Article
Plant Sciences
Yoshiharu Mimata, Shintaro Munemasa, Toshiyuki Nakamura, Yoshimasa Nakamura, Yoshiyuki Murata
Summary: This study reveals that malate can induce stomatal closure by directly activating SLAC1 and stimulating Ca2+ signaling. It provides insights into the molecular mechanism of malate-induced stomatal closure.
Article
Medicine, Research & Experimental
Peng Wang, Esra Karakose, Carmen Argmann, Huan Wang, Metodi Balev, Rachel Brody, Hembly G. Rivas, Xinyue Liu, Olivia Wood, Hongtao Liu, Lauryn Choleva, Dan Hasson, Emily Bernstein, Joao A. Paulo, Donald K. Scott, Luca Lambertini, James A. DeCaprio, Andrew F. Stewart
Summary: Resistance to regeneration of insulin-producing pancreatic β cells is a challenge in diabetes. Small molecule inhibitors of DYRK1A kinase have been found to induce proliferation of adult human β cells, but their mechanism of action is not fully understood. Through analysis of transcriptomic databases, researchers identified the DREAM complex as a central regulator of quiescence in human β cells. The DREAM complex consists of transcriptionally repressive proteins that assemble in response to DYRK1A kinase activity, inducing and maintaining cellular quiescence.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Multidisciplinary Sciences
Camila Goldy, Jose-Antonio Pedroza-Garcia, Natalie Breakfield, Toon Cools, Rodrigo Vena, Philip N. Benfey, Lieven De Veylder, Javier Palatnik, Ramiro E. Rodriguez
Summary: Gene expression is rapidly reconfigured during the cell cycle to carry out specific cellular functions for each phase. The use of fluorescence-activated cell sorting allowed for analysis of gene expression profile in G2/M cells in the growing root and identification of key regulatory factors. SCL28, a transcription factor, was found to play a crucial role in promoting progression through G2/M and modulating cell division plane selection.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Developmental Biology
Constance Le Gloanec, Loann Collet, Sylvia R. Silveira, Binghan Wang, Anne-Lise Routier-Kierzkowska, Daniel Kierzkowski
Summary: Coordination of growth, patterning, and differentiation is essential for shaping organs in multicellular organisms. In plants, cell growth is regulated by positional information, but individual cells often exhibit high heterogeneity. This study used time-lapse imaging to investigate the source and relevance of cellular growth variability during organ development in Arabidopsis thaliana. The findings suggest that growth variability is mainly driven by stomata differentiation, and the cell-autonomous behavior of specialized cells is the primary source of local growth variability.
Article
Hematology
Zev J. Greenberg, Luana Chiquetto Paracatu, Darlene A. Monlish, Qian Dong, Michael Rettig, Nate Roundy, Rofaida Gaballa, Weikai Li, Wei Yang, Cliff J. Luke, Laura G. Schuettpelz
Summary: This study reveals that tetraspanin CD53 plays a crucial role in regulating the return to quiescence of hematopoietic stem cells (HSCs) in response to inflammatory and proliferative stimuli. CD53 promotes the activity of the DREAM transcriptional repressor complex, which downregulates genes associated with cycling and division. Loss of CD53 leads to prolonged cycling and reduced HSC function.
Article
Biochemistry & Molecular Biology
Moon Jong Kim, Christopher Cervantes, Youn-Sang Jung, Xiaoshan Zhang, Jie Zhang, Sung Ho Lee, Sohee Jun, Larisa Litovchick, Wenqi Wang, Junjie Chen, Bingliang Fang, Jae-Il Park
Summary: PAF drives cell quiescence exit to promote lung tumorigenesis by remodeling the DREAM complex. Its depletion induces cell quiescence in lung adenocarcinoma cells and inhibits tumor growth, suggesting the PAF-DREAM axis as a potential therapeutic target in lung cancer.
Review
Plant Sciences
Benedicte Desvoyes, Clara Echevarria, Crisanto Gutierrez
Summary: Organogenesis in plants relies on a balance between cell division and expansion, with the root serving as an ideal model to study cell proliferation. Cell proliferation activity is mainly restricted to the root apical meristem, and a combination of new tools, experimental strategies, and mathematical models has enhanced our understanding of cell proliferation in the RAM. Further research is needed to explore additional aspects of cell proliferation in plants.
