Article
Neurosciences
Signoriello Elisabetta, Mallardo Marta, Nigro Ersilia, Polito Rita, Casertano Sara, Di Pietro Andrea, Coletta Marcella, Monaco Maria Ludovica, Rossi Fabiana, Lus Giacomo, Daniele Aurora
Summary: Adiponectin levels in the cerebrospinal fluid were significantly elevated in multiple sclerosis (MS) patients and positively correlated with CSF IgG levels, suggesting a potential relationship with disease severity and prognosis. Changes in the oligomerization profile of adiponectin in CSF from MS patients, with increased high molecular weight and medium molecular weight forms, were also observed.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Immunology
Klaus Berek, Angelika Bauer, Dagmar Rudzki, Michael Auer, Robert Barket, Anne Zinganell, Magdalena Lerch, Livia Hofer, Astrid Grams, Paulina Poskaite, Sebastian Wurth, Thomas Berger, Franziska Di Pauli, Florian Deisenhammer, Harald Hegen, Markus Reindl
Summary: This study investigated the distribution of 65 different cytokines, chemokines, and related molecules in the cerebrospinal fluid (CSF) and serum of newly diagnosed people with multiple sclerosis (pwMS). The results showed that 29 cytokines and chemokines were significantly elevated in the CSF, while 15 were elevated in the serum. Additionally, associations were found between 34 analytes and sex, age, CSF, MRI parameters, and disease progression. These findings contribute to a better understanding of the pathophysiology of multiple sclerosis and its association with disease progression.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Yijun Shi, Yaowei Ding, Guoge Li, Lijuan Wang, Rasha Alsamani Osman, Jialu Sun, Lingye Qian, Guanghui Zheng, Guojun Zhang
Summary: By analyzing CSF samples, 83 differentially expressed proteins related to MS were identified, with pathways including platelet degranulation, negative regulation of proteolysis, and post-translational protein modification. IGFBP7, IGF2, and SST were identified as potential key proteins in the protein-protein interaction network.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Daniel Sandi, Zsanett Fricska-Nagy, Krisztina Bencsik, Laszlo Vecsei
Summary: Neurodegeneration plays a crucial role in the pathogenesis of multiple sclerosis, leading to progression, pathopsychological disturbances, and optic neuropathy. The kynurenine pathway has been highlighted as a potential therapeutic target for neuroprotective drugs in MS, with promising data emerging from clinical evaluations. Further research on the pathway is expected to provide concrete results for everyday medicine in the future.
Review
Pharmacology & Pharmacy
Yaoxiang Tang, Ying Zhou, Songqing Fan, Qiuyuan Wen
Summary: This review article summarizes the importance of HSP60 in cancer, including its structure, functional cycle, regulatory mechanism, and its applications in diagnosis and therapy.
BIOCHEMICAL PHARMACOLOGY
(2022)
Review
Clinical Neurology
Virginia Meca-Lallana, Leticia Berenguer-Ruiz, Joan Carreres-Polo, Sara Eichau-Madueno, Jaime Ferrer-Lozano, Lucia Forero, Yolanda Higueras, Nieves Tellez Lara, Angela Vidal-Jordana, Francisco Carlos Perez-Miralles
Summary: Multiple sclerosis is an inflammatory and degenerative disease of the central nervous system triggered by unknown environmental factors in patients with genetic risk profiles. Prevention of neurological disability is essential, but mechanisms driving disease progression remain unknown. Lack of markers for early detection and varying definitions of disability progression complicate assessment in clinical practice.
FRONTIERS IN NEUROLOGY
(2021)
Review
Clinical Neurology
Stefan Bittner, Frauke Zipp
Summary: This article discusses current views and concepts for targeting progressive multiple sclerosis (MS). Recent clinical studies have found a closer relationship between relapse-remitting and progressive MS, leading to the introduction of new concepts such as "progression independent of relapse activity". Research on molecular and imaging biomarkers for progressive MS holds promise for identifying high-risk patients at an earlier stage. Novel treatment approaches focus on neuroaxonal protection, myelin regeneration, and modulation of CNS inflammation. Despite some unsuccessful trials, important lessons can still be learned from novel trial designs.
