期刊
BIOCHEMICAL SOCIETY TRANSACTIONS
卷 43, 期 -, 页码 246-252出版社
PORTLAND PRESS LTD
DOI: 10.1042/BST20150018
关键词
ghrelin O-acyltransferase (GOAT); hedgehog acyltransferase (HHAT); membrane-bound O-acyltransferases (MBOATs); octanoylation; palmitoleoylation; palmitoylation; porcupine (PORCN)
资金
- Imperial College London Institute of Chemical Biology EPSRC Centre for Doctoral Training [EP/F500416/1]
- Cancer Research UK [C6433/A16402]
- Pancreatic Cancer Research Fund
- MRC [G0400710] Funding Source: UKRI
- Cancer Research UK [16402] Funding Source: researchfish
- Medical Research Council [G0400710] Funding Source: researchfish
Since the identification of the membrane-bound O-acyltransferase (MBOATs) protein family in the early 2000s, three distinct members [porcupine (PORCN), hedgehog (Hh) acyltransferase (HHAT) and ghrelin O-acyltransferase (GOAT)] have been shown to acylate specific proteins or peptides. In this review, topology determination, development of assays to measure enzymatic activities and discovery of small molecule inhibitors are compared and discussed for each of these enzymes.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据