期刊
DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY
卷 61, 期 6, 页码 680-+出版社
WILEY
DOI: 10.1111/dmcn.14128
关键词
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资金
- National Natural Science Foundation of China [81301609, 81570935]
- Natural Science Foundation of Guangdong Province [2017A030313611]
- Yat-sen Scholarship for Young Scientists
Aim To explore how auditory and speech function developed post-cochlear implantation (pCI) in prelingually deaf children with white matter lesions (WML). Method Patients (41 males, 29 females; mean age at implantation 2y 11mo [SD 7.5mo], range 1y 8mo-5y) were divided into the following groups according to preoperative brain magnetic resonance imaging evaluation: mild WML, moderate WML, severe WML, and control. We assessed auditory and speech performance at baseline, 6 months, 12 months, and 24 months pCI. As well as auditory event-related potentials, topographic maps and electroencephalography source imaging were recorded and analysed at 24 months pCI. Results For children with WML (any level), postoperative auditory or speech performance at 6 months was significantly below that of control participants. After stratification, auditory and speech performance was highly related to WML grading. Auditory or speech performance in mild WML or control groups was comparatively better than the moderate WML and severe WML groups. The recovery rate of speech performance fell behind that of the auditory perception. With the increasing severity of WML, N1 amplitude was significantly smaller with a consistent presentation in the topographic map, which was similar in the mild WML and control group. The dominant auditory centre was activated in the control or mild WML groups, but not in the moderate WML and severe WML groups. Interpretation WML gradually affect auditory and speech development, and electrophysiological performance pCI in prelingually deaf children.
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