Review
Biochemistry & Molecular Biology
Giorgia Mori, Maria Rosalia Pasca
Summary: Colorectal cancer is the third most common cancer worldwide and is mainly classified as either sporadic or hereditary. Screening for hereditary-related cancers is important for prevention in individuals at risk. Studying the correlation between colorectal cancer and gut microbiota, especially in hereditary syndromes, may have implications for both prevention and potential therapeutic treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Alice Bertocchi, Sara Carloni, Paola Simona Ravenda, Giovanni Bertalot, Ilaria Spadoni, Antonino Lo Cascio, Sara Gandini, Michela Lizier, Daniele Braga, Francesco Asnicar, Nicola Segata, Chris Klaver, Paola Brescia, Elio Rossi, Achille Anselmo, Silvia Guglietta, Annalisa Maroli, Paola Spaggiari, Noelia Tarazona, Andres Cervantes, Silvia Marsoni, Luca Lazzari, Maria Giovanna Jodice, Chiara Luise, Marco Erreni, Salvatore Pece, Pier Paolo Di Fiore, Giuseppe Viale, Antonino Spinelli, Chiara Pozzi, Giuseppe Penna, Maria Rescigno
Summary: Bacteria from primary tumors can lead to bacterial dissemination from the intestine to the liver, disrupting the gut vascular barrier, boosting the formation of a premetastatic niche, and enhancing the recruitment of metastatic cells. High levels of PV-1, a marker of impaired gut vascular barrier, are associated with liver bacteria dissemination and metachronous distant metastases in colorectal cancer patients, making it a prognostic marker for distant recurrence and vascular impairment.
Review
Immunology
Sisi Mo, Haiming Ru, Maosen Huang, Linyao Cheng, Xianwei Mo, Linhai Yan
Summary: Microbial disorders are associated with the pathogenesis of various malignant tumors. The oral and intestinal tract are important microbial habitats in the human body, but they have limited communication. However, evidence suggests that oral microbiota can colonize the gut, leading to dysregulation of gut microbes and promoting the development of colorectal cancer.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Article
Microbiology
Hao Yu, Xing-Xiu Li, Xing Han, Bin-Xin Chen, Xing-Hua Zhang, Shan Gao, Dan-Qi Xu, Yao Wang, Zhan-Kui Gao, Lei Yu, Song-Ling Zhu, Li-Chen Yao, Gui-Rong Liu, Shu-Lin Liu, Xiao-Qin Mu
Summary: Many lines of evidence suggest that maintaining the homeostasis of microbiota and host might be beneficial to colorectal cancer (CRC) patients, but the underlying mechanisms are still unclear. This study established a CRC mouse model of microbial dysbiosis and found that fecal microbiota transplantation (FMT) could effectively reverse the disordered gut microbiota of CRC mice. FMT also suppressed cancer progression, reduced excessive intestinal inflammation, and promoted anti-cancer immune responses. Furthermore, FMT regulated the expressions of inflammatory cytokines and cancer-related genes, which contributed to its anti-cancer efficacy.
FRONTIERS IN MICROBIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Povilas Miknevicius, Ruta Zulpaite, Bettina Leber, Kestutis Strupas, Philipp Stiegler, Peter Schemmer
Summary: Probiotics can help prevent or reduce the side effects induced by chemotherapy, including gastrointestinal toxicity, weight loss, and diarrhea. However, further clinical studies are needed to determine the most effective dosage and combination of probiotics.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Yoshimitsu Shimomura, Ling Zha, Sho Komukai, Nobuhiro Narii, Tomotaka Sobue, Tetsuhisa Kitamura, Satoshi Shiba, Sayaka Mizutani, Takuji Yamada, Norie Sawada, Shinichi Yachida
Summary: Higher fiber intake is associated with a lower risk of colorectal cancer. The study found that certain intestinal bacteria, including Fusobacterium nucleatum and Gemella morbillorum, mediate the relationship between fiber intake and CRC risk.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Review
Immunology
Siti Maryam Ahmad Kendong, Raja Affendi Raja Ali, Khairul Najmi Muhammad Nawawi, Hajar Fauzan Ahmad, Norfilza Mohd Mokhtar
Summary: Colorectal cancer is a heterogeneous disease that mainly affects individuals over 50 years old, with regular screening reducing the number of cancer deaths. However, the incidence of CRC is rising among younger individuals, potentially due to environmental factors and lack of genetic susceptibility.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Review
Allergy
Maryam Azimi, Sanaz Keshavarz Shahbaz, Amir Hossein Mansourabadi, Leila Mohamed Khosroshahi, Shahryar Pourkalhor, Mehran Rezakhani, Farimah Masoumi
Summary: The intestinal microbiome plays a fundamental role in colorectal cancer (CRC), and its dysbiosis has been associated with the development of CRC. By studying the interaction between host genetics, intestinal microbiota, and lifestyle, we can better understand how they influence, prevent, and treat CRC. Additionally, various microbiome compositions have shown anticancer and anti-inflammatory properties. Understanding the role of the microbiota through molecular detection and metabolomic techniques opens up new possibilities for the treatment of CRC.
