Review
Cardiac & Cardiovascular Systems
Andrea Lorenzo Poggi, Benedicte Gaborit, Thomas Hellmut Schindler, Luca Liberale, Fabrizio Montecucco, Federico Carbone
Summary: Obesity is a heterogeneous condition that may have a closer link with cardiovascular disease burden and atrial fibrillation. Dysfunction of epicardial adipose tissue (EAT) due to ectopic fat deposition is associated with atrial remodelling and may play a significant role in the development and recurrence of atrial fibrillation. This study provides an updated understanding of the relationship between dysfunctional EAT, LA remodelling, and atrial fibrillation onset and recurrence.
Article
Cardiac & Cardiovascular Systems
Olga Shaihov-Teper, Eilon Ram, Nimer Ballan, Rafael Y. Brzezinski, Nili Naftali-Shani, Rula Masoud, Tamar Ziv, Nir Lewis, Yeshai Schary, La-Paz Levin-Kotler, David Volvovitch, Elchanan M. Zuroff, Sergei Amunts, Neta Regev-Rudzki, Leonid Sternik, Ehud Raanani, Lior Gepstein, Jonathan Leor
Summary: This study revealed, for the first time, a distinctive proinflammatory, profibrotic, and proarrhythmic signature of epicardial fat-derived extracellular vesicles in patients with atrial fibrillation, uncovering another pathway by which epicardial fat promotes the development of atrial myopathy and fibrillation.
Article
Cardiac & Cardiovascular Systems
Alexander R. van Rosendael, Jeff M. Smit, Mohammed El'Mahdiui, Philippe J. van Rosendael, Melissa Leung, Victoria Delgado, Jeroen J. Bax
Summary: This study evaluated the association between left atrial epicardial fat and left atrial volume in patients with different types of atrial fibrillation (AF). The results showed that left atrial epicardial fat was larger in patients with paroxysmal AF, while larger left atrial volumes were associated with persistent/permanent AF.
Article
Multidisciplinary Sciences
Daniel Enriquez-Vazquez, Jorge G. Quintanilla, Alba Garcia-Escolano, Marinela Couselo-Seijas, Ana Simon-Chica, Peter Lee, Jose Manuel Alfonso-Almazan, Patricia Mahia, Andres Redondo-Rodriguez, Javier Modrego, Adriana Ortega-Hernandez, Pedro Marcos-Alberca, Ricardo Magni, Enrique Calvo, Ruben Gomez-Gordo, Ping Yan, Giulio La Rosa, Jose Bustamante-Madrion, Carlos Nicolas Perez-Garcia, F. Javier Martin-Sanchez, David Calvo, Jesus M. de la Hera, Maria Jesus Garcia-Torrent, Alvaro Garcia-Osuna, Jordi Ordonez-Llanos, Jesus Vazquez, Julian Perez-Villacastin, Nicasio Perez-Castellano, Leslie M. Loew, Javier Sanchez-Gonzalez, Dulcenombre Gomez-Garre, David Filgueiras-Rama
Summary: The authors use non-invasive atrial electromechanical assessment during atrial fibrillation to identify early remodeling changes associated with underlying myopathy, which decreases the probability of successful rhythm control. This study provides mechanistic insights into the electromechanical remodeling process associated with AF progression and demonstrates its prognostic value in the clinic.
