Review
Cardiac & Cardiovascular Systems
Rasha K. Al-Lamee, Christopher A. Rajkumar, Sashiananthan Ganesananthan, Allen Jeremias
Summary: Invasive coronary physiology has become established as an important component in guidelines for managing stable coronary artery disease, improving clinical outcomes and cost efficiency. Despite recent doubts from randomized controlled trials, it remains crucial for selecting patients for coronary revascularization.
Article
Biotechnology & Applied Microbiology
Gaurav Chandola, Jun-Mei Zhang, Ru-San Tan, Ping Chai, Lynette Teo, John C. Allen, Ris Low, Weimin Huang, Shuang Leng, Jiang Ming Fam, Chee Yang Chin, Ghassan S. Kassab, Adrian Fatt Hoe Low, Swee Yaw Tan, Terrance Chua, Soo Teik Lim, Liang Zhong
Summary: The study assessed the feasibility and accuracy of a non-invasive FFR calculation based on CTCA for predicting coronary hemodynamics before and after stenting, finding a good correlation and agreement with invasive FFR, especially in predicting the hemodynamic effects post-stenting, indicating its potential as a useful tool in PCI planning.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Damien Collison, Matthaios Didagelos, Muhammad Aetesam-ur-Rahman, Samuel Copt, Robert McDade, Peter McCartney, Thomas J. Ford, John McClure, Mitchell Lindsay, Aadil Shaukat, Paul Rocchiccioli, Richard Brogan, Stuart Watkins, Margaret McEntegart, Richard Good, Keith Robertson, Patrick O'Boyle, Andrew Davie, Adnan Khan, Stuart Hood, Hany Eteiba, Colin Berry, Keith G. Oldroyd
Summary: The study aimed to evaluate the feasibility and efficacy of a post-PCI FFR-guided optimization strategy compared to standard coronary angiography in achieving final post-PCI FFR values >= 0.90. While the FFR-guided optimization strategy did not significantly increase the proportion of patients with final FFR >= 0.90, it did significantly reduce the proportion of patients with final FFR <= 0.80.
EUROPEAN HEART JOURNAL
(2021)
Article
Cardiac & Cardiovascular Systems
Damien Collison, Matthaios Didagelos, Muhammad Aetesam-Ur-Rahman, Samuel Copt, Robert McDade, Peter McCartney, Thomas J. Ford, John McClure, Mitchell Lindsay, Aadil Shaukat, Paul Rocchiccioli, Richard Brogan, Stuart Watkins, Margaret McEntegart, Richard Good, Keith Robertson, Patrick O'Boyle, Andrew Davie, Adnan Khan, Stuart Hood, Hany Eteiba, Colin Berry, Keith G. Oldroyd
Summary: The TARGET-FFR trial examined the importance of FFR value >= 0.90 after PCI, finding that an FFR-guided optimization strategy did not significantly increase this proportion, but did reduce the proportion of patients with FFR value <= 0.80.
EUROPEAN HEART JOURNAL
(2021)
Article
Cardiac & Cardiovascular Systems
Rikuta Hamaya, Shinichi Goto, Doyeon Hwang, Jinlong Zhang, Seokhun Yang, Joo Myung Lee, Masahiro Hoshino, Chang-Wook Nam, Eun-Seok Shin, Joon-Hyung Doh, Shao-Liang Chen, Gabor G. Toth, Zsolt Piroth, Abdul Hakeem, Barry F. Uretsky, Yohei Hokama, Nobuhiro Tanaka, Hong-Seok Lim, Tsuyoshi Ito, Akiko Matsuo, Lorenzo Azzalini, Massoud A. Leesar, Carlos Collet, Bon-Kwon Koo, Bernard De Bruyne, Tsunekazu Kakuta
Summary: This study used machine learning algorithms to predict post-percutaneous coronary intervention (PCI) fractional flow reserve (FFR) based on baseline information and clinical relevance. The study found a moderate correlation between predicted and actual post-PCI FFR, and the deviation of post-PCI FFR from the predicted value was associated with incident target vessel failure.
