Article
Endocrinology & Metabolism
Ladan Mehran, Negar Delbari, Atieh Amouzegar, Mitra Hasheminia, Maryam Tohidi, Fereidoun Azizi
Summary: Recently, reduced sensitivity to thyroid hormone has become more common in the general population and is thought to be associated with metabolic parameters. This study found that TFQI, a new index for thyroid hormone resistance, is significantly associated with high blood pressure and diabetes in euthyroid subjects. However, caution is needed when interpreting the results for diabetes, and further studies are necessary.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Xiaoyu Ding, Ying Wang, Jia Liu, Guang Wang
Summary: The study found that individuals with decreased sensitivity to thyroid hormones are more likely to have elevated Hcy levels, even after adjusting for multiple risk factors.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Yingning Lu, Jie Wang, Yu An, Jia Liu, Ying Wang, Guang Wang, Song Leng
Summary: This study investigated the relationship between thyroid hormone sensitivity and uric acid metabolism in a Chinese population. The results showed that impaired thyroid hormone sensitivity was associated with elevated uric acid levels. This finding is important for understanding the role of thyroid hormone sensitivity in uric acid metabolism.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Yuanmeng Li, Juan Sun, Yang Jiao, Naishi Li, Weigang Zhao
Summary: This study explores the relationship between vitamin D levels and thyroid hormone sensitivity among euthyroid individuals. The results suggest that impaired thyroid hormone sensitivity correlates with decreased vitamin D levels, with associations varying by age, sex, race, and BMI.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Lu Yu, Zhu Li, Rongrong Yang, Guangwei Pan, Qi Cheng, Yuanyuan He, Yijia Liu, Fanfan Liu, Mei Ma, Tong Yang, Yang Wang, Jinyu Su, Yanchao Zheng, Shan Gao, Qiang Xu, Lin Li, Chunquan Yu
Summary: The study revealed a significant association between thyroid hormone sensitivity and elevated blood glucose in patients with coronary heart disease. This association was higher in females compared to males and in patients aged over 60 years old than those aged 60 and below.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
V. Calcaterra, A. Gazzarri, A. De Silvestri, C. Madia, P. Baldassarre, V. Rossi, V. Garella, G. Zuccotti
Summary: The objective of this study was to evaluate the prevalence of metabolic syndrome (MS) in pediatric patients with Down Syndrome (DS), and to examine the relationship between metabolic parameters, thyroid hormones (THs), and sensitivity to thyroid hormone indices (STHI). The results showed that DS patients had higher levels of FT3, FT4, and TSH compared to the control group. There was a significant correlation between THs, STHI, and glucose and lipid metabolism parameters, supporting their role in metabolic alterations related to DS.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2023)
Article
Nutrition & Dietetics
Liyuan Zhou, Ying Wang, Jingru Su, Yu An, Jia Liu, Guang Wang
Summary: The study aimed to explore the association between vitamin D deficiency and sensitivity to thyroid hormones. The results showed that vitamin D deficiency was associated with impaired sensitivity to thyroid hormones, with several abnormal indicators in individuals with vitamin D deficiency. This suggests that vitamin D plays an important role in the normal regulation of thyroid function.
Article
Geriatrics & Gerontology
Zi-Wei Yu, Sheng-Dan Pu, Xiao-Tong Sun, Xi-Chang Wang, Xin-Yuan Gao, Zhong-Yan Shan
Summary: This study investigates the relationship between thyroid hormone sensitivity and mild cognitive impairment (MCI) in euthyroid patients with type 2 diabetes (T2D). The results show that lower free triiodothyronine to free thyroxine (FT3/FT4) ratio and higher thyroid-stimulating hormone index (TSHI), thyrotrophic thyroxine resistance index (TT4RI), and thyroid feedback quantile-based index (TFQI) are associated with MCI. Impaired sensitivity to thyroid hormones is independently related to MCI in euthyroid T2D patients.
