Article
Nutrition & Dietetics
Camille Dugardin, Lea Fleury, Veronique Touche, Farah Ahdach, Jean Lesage, Mathie Tenenbaum, Nadia Everaert, Olivier Briand, Sophie Lestavel, Rozenn Ravallec, Benoit Cudennec
Summary: High protein diets have been shown to improve glucose homeostasis. This study investigates the acute effects of proteins from different sources on intestinal glucose absorption. The digested proteins were found to decrease intestinal glucose absorption and ingestion of certain proteins improved glucose tolerance without affecting insulin secretion. These results suggest that protein-derived peptides and amino acids play a key role in regulating glucose homeostasis and intestinal glucose absorption.
FRONTIERS IN NUTRITION
(2022)
Article
Nutrition & Dietetics
Masa Primec, Dejan Skorjanc, Tomaz Langerholc, Dusanka Micetic-Turk, Mario Gorenjak
Summary: Selective Lactobacillus probiotic strains can regulate the transcription and expression of intestinal glucose transporters, leading to decreased transepithelial glucose transport rates. Careful selection of specific probiotic strains may be beneficial in supporting treatments related to glucose homeostasis.
NUTRITION RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Min Zhang, Hongyan Yang, Erwan Yang, Jia Li, Ling Dong
Summary: Berberine reduces intestinal glucose absorption through inhibiting the IGF-1R-PLC-beta 2-GLUT2 signal pathway, improving postprandial hyperglycemia and enhancing insulin sensitivity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Food Science & Technology
Yaoyao Liu, Daorui Pang, Dongxu Xing, Weifei Wang, Qian Li, Sentai Liao, Erna Li, Yuxiao Zou
Summary: This study determined the effects of cinnamon free phenolic extract (CFPE) on glucose transport in intestinal cells and its possible mechanisms of action. The results showed that CFPE suppressed glucose transport across the cells in a dose-dependent manner by affecting the signaling pathway and glucose transporters involved in glucose absorption. Thus, CFPE has potential applications in preventing postprandial hyperglycemia.
Article
Endocrinology & Metabolism
Qinghe Meng, Derek M. Culnan, Tamer Ahmed, Mingjie Sun, Robert N. Cooney
Summary: Roux-en-Y gastric bypass (RYGB) has significant effects on intestinal GLP-1 release and glucose transport in obese rats, potentially improving glycemic control by increasing GRP119 and FFAR2/3.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Veterinary Sciences
Franziska Dengler, Harald M. Hammon, Wendy Liermann, Solvig Goers, Lisa Bachmann, Christiane Helm, Reiner Ulrich, Cora Delling
Summary: Cryptosporidiosis, a common cause of diarrhea in infants and young livestock, has a potential impact on glucose metabolism in neonatal calves infected with C. parvum. The study showed that despite an increased transepithelial transport of glucose, infected calves experienced decreased plasma glucose concentration and oral glucose absorption. However, no differences in the abundance of glucose transporters were observed in infected calves, suggesting that the upregulation of uptake mechanisms and metabolic machinery in host cells compensate for the energy losses caused by the parasite.
VETERINARY RESEARCH
(2023)
Article
Nutrition & Dietetics
Lovemore Nkhata Malunga, Nancy Ames, Haonan Zhouyao, Heather Blewett, Sijo Joseph Thandapilly
Summary: The study found that beta-glucan (BG) from barley attenuates post-prandial glycemic response by altering alpha-glucosidase, GLUT2, and SGLT1 activity, rather than affecting amylolysis of starch. The decrease in post-prandial blood glucose in the presence of BG is likely due to the interaction between BG and membrane active proteins, rather than increased viscosity inhibiting starch digestion.