CURRENT OPINION IN NEUROLOGY
(2022)
Letter
Medicine, General & Internal
Arie R. Gafson, Xiaotong Jiang, Changyu Shen, Raj Kapoor, Henrik Zetterberg, Robert J. Fox, Shibeshih Belachew
Summary: This cohort study examines the serum neurofilament light concentration as a biomarker in relation to disability progression in multiple sclerosis, without considering the presence of acute inflammation.
Article
Immunology
Jin Wang, Kellie Brown, Caroline Danehy, Emmanuel Merigeon, Stephen Goralski, Samuel Rice, Kwame Torgbe, Fridtjof Thomas, David Block, Henrik Olsen, Scott E. Strome, Elizabeth A. Fitzpatrick
Summary: This study tested the efficacy of a recombinant Fc multimer (M019) in treating multiple sclerosis using a murine model. The results showed that M019 effectively reduced clinical symptoms, inhibited immune cell infiltration into the central nervous system, and interacted with Fc gamma R bearing-monocytes.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Baoya Wang, Qiong Ma, Xuelin Wang, Kunshan Guo, Zhendong Liu, Gang Li
Summary: TGIF1 is significantly overexpressed in gliomas and is associated with unfavorable prognostic factors and shorter overall survival. Gene set enrichment analysis (GSEA) reveals TGIF1's involvement in extracellular matrix receptor and cell cycle pathways in gliomas. This study comprehensively analyzes the role of TGIF1 in gliomas for the first time, revealing its association as a novel oncogene with the disease.
Article
Clinical Neurology
Eleonora Virgilio, Domizia Vecchio, Ilaria Crespi, Roberto Serino, Roberto Cantello, Umberto Dianzani, Cristoforo Comi
Summary: CSF Tau levels may predict early disability accumulation in Multiple Sclerosis patients. Other predictors of disability include spinal cord involvement, age at MS diagnosis, and high brain lesion load.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2021)
Article
Biochemistry & Molecular Biology
Despoina D. Gianniou, Aimilia D. Sklirou, Maria-Alexandra Papadimitriou, Katerina-Marina Pilala, Konstantinos Stravodimos, Margaritis Avgeris, Andreas Scorilas, Ioannis P. Trougakos
Summary: This study investigated the expression and role of HSPB2 and HSPB3 genes in bladder cancer patients and bladder cancer cells. The results showed increased expression levels of HSPB2 and HSPB3 genes and proteins in high-grade bladder cancer cells. In clinical samples, the expression levels of HSPB2 and HSPB3 genes were significantly downregulated in bladder tumors but showed an upregulation trend in muscle-invasive and high-grade tumors. These findings suggest that HSPB2 and HSPB3 have a pro-survival role in advanced bladder cancer and can be targeted as novel molecular markers for treatment optimization.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Medical Laboratory Technology
Yan Gao, Dong Han, Juan Feng
Summary: Multiple sclerosis is an autoimmune disease affecting the CNS, with miRNAs playing a key role in its pathogenesis. MiRNAs have emerged as potential new biomarkers and therapeutic targets for MS. They show high specificity and stability in peripheral body fluids, presenting promising applications in the diagnosis and treatment of MS.
CLINICA CHIMICA ACTA
(2021)
Article
Medicine, General & Internal
Amit Bar-Or, Gian-Andrea Thanei, Christopher Harp, Corrado Bernasconi, Ulrike Bonati, Anne H. Cross, Saloumeh Fischer, Laura Gaetano, Stephen L. Hauser, Robert Hendricks, Ludwig Kappos, Jens Kuhle, David Leppert, Fabian Model, Annette Sauter, Harold Koendgen, Xiaoming Jia, Ann E. Herman
Summary: Baseline NfL levels are associated with brain atrophy, lesion expansion, and clinical progression in MS patients. Ocrelizumab treatment reduces NfL levels and eliminates the predictive value of baseline NfL on disability progression. Elevated NfL levels following ocrelizumab treatment may predict increased risk for clinical progression.