CLINICAL INTERVENTIONS IN AGING
(2023)
Article
Endocrinology & Metabolism
Honglin Sun, Wei Zhu, Jia Liu, Yu An, Ying Wang, Guang Wang
Summary: This study investigated the relationship between sensitivity to thyroid hormones and high remnant cholesterol levels in a euthyroid population in China. The results showed that reduced sensitivity to thyroid hormones was associated with high remnant cholesterol levels, suggesting an increased cardiometabolic risk.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Medicine, Research & Experimental
Zhiyuan Wu, Yue Jiang, Pingan Li, Yutao Wang, Haiping Zhang, Zhiwei Li, Xia Li, Lixin Tao, Bo Gao, Xiuhua Guo
Summary: This cross-sectional study found that impaired sensitivity to thyroid hormones was associated with an increased prevalence of hyperuricemia in euthyroid adults. Body mass index (BMI) mediated the association between impaired sensitivity to thyroid hormones and hyperuricemia. These findings suggest the potential clinical benefit of weight control in maintaining metabolic health among individuals with impaired thyroid hormone sensitivity.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
C. Liu, L. Hua, K. Liu, Z. Xin
Summary: This study explored the relationship between thyroid sensitivity and bone mineral density (BMD) and fractures. The results showed that in elderly euthyroid individuals, FT3/FT4 and SPINA-GD were positively correlated with BMD, while FT4, TSHI, TT4RI, TFQI, and PTFQI(FT4) were negatively correlated with BMD. In logistic regression analysis, TSHI, TFQI, and PTFQI(FT4) were positively associated with osteoporosis, while FT3/FT4 was negatively associated with osteoporosis.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2023)
Article
Endocrinology & Metabolism
Sejeong Lee, Jaehyun Bae, Doo Ri Jo, Minyoung Lee, Yong-ho Lee, Eun Seok Kang, Bong-Soo Cha, Byung-Wan Lee
Summary: In newly diagnosed type 2 diabetes patients, intact ketogenesis may be associated with a decreased risk of metabolic-associated fatty liver disease (MAFLD).
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Katie L. Davies, Danielle J. Smith, Tatiana El-Bacha, Max E. Stewart, Akshay Easwaran, Peter F. P. Wooding, Alison J. Forhead, Andrew J. Murray, Abigail L. Fowden, Emily J. Camm
Summary: Thyroid hormones play a crucial role in the prepartum development of cerebral mitochondria, affecting mitochondrial function and neurodevelopment, as demonstrated by alterations in respiration, mitochondrial density, and gene expression in hypothyroid fetal sheep.
Article
Endocrinology & Metabolism
Xueyan Lang, Bing Zhao, Shaohong Fang, Lulu Li, Zhaoying Li, Nilian Wu, Yuheng Zhang, Lei Xing, Yilan Li, Yao Zhang
Summary: This study aims to investigate the influence of the peripheral sensitivity to thyroid hormones, as measured by the FT3/FT4 ratio, on the risk of heart failure and mortality after acute myocardial infarction (AMI). The results show that a higher FT3/FT4 ratio is associated with reduced risk of in-hospital and out-of-hospital HF, as well as all-cause and cardiovascular death in AMI patients.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Dominik Pesta, Tomas Jelenik, Oana-Patricia Zaharia, Pavel Bobrov, Sven Gorgens, Kalman Bodis, Yanislava Karusheva, Nina Krako Jakovljevic, Nebojsa M. Lalic, Daniel F. Markgraf, Volker Burkart, Karsten Mussig, Birgit Knebel, Jorg Kotzka, Jurgen Eckel, Klaus Strassburger, Julia Szendroedi, Michael Roden
Summary: The rs540467 SNP in the NDUFB6 gene is associated with adaptations to exercise training, with a notable impact on individuals with diabetes, particularly those with type 2 diabetes. Additionally, increasing physical activity levels may not always lead to improved insulin sensitivity in diabetes patients, where the polymorphism of the NDUFB6 gene could be a crucial factor.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Victoria Marco-Benedi, Ana Cenarro, Martin Laclaustra, Asier Larrea-Sebal, Estibaliz Jarauta, Itziar Lamiquiz-Moneo, Pilar Calmarza, Ana M. Bea, Nuria Plana, Xavier Pinto, Cesar Martin, Fernando Civeira
Summary: This study aimed to compare Lp(a) concentration in controls, genetically diagnosed heFH, and mutation-negative hypercholesterolemia subjects, as well as to assess the influence of the genetic defect responsible for heFH on Lp(a) concentration. The results showed that Lp(a) concentration was elevated in mutation-negative subjects and heFH patients. Among heFH patients, APOB-dependent FH had the highest Lp(a) concentration, followed by LDLR-dependent FH.
