Article
Medicine, General & Internal
Pontus Thorild, Georgios Mourtzinis
Summary: This retrospective observational study assessed the usefulness of exercise ECG in patients with low pre-test probability (PTP) of significant coronary artery disease and stable chest pain. The study found that exercise ECG had a high negative predictive value and a low positive predictive value in this population.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Min-Kyung Kang, Dong Geum Shin, Donghoon Han, Seonghoon Choi, Jung Rae Cho, Namho Lee
Summary: In patients with elevated cardiac troponin I (cTnI), 60% were diagnosed with coronary artery disease (CAD), 17% were suspected to have microvascular angina (MVA), and the remaining 23% had non-angina (NA). Patients with CAD had elevated blood pressure and slightly decreased heart rate, while those with NA had higher levels of high-density lipoprotein (HDL). Reduced HDL level was independently associated with the presence of CAD.
Article
Cardiac & Cardiovascular Systems
Kristian Taekker Madsen, Karsten Tange Veien, Pia Larsen, Majed Husain, Lone Deibjerg, Anders Junker, Martin Weber Kusk, Kristian Korsgaard Thomsen, Allan Rohold, Lisette Okkels Jensen, Niels Peter Ronnow Sand
Summary: This study aimed to evaluate the association between CCTA-derived FFRCT and recurrent chest pain in patients with SAP. The results showed that an abnormal FFRCT test result was associated with an increased risk of recurrent chest pain, independent of coronary calcification and stenosis. Additionally, a negative association between per-patient minimal d-FFRCT and recurrent chest pain was demonstrated, highlighting the importance of FFRCT testing in predicting long-term outcomes for patients with SAP.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2022)
Article
Medicine, General & Internal
Pal Maurovich-Horvat, Maria Bosserdt, Klaus F. Kofoed, Nina Rieckmann, Theodora Benedek, Patrick Donnelly, Jose Rodriguez-Palomares, Andrejs Erglis, Cyril Stechovsk, Gintare Sakalyte, Nada Cemerlic Adic, Matthias Gutberlet, Jonathan D. Dodd, Ignacio Diez, Gershan Davis, Elke Zimmermann, Cezary Kepka, Radosav Vidakovic, Marco Francone, Malgorzata Ilnicka-Suckiel, Fabian Plank, Juhani Knuuti, Rita Faria, Stephen Schroder, Colin Berry, Luca Saba, Balazs Ruzsics, Christine Kubiak, Inaki Gutierrez-Ibarluzea, Kristian Schultz Hansen, Jacqueline Muller-Nordhorn, Bela Merkely, Andreas D. Knudsen, Imre Benedek, Clare Orr, Filipa Xavier Valente, Ligita Zvaigzne, Vojtech Suchanek, Laura Zajanckauskiene, Flip Adic, Michael Woinke, Mark Hensey, Inigo Lecumberri, Erica Thwaite, Michael Laule, Mariusz Kruk, Aleksandar N. Neskovic, Massimo Mancone, Gudrun Feuchtner, Donata Kugrnierz, Mikko Pietila, Vasco Gama Ribeiro, Tanja Drosch, Christian Delles, Gildo Matta, Michael Fisher, Balint Szilveszter, Linnea Larsen, Mihaela Ratiu, Stephanie Kelly, Bruno Garcia del Blanco, Ainhoa Rubio, Zsofia D. Drobni, Birgit Jurlander, Ioana Rodean, Susan Regan, Hug Cuellar Calabria, Melinda Boussoussou, Thomas Engstrom, Roxana Hodas, Adriane E. Napp, Robert Haase, Sarah Feger, Lina M. Serna-Higuita, Konrad Neumann, Henryk Dreger, Matthias Rief, Viktoria Wieske, Melanie Estrella, Peter Martus, Marc Dewey
Summary: This study compared the effectiveness of CT and ICA in diagnosing obstructive CAD. The results showed that among patients with stable chest pain and intermediate pretest probability of CAD, the risk of major adverse cardiovascular events was similar between the CT group and the ICA group. However, the frequency of major procedure-related complications was lower in the CT group.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Review
Cardiac & Cardiovascular Systems
Divaka Perera, Colin Berry, Stephen P. Hoole, Aish Sinha, Haseeb Rahman, Paul D. Morris, Rajesh K. Kharbanda, Ricardo Petraco, Keith Channon
Summary: Nearly half of patients with angina have non-obstructive coronary artery disease (ANOCA), with two-thirds of these patients having coronary microvascular disease (CMD). Impaired coronary flow reserve (CFR) is associated with myocardial ischemia and adverse cardiovascular outcomes. The CMD workstream aims to improve accuracy of diagnosis and treatment through standardized procedures and various assessment methods.