Article
Medicine, General & Internal
Alida Linda Patrizia Caforio, Giacomo De Luca, Anna Baritussio, Mara Seguso, Nicoletta Gallo, Elisa Bison, Maria Grazia Cattini, Elena Pontara, Luna Gargani, Alessia Pepe, Corrado Campochiaro, Mario Plebani, Sabino Iliceto, Giovanni Peretto, Antonio Esposito, Lorenzo Tofani, Alberto Moggi-Pignone, Lorenzo Dagna, Renzo Marcolongo, Marco Matucci-Cerinic, Cosimo Bruni
Summary: The study found that the frequencies of AHA and AIDA in SSc were significantly higher compared to other cardiac disease groups and normal blood donors, suggesting a high burden of underdiagnosed autoimmune heart involvement in SSc. AHA was associated with interstitial lung disease, chest pain history, abnormal troponin, AIDA, and current immunosuppression, as well as death and overall cardiac events during follow-up.
Article
Clinical Neurology
Elisabetta Signoriello, Giacomo Lus, Simona Bonavita, Roberta Lanzillo, Francesco Sacca, Doriana Landi, Jessica Frau, Damiano Baroncini, Mauro Zaffaroni, Giorgia Teresa Maniscalco, Erica Curti, Arianna Sartori, Simone Cepparulo, Girolama Alessandra Marfia, Carolina Gabri Nicoletti, Antonio Carotenuto, Viviana Nociti, Francesca Caleri, Maria Pia Sormani, Alessio Signori
Summary: The study found that discontinuation of sequestering agents like fingolimod increases the risk of relapses in multiple sclerosis patients during wash-out period, while starting ocrelizumab before achieving complete immune reconstitution may limit its effectiveness in the first 6 months.
MULTIPLE SCLEROSIS JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Mariarita Brancaccio, Cristina Mennitti, Mariella Calvanese, Alessandro Gentile, Roberta Musto, Giulia Gaudiello, Giulia Scamardella, Daniela Terracciano, Giulia Frisso, Raffaela Pero, Laura Sarno, Maurizio Guida, Olga Scudiero
Summary: During pregnancy, mothers infected with COVID-19 have altered levels of inflammatory and anti-inflammatory cytokines, as well as an increase in antimicrobial peptides, potentially providing protection to the fetus from the ongoing infection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Clinical Neurology
Roberto Bergamaschi, Ettore Beghi, Cristina Bosetti, Michela Ponzio, Claudia Santucci, Vito Lepore, Paola Mosconi, U. Aguglia, M. P. Amato, A. L. Ancona, B. Ardito, C. Avolio, R. Balgera, P. Banfi, V. Barcella, P. Barone, P. Bellantonio, A. Berardinelli, R. Bergamaschi, P. Bertora, M. Bianchi, P. Bramanti, V. Brescia Morra, G. Brichetto, A. M. Brioschi, M. Buccafusca, S. Bucello, V. Busillo, B. Calchetti, R. Cantello, M. Capobianco, F. Capone, L. Capone, D. Cargnelutti, M. Carrozzi, E. Cartechini, G. Cavaletti, P. Cavalla, M. G. Celani, R. Clerici, M. Clerico, E. Cocco, P. Confalonieri, M. G. Coniglio, A. Conte, F. Corea, S. Cottone, P. Crociani, F. D'Andrea, M. C. Danni, G. De Luca, D. de Pascalis, M. De Riz, F. De Robertis, G. De Rosa, N. De Stefano, M. Della Corte, A. Di