Article
Agriculture, Dairy & Animal Science
Martina Contino, Greta Ferruggia, Stefania Indelicato, Roberta Pecoraro, Elena Maria Scalisi, Antonio Salvaggio, Maria Violetta Brundo
Summary: This study evaluated the lethal and sublethal effects of amino-modified polystyrene nanoplastics on Artemia salina. The results showed that while no lethal impact was observed, the nanoparticles caused gut and body size malformations, as well as increased apoptosis and oxidative stress at higher concentrations and smaller particle sizes.
Article
Environmental Sciences
Pazhamthavalathil Anil Athulya, Zachariah Sunil, Sonia Manzo, Natarajan Chandrasekaran
Summary: This study examines the effects of microplastics and low pH on the physiology and development of Artemia salina through exposure experiments. The results indicate that the combined exposure to microplastics and low pH induces oxidative stress and adversely affects the development of Artemia salina. These findings underscore the need for further research on the combined toxicological impacts of ocean acidification and predominant pollutants like microplastics on other marine animals.
JOURNAL OF ENVIRONMENTAL MANAGEMENT
(2023)
Article
Biochemistry & Molecular Biology
Josefa Domenech, Mariana de Britto, Antonia Velazquez, Susana Pastor, Alba Hernandez, Ricard Marcos, Constanza Cortes
Summary: The study assessed the long-term effects of polystyrene nanoparticles on human intestinal cells, showing that PSNPs accumulated in cells over time and induced changes at the ultrastructural and molecular levels. However, minor effects were observed in genotoxicity-related biomarkers, indicating no DNA damage or oxidative stress after long-term exposure to PSNPs.
Article
Spectroscopy
Ruben Araujo, Luis Ramalhete, Helder Paz, Carina Ladeira, Cecilia R. C. Calado
Summary: This study demonstrated that Fourier Transform Infrared spectroscopic analysis of serum can rapidly and simply predict genotoxic effects of cytostatic drugs. Analysis of serum spectra from exposed and non-exposed individuals effectively distinguished between the two groups, and the support vector machine model showed high prediction accuracy.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2021)
Article
Food Science & Technology
Margarita Dormousoglou, Vasiliki Boti, Dimitra Hela, Dimitris Vlastos, Maria Antonopoulou, Christos Chondrogiannis, Yiola Petropoulou, Stefanos Dailianis
Summary: This study investigated the phytochemical profile and biological effects of Drimia numidica leaf methanolic extract on healthy human lymphocytes. The results showed that the extract, rich in carotenoids, phenolics, flavonoids, organic acids, and bufadienolides, could protect against the cytogenotoxic potential of mitomycin C. The presence of antioxidant and antitumor compounds in the extract suggests potential benefits and encourages further research.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Environmental Sciences
Mohamed Alaraby, Doaa Abass, Aliro Villacorta, Alba Hernandez, Ricard Marcos
Summary: This study found that coexposure of silver compounds and polystyrene nanoplastics can alleviate the delayed fly emergence and cellular oxidative stress induced by silver compounds. Polystyrene nanoplastics can transport silver compounds across the intestinal barrier and deliver them into the hemolymph of Drosophila larvae. The antagonistic effect may be attributed to the confinement of silver by polystyrene nanoplastics, reducing its bioavailability.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Biochemistry & Molecular Biology
Margarita Dormousoglou, Ioanna Efthimiou, Maria Antonopoulou, Damian L. Fetzer, Fabiane Hamerski, Marcos L. Corazza, Maria Papadaki, Samir Santzouk, Stefanos Dailianis, Dimitris Vlastos
Summary: This study investigated the effects of different extracts of Equisetum arvense L. on human lymphocytes. The extracts showed increased antioxidant activity and no genotoxicity. The ethanol/water extract exhibited the strongest antigenotoxic activity and contained various compounds and minerals.