NATURE COMMUNICATIONS
(2023)
Article
Cardiac & Cardiovascular Systems
Jing Zhu, Kaimin Zhuo, Bo Zhang, Zhen Xie, Wenjia Li
Summary: Gender has a significant impact on the prevalence and prognosis of atrial fibrillation. Women have a higher ratio of epicardial adipose tissue and higher recurrence rate after catheter ablation for atrial fibrillation.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Medicine, General & Internal
Paritosh Prasai, Dhan Bahadur Shrestha, Eltaib Saad, Angkawipa Trongtorsak, Aarya Adhikari, Suman Gaire, Prakash Raj Oli, Jurgen Shtembari, Pabitra Adhikari, Yub Raj Sedhai, Muhammad Sikander Akbar, Islam Y. Elgendy, Ghanshyam Shantha
Summary: There is no clear consensus on the preference for pharmacological cardioversion (PC) compared to electric cardioversion (EC) for hemodynamically stable new-onset atrial fibrillation (NOAF) patients. This meta-analysis suggests that there is no difference in successful restoration of sinus rhythm with either modality among patients with hemodynamically stable NOAF.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Medicine, General & Internal
Ioannis Anagnostopoulos, Maria Kousta, Charalampos Kossyvakis, Nikolaos Taxiarchis Paraskevaidis, Dimitrios Vrachatis, Spyridon Deftereos, Georgios Giannopoulos
Summary: This study investigated the relationship between total and peri-left atrium (peri-LA) epicardial adipose tissue (EAT) and post-ablation atrial fibrillation (AF) recurrence. The results suggest that only peri-LA EAT may be predictive of post-ablation AF recurrence.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Ozan Demirel, Alexander E. Berezin, Moritz Mirna, Elke Boxhammer, Sarah X. Gharibeh, Uta C. Hoppe, Michael Lichtenauer
Summary: Atrial fibrillation (AF) is associated with atrial remodeling, cardiac dysfunction, and poor clinical outcomes. External direct current electrical cardioversion is an effective urgent treatment strategy for recent-onset AF. However, accurate predictive serum biomarkers for AF relapse after cardioversion are lacking. Many biomarkers have been associated with AF occurrence, but their predictive ability for post-cardioversion outcomes remains controversial. Novel circulating biomarkers are needed to improve the predictive tools for AF treatment.
Article
Cardiac & Cardiovascular Systems
Laura Petraglia, Maddalena Conte, Giuseppe Comentale, Serena Cabaro, Pasquale Campana, Carmela Russo, Ilaria Amaranto, Dario Bruzzese, Pietro Formisano, Emanuele Pilato, Nicola Ferrara, Dario Leosco, Valentina Parisi
Summary: This study aimed to evaluate the association between inflammatory mediators produced by EAT and the occurrence of POAF. The results showed that higher levels of IL-6 and MCP-1 in EAT were significantly associated with POAF, and statin therapy may play a role in preventing POAF. These findings suggest a potential targeted use of these drugs in the perioperative period.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cell Biology
Serena Cabaro, Maddalena Conte, Donato Moschetta, Laura Petraglia, Vincenza Valerio, Serena Romano, Michele Francesco Di Tolla, Pasquale Campana, Giuseppe Comentale, Emanuele Pilato, Vittoria D'Esposito, Annabella Di Mauro, Monica Cantile, Paolo Poggio, Valentina Parisi, Dario Leosco, Pietro Formisano
Summary: The study explored the link between epicardial adipose tissue (EAT)-secreted interleukin (IL)-1 beta, atrial remodeling, and post-operative atrial fibrillation (POAF) in patients with coronary artery disease (CAD). Results showed that EAT-mediated IL-1 beta secretion was significantly higher in patients with POAF compared to those without POAF, suggesting a potential role of EAT in both POAF occurrence and atrial fibrotic remodeling.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Endocrinology & Metabolism
Marinela Couselo-Seijas, Moises Rodriguez-Manero, Jose R. Gonzalez-Juanatey, Sonia Eiras
Summary: This study highlights the important role of epicardial fat in the occurrence and maintenance of atrial fibrillation, emphasizing the pathophysiological mechanisms involved and preventive therapeutic strategies. The increase in volume and activity of epicardial fat may alter cardiac autonomic activity, making reducing adiposity and weight crucial for preventing atrial fibrillation.
Review
Biochemistry & Molecular Biology
Homa Nomani, Sara Saei, Thomas P. Johnston, Amirhossein Sahebkar, Amir Hooshang Mohammadpour
Summary: Inflammation has been associated with the recurrence of Atrial Fibrillation (AF), and using anti-inflammatory drugs may help reduce recurrences. However, current studies on the efficacy of specific drugs remain inconclusive, and further clinical trials are needed to explore the impact of different factors on AF recurrence.