Article
Environmental Sciences
Arce Domingo-Relloso, Anne Bozack, Samara Kiihl, Zulema Rodriguez-Hernandez, Pilar Rentero-Garrido, J. Antonio Casasnovas, Montserrat Leon-Latre, Tamara Garcia-Barrera, J. Luis Gomez-Ariza, Belen Moreno, Ana Cenarro, Griselda de Marco, Faruque Parvez, Abu B. Siddique, Hasan Shahriar, Mohammad N. Uddin, Tariqul Islam, Ana Navas-Acien, Mary Gamble, Maria Tellez-Plaza
Summary: The study identified common 5-hmC and 5-mC signatures in two populations exposed to varying levels of inorganic As, but differences in As-related epigenetic sites across the study populations may also reflect low and high As-specific associations. This work contributes to a deeper understanding of potential epigenetic dysregulations of As, with further research needed to confirm biological consequences associated with DIP2C epigenetic regulation and investigate the role of 5-hmC and 5-mC separately in As-induced health disorders at different exposure levels.
ENVIRONMENTAL RESEARCH
(2022)
Article
Medicine, General & Internal
Victoria Marco-Benedi, Martin Laclaustra, Rosa M. Sanchez-Hernandez, Emilio Ortega-Martinez De Victoria, Juan Pedro-Botet, Jose Puzo, Fernando Civeira
Summary: This study investigated the prevalence of cataract surgery among elderly patients with genetically diagnosed heterozygous familial hypercholesterolemia (HeFH) receiving statin treatment for at least 5 years, finding no significant difference in cataract surgery rates between HeFH patients and controls. Factors related to cataract surgery were not associated with LDL cholesterol levels or the duration of statin therapy, suggesting that statin treatment is not a risk factor for cataracts.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Hematology
Maria Grau-Perez, Maria J. Caballero-Mateos, Arce Domingo-Relloso, Ana Navas-Acien, Jose L. Gomez-Ariza, Tamara Garcia-Barrera, Montse Leon-Latre, Zoraida Soriano-Gil, Estibaliz Jarauta, Ana Cenarro, Belen Moreno-Franco, Martin Laclaustra, Fernando Civeira, Jose A. Casasnovas, Eliseo Guallar, Maria Tellez-Plaza
Summary: This study evaluated the association of nonessential metals exposure with subclinical atherosclerosis and found strong associations between arsenic, cadmium, and titanium with the presence of subclinical atherosclerosis. Additionally, there was an interaction between arsenic and the joint exposure of cadmium and titanium.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)
Letter
Nutrition & Dietetics
Carolina Donat-Vargas, Helena Sandoval-Insausti, Jose L. Penalvo, Maira Bes-Rastrollo, Belen Moreno-Franco, Martin Laclaustra, Carmen De La Fuente Arrillaga, Miguel Angel Martinez-Gonzalez, Guallar-Castillon Pilar
CLINICAL NUTRITION
(2022)
Article
Nutrition & Dietetics
Carolina Donat-Vargas, Helena Sandoval-Insausti, Jose L. Penalvo, Maria Concepcion Moreno Iribas, Pilar Amiano, Maira Bes-Rastrollo, Esther Molina-Montes, Belen Moreno-Franco, Antonio Agudo, Cristina Lasheras Mayo, Martin Laclaustra, Carmen De la Fuente Arrillaga, Maria Dolores Chirlaque Lopez, Maria-Jose Sanchez, Miguel Angel Martinez-Gonzalez, Guallar-Castillon Pilar
Summary: Olive oil consumption is associated with a lower risk of cardiovascular disease and stroke, with the maximum benefit obtained at a daily consumption between 20 and 30 grams.
CLINICAL NUTRITION
(2022)
Article
Nutrition & Dietetics
Itziar Lamiquiz-Moneo, Sofia Perez-Calahorra, Irene Gracia-Rubio, Alberto Cebollada, Ana M. Bea, Antonio Fumanal, Ana Ferrer-Mairal, Ascension Prieto-Martin, Maria Luisa Sanz-Fernandez, Ana Cenarro, Fernando Civeira, Rocio Mateo-Gallego
Summary: This study found that an alcohol-free beer with modified carbohydrate composition has better postprandial effects compared to a conventional alcohol-free beer, leading to reduced levels of blood glucose, insulin, and incretin hormones.
Article
Health Care Sciences & Services
Armando Chaure-Pardos, Isabel Aguilar-Palacio, Ma Jose Rabanaque, Ma Jesus Lallana, Lina Maldonado, Sara Castel-Feced, Julian Librero, Jose Antonio Casasnovas, Sara Malo
Summary: This study analyzed the effectiveness of statin therapy for primary prevention of cardiovascular disease in low- and medium-risk patients. The results suggest that statin treatment for primary prevention in individuals with low and medium cardiovascular risk may be inefficient, but improves with better adherence and in patients with higher risk.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Endocrinology & Metabolism
Maria Ramos-Caceres, Itziar Lamiquiz-Moneo, Ana Cenarro, Pilar Calmarza, Victoria Marco-Benedi, Ana M. Bea, Rocio Mateo-Gallego, Jose Puzo, Jose M. Ordovas, Fernando Civeira, Martin Laclaustra
Summary: This study analyzes the relationship between triglycerides (TGs) and lipoprotein(a) (Lp(a)) concentrations. It found an inverse relationship between TG and Lp(a). Larger VLDL size, VLDLs enriched in apoE, and the apoE2/E2 genotype were associated with lower levels of Lp(a).