Article
Cardiac & Cardiovascular Systems
Rikuta Hamaya, Taishi Yonetsu, Kodai Sayama, Kazuki Matsuda, Hiroki Ueno, Tatsuhiro Nagamine, Toru Misawa, Masahiro Hada, Masahiro Hoshino, Tomoyo Sugiyama, Tetsuo Sasano, Tsunekazu Kakuta
Summary: This study investigated the determinants and prognostic implications of changes in coronary flow capacity (CFC) following percutaneous coronary intervention (PCI) in patients with chronic coronary syndrome (CCS). The results showed that changes in CFC were associated with the risk of incident target vessel failure (TVF) and were largely predicted by the pre-PCI CFC status.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Hu Ai, Naixin Zheng, Le Li, Guojian Yang, Hui Li, Guodong Tang, Qi Zhou, Huiping Zhang, Xue Yu, Feng Xu, Ying Zhao, Fucheng Sun
Summary: This study found that caFFR measurements are well-correlated and in agreement with invasive wire-based FFR measurements before and after PCI. Post-PCI caFFR measurements, similar to wire-based FFR measurements, can help identify patients at higher risk for adverse events.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Jinlong Zhang, Jun Jiang, Xinyang Hu, Yong Sun, Changling Li, Lingjun Zhu, Feng Gao, Liang Dong, Yabin Liu, Jian Shen, Cheng Ni, Kan Wang, Zexin Chen, Haibo Chen, Shiqiang Li, Seokhun Yang, Jeehoon Kang, Doyeon Hwang, Joo-Yong Hahn, Chang-Wook Nam, Joon-Hyung Doh, Bong-Ki Lee, Weon Kim, Jinyu Huang, Fan Jiang, Hao Zhou, Peng Chen, Lijiang Tang, Wenbing Jiang, Xiaomin Chen, Wenming He, Sung Gyun Ahn, Myeong-Ho Yoon, Ung Kim, Joo Myung Lee, You-Jeong Ki, Eun-Seok Shin, Chee Hae Kim, Seung-Jea Tahk, Bon-Kwon Koo, Jian'an Wang
Summary: In cases of intermediate stenosis, women had more favorable outcomes compared to men despite receiving fewer interventions. The use of FFR led to a lower PCI rate but had a similar prognostic value compared to IVUS in both women and men.
JACC-CARDIOVASCULAR INTERVENTIONS
(2023)
Article
Cardiac & Cardiovascular Systems
Tara Neleman, Alessandra Scoccia, Kaneshka Masdjedi, Mariusz Tomaniak, Jurgen M. R. Ligthart, Karen T. Witberg, Alise Vermaire, Quinten Wolff, Leon Visser, Paul Cummins, Isabella Kardys, Jeroen Wilschut, Roberto Diletti, Wijnand K. Den Dekker, Felix Zijlstra, Nicolas M. Van Mieghem, Joost Daemen
Summary: Lower post-PCI vFFR values are significantly associated with an increased risk of TVF and TVR at 5 years follow-up.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Article
Medicine, General & Internal
Povilas Budrys, Aaron Peace, Arvydas Baranauskas, Giedrius Davidavicius
Summary: This study compared the effectiveness of FFR and IVUS PCI optimization strategies for long coronary lesions. The results showed that the FFR optimization strategy resulted in poorer functional PCI outcomes and larger myocardial ischemia burden compared to the IVUS optimization strategy. However, this difference did not have a statistically significant impact on clinical outcomes.
Article
Cardiac & Cardiovascular Systems
Sakura Nagumo, Carlos Collet, Bjarne L. Norgaard, Hiromasa Otake, Brian Ko, Bon-kwon Koo, Jonathon Leipsic, Daniele Andreini, Ward Heggermont, Jesper M. Jensen, Yu Takahashi, Abdul Ihdayhid, Zinlong Zhang, Emanuele Barbato, Michael Maeng, Takuya Mizukami, Jozef Bartunek, Adam Updegrove, Martin Penicka, Campbell Rogers, Charles Taylor, Bernard De Bruyne, Jeroen Sonck
Summary: This study aims to validate the accuracy of FFRCT Planner in predicting post-PCI FFR with invasive FFR as a reference standard. The study includes 127 patients, with 100 patients already enrolled, and the final results are expected in 2021.
CLINICAL CARDIOLOGY
(2021)
Article
Multidisciplinary Sciences
Takuro Abe, Kensuke Shimazaki, Tetsu Moriyama, Akira Murohashi, Yuji Iwanami, Akihito Sasaki, Katsumi Saito, Kentaro Jujo
Summary: Deferring percutaneous coronary intervention (PCI) for functionally insignificant stenosis with a fractional flow reserve (FFR) > 0.80 is associated with favorable long-term outcomes. This study examined the optimal management of low-density lipoprotein cholesterol (LDL-C) in patients with intermediate coronary stenosis and deferred PCI based on FFR values. The results showed that uncontrolled LDL-C levels were associated with higher major adverse cardiovascular and cerebrovascular events (MACCE) rates in patients with FFR values of 0.81-0.85, highlighting the importance of strict LDL-C-lowering therapy for this high-risk population.
