Article
Neurosciences
Martina Baggio, Alberto Danieli, Cristiano Crescentini, Gian Marco Duma, Martina Da Rold, Sara Baldini, Eric Pascoli, Lisa Antoniazzi, Alec Vestri, Franco Fabbro, Paolo Bonanni
Summary: This study retrospectively reviewed the neuropsychological evaluation of 46 patients with refractory TLE and found that BTLE and UTLE have different neuropsychological profiles, supporting their classification as different disorders within the TLE spectrum.
Article
Clinical Neurology
Jonas Christian Bruder, Kathrin Wagner, Daniel Lachner-Piza, Kerstin Alexandra Klotz, Andreas Schulze-Bonhage, Julia Jacobs
Summary: This study aimed to investigate the relationship between mesial-temporal spindle-ripples and memory performance. The study found that all ripple rates were significantly higher in seizure onset zone channels. Patients with pre-surgical verbal memory impairment had significantly higher overall ripple rates in the left mesial-temporal channels. There was a highly significant negative correlation between pre-surgical verbal memory performance and left mesial-temporal spike-associated ripples and overall ripples.
FRONTIERS IN NEUROLOGY
(2022)
Article
Psychology, Multidisciplinary
Judit Catalan-Aguilar, Esperanza Gonzalez-Bono, Alejandro Lozano-Garcia, Paula Tormos-Pons, Kevin G. Hampel, Vicente Villanueva, Irene Cano-Lopez
Summary: This study aims to establish phenotypes according to how patients face a stressful condition (epilepsy) and examine differences in cognition and quality of life depending on these phenotypes. The results suggest that dealing with stress in patients with epilepsy is related to cognitive performance and quality of life. These findings underline the relevance of considering comorbidities in epilepsy and may be useful for detecting vulnerable or resilient profiles as risk or protective factors for cognitive and quality of life decline.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Clinical Neurology
Yuriz Bakhtiar, Surya Pratama Brilliantika, Jacob Bunyamin, Muhammad Thohar Arifin, Hardian Hardian, Aris Catur Bintoro, Zainal Muttaqin
Summary: This study evaluated postoperative Quality of Life (QoL) in Indonesian drug-resistant epilepsy patients, finding that postoperative seizure freedom and surgery type were related to QoL level, while anxiety and depression levels were negatively correlated with QoL dimensions.
FRONTIERS IN NEUROLOGY
(2021)
Article
Health Care Sciences & Services
Irene Cano-Lopez, Alejandro Lozano-Garcia, Judit Catalan-Aguilar, Kevin G. Hampel, Vicente Villanueva, Esperanza Gonzalez-Bono
Summary: This study found that trait anxiety plays an important mediating role in understanding the relationship between memory and quality of life in patients with drug-resistant temporal lobe epilepsy. The study also considered the influence of demographic and seizure-related factors.
QUALITY OF LIFE RESEARCH
(2023)
Article
Behavioral Sciences
William A. Schraegle, Jeffrey B. Titus
Summary: The study found that executive dysfunction and depressive features were negatively correlated with health-related quality of life (HRQOL) in children with temporal lobe epilepsy, with depressive features indirectly affecting HRQOL through executive functioning.
EPILEPSY & BEHAVIOR
(2021)
Article
Clinical Neurology
Monica Bolocan, Claudia I. Iacob, Eugen Avram
Summary: The study found that in patients with unilateral drug-resistant temporal lobe epilepsy, working memory and language both contribute to verbal learning and memory. While left-sided patients showed deficits in language and verbal learning, language was the primary predictor for most verbal learning performances in right-sided patients, with working memory affecting story memory outcomes.