Article
Environmental Sciences
Shuai Guo, Xiajie Zhang, Haifeng Sun
Summary: Nanoplastics are emerging pollutants that pose potential threats to agriculture and food security. Nano-ZnO, as an ideal nano-fertilizer dispersion, shows promise for managing nanoplastic stress. This study found that nano-ZnO significantly reduced the accumulation of polystyrene nanoplastics (PSNPs) in corn plants and weakened their toxic effects by regulating photosynthesis, glutathione metabolism, and phytohormone signal transduction pathways. These findings contribute to the understanding of how nano-ZnO can improve the sustainable utilization of nano-fertilizers in agriculture.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Biology
Martina Contino, Greta Ferruggia, Stefania Indelicato, Roberta Pecoraro, Elena Maria Scalisi, Giovanni Bracchitta, Jessica Dragotto, Antonio Salvaggio, Maria Violetta Brundo
Summary: This evaluation focuses on the interaction between nanoplastics, especially polystyrene nanoparticles, and reproductive cells, particularly sperm cells. The study finds that the size of the nanoparticles, specifically 50 nm, is associated with deleterious effects on sperm cells, including decreased motility, acrosome and DNA integrity, and increased physiological production of reactive oxygen species (ROS). However, the expression of protective biomarkers, such as HSP70s, can contribute to damage recovery. This research emphasizes the importance of investigating the persistent and chronic contamination of plastics, specifically Polystyrene nanoplastics (PS-NPs), in relation to infertility and the metabolic and biochemical changes of sperm cells.
Article
Environmental Sciences
Sun-Hwa Nam, Dokyung Kim, Youn-Joo An
Summary: This study evaluated the effects of nanoplastics on two green algal species in soil. The results showed that nanoplastics aggregated with algal cells, but had no significant effects on their photosynthetic activity and growth. Soil algae may serve as potential carriers of nanoplastics to other organisms in the food chain through plastic aggregation.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Environmental Sciences
Radek Vurm, Lucia Tajnaiova, Jana Kofronova
Summary: This study aimed to determine the toxic effects of commonly used herbicides on marine organisms, with the results indicating the need to monitor and be mindful of herbicide use in the environment.
Article
Environmental Sciences
Nathalie Leroux, Mahboubeh Hosseinzadeh, Alberto Katsumiti, Cinta Porte, Miren P. Cajaraville
Summary: The production and usage of plastics have significantly increased in the past decades, leading to insufficient waste management and the accumulation of plastic particles in the environment. This study focuses on the impact of polystyrene nanoparticles on the lipid composition of mussel hemocytes, showing that exposure to these particles leads to membrane reorganization and oxidation of highly unsaturated lipids. The findings suggest potential effects on the immune function of hemocytes, although further investigation is needed.
ENVIRONMENTAL RESEARCH
(2022)
Article
Environmental Sciences
Fernanda Neves Estrela, Abraao Tiago Batista Guimaraes, Amanda Pereira da Costa Araujo, Fabiano Guimaraes Silva, Thiarlen Marinho da Luz, Abner Marcelino Silva, Paulo Sergio Pereira, Guilherme Malafaia
Summary: The study evaluated the effects of zinc oxide and polystyrene nanoplastics on Swiss mice, showing that exposure led to cognitive impairment without causing changes in locomotor or anxiety-related behaviors. Accumulation of nanomaterials in the brain was observed, but there were no differences between the effects of exposure to the binary combination of pollutants and the control group.
Article
Environmental Sciences
Ranran Zhou, Dao Zhou, Shixin Yang, Zhiqiao Shi, Hui Pan, Qijie Jin, Zhuhong Ding
Summary: This study explores the neurotoxicity of nanoparticles and finds that polystyrene nanoparticles induce developmental toxicity and neuronal damage in zebrafish embryos, with smaller particle sizes showing more severe effects. The nanoparticles also interfere with the functioning of GABAergic, cholinergic, and serotonergic systems. These findings reveal the neurotoxic risks of nanoparticles and highlight the greater ecological risk associated with smaller particles.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Environmental Sciences
Gefei Huang, Yiming Ma, Dongying Xie, Cunmin Zhao, Lin Zhu, Guangshan Xie, Pengfei Wu, Wei Wang, Zhongying Zhao, Zongwei Cai
Summary: Plastic pollution poses a significant threat to ecosystems. While the adverse effects of microplastics have been extensively studied, the toxicity of nanoplastics remains unclear, particularly at the protein level. This study used quantitative proteomics to investigate the proteome dynamics in a soil nematode exposed to 100 nm polystyrene nanoplastics (PS-NPs). The results showed that exposure to PS-NPs led to differential expression of proteins related to various cellular processes, and these changes were consistent with the observed phenotypic defects. Overall, this study provides insights into the molecular mechanisms underlying the toxicity of nanoplastics.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Review
Nanoscience & Nanotechnology
Debolina Chakraborty, Debayan Ghosh, Sanjit Kumar, David Jenkins, Natarajan Chandrasekaran, Amitava Mukherjee
Summary: Oral cancer is a global problem, mainly caused by tobacco, alcohol, and poor dental hygiene. Conventional diagnostic and therapeutic approaches have limitations, and there is a need to enhance analytical performance. Nanoprobes have shown promise for early screening and predicting treatment outcomes for oral cancer.
WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY
(2023)
Article
Chemistry, Physical
Pazhamthavalathil Anil Athulya, Natarajan Chandrasekaran
Summary: The demand for plastics is expected to rise due to the exponential growth of the manufacturing sector. The plastic industries receive subsidies to boost foreign exchange. Mismanagement of plastic waste has caused contamination of water bodies with macro, micro, and nano plastics, leading to toxicological impairment in aquatic and terrestrial environments. The study investigates the interaction of polystyrene and polyethylene microplastics with natural colloids in waters, observing the formation of an eco-corona layer and its impact on detection methods.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Pharmacology & Pharmacy
Shramana Koner, Ida Florance, Amitava Mukherjee, Natarajan Chandrasekaran
Summary: This study investigates the toxic effects of polystyrene nanoparticles (PSNPs) on human macrophages. The results show that exposure to PSNPs leads to cytotoxicity, oxidative stress, decreased cell proliferation, decreased mitochondrial membrane potential, and DNA damage in human macrophages.
Article
Fisheries
Haimanti Mondal, Natarajan Chandrasekaran, Amitava Mukherjee, John Thomas
Summary: Marine actinomycetes are under-explored but have the potential to be a source of novel bacterial species. In this study, 16 bacterial strains were isolated using Actinomycetes Isolation Agar medium, and two of them showed antibacterial activity against shrimp pathogens. One of the strains, Bacillus licheniformis VIT02, exhibited potent antibacterial properties. The bioactive compounds extracted from B. licheniformis were found to have antimicrobial properties and showed promise as antimicrobial drugs. The study also demonstrated the effectiveness of the bioactive compounds in treating A. hydrophila infection in M. rosenbergii.
AQUACULTURE INTERNATIONAL
(2023)
Article
Biochemistry & Molecular Biology
Soupam Das, N. Chandrasekaran, Amitava Mukherjee
Summary: During the COVID-19 pandemic, improper disposal of face masks has led to them becoming a significant source of microplastics and nano plastics in the environment. This study quantified and characterized the microplastics released from different layers of masks and investigated their effects on two algal species. The results showed negative impacts on cell viability, photosynthetic yield, and electron transport rate, as well as increased oxidative stress markers and antioxidant enzyme levels. Optical microscopy and FTIR spectroscopy confirmed morphological and chemical changes in the algae. The study highlights the environmental risks posed by microplastics released from surgical face masks and emphasizes the need for further research on their impacts.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2023)
Article
Cell Biology
Haimanti Mondal, D. Delsy Gnana Silvia, I. Arnold Emerson, Natarajan Chandrasekaran, Amitava Mukherjee, John Thomas
Summary: Seven novel compounds were extracted from the ethyl acetate extract of a novel marine bacterium Bacillus licheniformis, which were identified using GC-MS. One bioactive compound with potent antibacterial activity was virtually screened and found to satisfy Lipinski's rule, making it suitable for preventing infection by A. hydrophila and V. parahemolyticus. Molecular docking and dynamics simulations showed strong binding efficacy of the bioactive compound against the core proteins of the two pathogens. In vitro toxicity analysis revealed the non-toxic nature of the ethyl acetate extract. Thus, the bioactive compound of B. licheniformis was proven to be a potent antibacterial agent against A. hydrophila and V. parahemolyticus.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Article
Plant Sciences
Sayani Giri, Abisha Christy Christudoss, Natarajan Chandrasekaran, Willie J. G. M. Peijnenburg, Amitava Mukherjee
Summary: Both BPA and PSNPs are commonly found in consumer products and pose serious threats to the environment and aquatic life. This study examined the toxic effects of PS-NPs and BPA on the microalgae Scenedesmus obliquus, as well as the impact of algal EPS on their interaction. The results showed that EPS-containing mixtures reduced toxicity by decreasing reactive oxygen species levels, antioxidant enzyme activity, and cell membrane damage, leading to improved photosynthetic pigment content in the cells.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2023)
Article
Environmental Sciences
Namrata Roy, Krishnan Kannabiran, Amitava Mukherjee
Summary: Ferrocene functionalized rGO-ZnO nanocomposite was synthesized via hydrothermal method and showed superior photocatalytic activity in the degradation of pharmaceuticals under UV C light. The integration of Fc@rGO and ZnO enhanced light harvesting, charge carrier interface, and charge separation, leading to a fivefold increase in removal efficiency compared to pristine ZnO. The nanocomposite also exhibited low toxicity and reusability for multiple cycles, making it environmentally sustainable and suitable for practical applications in antibiotic treatment.