SCIENTIFIC REPORTS
(2023)
Article
Cardiac & Cardiovascular Systems
Haseong Chang, Hyun Kuk Kim, Doosup Shin, Kyung Seob Lim, Sun-Uk Kim, Chang-Yeop Jeon, Hwal-Yong Lee, Youngjeon Lee, Jinyoung Won, Seung Hun Lee, Tsunekazu Kakuta, Joo Myung Lee
Summary: This study evaluated the temporal changes of coronary circulatory indexes in tandem stenoses before and after angioplasty for proximal stenosis. The results showed significant changes in coronary circulatory indexes after angioplasty for proximal stenosis, with alterations in blood flow indexes and pressure gradient.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Cardiac & Cardiovascular Systems
Rikuta Hamaya, Joo Myung Lee, Masahiro Hoshino, Taishi Yonetsu, Bon-Kwon Koo, Javier Escaned, Tsunekazu Kakuta
Summary: This study investigated the effect of PCI on vessel-related MACE in stable coronary lesions based on CFC status. The results showed that FFR-guided PCI for low CFC lesions was associated with a reduced incidence of MACE.
Article
Cardiac & Cardiovascular Systems
Ashkan Eftekhari, Tim P. van de Hoef, Masahiro Hoshino, Joo Myung Lee, Coen K. M. Boerhout, Guus A. de Waard, Ji-Hyun Jung, Seung Hun Lee, Hernan Mejia-Renteria, Mauro Echavarria-Pinto, Martijn Meuwissen, Hitoshi Matsuo, Maribel Madera-Cambero, Mohamed A. Effat, Koen Marques, Joon-Hyung Doh, Rupak Banerjee, Chang-Wook Nam, Giampaolo Niccoli, Tadashi Murai, Masafumi Nakayama, Nobuhiro Tanaka, Eun-Seok Shin, Paul Knaapen, Niels van Royen, Javier Escaned, Bon Kwon Koo, Steven A. J. Chamuleau, Tsunekazu Kakuta, Jan J. Piek, Evald Hoj Christiansen
Summary: This study investigated the association between changes in microvascular resistance (MR) and target vessel failure (TVF) in patients undergoing percutaneous coronary intervention (PCI). The results showed that increased MR post-PCI was associated with lesions of less severe hemodynamic influence at baseline and higher rates of TVF at follow-up.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Anne-Sophie Juul, Kasper Kyhl, Kathrine Ekstr, Jasmine Melissa Madsen, Muhammad Sabbah, Kiril Aleksov Ahtarovski, Lars Nepper-Christensen, Niels Vejlstrup, Dan Hofsten, Henning Kelbaek, Lars Kober, Jacob Lonborg, Thomas Engstrom
Summary: Mounting evidence shows that right ventricle (RV) function carries independent prognostic influence in various disease states. This study investigated the incidence and impact of permanent RV infarction in patients with inferior ST-segment elevation myocardial infarction (STEMI) and culprit lesion in the right coronary artery (RCA). The results revealed that permanent RV infarction occurred in 20% of these patients and independently predicted the size of the final left ventricular infarct.
AMERICAN JOURNAL OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Jonas Bruhn, Morten Malmborg, Caroline H. Garred, Pauline Ravn, Deewa Zahir, Charlotte Andersson, Gunnar Gislason, Christian Torp-Pedersen, Kristian Kragholm, Emil Fosbol, Jawad H. Butt, Ninian N. Lang, Mark C. Petrie, John McMurray, Lars Kober, Morten Schou
Summary: This study investigated the temporal trends of new onset cancer in patients with HF between 1997 and 2016. It found that the incidence of cancer did not increase over time in HF patients, but long-term survival following an HF diagnosis significantly increased.
EUROPEAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
James P. Curtain, Carly Adamson, Toru Kondo, Jawad Butt, Akshay S. Desai, Faiez Zannad, Jean L. Rouleau, Luis E. Rohde, Lars Kober, Inder S. Anand, Dirk J. van Veldhuisen, Michael R. Zile, Martin P. Lefkowitz, Scott D. Solomon, Milton Packer, Mark C. Petrie, Pardeep S. Jhund, John J. McMurray
Summary: This study examined the incidence of ventricular tachycardia (VT) and ventricular fibrillation (VF) in patients with heart failure and their relationship with mortality. The results showed that VT/VF events were uncommon but strongly associated with mortality in heart failure patients. These events seem to be markers of disease severity rather than risk of sudden death.
EUROPEAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Elke Platz, Brian Claggett, Karola S. Jering, Attila Kovacs, Maja Cikes, Ephraim B. Winzer, Aria Rad, Martin P. Lefkowitz, Jianjian Gong, Lars Kober, John J. McMurray, Scott D. Solomon, Marc A. Pfeffer, Amil Shah
Summary: This study examined the efficacy of sacubitril/valsartan in patients with acute myocardial infarction (AMI) and reduced left ventricular ejection fraction (LVEF), pulmonary congestion, or both. The study used lung ultrasound (LUS) to assess the trajectory of pulmonary congestion and its association with cardiac structure and function.
EUROPEAN HEART JOURNAL-ACUTE CARDIOVASCULAR CARE
(2023)
Article
Cardiac & Cardiovascular Systems
Jawad H. Butt, Brian L. Claggett, Zi M. Miao, Karola S. Jering, David Sim, Peter van der Meer, Mpiko Ntsekhe, Offer Amir, Myeong-Chan Cho, Jorge Carrillo-Calvillo, Julio E. Nunez, Alberto Cadena, Prafulla Kerkar, Aldo P. Maggioni, Philippe G. Steg, Christopher B. Granger, Douglas L. Mann, Bela Merkely, Eldrin F. Lewis, Scott D. Solomon, Yinong Zhou, Lars Kober, Eugene Braunwald, John J. V. McMurray, Marc A. Pfeffer
Summary: This study investigated the geographic differences in patient characteristics, treatments, and outcomes in global clinical trials. Patients from Asia, especially South Asia, differed from patients in other regions in terms of age, weight, comorbidities, type of myocardial infarction, and treatment. On the other hand, patients from Latin America did not differ significantly from European or North American patients. These findings highlight the importance of considering regional differences when designing global clinical trials.
EUROPEAN JOURNAL OF HEART FAILURE
(2023)
Article
Cardiac & Cardiovascular Systems
Niklas Dyrby Johansen, Muthiah Vaduganathan, Ankeet S. Bhatt, Simin Gharib Lee, Daniel Modin, Brian L. Claggett, Erica L. Dueger, Sandrine Samson, Matthew M. Loiacono, Rebecca C. Harris, Lars Kober, Scott D. Solomon, Pradeesh Sivapalan, Jens Ulrik Staehr Jensen, Cyril Jean-Marie Martel, Palle Valentiner-Branth, Tyra Grove Krause, Tor Biering-Sorensen
Summary: This study analyzed the effects of two behavioral nudging letter strategies on influenza vaccination rates in patients with heart failure (HF). The results showed that the vaccination rate in HF patients was relatively low, but the behavioral nudging letter strategies were effective in increasing the vaccination rate and had no negative impact on the use of guideline-directed medical therapy (GDMT) in the long term.
EUROPEAN JOURNAL OF HEART FAILURE
(2023)
Article
Cardiac & Cardiovascular Systems
Anders Holt, Jarl E. Strange, Nina Nouhravesh, Sebastian Kinnberg Nielsen, Mariam Elmegaard Malik, Anne -Marie Schjerning, Lars Kober, Christian Torp-Pedersen, Gunnar H. Gislason, Patricia McGettigan, Morten Schou, Morten Lamberts
Summary: This study found an association between short-term use of NSAIDs and an increased risk of first-time hospitalization for heart failure in patients with type 2 diabetes. Patients in subgroups with advanced age, elevated HbA1c levels, and new users of NSAIDs were particularly susceptible.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Antonio Molinaro, Ina Nemet, Pierre Bel Lassen, Rima Chakaroun, Trine Nielsen, Judith Aron-Wisnewsky, Per-Olof Bergh, Lin Li, Marcus Henricsson, Lars Kober, Richard Isnard, Gerard Helft, Michael Stumvoll, Oluf Pedersen, J. Gustav Smith, W. H. Wilson Tang, Karine Clement, Stanley L. Hazen, Fredrik Backhed
Summary: The gut microbial metabolite ImP is associated with heart failure and predicts overall survival. This study sheds light on the relationship between ImP and heart failure.