FRONTIERS IN NUTRITION
(2021)
Article
Pharmacology & Pharmacy
Kunkun Guo, Xin Wang, Baolin Huang, Xiaoyun Wu, Shuimei Shen, Zimin Lin, Jie Zhao, Zheng Cai
Summary: The study found that the slight differences in chemical structure of gastrodin analogues can affect drug intestinal absorption via the glucose transport pathway. Biopharmaceutical experiments and molecular docking tests showed differences in intestinal absorption characteristics and receptor affinity among the analogues.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Gastroenterology & Hepatology
Yihang Li, Kyan M. Thelen, Karina Matos Fernandez, Rahul Nelli, Mahsa Fardisi, Mrigendra Rajput, Nathalie L. Trottier, Genaro A. Contreras, Adam J. Moeser
Summary: These studies reveal that early-life adversity in the form of early weaning in pigs causes a developmental shift in intestinal glucose transport from SGLT1 toward GLUT2-mediated transport. Early weaning also induced markers of metabolic inflammation including persistent elevations in blood glucose and the inflammatory marker CRP, along with increased visceral adiposity. Altered intestinal glucose transport might contribute to increased risk for inflammatory and metabolic diseases associated with early-life adversity.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2022)
Article
Endocrinology & Metabolism
Leticia Maria de Souza Cordeiro, Lauren Bainbridge, Nagavardhini Devisetty, David H. McDougal, Dorien J. M. Peters, Kavaljit H. Chhabra
Summary: This study found that knocking out Glut2 in the kidneys can reverse hyperglycemia and normalize body weight in mouse models of diabetes and obesity. The results also revealed a novel crosstalk between renal GLUT2 and SGLT2 in regulating systemic glucose homeostasis.
Article
Parasitology
Sarina Koehler, Andrea Springer, Nicole Issel, Stefanie Klinger, Michael Wendt, Gerhard Breves, Christina Strube
Summary: This study found that infection of Ascaris suum has a negative impact on intestinal nutrient transport in pigs, with significant downregulation of certain transcription factors and transporter proteins in the jejunum. On the other hand, A. suum antigens mainly induced an upregulation of transport processes, particularly in the duodenum and jejunum.
Article
Pharmacology & Pharmacy
Baolin Huang, Zimin Lin, Zhenzhen Chen, Jiasheng Chen, Birui Shi, Jingjing Jia, Yuan Li, Yueqing Pan, Yuntao Liang, Zheng Cai
Summary: Designing oral drug delivery systems using intestinal glucose transporters (IGTs) is a potential strategy for improving oral bioavailability of drugs. However, the biological factors affecting the drug transport capacity of IGTs are not well understood. This study demonstrated that gastrodin, a sedative drug with a structure similar to glucose, is absorbed via the intestinal glucose transport pathway and can be used to evaluate the drug transport capacity of IGTs. Different strains of rats and mice showed variation in the drug transport capacity of IGTs, with SD rats and C57 mice being more suitable for evaluating the pharmacokinetics of glycosides' active ingredients absorbed via the intestinal glucose transport pathway.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Endocrinology & Metabolism
Ryon Sun S. Rhodes, Satish K. Singh, Vazhaikkurichi M. Rajendran, Seth T. Walk, Steven D. Coon
Summary: Recent studies have shown that GIP enhances glucose absorption in mouse jejunum through SGLT1. As obesity progresses, there is a shift from SGLT1-dependent glucose absorption to a Na-independent mechanism, possibly involving GLUT2.
JOURNAL OF DIABETES RESEARCH
(2022)
Article
Endocrinology & Metabolism
Kimihiro Nishimura, Yukihiro Fujita, Shogo Ida, Tsuyoshi Yanagimachi, Natsuko Ohashi, Kiyoto Nishi, Atsushi Nishida, Yasumasa Iwasaki, Katsutaro Morino, Satoshi Ugi, Eiichiro Nishi, Akira Andoh, Hiroshi Maegawa
Summary: Loss of O-GlcNAcylation in the intestine reduces glucose absorption by suppressing SGLT1 expression. This study provides new insights into the role of O-GlcNAcylation in glucose metabolism and suggests potential treatments for malabsorption, obesity, and diabetes.
MOLECULAR METABOLISM
(2022)
Article
Endocrinology & Metabolism
Maximilian G. Posch, Niklas Walther, Ele Ferrannini, David R. Powell, Phillip Banks, Suman Wason, Raphael Dahmen
Summary: This study compared the effects of selective SGLT2 inhibition and dual inhibition of SGLT1 and SGLT2. The results showed that both treatments had similar impacts on glycemic control, blood pressure control, and cardiovascular biomarkers. However, only the dual inhibitor of SGLT1 and SGLT2 was able to inhibit intestinal SGLT1 after breakfast, leading to larger changes in incretin responses.