Article
Cardiac & Cardiovascular Systems
Byoung Geol Choi, Ji Young Park, Seung-Woon Rha, Yung-Kyun Noh
Summary: This study developed a high-performance model of ML-PTP for coronary artery disease (CAD) using machine learning techniques. This model has the potential to reduce the need for non-invasive tests in patients with chest pain. However, further multicenter validation is needed to establish this ML-PTP as a recommended tool by major cardiology societies.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Juntae Kim, Su Yeon Lee, Byung Hee Cha, Wonseop Lee, JiWung Ryu, Young Hak Chung, Dongmin Kim, Seong-Hoon Lim, Tae Soo Kang, Byoung-Eun Park, Myung-Yong Lee, Sungsoo Cho
Summary: This study developed machine learning models using clinically relevant biomarkers to predict the presence of stable obstructive coronary artery disease (CAD). The best-performing model showed an accuracy of 74.6% and outperformed established pre-test probability models. This approach could improve discrimination of patients with suspected obstructive CAD and guide non-invasive testing for ischemia.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Jane Lange Dalsgaard, Michael Skov Hansen, Lars Thrysoee, Ola Ekholm, Charlotte Brun Thorup, Rikke Mols, Trine Bernholdt Rasmussen, Anne Vinggaard Christensen, Selina Kikkenborg Berg, Andreas Kristian Pedersen, Lisette Okkels Jensen, Christian Backer Mogensen, Britt Borregaard
Summary: This study aimed to compare self-reported health at discharge between women diagnosed with angina or unspecific chest pain and investigate the association between self-reported health and adverse outcomes within 3 years. The results showed that women with angina reported significantly worse self-reported health on several outcomes compared to women with unspecific chest pain. Women with angina were more likely to be readmitted and undergo revascularization within the 3-year follow-up period.
EUROPEAN JOURNAL OF CARDIOVASCULAR NURSING
(2023)
Review
Medicine, General & Internal
Rasha K. Al-Lamee, Michael Foley, Christopher A. Rajkumar, Darrel P. Francis
Summary: The management of stable coronary artery disease focuses on preventing myocardial infarction and death. Recent studies have questioned the effectiveness of revascularization procedures. It is important to consider high-risk patients and address communication issues in doctor-patient consultations.
BMJ-BRITISH MEDICAL JOURNAL
(2022)
Article
Cardiac & Cardiovascular Systems
Aitor Hernandez-Hernandez, Carles Diez-Lopez, Olga Azevedo, Julian Palomino-Doza, Fernando Alfonso, Maria Eugenia Fuentes-Canamero, Maria Victoria Mogollon Jimenez, Carlos Casanova Rodriguez, Aurora Ruz, Coloma Tiron, Vicente Climent, Pablo Garcia-Pavia
Summary: A study of 663 chest pain patients showed that AFD is rare in patients without obstructive coronary artery disease, with an overall prevalence of only 0.15%. Screening efforts for AFD should not be conducted in this patient population.
JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Christopher A. Rajkumar, Matthew Shun-Shin, Henry Seligman, Yousif Ahmad, Takayuki Warisawa, Christopher M. Cook, James P. Howard, Sashiananthan Ganesananthan, Laura Amarin, Caitlin Khan, Ayesha Ahmed, Alexandra Nowbar, Michael Foley, Ravi Assomull, Niall G. Keenan, Joban Sehmi, Thomas R. Keeble, John R. Davies, Kare H. Tang, Robert Gerber, Graham Cole, Peter O'Kane, Andrew S. P. Sharp, Ramzi Khamis, Gajen Kanaganayagam, Ricardo Petraco, Neil Ruparelia, Iqbal S. Malik, Sukhjinder Nijjer, Sayan Sen, Darrel P. Francis, Rasha Al-Lamee
Summary: The study found that PCI achieved a significantly greater reduction in stress echocardiography ischemia in focal compared with diffuse CAD cases. However, there was no observed difference in symptom end points between the two CAD patterns.
CIRCULATION-CARDIOVASCULAR INTERVENTIONS
(2021)
Article
Cardiac & Cardiovascular Systems
Jules Mesnier, Gregory Ducrocq, Nicolas Danchin, Roberto Ferrari, Ian Ford, Jean-Claude Tardif, Michal Tendera, Kim M. Fox, Philippe Gabriel Steg
Summary: The study found that angina affects almost one-quarter of stable coronary artery disease patients, but resolves without events or coronary revascularization in most cases. Patients whose angina resolved within one year with conservative management had outcomes similar to those without angina, while persistence or occurrence of angina was associated with worse outcomes.