JOURNAL OF EXPERIMENTAL BOTANY
(2021)
Article
Chemistry, Multidisciplinary
Zhijun Li, Meizi Wu, Lu Yang, Kunpeng Guo, Yuwei Duan, Yong Li, Kun He, Yifan Xing, Zheng Zhang, Hui Zhou, Dongfang Xu, Jungang Wang, Hong Zou, Da Li, Zhike Liu
Summary: High density of defects at the interface greatly affects the performance of perovskite solar cells (PSCs). In this study, a hinge-type fluorine-rich complex, cobalt (II) hexafluoro-2,4-pentanedionate (CoFAc), is introduced onto the surface of formamidinium cesium lead iodide (FACsPbI(3)) film to address the issues related to the perovskite/Spiro-OMeTAD interface. CoFAc passivates vacancies in the organic cation and halide anion by forming strong hydrogen bonds with HC(NH2)(2)(+) (FA(+)) and strong ionic bonds with Pb2+ in the perovskite film. Additionally, CoFAc improves interfacial hole-transport kinetics by interacting with Spiro-OMeTAD. As a result, FACsPbI(3) PSCs with CoFAc modification demonstrate a record power conversion efficiency (PCE) of 24.64% and an impressive open-circuit voltage (V-OC) of 1.191 V, the highest reported V-OC among all organic-inorganic hybrid PSCs with TiO2 as the electron transport layer. Furthermore, CoFAc-modified devices exhibit exceptional long-term stability, retaining 95% of their initial PCE after exposure to ambient atmosphere for 1500 hours without any encapsulation.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Multidisciplinary Sciences
Lukas S. Tombor, David John, Simone F. Glaser, Guillermo Luxan, Elvira Forte, Milena Furtado, Nadia Rosenthal, Nina Baumgarten, Marcel H. Schulz, Janina Wittig, Eva-Maria Rogg, Yosif Manavski, Ariane Fischer, Marion Muhly-Reinholz, Kathrin Klee, Mario Looso, Carmen Selignow, Till Acker, Sofia-Iris Bibli, Ingrid Fleming, Ralph Patrick, Richard P. Harvey, Wesley T. Abplanalp, Stefanie Dimmeler
Summary: Endothelial cells play a critical role in tissue adaptation to injury and demonstrate a transient mesenchymal activation with metabolic adaptation following myocardial infarction, which returns to baseline over time and potentially aids in vascular network regeneration.
NATURE COMMUNICATIONS
(2021)
Article
Oncology
Claire D. James, Siddharth Saini, Fatmata Sesay, Kevin Ko, Jessica Felthousen-Rusbasan, Audra N. Iness, Tara Nulton, Brad Windle, Mikhail G. Dozmorov, Iain M. Morgan, Larisa Litovchick
Summary: Human papillomaviruses, responsible for 5% of cancers, disrupt the DREAM complex in HPV positive cells, leading to increased expression of DREAM target genes. The mutant DREAM component LIN52 S20C can compete with E7 and partially restore DREAM complex formation, inhibiting the growth of HPV positive cells. Restoring the DREAM complex in HPV positive cancers could be a novel therapeutic approach.
Article
Plant Sciences
Paige E. Panter, Jacob Seifert, Maeve Dale, Ashley J. Pridgeon, Rachel Hulme, Nathan Ramsay, Sonia Contera, Heather Knight
Summary: We demonstrate the importance of fucose-dependent pectin cross-linking in stomatal development and leaf water loss control. The reduction of guard cell wall stiffness in a fucosylation-defective mutant does not affect stomatal closure. The fucosylation levels of cell walls and freezing tolerance of the Arabidopsis sensitive-to-freezing8 (sfr8) mutant are compromised. Leaf water loss is significantly higher in sfr8 and the allelic mutant mur1-1, indicating that CW fucosylation affects the response to desiccation.
JOURNAL OF EXPERIMENTAL BOTANY
(2023)
Review
Biochemistry & Molecular Biology
Crisanto Gutierrez
Summary: Cell division cycle is a fundamental process for the perpetuation of organisms, including plants. Studies on plant cell division cycle started with cytological and physiological approaches in the 1950s and 1960s, and later experienced rapid growth with the development of genetics and genomics. Current research not only focuses on understanding the plant cell cycle machinery, but also examines the interaction of cell cycle components with various aspects of plant biology.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Renuka Kandhaya-Pillai, Francesc Miro-Mur, Jaume Alijotas-Reig, Tamar Tchkonia, Simo Schwartz, James L. Kirkland, Junko Oshima
Summary: Cellular senescence is a dynamic stress response process that contributes to aging. Understanding the molecular architecture of senescent cells and the changes they undergo will provide new therapeutic avenues to alleviate or delay the consequences of aging.
Article
Biochemistry & Molecular Biology
Xiaotian Wang, Zhiqiang Liu, Jingwei Bai, Shuai Sun, Jia Song, Ren Li, Xia Cui
Summary: The MADS-box transcription factors STM3 and J2 control tomato inflorescence branch number by mutually affecting each other's binding to FUL1. They activate or repress a set of common target genes through recognition and binding to CArG box motifs. STM3 physically interacts with J2 to mediate its cytosolic redistribution and inhibits its binding to target genes, while J2 limits STM3 regulation of target genes by transcriptional repression of the STM3 promoter and reducing STM3-binding activity.
Article
Immunology
Selma Tuzlak, Anne S. Dejean, Matteo Iannacone, Francisco J. Quintana, Ari Waisman, Florent Ginhoux, Thomas Korn, Burkhard Becher
Summary: Three decades ago, the description of helper T cell polarization led to a dramatic growth in the T cell universe, with new subsets emerging. Categorizing T helper cells based on the help they provide offers a better understanding of their complexity and diversity.