CURRENT MEDICINAL CHEMISTRY
(2021)
Article
Cardiac & Cardiovascular Systems
Maria Teresa Barrio-Lopez, Miguel Ruiz-Canela, Leticia Goni, Almudena Martinez Valiente, Silvia Romero Garcia, Victor de la O, Belen Diaz Anton, Leticia Fernandez-Friera, Eduardo Castellanos, Miguel Angel Martinez-Gonzalez, Jesus Almendral
Summary: There is an association between adherence to the Mediterranean diet (MedDiet) and epicardial adipose tissue (EAT) in patients with atrial fibrillation (AF). EAT measurements and MedDiet adherence at baseline are also associated with AF recurrence after ablation.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Medicine, General & Internal
Lukas Fiedler, Lara Hallsson, Maximilian Tscharre, Sabrina Oebel, Michael Pfeffer, Robert Schoenbauer, Lyudmyla Tokarska, Laura Stix, Anton Haiden, Johannes Kraus, Hermann Blessberger, Uwe Siebert, Franz Xaver Roithinger
Summary: Statin therapy is associated with a reduced risk of long-term atrial fibrillation recurrence after successful cardioversion, significantly lowering the rate of AF recurrence. The propensity score matching analysis further demonstrates a significant absolute risk reduction in recurrent AF with statin treatment.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Medicine, General & Internal
Fabiana Luca, Simona Giubilato, Stefania Angela Di Fusco, Laura Piccioni, Carmelo Massimiliano Rao, Annamaria Iorio, Laura Cipolletta, Emilia D'Elia, Sandro Gelsomino, Roberta Rossini, Furio Colivicchi, Michele Massimo Gulizia
Summary: The therapeutic dilemma between rhythm and rate control remains unresolved in the management of AF, with electrical or pharmacological cardioversion often being useful. Anticoagulation should be based on individual thromboembolic risk, with NOACs representing a significant advancement. Emergency ECV is necessary for hemodynamically unstable patients, with anticoagulation administered prior to CV.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Peripheral Vascular Disease
Sinan Cersit, Lutfi ocal, Muhammed Keskin, Mustafa Ozan Gursoy, Macit Kalcik, Emrah Bayam, Ahmet Karaduman, Samet Uysal, Abdulkadir Uslu, Ayhan Kup, Seckin Dereli, Ugur Arslantas, Mehmet Muhsin Turkmen
Summary: The study suggests a possible relationship between increased serum CRP-to-albumin ratio (CAR) and the presence and progression of abdominal aortic aneurysms (AAAs). Results indicate that CAR may serve as an inflammatory biomarker for evaluating the presence and progression of AAA.
Article
Cardiac & Cardiovascular Systems
Mustafa Yenercag, Ugur Arslan, Seckin Dereli, Metin Coksevim, Mustafa Dogdus, Ahmet Kaya
Summary: The study investigated the effect of sacubitril/valsartan treatment on pulmonary artery stiffness in HFrEF patients. Results showed a significant reduction in PAS after sacubitril/valsartan treatment, along with improvements in patient's functional capacity and cardiac parameters.
INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING
(2021)
Article
Cardiac & Cardiovascular Systems
Sinan Cersit, Lutfi Ocal, Muhammed Keskin, Mustafa Ozan Gursoy, Ayhan Kup, Mehmet Celik, Hayati Eren, Selahattin Akyol, Seckin Dereli, Mehmet Muhsin Turkmen
Summary: The study demonstrated that the CHA(2)DS(2)-VASc score can accurately predict in-hospital and long-term outcomes in patients undergoing carotid artery stenting, with higher scores indicating increased risk of stroke and mortality.
INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING
(2021)
Article
Medicine, General & Internal
Gokhan Aksan, Ahmet Yanik, Osman Can Yontar, Omer Gedikli, Ugur Arslan, Korhan Soylu
Summary: This study revealed a significant relationship between AHRE and CS galectin-3 levels, indicating that high CS galectin-3 levels can predict the development of AHRE in CRT patients.
JOURNAL OF INVESTIGATIVE MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Kadir Idin, Seckin Dereli, Ahmet Kaya, Mustafa Yenercag, Ahmet Seyda Yilmaz, Kaptaniderya Tayfur, Oktay Gulcu
Summary: The study found that in high-risk acute pulmonary embolism (APE) patients, MELD scores can serve as independent predictors of 30-day mortality, with the MELD-Albumin score showing higher predictive power.
SCANDINAVIAN CARDIOVASCULAR JOURNAL
(2021)
Editorial Material
Cardiac & Cardiovascular Systems
Osman Can Yontar, Bulent Gorenek
AMERICAN JOURNAL OF CARDIOLOGY
(2021)
Article
Medicine, General & Internal
Yasemin Kaya, Sedat Bostan, Ahmet Kaya, Omer Karaman, Ahmet Karatas, Seckin Dereli
Summary: The study found that during the COVID-19 pandemic, half of the participants did not have intentions to go to the hospital. Anxiety and depression levels were found to increase when encountering COVID-19 patients or having a relative with COVID-19, showing a negative correlation.