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Biochemistry & Molecular Biology
Maria Civeira-Marin, Ana Cenarro, Victoria Marco-Benedi, Ana M. Bea, Rocio Mateo-Gallego, Belen Moreno-Franco, Jose M. Ordovas, Martin Laclaustra, Fernando Civeira, Itziar Lamiquiz-Moneo
Summary: The association between APOE genotypes and cardiovascular disease (CVD) is partially mediated by LDL-cholesterol concentration but persists after adjusting for lipid levels and other cardiovascular risk factors. APOE4 carriers have lower levels of CRP and cholesterol-enriched LDL particles compared to APOE3 carriers. CRP levels are not associated with lipoprotein particle number, size, or composition, but GlycA levels are significantly associated with the size and cholesterol amount in HDL, VLDL, and LDL particles.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Pharmacology & Pharmacy
Fernando Civeira, Marcello Arca, Ana Cenarro, Robert A. Hegele
Summary: Contrary to the well-established evidence-based clinical recommendations for lipid-lowering treatment, there is a lack of definitive diagnostic definition for hypercholesterolemia and its subtypes. This statement proposes a unified definition and mechanism-based classification of hypercholesterolemia, aiming to stratify patients and guide efficient diagnosis.
JOURNAL OF CLINICAL LIPIDOLOGY
(2022)
Article
Medical Laboratory Technology
Ana M. Bea, Ana Cenarro, Victoria Marco-Benedi, Martin Laclaustra, Cesar Martin, Daiana Ibarretxe, Xavier Pinto, Teresa Arrobas, Clara Vinals, Fernando Civeira, Salvador Olmos
Summary: This study aimed to define the characteristics of dysbetalipoproteinemia (DBL) based on APOE analysis and propose a screening algorithm for familial dysbetalipoproteinemia (FDBL). The combination of non-HDLc/apoB>=1.7 and triglycerides/apoB>=1.35 showed the best diagnostic performance for identifying subjects with hyperlipidemia and APOE2/2 genotype.
CLINICAL CHEMISTRY
(2023)
Review
Nutrition & Dietetics
Ainara Munoz-Cabrejas, Pilar Guallar-Castillon, Martin Laclaustra, Helena Sandoval-Insausti, Belen Moreno-Franco
Summary: This study examined the association between the consumption of sugar-sweetened beverages (SSBs) and metabolic syndrome (MetS) by synthesizing existing evidence. The results showed that the intake of SSBs was positively associated with an increased risk of MetS. Therefore, public health strategies should focus on reducing the consumption of SSBs to prevent MetS.
Article
Multidisciplinary Sciences
Jose Luis Perez-Lasierra, Jose A. Casajus, Alejandro Gonzalez-Aguero, Jose Miguel Arbones-Mainar, Jose A. Casasnovas, Martin Laclaustra, Belen Moreno-Franco
Summary: This study analyzed the association between the APOE e4 genetic variant and carotid atherosclerosis, as well as the association between cardiorespiratory fitness (CRF) and atherosclerosis in individuals with the APOE e4 genetic variant. The findings showed that the APOE e4e4 genotype was associated with increased carotid atherosclerosis, while CRF was a modifiable factor that could be targeted to decrease the atherosclerotic risk in individuals with the APOE e4e4 genetic variant.
SCIENTIFIC REPORTS
(2022)
Article
Nutrition & Dietetics
Diana Maria Merida, Facundo Vitelli-Storelli, Belen Moreno-Franco, Montserrat Rodriguez-Ayala, Esther Lopez-Garcia, Jose R. Banegas, Fernando Rodriguez-Artalejo, Pilar Guallar-Castillon
Summary: Polyphenol intake was associated with a lower risk of all-cause mortality and cardiovascular mortality in the Spanish adult population. Specifically, the intake of dihydroflavonols, flavonols, methoxyphenols, tyrosols, alkylmethoxyphenols, hydroxycinnamic acids, and hydroxyphenilacetic acids was associated with a decreased risk of mortality.
CLINICAL NUTRITION
(2023)