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
(2022)
Article
Oncology
Jingjing Kang, Mingzhong Sun, Yi Chang, Hongmei Chen, Juan Zhang, Xiaodong Liang, Tengfei Xiao
Summary: This study explored the role and mechanism of butyrate in regulating colon cancer and its intestinal microecological balance using an azoxymethane/dextran sodium sulfate induced mouse CRC model. The results showed that butyrate alleviated weight loss, disease activity index, and survival in CRC mice, and inhibited tumor number and progression. Further research revealed that butyrate inhibited the aggregation of harmful bacteria while promoting the colonization of beneficial flora (such as Actinobacteriota, Bifidobacteriales, and Muribaculacea) through 16S rDNA sequence analysis. This study confirmed that butyrate can ameliorate CRC by repairing intestinal microecology, providing ideas and evidence for chemical prophylactic agents, such as butyrate, to remedy tumors and regulate tumor microbiota.
Article
Biochemistry & Molecular Biology
Liuyang Zhao, Xiang Zhang, Yunfei Zhou, Kaili Fu, Harry Cheuk-Hay Lau, Tommy Wai-Yiu Chun, Alvin Ho-Kwan Cheung, Olabisi Oluwabukola Coker, Hong Wei, William Ka-Kei Wu, Sunny Hei Wong, Joseph Jao-Yiu Sung, Ka Fai To, Jun Yu
Summary: Large-scale fecal shotgun metagenomic sequencing revealed the high abundance of Parvimonas micra in colorectal cancer patients. P. micra was found to promote colorectal tumorigenesis in mice by inducing colonocyte proliferation and altering Th17 immune response. It may act as a potential prognostic biomarker for poor survival of CRC patients.
Review
Pharmacology & Pharmacy
Miguel Silva, Valentina Brunner, Markus Tschurtschenthaler
Summary: Colorectal cancer is a complex condition caused by a combination of environmental, genetic, and epigenetic factors, with disruptions in gut microbiota structure associated with various intestinal diseases, including cancer. Bacteria can induce cellular transformation and promote tumor progression through mechanisms such as biofilm formation and genotoxin secretion. The gut microbiota is also involved in drug metabolism, radiotherapy responses, and targeted immunotherapy, with therapy efficacy varying based on the composition of the host's gut microbiota.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Nutrition & Dietetics
Lanzhou Li, Honghan Liu, Jinqi Yu, Zhen Sun, Ming Jiang, Han Yu, Chunyue Wang
Summary: Auricularia delicate can inhibit colitis-associated colorectal cancer (CAC) through regulating intestinal microbiota and affecting the NF-kappa B pathway and inflammation.
Review
Oncology
Wenjie Zhang, Jie Zhang, Tian Liu, Juan Xing, Huan Zhang, Daorong Wang, Dong Tang
Summary: The interaction between intestinal microbiota and antibiotics plays a key role in the treatment of colorectal cancer, enhancing the treatment outcomes. However, the use of antibiotics may affect the effectiveness of the treatment, so caution should be exercised.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2022)
Article
Oncology
Josefine Schardey, Can Lu, Jens Neumann, Ulrich Wirth, Qiang Li, Tianxiao Jiang, Petra Zimmermann, Joachim Andrassy, Alexandr V. Bazhin, Jens Werner, Florian Kuehn
Summary: Chronic inflammation plays a significant role in the development of colorectal cancer, particularly in colitis-associated colorectal cancer. This study examined the differences in immune infiltration patterns between colitis-associated colorectal cancer and sporadic colorectal cancer and their impact on prognosis.