Article
Cardiac & Cardiovascular Systems
Yao Shen, Tingting Yan, Qian Peng, Baofeng Zhang, Ke Zhao, Zhan Yang
Summary: Patients with angina pectoris of coronary artery disease often experience moderate pain episodes and exhibit moderate to high levels of kinesiophobia. Factors such as personal monthly income, New York Heart Function Assessment classification, pain intensity, and pain resilience are associated with kinesiophobia. This study emphasizes the importance of addressing kinesiophobia in patients with coronary artery disease.
Article
Multidisciplinary Sciences
Ye-fei Li, Yu Zhang, Liang Chen, Kou-long Zheng, Hui-he Lu, Zhen-qiang Sheng
Summary: The ergonovine provocation test of radial artery showed high sensitivity, specificity, and safety in diagnosing coronary artery spasm, with an ROC curve area of 0.912, specificity of 92.86%, and sensitivity of 84.21%.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, General & Internal
Daniel M. Blumenthal, Sidney E. Howard, Jennifer Searl Como, Sandra M. O'Keefe, Steven J. Atlas, Daniel M. Horn, Neil W. Wagle, Jason H. Wasfy, Robert W. Yeh, Joshua P. Metlay
Summary: Among stable outpatients with CAD receiving primary care through an integrated primary care network, 21.2% of surveyed patients reported experiencing angina at least once monthly. Several objective demographic and clinical characteristics were associated with angina frequency.
Article
Cardiac & Cardiovascular Systems
Flemming J. Olsen, Louisa M. Christensen, Derk W. Krieger, Soren Hojberg, Nis Host, Finn M. Karlsen, Jesper H. Svendsen, Hanne Christensen, Tor Biering-Sorensen
INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING
(2020)
Article
Cardiac & Cardiovascular Systems
Soren Zoga Diederichsen, Ketil Jorgen Haugan, Axel Brandes, Claus Graff, Derk Krieger, Christian Kronborg, Anders Gaarsdal Holst, Jonas Bille Nielsen, Lars Kober, Soren Hojberg, Jesper Hastrup Svendsen
AMERICAN HEART JOURNAL
(2020)
Article
Cardiac & Cardiovascular Systems
Litten Bertelsen, Soren Zoga Diederichsen, Ketil Jorgen Haugan, Axel Brandes, Claus Graff, Derk Krieger, Christian Kronborg, Lars Kober, Soren Hojberg, Niels Vejlstrup, Jesper Hastrup Svendsen
Article
Cardiac & Cardiovascular Systems
Maria Uggen Rasmussen, Preman Kumarathurai, Andreas Fabricius-Bjerre, Bjorn Stroier Larsen, Helena Dominguez, Ulla Davidsen, Thomas Alexander Gerds, Jorgen K. Kanters, Ahmad Sajadieh
ANNALS OF NONINVASIVE ELECTROCARDIOLOGY
(2020)
Article
Cardiac & Cardiovascular Systems
Sadaf Kamil, Thomas S. G. Sehested, Kim Houlind, Jens F. Lassen, Gunnar H. Gislason, Helena Dominguez
Summary: This study found that the use of cardioprotective medication increased over time in patients with peripheral artery disease, but there remains an underuse of guideline-based medical therapy compared to patients with other atherosclerotic diseases.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Cardiac & Cardiovascular Systems
Molly D. Kaagaard, Luan O. Matos, Anna Engell Holm, Laura Cordeiro Gomes, Alma Wegener, Karine O. Lima, Isabelle V. M. Vieira, Rodrigo Medeiros de Souza, Claudio Romero Farias Marinho, Lars Hviid, Lasse S. Vestergaard, Helena Dominguez, Tor Biering-Sorensen, Philip Brainin, Odison M. Silvestre
Summary: Studies have shown that malaria can cause changes in electrocardiographic (ECG) patterns and pericardial inflammation. This study aimed to investigate the frequency of ECG alterations and pericardial effusion in patients with malaria infection. The results suggest that ECG changes can be useful in detecting pericardial effusion in malaria and that these changes decrease after antimalarial treatment.
AMERICAN JOURNAL OF CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Dorte Marie Stavnem, Rakin Hadad, Bjorn Stroier Larsen, Olav Wendelboe Nielsen, Mark Aplin Frederiksen, Ulla Davidsen, Soren Hojbjerg, Finn Michael Karlsen, Maria Helena Dominguez Vall-Lamora, Hanne Kruuse Rasmusen, Ahmad Sajadieh
Summary: Prolonged electrocardiographic pauses of >= 2.5 s or >= 3.0 s are not markers for increased mortality in patients with atrial fibrillation, according to this real-life clinical study.