Sapio, R. Docimo, M. Falcini, N. Falcone, S. Fermi, E. Ferraro, M. T. Ferro, M. Fortunato, M. Foschi, A. Gajofatto, A. Gallo, P. Gallo, M. Gatto, P. Gazzola, A. Giordano, F. Granella, M. F. Grasso, M. G. Grasso, L. M. E. Grimaldi, P. Iaffaldano, D. Imperiale, M. Inglese, R. Iodice, S. Leva, V. Luezzi, A. Lugaresi, G. Lus, D. Maimone, L. Mancinelli, G. T. Maniscalco, G. A. Marfia, B. Marini, A. Marson, N. Mascoli, L. Massacesi, F. Melani, M. Merello, G. Meucci, M. Mirabella, S. Montepietra, D. Nasuelli, P. Nicolao, F. Passantino, F. Patti, M. Peresson, I. Pesci, C. Piantadosi, M. L. Piras, M. Pizzorno, K. Plewnia, C. Pozzilli, A. Protti, R. Quatrale, S. Realmuto, G. Ribizzi, S. Rinalduzzi, A. Rini, S. Romano, M. Romeo, M. Ronzoni, P. Rossi, M. Rovaris, G. Salemi, G. Santangelo, M. Santangelo, G. Santuccio, P. Sarchielli, L. Sinisi, P. Sola, C. Solaro, D. Spitaleri, S. Strumia, T. Tassinari, S. Tonietti, C. Tortorella, R. Totaro, A. Tozzo, G. Trivelli, M. Ulivelli, P. Valentino, S. Venturi, M. Vianello, M. Zaffaroni, R. Zarbo, Maria Trojano, Mario Alberto Battaglia, Marco Capobianco, Maura Pugliatti, Monica Ulivelli, Paola Mosconi, Claudio Gasperini, Francesco Patti
Summary: The phenotypical heterogeneity of MS patients seen for the first time in Italian centers can only be partly explained by differences in the centers' characteristics, while the demographic and socio-economic characteristics of the patients seem to be the main determinants of the phenotypes at first referral.
NEUROLOGICAL SCIENCES
(2022)
Article
Clinical Neurology
Damiano Baroncini, Angelo Ghezzi, Clara Guaschino, Lucia Moiola, Massimo Filippi, Antonio Ianniello, Carlo Pozzilli, Roberta Lanzillo, Vincenzo Brescia-Morra, Monica Margoni, Paolo Gallo, Graziella Callari, Luigi Grimaldi, Giacomo Lus, Massimiliano Calabrese, Marta Simone, Girolama Alessandra Marfia, Sarah Rasia, Daniela Cargnelutti, Giancarlo Comi, Mauro Zaffaroni
Summary: Natalizumab treatment has a long-term significant impact on disease activity in pediatric multiple sclerosis, without new safety concerns.
NEUROLOGICAL SCIENCES
(2022)
Review
Clinical Neurology
Giacomo Lus, Marco Andre Bassano, Vincenzo Brescia Morra, Simona Bonavita, Antonio Gallo, Davide Maimone, Laura Malerba, Giorgia Teresa Maniscalco, Francesco Sacca, Giuseppe Salemi, Renato Turrini, Salvatore Cottone, Edoardo Sessa, Maria Buccafusca, Luigi Maria Edoardo Grimaldi
Summary: Multiple sclerosis (MS) is a chronic disease with different clinical courses and a tendency to worsening. Early identification of signs, symptoms, markers of progression, and management strategies is crucial in preventing the conversion to secondary progressive MS (SPMS).
NEUROLOGICAL SCIENCES
(2023)
Article
Environmental Sciences
Cristina Mennitti, Annaluisa Ranieri, Ersilia Nigro, Lorella Tripodi, Mariarita Brancaccio, Jacopo Ulisse, Luca Gentile, Fabio Fimiani, Arturo Cesaro, Giovanni D'Alicandro, Giuseppe Limongelli, Aurora Daniele, Raffaela Pero, Giulia Frisso, Paolo Calabro, Lucio Pastore, Maria Rosaria Licenziati, Olga Scudiero, Barbara Lombardo
Summary: This study evaluated the differences in biochemical parameters between obese children who engage in physical exercise and sedentary obese children. It found that physical exercise reduces the inflammatory state in obese children and identified a panel of biomarkers that can help prevent obesity-related complications.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2023)
Article
Genetics & Heredity
Ferdinando Barretta, Fabiana Uomo, Filomena Caldora, Rossella Mocerino, Daniela Adamo, Francesco Testa, Francesca Simonelli, Olga Scudiero, Nadia Tinto, Giulia Frisso, Cristina Mazzaccara
Summary: This study presents a custom MITO-NUCLEAR assay that enables simultaneous identification of genetic variants in both mtDNA and nuclear genes, providing a potential one-step investigation for the genetic diagnosis of mitochondrial diseases.