Article
Immunology
Hongyan Lin, Xiaopeng Ma, Xiaorong Yang, Qingqing Chen, Zhongling Wen, Minkai Yang, Jiangyan Fu, Tongming Yin, Guihua Lu, Jinliang Qi, Hongwei Han, Yonghua Yang
Summary: This study identified SK and acetyl-SK, especially SK, as potential preventive agents for CAC through regulating both gut microbes and pathways involved in inflammation and cancer such as Wnt/β-catenin signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Anesthesiology
E. Li
Summary: Surgical patients with peri-operative or recent SARS-CoV-2 infection are at increased risk of postoperative venous thromboembolism compared to those without a history of SARS-CoV-2. However, the optimal prophylaxis and treatment for venous thromboembolism in this patient population remains unknown. Venous thromboembolism is independently associated with 30-day mortality.
Article
Virology
Ufuk O. Idiz, Tahir T. Yurttas, Serife Degirmencioglu, Bagnu Orhan, Emre Erdogan, Husnu Sevik, Mert M. Sevinc
Summary: The study revealed significant differences in various parameters including temperature, heart rate, white blood cell count, lymphocyte count, and cytokine levels among different disease severity groups.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Hematology
Hayri Canbaz, Ufuk Ofuz Idiz, Hayriye Cankar Dal, Fatih Kaciroglu, Seher Tas, Hikmet Can Cubukcu, Attila Bestemir, Murat Gulsen, Istemi Taha Polat, Abubekir Laloglu, Ibrahim Hakki Tor, Halik Ekrem Akkurt, Utku Ates, Ismail Reisli, Esin Koc, Ahmet Cagkan Inkaya, Musa Karakukcu, Mustafa Ceylan, Ibrahim Celalettin Haznedaroglu, Haluk Akin
Summary: This retrospective study evaluated the effect of MSC treatment on the survival rate of COVID-19 patients. Contrary to other studies in the literature, it was observed that MSC treatment may not significantly affect overall survival or survival based on comorbid diseases.
TURKISH JOURNAL OF HEMATOLOGY
(2022)
Article
Surgery
Erhan Aysan, Beril Guler, Tugce Kiran, Ufuk O. Idiz
Summary: Core needle biopsy is a highly sensitive, specific, and reliable method for the diagnosis of thyroid nodules. It can be performed by a single physician and does not require on-site pathological analysis. The procedure has a low incidence of complications and non-diagnostic rates.
Article
Medicine, Research & Experimental
Ayse Gul Ferlengez, Cihad Tatar, Mahmut Said Degerli, Adil Koyuncu, Fatih Alper Ahlatci, Ali Emre Nayci, Aziz Ari, Ufuk Oguz Idiz
Summary: This study investigated the utility of serum nesfatin-1 levels in the diagnosis of acute pancreatitis (AP). The results showed a considerable decrease in serum nesfatin-1 levels in parallel to the severity of pancreatitis, suggesting its potential as a diagnostic and severity marker in AP.
ADVANCES IN CLINICAL AND EXPERIMENTAL MEDICINE
(2023)
Article
Immunology
Selim Dogan, Fatih Dal, Mert Guler, Husnu Sevik, Ufuk Oguz Idiz
Summary: This study aimed to investigate the immunophenotyping of immune cells in order to help clarify the etiopathogenesis of idiopathic granulomatous mastitis (IGM). The study included patients with IGM and healthy volunteers, and found that there were changes in certain cell types in IGM patients that were similar to cell profiles of some autoimmune diseases.
Article
Surgery
Furkan Turkoglu, Mert Guler, Hasan Erdem, Mehmet Gencturk, Erdem Kinaci, Cihad Tatar, Ufuk Oguz Idiz
Summary: This study aimed to evaluate the changes in Nesfatin-1 and serum cytokine levels in patients who underwent sleeve gastrectomy or gastric bypass surgery. The results showed that weight loss surgery led to improvements in body weight, excess body weight, blood glucose levels, liver function markers, inflammation markers, and certain cytokines.
SURGEON-JOURNAL OF THE ROYAL COLLEGES OF SURGEONS OF EDINBURGH AND IRELAND
(2023)
Article
Medicine, Research & Experimental
Cemile Idiz, Ufuk Oguz Idiz
Summary: Intermittent fasting has positive effects on obesity-induced inflammation and promotes an increase in anti-inflammatory cytokines while decreasing pro-inflammatory cytokines. IL-33 is strongly negatively correlated with BMI change over time.