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
(2021)
Article
Cardiac & Cardiovascular Systems
Osman Can Yontar, Ahmet Yanik, Gokhan Aksan
Summary: The study found a correlation between the shortest P- to delta-wave time interval (PDI) and the surface electrocardiogram's conduction properties expressed as ante grade effective refractory period (APERP), showing that PDI can predict the APERP value with a good sensitivity and specificity.
CARDIOVASCULAR JOURNAL OF AFRICA
(2021)
Article
Medical Laboratory Technology
Idris Bugra Cerik, Ferhat Dindas, Emin Koyun, Seckin Dereli, Anil Sahin, Okan Onur Turgut, Ibrahim Gul
Summary: This study suggests that simple markers such as CAR and uric acid can provide prognostic information in PAH patients.
CLINICAL BIOCHEMISTRY
(2022)
Article
Cardiac & Cardiovascular Systems
Gokhan Aksan, Ahmet Yanik, Osman Can Yontar, Faruk Boyaci, Melisa Ucar, Mustafa Kursat Sahin, Korhan Soylu
Summary: This study found that the levels of galectin-3 in CS serum samples were associated with the presence and extent of LVA in patients with paroxysmal AF, and it could be an independent predictor for the presence of LVA.
JOURNAL OF ARRHYTHMIA
(2022)
Article
Medicine, General & Internal
Gokhan Aksan, Osman Can Yontar, Ahmet Yanik, Guney Erdogan, Ugur Arslan
Summary: This study presents a successful treatment of palpitation symptoms in a 58-year-old female patient through cardiac electrophysiological study and radiofrequency ablation. The research indicates that radiofrequency ablation in the para-hisian region can alleviate abnormal ventricular activation and reduce the risk of atrioventricular block.
NORTHERN CLINICS OF ISTANBUL
(2022)
Article
Cardiac & Cardiovascular Systems
Ozer Badak, Ali Riza Demir, Tugay Onal, Taylan Akgun, Osman Can Yontar, Omer Satiroglu, Hakan Duman, Ertugrul Okuyan, Mehmet Melek, Ibrahim Etem Dural
Summary: The study found that Turkish atrial fibrillation patients had varied levels of understanding about their disease and anticoagulation treatment. Most patients continued NOAC treatment throughout the study, but some were prescribed inappropriate reduced doses.
IJC HEART & VASCULATURE
(2022)
Article
Cardiac & Cardiovascular Systems
Osman Can Yontar, Guney Erdogan, Mustafa Yenercag, Sefa Gul, Ugur Arslan, Ali Karagoz
Summary: The Selvester score has prognostic value for cardiovascular outcomes in NSTEMI patients, with factors such as age, ejection fraction, cholesterol levels, and other risk scores contributing to adverse events in the high score group.
ACTA CARDIOLOGICA SINICA
(2021)
Article
Cardiac & Cardiovascular Systems
Berkay Ekici, Mehmet Yaman, Murathan Kucuk, Seckin Dereli, Mustafa Yenercag, Zerrin Yigit, Mehmet Memduh Bas, Yusuf Karavelioglu, Huseyin Altug Cakmak, Tarik Kivrak, Hakan Ozkan, Cihan Altin, Cengiz Sabanoglu, Burcu Demirkan, Ali Ekber Atas, Fethi Kilicaslan, Hakan Altay, Istemihan Tengiz, Aycan Fahri Erkan, Baris Kilicaslan, Fatih Erkam Olgun, Murtaza Emre Durakoglugil, Aslihan Alhan, Mehdi Zoghi
Summary: The study conducted in multiple centers in Turkey showed that the use of ARNi in HFrEF patients led to significant improvements in FC, NT-proBNP, HbA1c levels, and LV-EF. Additionally, reductions in the number of annual hospitalizations and daily diuretic doses for HF were observed after ARNi use.
TURK KARDIYOLOJI DERNEGI ARSIVI-ARCHIVES OF THE TURKISH SOCIETY OF CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Mustafa Yenercag, Ugur Arslan, Onur O. Seker, Seckin Dereli, Ahmet Kaya, Mustafa Dogdus, Cagatay E. Ozturk, Cetin K. Akpinar, Ahmet Sen
Summary: This study found a positive correlation between P-wave dispersion (PWD) and atrial fibrillation risk in patients with newly diagnosed COVID-19, as well as significant associations with inflammatory markers such as CRP level and neutrophil-to-lymphocyte ratio (NLR). During follow-up, it was observed that some patients developed new atrial fibrillation, especially those who were admitted to the ICU.
JOURNAL OF CARDIOVASCULAR MEDICINE
(2021)