Article
Multidisciplinary Sciences
Kathleen B. Quast, Rebecca K. Reh, Maddalena D. Caiati, Nancy Kopell, Michelle M. McCarthy, Takao K. Hensch
Summary: Early-life experiences have long-lasting effects on the development of thalamocortical axons and sensory processing. This study identifies the initial synaptic events underlying critical period plasticity, which is characterized by changes in cortical oscillations. Monocular deprivation induces a transient increase in γ-power specifically within the visual cortex, but only during the critical period. Rapid loss of thalamocortical input onto inhibitory interneurons is observed after monocular deprivation, leading to the dissociation of thalamic input from cortical spiking and subsequent plasticity of connections. These findings provide insights into the mechanisms of critical period plasticity and suggest a potential readout of the thalamocortical network state for developmental studies.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Biochemistry & Molecular Biology
Eline A. Verberne, Liselot van der Laan, Sadegheh Haghshenas, Kathleen Rooney, Michael A. Levy, Marielle Alders, Saskia M. Maas, Sandra Jansen, Agne Lieden, Britt-Marie Anderlid, Louise Rafael-Croes, Philippe M. Campeau, Ayeshah Chaudhry, David A. Koolen, Rolph Pfundt, Anna C. E. Hurst, Frederic Tran-Mau-Them, Ange-Line Bruel, Laetitia Lambert, Bertrand Isidor, Marcel M. A. M. Mannens, Bekim Sadikovic, Peter Henneman, Mieke M. van Haelst
Summary: JARID2-neurodevelopmental syndrome is characterized by various neurological symptoms. In this study, researchers aimed to identify a specific DNA methylation signature for this syndrome. By analyzing DNA methylation profiles from control subjects, patients with (likely) pathogenic JARID2 variants, and patients with JARID2 VUSs, a distinct DNA methylation signature was identified, allowing for accurate classification of patients with the JARID2-neurodevelopmental syndrome.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Kathleen Rooney, Bekim Sadikovic
Summary: This review discusses the role of large structural chromosome rearrangements in genomic disorders related to neurodevelopmental disorders (NDDs). The review also highlights the significance of DNA methylation (DNAm) and its implications in NDDs and genomic disorders. Additionally, the potential clinical impact of copy number and genomic DNAm testing in the diagnosis of genetic NDDs is discussed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Lige Leng, Kai Zhuang, Hui Lin, Jinjun Ding, Shangchen Yang, Ziqi Yuan, Changquan Huang, Guimiao Chen, Zhenlei Chen, Mengdan Wang, Han Wang, Hao Sun, Huifang Li, He Chang, Zhenyi Chen, Qi Xu, Tifei Yuan, Jie Zhang
Summary: This study demonstrates the critical role of Menin in depression and proves that Menin is key to the antidepressant function of ketamine. Dysregulation of PV levels is closely associated with depression, and Menin stabilizes PV levels in a PKA-dependent manner.
Review
Biochemistry & Molecular Biology
Jessica A. Burket, Jason D. Webb, Stephen Deutsch
Summary: The free concentrations of redox reactive metals iron and copper are highly regulated due to their ability to catalyze the generation of toxic free radicals. The perineuronal net, a specialized component of brain extracellular matrix, not only binds metal cations for protective function but also supports fast-spiking electrophysiological properties of surrounding neurons.
Article
Cell Biology
Cornelius Mueller-Buehl, Jacqueline Reinhard, Lars Roll, Verian Bader, Konstanze F. Winklhofer, Andreas Faissner
Summary: This study investigated the relationship between fast-spiking parvalbumin interneurons, perineuronal nets (PNNs), and synaptic distribution in the mature cortical inhibitory circuits. The results suggest that the specialized extracellular matrix structure plays a crucial role in regulating the interaction between these factors.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Anatomy & Morphology
John H. Harkness, Angela E. Gonzalez, Priyanka N. Bushana, Emily T. Jorgensen, Deborah M. Hegarty, Ariel A. Di Nardo, Alain Prochiantz, Jonathan P. Wisor, Sue A. Aicher, Travis E. Brown, Barbara A. Sorg
Summary: The study found diurnal fluctuations in perineuronal nets (PNNs) surrounding parvalbumin (PV) interneurons and PV cells, impacting the excitatory:inhibitory balance in the cortex and providing new insights into treatments for diseases affected by disruptions in sleep and circadian rhythms.
