkinson's disease (PD) is the second most common neurodegenerative disease. Two percent of the population above the age of 60 is affected by the disease. The pathological hallmarks of PD include loss of dopaminergic neurons and the presence of Lewy bodies. Mitochondrial dysfunction and oxidative stress are thought to play a pivotal role in both sporadic and familial forms of the disease. In this review we focus on the role of mitochondrial dysfunction and oxidative stress in induced pluripotent stem cell (IPSC) models of PD.We also provide an overview of therapeutics that have been tested and some possible new therapeutics that can be tested in IPSC models of PD.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据