Article
Biochemistry & Molecular Biology
Anne Abot, Steven Fried, Patrice D. Cani, Claude Knauf
Summary: The role of reactive oxygen/nitrogen species as friend or foe messengers in the body is well studied, with their effects depending on concentration in tissues. The intestine, affected by oxidation and inflammation, plays a crucial role in diabetic symptoms. Controlling levels of intestinal reactive oxygen/nitrogen species is a complex balance with potential therapeutic implications.
ANTIOXIDANTS & REDOX SIGNALING
(2022)
Article
Nutrition & Dietetics
Eve Wemelle, Lucie Marousez, Marie de Lamballerie, Claude Knauf, Jean Lesage
Summary: This study found that high hydrostatic pressure (HHP) processing preserves apelin and glucagon-like peptide 1 (GLP-1) in breast milk (BM) compared to Holder pasteurization (HoP). It also improves glucose tolerance by acting on gut contractions.
Article
Cell Biology
Bessem Mornagui, Raja Rezg, Cendrine Repond, Luc Pellerin
Summary: Bisphenol S (BPS), a substitute for bisphenol A (BPA), may act as an obesogenic endocrine disruptor and affect monocarboxylate transporters and mitochondrial respiratory system in the liver, leading to the development of hepatic steatosis.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Medicine, Research & Experimental
Patricia Pereira Almeida, Beatriz Bastos de Moraes Thomasi, Agatha Cristie Menezes, Beatriz Oliveira Da Cruz, Nathalia da Silva Costa, Michele Lima Brito, Aline D'Avila Pereira, Cecilia Ribeiro Castanon, Viviane Alexandre Nunes Degani, D'Angelo Carlo Magliano, Claude Knauf, Ana Lucia Tavares-Gomes, Milena Barcza Stockler-Pinto
Summary: Chronic kidney disease (CKD) affects the gastrointestinal tract (GIT) by altering motility, gut microbiota, intestinal permeability, and increasing oxidative stress. This study investigates the changes in colonic glial markers, inflammation, and antioxidant parameters in CKD. The findings show that CKD animals display abnormalities in colonic cytoarchitecture, reduced antioxidant activity, and increased inflammation in the enteric glial network of the neuromuscular layer.
Article
Nutrition & Dietetics
Eve Wemelle, Lionel Carneiro, Anne Abot, Jean Lesage, Patrice D. Cani, Claude Knauf
Summary: This study investigates the role of glucose in duodenal contraction in the fasted and fed states in normal and diabetic mice. The findings suggest that glucose acts as an enterosyne to control intestinal motility and glucose absorption through the enteric nervous system. Alterations in glucose sensing and mechanosensing are observed in type 2 diabetes.
Article
Biochemistry & Molecular Biology
Eve Wemelle, Lucie Marousez, Jean Lesage, Marie De Lamballerie, Claude Knauf, Lionel Carneiro
Summary: The study found that high hydrostatic pressure (HHP) processing of donor milk provides better protection against gut and liver pathologies in preterm infants compared to Holder pasteurization (HoP). HHP treatment preserves vitamins and reduces H2O2 content in the milk. In mice experiments, HHP-DM administration stimulates antioxidant defenses and reduces inflammatory markers.
Article
Biochemistry & Molecular Biology
Anne Abot, Amandine Brochot, Nicolas Pomie, Eve Wemelle, Celine Druart, Marion Regnier, Nathalie M. Delzenne, Willem M. de Vos, Claude Knauf, Patrice D. Cani
Summary: In this study, the effects of Camu-Camu extract on obesity and associated disorders were evaluated. It was found that low doses of Camu-Camu extract improved glucose and lipid homeostasis and increased the abundance of Akkermansia muciniphila. High doses of Camu-Camu extract prevented excessive body weight gain, fat mass gain, and hepatic steatosis. These findings suggest that plant extracts, particularly Camu-Camu extract, may be beneficial in weight management and glucose homeostasis.
Article
Ecology
Raja Rezg, Rahime Oral, Serkan Tez, Bessem Mornagui, Giovanni Pagano, Marco Trifuoggi
Summary: This study evaluates the toxic effects of bisphenol S (BP-S) on the early life stages of Arbacia lixula sea urchins and finds that it exhibits similar toxicity to bisphenol A (BP-A). The results suggest that bisphenol compounds may have adverse effects on embryonic development within a certain concentration range.