Article
Medicine, General & Internal
Elisabetta Signoriello, Giacomo Lus, Francesco Sacca, Marco Puthenparampil, Cinzia Coppola, Andrea Di Pietro, Gianfranco Puoti, Maria Cristina Criscuolo, Matteo Foschi, Giuseppina Miele, Gianmarco Abbadessa, Vincenzo Brescia Morra, Paolo Gallo, Simona Bonavita, Maria Pia Sormani, Alessio Signori
Summary: This study analyzed the changes in lymphocyte subsets after alemtuzumab administration in relation to disease activity and autoimmune adverse events in highly active multiple sclerosis (MS) patients. The results showed a significant decrease in total lymphocytes, CD4, CD8, and CD20 in all patients over 2 years. Additionally, the early use of alemtuzumab as an induction therapy may mitigate the risk of treatment failure.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Cristina Mennitti, Ciro Miele, Carmela Scarano, Iolanda Veneruso, Alessandro Gentile, Rosaria Mormile, Francesca Saviano, Giovanni D'Alicandro, Cristina Mazzaccara, Giulia Frisso, Filomena Capasso, Valeria D'Argenio, Olga Scudiero
Summary: Acute or intense exercise can lead to metabolic imbalances, muscle injuries, or expose underlying disorders. Laboratory medicine in sports is crucial in monitoring athletes' health. This study presents an integrated approach to investigating the causes of deep venous thrombosis in an elite basketball player.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Nutrition & Dietetics
Ersilia Nigro, Vito D'Agnano, Gianluca Quarcio, Domenica Francesca Mariniello, Andrea Bianco, Aurora Daniele, Fabio Perrotta
Summary: Adipose tissue is not only a store of energy but also an endocrine organ. Obesity has been identified as a major risk factor for severe COVID-19 outcomes, likely due to the abnormal production of adipokines that can cause metabolic alterations, vascular endothelium dysfunction, and chronic inflammation. Understanding the link between obesity and COVID-19 severity can greatly contribute to the development of effective therapeutic strategies.
Article
Genetics & Heredity
Alessandro Gentile, Carolina Punziano, Mariella Calvanese, Renato De Falco, Luca Gentile, Giovanni D'Alicandro, Ciro Miele, Filomena Capasso, Raffaela Pero, Cristina Mazzaccara, Barbara Lombardo, Giulia Frisso, Paola Borrelli, Cristina Mennitti, Olga Scudiero, Raffaella Faraonio
Summary: Intense physical activity can modify biochemical biomarkers and gene expression without causing damage to the liver or kidney. This information is helpful for injury prevention in professional athletes.
Article
Clinical Neurology
Giancarlo Comi, Letizia Leocani, Luigi Ferini-Strambi, Marta Radaelli, Gloria D. Costa, Roberta Lanzillo, Giacomo Lus, Valentina Bianchi, Sebastiano Traccis, Fioravante Capone, Luigi M. E. Grimaldi, Giuseppe Salemi, Alessandra Cardillo, Valentina Zipoli
Summary: This multicentre observational study evaluated the effects of treatment with oral dimethyl fumarate on the quality of sleep in patients with relapsing-remitting multiple sclerosis. The results showed significant improvement in the quality of sleep and depression symptoms in patients treated with dimethyl fumarate. However, further randomised clinical trials are needed to confirm the long-term treatment benefits.
MULTIPLE SCLEROSIS JOURNAL-EXPERIMENTAL TRANSLATIONAL AND CLINICAL
(2023)
Meeting Abstract
Clinical Neurology
Ermelinda De Meo, Massimo Filippi, Vincenzo Brescia Morra, Francesco Patti, Giorgia Teresa Maniscalco, Valentina Torri Clerici, Giuseppe Salemi, Marco Onofrj, Giacomo Lus, Marta Simone, Maria Trojano, Maria Pia Amato
Meeting Abstract
Clinical Neurology
E. Signoriello, G. Lus, F. Sacca, M. Puthenparampil, C. Coppola, A. Di Pietro, M. Criscuolo, M. Foschi, V. Brescia Morra, P. Gallo, S. Bonavita, M. Sormani, A. Signori
EUROPEAN JOURNAL OF NEUROLOGY
(2022)