BRAIN STRUCTURE & FUNCTION
(2021)
Article
Neurosciences
Wei-Jun Zhang, Hou-Zhen Shi, Mei-Na Guo, Long-Fei Xu, Hong-Ru Zhai, Zi-Zhong Liu, Yong-Qiang Zhu, Wei-Ning Zhang, Jia Wang
Summary: In this study, the association between Pgc-1alpha gene deletion and SZ-like behavioral deficits, PVI maturation, PNN integrity, and synaptic ultrastructure was investigated. The results suggest that Pgc-1alpha gene deletion leads to a failure of critical period onset and closure, prolonging cortical plasticity timing. Furthermore, by manipulating the PNN structure, synaptic ultrastructure and behavioral deficits associated with SZ can be ameliorated.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2023)
Review
Cell Biology
Shilin Luo, Nanxi Zheng, Bing Lang
Summary: This paper summarizes the structure and function of the ULK4 protein, providing comprehensive insights into ULK4-related neurodevelopmental and neuropsychiatric disorders, and assisting in the development of a ULK4-based therapeutic strategy.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Neurosciences
Nazim Kourdougli, Anand Suresh, Benjamin Liu, Pablo Juarez, Ashley Lin, David T. Chung, Anette Graven Sams, Michael J. Gandal, Veronica Martinez-Cerdeno, Dean V. Buonomano, Benjamin J. Hall, Cedric Mombereau, Carlos Portera-Cailliau
Summary: Changes in the function of inhibitory interneurons during cortical development could contribute to neurodevelopmental disorders like fragile X syndrome. The loss of parvalbumin INs in both mice and humans with fragile X syndrome leads to circuit dysfunction. Increasing the activity of future PV-INs in neonatal mice can restore PV-IN density, while administering an allosteric modulator of Kv3.1 channels can rescue circuit dynamics and tactile defensiveness.
Article
Neurosciences
Yoshi-Taka Matsuda, Hiroyuki Miyamoto, Rolf H. Joho, Takao K. Hensch
Summary: Experience-dependent plasticity in the visual cortex is influenced by the postnatal development of inhibitory circuits, specifically those involving the K(v)3.1 potassium channel. Disruption of this channel affects the inhibitory function of GABA subtypes. Loss of K(v)3.1 in mice results in a slowed rate of ocular dominance changes, which can be restored by enhancing GABA transmission.
NEUROSCIENCE RESEARCH
(2021)
Article
Biology
Ethiraj Ravindran, Nobuto Arashiki, Lena-Luise Becker, Kohtaro Takizawa, Jonathan Levy, Thomas Rambaud, Konstantin L. Makridis, Yoshio Goshima, Na Li, Maaike Vreeburg, Benedicte Demeer, Achim Dickmanns, Alexander P. A. Stegmann, Hao Hu, Fumio Nakamura, Angela M. Kaindl
Summary: Variants in the CRMP1 gene are discovered to be associated with neurodevelopmental disorders such as muscular hypotonia, intellectual disability, and/or autism spectrum disorder. These variants may affect the protein structure and function of CRMP1, leading to alterations in cellular processes and neurite outgrowth.
Review
Neurosciences
Rachel Gibel-Russo, David Benacom, Ariel A. Di Nardo
Summary: From birth to adolescence, the brain undergoes structural and functional remodeling in response to environmental stimuli during critical periods of heightened plasticity. Disruption of these critical periods by early-life adverse experiences or genetic deficiencies can have lasting consequences on behavior, physiology, and cognition. The timing of critical periods is regulated by neural activity and various signaling factors, which play a role in the maturation and consolidation of neural circuits. Understanding the interplay between these signals and signaling factors is crucial for comprehending the effects of early adversity and developmental defects on perception and behavior.
FRONTIERS IN NEURAL CIRCUITS
(2022)
Article
Medicine, General & Internal
Huiwen Lo, Shih-Feng Weng, Eing-Mei Tsai
Summary: The study found that offspring conceived through assisted reproductive technology with ICSI had higher risks of autism spectrum disorder and developmental delay, regardless of whether the couples had male or female infertility. Male infertility itself was not associated with an increased risk of neurodevelopmental disorders in offspring.
Article
Neurosciences
Joanne L. Doherty, Adam C. Cunningham, Samuel J. R. A. Chawner, Hayley M. Moss, Diana C. Dima, David E. J. Linden, Michael J. Owen, Marianne B. M. van den Bree, Krish D. Singh
Summary: The study utilized magnetoencephalography to investigate the electrophysiological markers of brain activity in individuals with 22q11.2 deletion syndrome. The findings revealed alterations in local and global network function, which may contribute to the increased vulnerability to neurodevelopmental and psychiatric disorders in this population.
NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
Kiyoshi Nakahara, Ken Adachi, Keisuke Kawasaki, Takeshi Matsuo, Hirohito Sawahata, Kei Majima, Masaki Takeda, Sayaka Sugiyama, Ryota Nakata, Atsuhiko Iijima, Hisashi Tanigawa, Takafumi Suzuki, Yukiyasu Kamitani, Isao Hasegawa
NATURE COMMUNICATIONS
(2016)
Article
Biochemistry & Molecular Biology
Michihiro Igarashi, Kosei Takeuchi, Sayaka Sugiyama
NEUROCHEMISTRY INTERNATIONAL
(2018)
Article
Neurosciences
Akiko Sakai, Ryuichiro Nakato, Yiwei Ling, Xubin Hou, Norikazu Hara, Tomoya Iijima, Yuchio Yanagawa, Ryozo Kuwano, Shujiro Okuda, Katsuhiko Shirahige, Sayaka Sugiyama
FRONTIERS IN NEUROSCIENCE
(2017)
Article
Developmental Biology
Xubin Hou, Tatsuya Katahira, Kazumasa Ohashi, Kensaku Mizuno, Sayaka Sugiyama, Harukazu Nakamura
DEVELOPMENTAL BIOLOGY
(2013)
Article
Neurosciences
Marine Beurdeley, Julien Spatazza, Henry H. C. Lee, Sayaka Sugiyama, Clemence Bernard, Ariel A. Di Nardo, Takao K. Hensch, Alain Prochiantz
JOURNAL OF NEUROSCIENCE
(2012)
Article
Multidisciplinary Sciences
Jonathan I. Schneiderman, Akiko Sakai, Sara Goldstein, Kami Ahmad
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2009)
Article
Multidisciplinary Sciences
Sushmita Roy, Jason Ernst, Peter V. Kharchenko, Pouya Kheradpour, Nicolas Negre, Matthew L. Eaton, Jane M. Landolin, Christopher A. Bristow, Lijia Ma, Michael F. Lin, Stefan Washietl, Bradley I. Arshinoff, Ferhat Ay, Patrick E. Meyer, Nicolas Robine, Nicole L. Washington, Luisa Di Stefano, Eugene Berezikov, Christopher D. Brown, Rogerio Candeias, Joseph W. Carlson, Adrian Carr, Irwin Jungreis, Daniel Marbach, Rachel Sealfon, Michael Y. Tolstorukov, Sebastian Will, Artyom A. Alekseyenko, Carlo Artieri, Benjamin W. Booth, Angela N. Brooks, Qi Dai, Carrie A. Davis, Michael O. Duff, Xin Feng, Andrey A. Gorchakov, Tingting Gu, Jorja G. Henikoff, Philipp Kapranov, Renhua Li, Heather K. MacAlpine, John Malone, Aki Minoda, Jared Nordman, Katsutomo Okamura, Marc Perry, Sara K. Powell, Nicole C. Riddle, Akiko Sakai, Anastasia Samsonova, Jeremy E. Sandler, Yuri B. Schwartz, Noa Sher, Rebecca Spokony, David Sturgill, Marijke van Baren, Kenneth H. Wan, Li Yang, Charles Yu, Elise Feingold, Peter Good, Mark Guyer, Rebecca Lowdon, Kami Ahmad, Justen Andrews, Bonnie Berger, Steven E. Brenner, Michael R. Brent, Lucy Cherbas, Sarah C. R. Elgin, Thomas R. Gingeras, Robert Grossman, Roger A. Hoskins, Thomas C. Kaufman, William Kent, Mitzi I. Kuroda, Terry Orr-Weaver, Norbert Perrimon, Vincenzo Pirrotta, James W. Posakony, Bing Ren, Steven Russell, Peter Cherbas, Brenton R. Graveley, Suzanna Lewis, Gos Micklem, Brian Oliver, Peter J. Park, Susan E. Celniker, Steven Henikoff, Gary H. Karpen, Eric C. Lai, David M. MacAlpine, Lincoln D. Stein, Kevin P. White, Manolis Kellis
Article
Multidisciplinary Sciences
Xubin Hou, Nozomu Yoshioka, Hiroaki Tsukano, Akiko Sakai, Shinji Miyata, Yumi Watanabe, Yuchio Yanagawa, Kenji Sakimura, Kosei Takeuchi, Hiroshi Kitagawa, Takao K. Hensch, Katsuei Shibuki, Michihiro Igarashi, Sayaka Sugiyama
SCIENTIFIC REPORTS
(2017)
Article
Multidisciplinary Sciences
Hiroaki Tsukano, Xubin Hou, Masao Horie, Hiroki Kitaura, Nana Nishio, Ryuichi Hishida, Kuniyuki Takahashi, Akiyoshi Kakita, Hirohide Takebayashi, Sayaka Sugiyama, Katsuei Shibuki
SCIENTIFIC REPORTS
(2019)
Article
Neurosciences
Sayaka Sugiyama, Junko Sugi, Tomoya Iijima, Xubin Hou
FRONTIERS IN NEURAL CIRCUITS
(2020)
Article
Cell Biology
Xubin Hou, Motohiro Nozumi, Harukazu Nakamura, Michihiro Igarashi, Sayaka Sugiyama
Summary: In this study, the researchers investigated the role of the ADF-H domain-containing protein coactosin in axon growth, finding that coactosin promotes the assembly of protrusive actin filament arrays at the leading edge of growth cones. The promotion of axonal growth by coactosin was shown to be dependent on the activity of cofilin.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)