期刊
IMMUNE NETWORK
卷 15, 期 4, 页码 191-198出版社
KOREA ASSOC IMMUNOLOGISTS
DOI: 10.4110/in.2015.15.4.191
关键词
Hepatitis B Virus; Pathogenesis; Immune response
类别
Hepatitis B virus (HBV) is responsible for approximately 350 million chronic infections worldwide and is a leading cause of broad-spectrum liver diseases such as hepatitis, cirrhosis and liver cancer. Although it has been well established that adaptive immunity plays a critical role in viral clearance, the pathogenetic mechanisms that cause liver damage during acute and chronic HBV infection remain largely known. This review describes our current knowledge of the immune-mediated pathogenesis of HBV infection and the role of immune cells in the liver injury during hepatitis B.
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