FRONTIERS IN NEUROLOGY
(2021)
Article
Behavioral Sciences
Agnes Balint Bjorke, Ylva Ostby, Simon Gevert Grahl, Pal Gunnar Larsson, Ketil Berg Olsen, Marianne C. Johansen Naevra, Geir Andre Ringstad, Atle Bjornerud, Leif Gjerstad, Erik Tauboll, Kjell Heuser
Summary: The study found that newly diagnosed non-lesional temporal lobe epilepsy patients performed worse compared to controls in delayed visual memory and certain executive function tasks. While there were no differences in other cognitive domains, it suggests that patients may have specific cognitive deficits at the time of diagnosis.
EPILEPSY & BEHAVIOR
(2021)
Article
Clinical Neurology
Dahye Kim, June Sic Kim, Woorim Jeong, Min-Sup Shin, Chun Kee Chung
Summary: Selective resection in mesial temporal lobe epilepsy surgery has been shown to effectively preserve postoperative memory function, with specific areas of resection correlating with memory decline. This suggests the importance of selective resection to protect memory function in temporal lobe surgery.
JOURNAL OF NEUROSURGERY
(2021)
Article
Behavioral Sciences
Alessia Longo, Marion Houot, Bastien Herlin, Marie Mere, Marisa Denos, Severine Samson, Sophie Dupont
Summary: The study found that the localization of the epileptic focus within the lateral temporal lobe affects the neuropsychological characteristics of patients with LTLE, resulting in differences in learning, executive performance, and language difficulties. Antiepileptic drugs have a greater impact on patient performance, while age, education level, and gender also influence cognitive performance.
EPILEPSY & BEHAVIOR
(2021)
Article
Clinical Neurology
Daniel Delev, Karlijn Hakvoort, Marie Therese Kruger, Christian Blume, Hans Clusmann, Georg Neuloh
Summary: This study aimed to evaluate the rate, clinical presentation, and impact of ischemic events on health-related quality of life (HRQoL) after surgery for temporal lobe epilepsy (TLE). Choroidal artery infarctions are rare but relevant complications after TLE surgery, presenting with variable clinical courses ranging from devastating neurological deterioration to complete recovery. Despite the occurrence of postoperative infarction, most patients report improvement of HRQoL after TLE surgery. The type of surgery appears to modulate the risk for these ischemic events.
JOURNAL OF NEUROSURGERY
(2022)
Article
Behavioral Sciences
Gilvano Amorim Oliveira, Gloria M. A. S. Tedrus, Luciana Bertoldi Nucci
Summary: The study demonstrated a reduction in seizure frequency and improvement in quality of life in adults with temporal lobe epilepsy with hippocampal sclerosis after 10 weeks of systemic acupuncture sessions. Acupuncture significantly reduced seizures and led to better quality of life outcomes, suggesting a positive impact on managing the condition.
EPILEPSY & BEHAVIOR
(2021)
Article
Behavioral Sciences
Racheal M. Smetana, Prem P. Batchala, Bern G. Lee, Tamer Albataineh, Donna K. Broshek, Nathan B. Fountain, Salma Abbas, Mark Quigg
Summary: This study evaluated the pathophysiology behind verbal learning/memory deficits in patients with mesial temporal lobe epilepsy (MTLE) using 18-fluorodeoxyglucose positron emission tomography (FDG-PET). The results showed that verbal memory deficits were associated with hypometabolism in limbic structures, perisylvian cortex, and contralateral limbic and nonlimbic structures. This study has important implications for epilepsy surgery protocols that use neuropsychological data and FDG-PET to assess surgical risks.
EPILEPSY & BEHAVIOR
(2023)
Article
Neuroimaging
Anna Doll, Martin Wegrzyn, Anissa Benzait, Markus Mertens, Friedrich G. Woermann, Kirsten Labudda, Christian G. Bien, Johanna Kissler
Summary: In patients with mesial temporal lobe epilepsy, there is minor extra-temporal plasticity, with the activation of contralateral mesial temporal lobe supporting intact memory performance.