Article
Chemistry, Multidisciplinary
Kavita B. B. Hiremath, Murugesh Shivashankar, Natarajan Chandrasekaran
Summary: A series of new Tris hydroxymethyl aminomethane Schiff base derivatives were synthesized and characterized using various spectroscopic techniques. The binding interaction of these synthesized molecules with human serum albumin (HSA) was studied under pH=7.40 conditions. The results showed that the ligands had a high affinity for HSA and induced conformational changes in HSA. The antimicrobial activity of the synthesized compounds was also tested against Escherichia coli, Stap. aureus, Aspergillus niger, and Aspergillus flavus.
Article
Multidisciplinary Sciences
A. N. K. V. Sravani, Natarajan Chandrasekaran, John Thomas, Amitava Mukherjee
Summary: This study developed a new cisplatin loaded hydroxyl functionalized single-walled carbon nanotube nanocarrier system to selectively eliminate gastric cancer stem cells, overcoming the resistance caused by non-specific and non-targeted drug delivery by chemotherapy.
Article
Biochemistry & Molecular Biology
Parvathy Mohan Menon, Natarajan Chandrasekaran, C. George Priya Doss, Sivakumar Shanmugam
Summary: The aim of this research is to optimize and formulate a multi-drug loaded eugenol based nanoemulsion system for the treatment of tuberculosis caused by Mycobacterium tuberculosis. The study showed that the essential oil-based nanoemulsions exhibited promising results as antimycobacterial agents, especially when combined with a combination of drugs. The release kinetics studies also demonstrated a controlled and sustained release of the first-line anti-tubercular drugs. These findings highlight the potential of this nanoemulsion system as an efficient and desirable method in treating infections caused by Mycobacterium tuberculosis and its drug-resistant strains.
RSC MEDICINAL CHEMISTRY
(2023)
Review
Microbiology
Simpal Kumar Suman, Natarajan Chandrasekaran, C. George Priya Doss
Summary: Tuberculosis is a global health problem and drug resistance has made it increasingly difficult to treat. Researchers are exploring new drugs and drug delivery systems, such as nanotechnology, to combat drug resistance. However, the clinical translation of nanomedicines faces challenges such as safety, production, regulation, and intellectual property.
CLINICAL MICROBIOLOGY REVIEWS
(2023)
Article
Chemistry, Analytical
Pazhamthavalathil Anil Athulya, Natarajan Chandrasekaran, John Thomas
Summary: Gut probiotic bacteria play a significant role in the host health, immunity, and survival. Changes in the gut microbiome of fishes due to microplastic exposure could lead to alterations in bacterial growth and viability, exopolysaccharide production, and oxidative stress response. The study provides new insights into the interaction between microplastics and gut probiotics in aquaculture species.
ENVIRONMENTAL SCIENCE-PROCESSES & IMPACTS
(2023)
Article
Environmental Sciences
Pazhamthavalathil Anil Athulya, Zachariah Sunil, Sonia Manzo, Natarajan Chandrasekaran
Summary: This study examines the effects of microplastics and low pH on the physiology and development of Artemia salina through exposure experiments. The results indicate that the combined exposure to microplastics and low pH induces oxidative stress and adversely affects the development of Artemia salina. These findings underscore the need for further research on the combined toxicological impacts of ocean acidification and predominant pollutants like microplastics on other marine animals.
JOURNAL OF ENVIRONMENTAL MANAGEMENT
(2023)
Article
Chemistry, Analytical
Abisha Christy Christudoss, Natarajan Chandrasekaran, Amitava Mukherjee
Summary: Due to the escalating risk of plastic pollution, nanoplastics have received significant attention. A study examined the individual and combined effects of fluorescent polystyrene nanoplastics (FNPs) and diclofenac (DCF) on Scenedesmus obliquus. The toxicity of S. obliquus significantly increased upon exposure to DCF and FNPs, with oxidative stress being the major cause. When FNPs and DCF were mixed, a synergistic or antagonistic effect was observed depending on the concentrations. Oxidative stress parameters, antioxidant enzyme activity, and pigment content in the algae validated the cytotoxicity data. The study highlights the hazardous nature of nanoplastics and their co-exposure risks with pharmaceuticals.
ENVIRONMENTAL SCIENCE-PROCESSES & IMPACTS
(2023)