ADVANCES IN CLINICAL AND EXPERIMENTAL MEDICINE
(2023)
Article
Medicine, General & Internal
Hasan Okmen, Nagehan Didem Sari, Kivilcim Ulusan, Abdurrahman Tunay, Ufuk Oguz Idiz
Summary: Clinical and laboratory parameters play important roles in the differential diagnosis of necrotizing fasciitis and cellulitis patients, including fever, blood count results, and biochemical markers. For cellulitis patients with high levels of leukocytes, platelets, and neutrophils, clinicians should closely monitor the patient's clinical course and consider the possibility of necrotizing fasciitis.
MEDICAL BULLETIN OF SISLI ETFAL HOSPITAL
(2023)
Article
Medicine, General & Internal
Abdurrahman Tunay, Mert Guler, Mert Ali Dolek, Selim Dogan, Ozlem Atesal, Sevim Baltali, Hasan Okmen, Mensure Yilmaz Cakirgoz, Meral Kurt Durmus, Ufuk Oguz Idiz, Mehmet Toptas
Summary: This study compared local infiltration anesthesia (LIA) and spinal anesthesia (SA) for postoperative pain levels in patients with pilonidal sinus disease. The results showed that the pain scores with LIA were lower than SA at 8 hours and 24 hours postoperatively. There were no statistically significant differences in recurrence rates and age between the two groups. Therefore, LIA may be suggested as the anesthetic technique for pilonidal surgery.
ISTANBUL MEDICAL JOURNAL
(2023)
Article
Medicine, General & Internal
Ekrem Cakar, Mert Mahsuni Sevinc, Sukru Colak, Mete Demir, Enver Yarikkaya, Ufuk Oguz Idiz
Summary: Primary ANs are rare and easily overlooked, and patients with AN may have AA-like clinical presentation. This study analyzed a total of 2,906 patients who underwent appendectomy, and found that the prevalence of AN was 2.82%. Patients with AN were notably older and had a higher rate of perforation and diverticula compared to those with AA. The most common neoplasm was low-grade mucinous adenoma, followed by precancerous serrated adenoma and carcinoid tumor. Carcinoid tumors were mostly located at the tip of the appendix. No lymphovascular invasion or distant metastasis was observed in any of the patients.
ISTANBUL MEDICAL JOURNAL
(2023)
Article
Medicine, General & Internal
Ali Emre Nayci, Yigit Duzkoylu, Cihad Tatar, Ufuk Oguz Idiz, Mahmut Kaan Demircioglu, Mahmut Emin Cicek, Ishak Yildiz
Summary: This study aimed to investigate a clinical predictive model using the MELD-sodium scoring system for patients with acute pancreatitis. The results showed that the MELD-sodium score was significantly associated with the severity of the disease and mortality rates, which may guide future research.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Article
Emergency Medicine
Oguzhan Tekin, Mert Mahsuni Sevinc, Ozhan Albayrak, Oguzkagan Batikan, Ufuk Oguz Idiz
Summary: This study aimed to investigate the use of Nesfatin-1 in the diagnosis and grading of acute cholecystitis. The results showed that Nesfatin-1 levels were lower in the patient group compared to the control group, but no significant relationship was found between Nesfatin-1 and the severity of the disease.
ULUSAL TRAVMA VE ACIL CERRAHI DERGISI-TURKISH JOURNAL OF TRAUMA & EMERGENCY SURGERY
(2022)
Article
Medicine, General & Internal
Selim Dogan, Serkan Sari, Kivilcim Ulusan, Gungor Uzum, Ufuk Oguz Idiz
Summary: This study determined the location of thyroid-related nerves by nerve monitoring and demonstrated the usefulness of Nerve Integrity Monitor in thyroid surgery. The results showed variations in the location of the vagus nerve, recurrent laryngeal nerve (RLN), and superior laryngeal nerve (SLN). Surgeon experience and anatomical markers alone were insufficient in preventing nerve injuries, highlighting the importance of preoperative nerve monitoring for clearer identification of these variations and improved surgical safety.
JCPSP-JOURNAL OF THE COLLEGE OF PHYSICIANS AND SURGEONS PAKISTAN
(2022)
Article
Medicine, General & Internal
Coskun Cakir, Ali Emre Nayci, Ekrem Ferlengez, Mert Guler, Ufuk Oguz Idiz
Summary: This study investigated the roles of cytokines in the etiopathogenesis of idiopathic granulomatous mastitis. The results showed that certain cytokine levels were lower in patients with idiopathic granulomatous mastitis, suggesting that autoimmune and granulomatous reactions may not play a significant role in the pathogenesis of this disease.
JCPSP-JOURNAL OF THE COLLEGE OF PHYSICIANS AND SURGEONS PAKISTAN
(2022)