JACC-HEART FAILURE
(2023)
Letter
Cardiac & Cardiovascular Systems
Jawad H. Butt, Adelina Yafasova, Seiko N. Doi, Jens C. Nielsen, Jens Haarbo, Hans Eiskjaer, Axel Brandes, Anna M. Thogersen, Finn Gustafsson, Christian Hassager, Jesper H. Svendsen, Dan E. Hofsten, Lars Videbaek, Christian Torp-Pedersen, Steen Pehrson, Jens Jakob Thune, Lars Kober
Article
Cardiac & Cardiovascular Systems
Naja Emborg Vinding, Jawad H. Butt, Marie Dam Lauridsen, Soren Lund Kristensen, Soren Paaske Johnsen, Johanna Kroll, Peter L. Graversen, Christina Kruuse, Christian Torp-Pedersen, Lars Kober, Emil L. Fosbol
Summary: The incidence of ischemic stroke after a first-time transient ischemic attack (TIA) is 6.1% during a 5-year follow-up period, which is higher than the background population but lower than patients with recurrent ischemic stroke. TIA patients also have a higher mortality rate.
Article
Cardiac & Cardiovascular Systems
Mingming Yang, Toru Kondo, Carly Adamson, Jawad H. Butt, William T. Abraham, Akshay S. Desai, Karola S. Jering, Lars Kober, Mikhail N. Kosiborod, Milton Packer, Jean L. Rouleau, Scott D. Solomon, Muthiah Vaduganathan, Michael R. Zile, Pardeep S. Jhund, John J. V. McMurray
Summary: This study aimed to assess the relationship between patient-reported knowledge of self-management and clinical outcomes in patients with heart failure and reduced ejection fraction (HFrEF). It was found that poor self-rated knowledge may be associated with higher rates of mortality. Evaluation of knowledge of 'self-efficacy' may provide prognostic information and a guide to which patients may benefit from further education about self-management.
EUROPEAN JOURNAL OF HEART FAILURE
(2023)
Article
Cardiac & Cardiovascular Systems
Mingming Yang, Toru Kondo, Carly Adamson, Jawad H. Butt, William T. Abraham, Akshay S. Desai, Karola S. Jering, Lars Kober, Mikhail N. Kosiborod, Milton Packer, Jean L. Rouleau, Scott D. Solomon, Muthiah Vaduganathan, Michael R. Zile, Pardeep S. Jhund, John J. V. McMurray
Summary: This study aimed to assess the impact of different comorbidities on health status in patients with HFpEF and HFrEF. The results showed that chronic obstructive pulmonary disease, angina, anaemia, and obesity were associated with reduced health status. Patients with multiple comorbidities had worse health status.
EUROPEAN JOURNAL OF HEART FAILURE
(2023)
Article
Medicine, General & Internal
Willy B. Theel, Bianca M. Boxma-de Klerk, Femme Dirksmeier-Harinck, Elisabeth F. C. van Rossum, Danny A. Kanhai, Jan A. Apers, Bas M. van Dalen, Robert J. De Knegt, Bojou Neecke, Ellen M. van der Zwan, Diederick E. Grobbee, Thomas Hankemeier, Janneke Wiebolt, Manuel Castro Cabezas
Summary: The prevalence of NAFLD ranges from 25% in the general population to 90% in obese patients scheduled for bariatric surgery. NAFLD can progress to NASH, leading to serious complications. Weight loss and lifestyle changes are the current treatment options, and bariatric surgery has shown short-term improvements. However, the extent and long-term effects of surgery on NAFLD/NASH are still uncertain. The factors involved in the regression of NAFLD/NASH after bariatric surgery have not been fully understood.
Correction
Cardiac & Cardiovascular Systems
James P. Curtain, Carly Adamson, Toru Kondo, Jawad Haider Butt, Akshay S. Desai, Faiez Zannad, Jean L. Rouleau, Luis E. Rohde, Lars Kober, Inder S. Anand, Dirk J. van Veldhuisen, Michael R. Zile, Martin P. Lefkowitz, Scott D. Solomon, Milton Packer, Mark C. Petrie, Pardeep S. Jhund, John J. V. McMurray
EUROPEAN HEART JOURNAL
(2023)
Article
Urology & Nephrology
Katja Vu Bartholdy, Niklas Dyrby Johansen, Nino Landler, Kristoffer Grundtvig Skaarup, Jesper Jensen, Iain Bressendorff, Morten Schou, Jacob Christensen, Bo Feldt-Rasmussen, Muthiah Vaduganathan, Scott Solomon, Richard Haynes, Frederik Persson, Peter Rossing, Lars Kober, Faiez Zannad, Ditte Hansen, Tor Biering-Sorensen
Summary: This study aims to evaluate the effects of SGLT2 inhibitors on cardiac structure and function in patients with CKD. The results will provide insights into the cardioprotective mechanisms of SGLT2 inhibitors in patients with CKD.