☆ 4.4 Article

Kinesins in cell migration

BIOCHEMICAL SOCIETY TRANSACTIONS (2015)

期刊

BIOCHEMICAL SOCIETY TRANSACTIONS

卷 43, 期 -, 页码 79-83

出版社

PORTLAND PRESS LTD

DOI: 10.1042/BST20140280

关键词

cell adhesion; cell migration; force generation; intracellular transport; kinesin; microtubules

类别

Biochemistry & Molecular Biology

资金

British Heart Foundation [FS/13/42/30377]
British Heart Foundation [FS/13/42/30377] Funding Source: researchfish

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Protocol

Reagent

摘要

Human cells express 45 kinesins, microtubule motors that transport a variety of molecules and organelles within the cell. Many kinesins also modulate the tracks they move on by either bundling or sliding or regulating the dynamic assembly and disassembly of the microtubule polymer. In migrating cells, microtubules control the asymmetry between the front and rear of the cell by differentially regulating force generation processes and substrate adhesion. Many of these functions are mediated by kinesins, transporters as well as track modulators. In this review, we summarize the current knowledge on kinesin functions in cell migration.

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