NEUROIMAGE-CLINICAL
(2021)
Article
Clinical Neurology
Florian Johannes Muecke, Marc Petrus Hendriks, Christian Guenther Bien, Philip Grewe
Summary: The study found a mismatch between subjective and objective memory functioning in patients with epilepsy, with depressive symptoms playing a crucial role in explaining this discrepancy. Moreover, the relationship between objective memory change and quality of life is mediated by subjective memory change and depressive mood.
FRONTIERS IN NEUROLOGY
(2022)
Article
Oncology
Naeim Bahrami, Stephen J. Hartman, Yu-Hsuan Chang, Rachel Delfanti, Nathan S. White, Roshan Karunamuni, Tyler M. Seibert, Anders M. Dale, Jona A. Hattangadi-Gluth, David Piccioni, Nikdokht Farid, Carrie R. McDonald
JOURNAL OF NEURO-ONCOLOGY
(2018)
Article
Pediatrics
Stephen J. Hartman, James M. Prieto, John H. Naheedy, Romeo C. Ignacio, Stephen W. Bickler, Karen M. Kling, Nicholas C. Saenz, Timothy J. Fairbanks, David A. Lazar
Summary: The study aimed to identify ultrasound-based predictors of ovarian torsion in girls without an adnexal mass, and establish a set of normal values for ovarian volume ratio (OVR). OVR was found to be an excellent predictor of ovarian torsion, with a cutoff value of >2.5 demonstrating high sensitivity and specificity for identifying ovarian torsion in this population.
JOURNAL OF PEDIATRIC SURGERY
(2021)
Article
Clinical Neurology
A. C. Rosen, J. V. Bhat, V. A. Cardenas, T. J. Ehrlich, A. M. Horwege, D. H. Mathalon, B. J. Roach, G. H. Glover, B. W. Badran, S. D. Forman, M. S. George, M. E. Thase, D. Yurgelun-Todd, M. E. Sughrue, S. P. Doyen, P. J. Nicholas, J. C. Scott, L. Tian, J. A. Yesavage
Summary: This study analyzed imaging data from a failed clinical trial of rTMS in Veterans to investigate the association between treatment response and rTMS coil location. Findings revealed that the accuracy in targeting the region within DLPFC negatively correlated with the subgenual cingulate is related to clinical response to rTMS in treatment resistant major depression, providing evidence for a neuro-functionally informed rTMS therapy target in Veterans.
Article
Neuroimaging
Tobin J. Ehrlich, Jyoti Bhat, Andrea M. Horwege, Daniel H. Mathalon, Gary H. Glover, Brian J. Roach, Bashar W. Badran, Steven D. Forman, Mark S. George, J. Cobb Scott, Michael E. Thase, Jerome A. Yesavage, Deborah A. Yurgelun-Todd, Allyson C. Rosen
Summary: Patients with depression may engage in rumination, which can be divided into reflection and brooding. Reflection is associated with positive outcomes, while brooding is linked to negative outcomes. Repetitive pulse transcranial magnetic stimulation may alter abnormal connectivity associated with rumination, providing a potential mechanistic model for symptom-based neuromodulation of rumination.
BRAIN IMAGING AND BEHAVIOR
(2022)
Article
Clinical Neurology
V. A. Cardenas, J. Bhat, A. M. Horwege, T. J. Ehrlich, J. Lavacot, D. H. Mathalon, G. H. Glover, B. J. Roach, B. W. Badran, S. D. Forman, M. S. George, M. E. Thase, J. A. Yesavage, D. Yurgelun-Todd, A. C. Rosen
Summary: This study investigated the effects of various DLPFC stimulation rules on brain systems using structural and functional MRI, finding that scalp-targeting rules were precise in directly targeting DLPFC and frontal networks, while rules involving fixed distances led to variability in regions and networks targeted.