Article
Computer Science, Interdisciplinary Applications
Devender Kumar, Abdolrahman Peimankar, Kamal Sharma, Helena Dominguez, Sadasivan Puthusserypady, Jakob E. Bardram
Summary: This paper proposes a novel hybrid model called DeepAware, which combines deep learning and context-aware heuristics to effectively reduce false positive rates and improve atrial fibrillation detection performance in free-living ambulatory electrocardiogram data. The model utilizes various features and demonstrates good generalization on unseen datasets.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2022)
Article
Medicine, General & Internal
Bjorn Stroier Larsen, Mark Aplin, Nis Host, Helena Dominguez, Hanne Christensen, Louisa Marguerite Christensen, Inger Havsteen, Eva Prescott, Gorm Boje Jensen, Niels Vejlstrup, Litten Bertelsen, Ahmad Sajadieh
Summary: This study aims to evaluate atrial cardiomyopathy in stroke patients using cardiac magnetic resonance, comparing the differences between stroke of undetermined aetiology and stroke of known mechanism, with results to be published in peer-reviewed journals.
Article
Cardiac & Cardiovascular Systems
Sadaf Kamil, Thomas S. G. Sehested, Kim Houlind, Jens F. Lassen, Gunnar H. Gislason, Helena Dominguez
Summary: This study investigates the population-level incidence of myocardial infarction (MI), heart failure (HF), and cardiovascular mortality in patients with peripheral artery disease (PAD), and finds that the incidence of MI and HF has significantly decreased over time. The results suggest that preventive strategies have improved, likely due to the application of guidelines in clinical care.
EUROPEAN HEART JOURNAL-QUALITY OF CARE AND CLINICAL OUTCOMES
(2023)
Article
Environmental Sciences
Caroline Thorup Ladegaard, Carsten Bamberg, Mathias Aalling, Dorthea Marie Jensen, Nina Kamstrup-Larsen, Christoffer Valdorff Madsen, Sadaf Kamil, Henrik Gudbergsen, Thomas Saxild, Michaela Louise Schiotz, Julie Grew, Luana Sandoval Castillo, Anne Frolich, Helena Dominguez
Summary: This study tested the feasibility and acceptability of the cardio-share (CS) model in managing frail elderly patients with suspected atrial fibrillation (AF). The results showed that using the C3 monitor significantly reduced the time from referral to the Holter report, and 90% of the patients did not need to visit the cardiology clinic in person.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Computer Science, Artificial Intelligence
Devender Kumar, Sadasivan Puthusserypady, Helena Dominguez, Kamal Sharma, Jakob E. Bardram
Summary: This study aims to investigate the contextual and temporal distribution of false positives (FPs) in an advanced deep learning (DL)-based algorithm for atrial fibrillation (AF) detection when applied to a free-living ambulatory electrocardiogram (ECG) dataset. The study trains and evaluates a DL model on public arrhythmia datasets and applies it to a contextualized ECG dataset collected under free-living conditions. The results show that a significant portion of segments marked as AF by the model are FPs, with correlations to specific contextual events. These findings have implications for the use and design of DL models for AF detection and the role of context information in reducing FPs.
EXPERT SYSTEMS WITH APPLICATIONS
(2023)
Article
Cardiac & Cardiovascular Systems
Bjorn Stroier Larsen, Litten Bertelsen, Hanne Christensen, Rakin Hadad, Mark Aplin, Nis Host, Louisa Marguerite Christensen, Inger Havsteen, Eva Prescott, Helena Dominguez, Gorm Boje Jensen, Niels Vejlstrup, Ahmad Sajadieh
Summary: This study aims to evaluate the extent of left atrial fibrosis in stroke patients without atrial fibrillation and controls without cardiovascular disease. Cardiac magnetic resonance was used to detect late gadolinium enhancement as a proxy for left atrial fibrosis. The results showed that stroke patients had a higher extent of left atrial fibrosis compared to controls.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2023)
Article
Cardiac & Cardiovascular Systems
Christoffer Laessoe Madsen, Jesper Park-Hansen, Akhmadjon Irmukhamedov, Christian Lildal Carranza, Sulman Rafiq, Rafael Rodriguez-Lecoq, Neiser Palmer-Camino, Ivy Susanne Modrau, Emma C. Hansson, Anders Jeppsson, Rakin Hadad, Angel Moya-Mitjans, Anders Moller Greve, Robin Christensen, Helle Gervig Carstensen, Nis Baun Host, Ulrik Dixen, Christian Torp-Pedersen, Lars Kober, Ismail Gogenur, Thomas Clement Truelsen, Christina Kruuse, Ahmad Sajadieh, Helena Dominguez
Summary: This study aims to investigate the effectiveness of IAA closure during open-heart surgery in preventing thromboembolisms in patients with atrial fibrillation. The randomized multicenter trial includes patients from Denmark, Spain, and Sweden and is likely to influence the use of left atrial appendage closure in open-heart surgery.
AMERICAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Sadaf Kamil, Thomas Sehested, Kim Houlind, Jens Lassen, Gunnar Gislason, Helena Dominguez