Article
Cell Biology
Anne Abot, Vincent Robert, Renaud Fleurot, Hugues Dardente, Vincent Hellier, Pascal Froment, Anne Duittoz, Claude Knauf, Laurence Dufourny
Summary: Hypothalamic control of reproduction relies on secretions of GnRH and kisspeptin (KP). This study found neuroanatomical contacts between apelin fibers and both KP and GnRH neurons in the hypothalamus of male rodents. Intracerebroventricular apelin infusion did not decrease LH levels nor affect gene expression for KP, neurokinin B, and dynorphin. However, apelin did affect the secretory activity of GnRH neurons.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2022)
Editorial Material
Gastroenterology & Hepatology
Patrice D. Cani, Claude Knauf
Article
Public, Environmental & Occupational Health
Bessem Mornagui, Raja Rezg, Fadoua Neffati, Mohamed Fadhel Najjar, Ahmed Rejeb
Summary: This study evaluated the harmful effects of low levels of BPS on the liver of male mice and investigated the interaction between BPS and PPAR gamma. The results showed that BPS induced hypertriglyceridemia, increased liver injury markers, and initiated histopathological changes.
TOXICOLOGY AND INDUSTRIAL HEALTH
(2023)
Correction
Endocrinology & Metabolism
Domagoj Cikes, Kareem Elsayad, Erdinc Sezgin, Erika Koitai, Ferenc Torma, Michael Orthofer, Rebecca Yarwood, Leonhard X. Heinz, Vitaly Sedlyarov, Nasser Darwish Miranda, Adrian Taylor, Sophie Grapentine, Fathiya Al-Murshedi, Anne Abot, Adelheid Weidinger, Candice Kutchukian, Colline Sanchez, Shane J. F. Cronin, Maria Novatchkova, Anoop Kavirayani, Thomas Schuetz, Bernhard Haubner, Lisa Haas, Astrid Hagelkruys, Suzanne Jackowski, Andrey V. Kozlov, Vincent Jacquemond, Claude Knauf, Giulio Superti-Furga, Eric Rullman, Thomas Gustafsson, John McDermot, Martin Lowe, Zsolt Radak, Jeffrey S. Chamberlain, Marica Bakovic, Siddharth Banka, Josef M. Penninger
Article
Endocrinology & Metabolism
Domagoj Cikes, Kareem Elsayad, Erdinc Sezgin, Erika Koitai, Torma Ferenc, Michael Orthofer, Rebecca Yarwood, Leonhard X. Heinz, Vitaly Sedlyarov, Nasser Darwish Miranda, Adrian Taylor, Sophie Grapentine, Fathiya al-Murshedi, Anne Abot, Adelheid Weidinger, Candice Kutchukian, Colline Sanchez, Shane J. F. Cronin, Maria Novatchkova, Anoop Kavirayani, Thomas Schuetz, Bernhard Haubner, Lisa Haas, Astrid Hagelkruys, Suzanne Jackowski, Andrey Kozlov, Vincent Jacquemond, Claude Knauf, Giulio Superti-Furga, Eric Rullman, Thomas Gustafsson, John McDermot, Martin Lowe, Zsolt Radak, Jeffrey S. Chamberlain, Marica Bakovic, Siddharth Banka, Josef M. Penninger
Summary: Muscle degeneration is a common cause of frailty and dependency in inherited diseases and ageing. The enzyme PCYT2/ECT plays a critical role in muscle health. Deficiency in PCYT2 leads to severe disease and muscle weakness. Mechanistically, PCYT2 deficiency affects cellular bioenergetics and membrane lipid bilayer structure. PCYT2 activity declines in ageing muscles and therapeutic delivery of PCYT2 improves muscle weakness.
Article
Nutrition & Dietetics
Lionel Carneiro, Lucie Marousez, Matthias Van Hul, Lea Chantal Tran, Marie De Lamballerie, Delphine Ley, Patrice D. Cani, Claude Knauf, Jean Lesage
Summary: This study demonstrates that high hydrostatic pressure processing can reinforce intestinal barrier integrity without affecting gut microbiota composition and short chain fatty acid production.
Article
Multidisciplinary Sciences
Anne Abot, Amandine Brochot, Nicolas Pomie, Gwendoline Astre, Celine Druart, Willem M. de Vos, Claude Knauf, Patrice D. Cani
Summary: The use of pasteurized Akkermansia muciniphila has shown positive effects on metabolic parameters in obese mice, such as insulin, glycemia, and glucose tolerance, possibly through gut-brain axis signaling.