Article
Psychiatry
Anna L. Wrobel, Samantha E. Russell, Anuradhi Jayasinghe, Mojtaba Lotfaliany, Alyna Turner, Olivia M. Dean, Sue M. Cotton, Claudia Diaz-Byrd, Anastasia K. Yocum, Elizabeth R. Duval, Tobin J. Ehrlich, David F. Marshall, Michael Berk, Melvin G. McInnis
Summary: This study found that attachment insecurity in childhood and adulthood partially mediates the relationship between childhood trauma and depression severity in individuals with bipolar disorder.
ACTA PSYCHIATRICA SCANDINAVICA
(2022)
Article
Psychiatry
Tobin J. Ehrlich, Kelly A. Ryan, Katherine E. Burdick, Scott A. Langenecker, Melvin G. McInnis, David F. Marshall
Summary: Cognitive functioning in bipolar disorder is heterogeneous, with three subgroups identified, each associated with unique clinical characteristics. Over a five-year period, the low cognition subgroup showed improvement in auditory memory, the mid cognition subgroup showed improvement in visual memory, and the high cognition subgroup remained stable in inhibitory control.
ACTA PSYCHIATRICA SCANDINAVICA
(2022)
Article
Psychiatry
Anna L. Wrobel, Sue M. Cotton, Anuradhi Jayasinghe, Claudia Diaz-Byrd, Anastasia K. Yocum, Alyna Turner, Olivia M. Dean, Samantha E. Russell, Elizabeth R. Duval, Tobin J. Ehrlich, David F. Marshall, Michael Berk, Melvin G. McInnis
Summary: This study compared the networks of depressive symptoms among individuals with bipolar disorder with and without a history of childhood trauma. It found that depressed mood consistently emerged as a central symptom regardless of childhood trauma history. Among individuals with a history of childhood trauma, feelings of worthlessness emerged as a key symptom in the network of self-reported depressive symptoms. These findings provide insights into the impact of childhood trauma on depressive symptoms in bipolar disorder.
ACTA PSYCHIATRICA SCANDINAVICA
(2023)
Article
Surgery
Jenna N. Whitrock, Stephen J. Hartman, Shimul A. Shah
Summary: In patients with unresectable liver metastases from colorectal cancer, chemotherapy alone is associated with significant mortality. Liver transplant is emerging as a promising treatment alternative for appropriately selected patients. Several key clinical trials, including SECA-I and SECA-II, have demonstrated promising survival outcomes, and further trials are ongoing to evaluate the safety of this approach.
Review
Oncology
Emily J. Schepers, Kathryn Glaser, Harrison M. Zwolshen, Stephen J. Hartman, Alexander J. Bondoc
Summary: This article reviews the structure and function of GPC3 in liver cancer, specifically focusing on the posttranslational modifications (PTM) that regulate its tertiary and quaternary structures. The study proposes that GPC3's function in normal development can be influenced by extensive PTMs, and dysregulation of these processes can lead to disease. Understanding the regulatory impact of these modifications provides insights into GPC3's role in oncogenesis, epithelial-mesenchymal transition, and drug development.
Article
Pediatrics
Zishaan Farooqui, Michael Johnston, Emily Schepers, Nathalie Brewer, Stephen Hartman, Todd Jenkins, Alexander Bondoc, Ahna Pai, James Geller, Gregory M. Tiao
Summary: Hepatoblastoma, the most common malignant liver tumor in children, can be treated with liver transplant or extended resection. Although both surgeries have known complications, the impact on quality of life was not previously described. This study found that overall quality of life is similar between transplant and resection patients, but patients who underwent resection reported higher levels of procedural anxiety.
Article
Audiology & Speech-Language Pathology
Yu-Hsuan A. Chang, Nobuko Kemmotsu, Kelly M. Leyden, N. Erkut Kucukboyaci, Vicente J. Iragui, Evelyn S. Tecoma, Leena Kansal, Marc A. Norman, Rachelle Compton, Tobin J. Ehrlich, Vedang S. Uttarwar, Anny Reyes, Brianna M. Paul, Carrie R. McDonald
BRAIN AND LANGUAGE
(2017)