Article
Biochemistry & Molecular Biology
Ido Nir, Gabriel Amador, Yan Gong, Nicole K. Smoot, Le Cai, Hagai Shohat, Dominique C. Bergmann
Summary: Asymmetric and oriented stem cell divisions are crucial for the production of patterned tissues. This study identifies BASL as a eudicot-specific polarity protein that plays a major role in stomatal lineage division and cell fate asymmetries. The findings also reveal differences in how asymmetric cell divisions are used for pattern formation in different species.
Article
Plant Sciences
Mengting Pi, Ruhan Zhong, Shaoqiang Hu, Zhuoying Cai, Madison Plunkert, Weiyi Zhang, Zhongchi Liu, Chunying Kang
Summary: This study identified a new type of transcription regulator, SL1, that promotes compound leaf formation in woodland strawberries. SL1 functions in leaf morphogenesis by working synergistically with FveLFYa. This research sheds new lights on the diversity of leaf complexity control.
Article
Plant Sciences
Guanghui Zheng, Shaoqiang Hu, Simin Cheng, Liyang Wang, Lijun Kan, Zhengming Wang, Qiang Xu, Zhongchi Liu, Chunying Kang
Summary: The study identifies the crucial role of FveFDM1 in the growth and development of horticultural crops, specifically strawberry. FveFDM1 modulates organ size by regulating cell division and is involved in the RdDM-mediated DNA methylation process.
Article
Plant Sciences
Xi Luo, Madison Plunkert, Zi Teng, Kathryn Mackenzie, Lei Guo, Yaguang Luo, Timo Hytonen, Zhongchi Liu
Summary: FveMYB10 and FveMYB10L are two distinct transcription factors that regulate anthocyanin synthesis in the fruits and petioles of strawberry. They show tissue-specific expression and activate different downstream genes, and also respond differently to changes in light quality.
JOURNAL OF EXPERIMENTAL BOTANY
(2023)
Article
Biochemistry & Molecular Biology
Katelyn H. McKown, M. Ximena Anleu Gil, Andrea Mair, Shou-Ling Xu, Michael T. Raissig, Dominique C. Bergmann
Summary: It was found that BdFAMA transcription factor plays a crucial role in specifying stomatal guard cell fate in Brachypodium distachyon and can induce the recruitment of subsidiary cells even in the absence of its paralogue BdMUTE. Additionally, proteomic analysis revealed multiple shared interaction partners among these transcription factors in different species.
Article
Plant Sciences
Jiaming Li, Rongxiang Zhu, Mingyue Zhang, Beibei Cao, Xiaolong Li, Bobo Song, Zhongchi Liu, Jun Wu
Summary: Soluble sugars are important for plant growth, development, and fruit quality. A calcium-dependent protein kinase called PbCPK28 was identified in pears, and a single nucleotide polymorphism (SNP) in its regulatory region was found to be associated with diversity in fructose content. PbCPK28 was shown to interact with and phosphorylate proteins involved in sugar import into vacuoles, allowing for the genetic improvement of fruit sugar contents in pears.
Article
Plant Sciences
Yunming Zhang, Lijun Kan, Shaoqiang Hu, Zhongchi Liu, Chunying Kang
Summary: The LEAFY ortholog of woodland strawberry, which does not regulate APETALA1 at the transcriptional level, shows species-specific roles in flower and leaf development. The plant-specific transcription factor LEAFY (LFY), generally maintained as a single-copy gene in most angiosperm species, plays critical roles in flower development. Here, we identified and validated that mutations in one of the four LFY homologs, FveLFYa, cause homeotic conversion of floral organs and reiterative outgrowth of ectopic flowers.
Article
Developmental Biology
Fuxi Wang, Wanpeng Wang, Zhongchi Liu
Summary: The stem cell pools at the shoot apex and root tip in plants give rise to all above- and below-ground tissues. Previous studies on Arabidopsis have identified a TSO1-MYB3R1 transcriptional module that controls the number and size of these stem cell pools. In this study, it was found that an Arabidopsis cyclin A gene, CYCA3;4, is a member of the TSO1-MYB3R1 regulatory module and mutations in this gene can suppress the tso1-1 mutant phenotype specifically in the shoot. These findings reveal the integration of the TSO1-MYB3R1 module with the cell cycle machinery to control cell division in the shoot meristem.
Article
Cell Biology
Margot E. Smit, Anne Vaten, Andrea Mair, Carrie A. M. Northover, Dominique C. Bergmann
Summary: Plant leaves have organized epidermal stomata in stereotyped patterns. Arabidopsis embryos use known stomatal fate and patterning factors to create regularly spaced stomatal precursors. The embryonic stomatal pattern enables fast stomatal differentiation and guides the formation of additional stomata as the leaf expands. The regulation of stomatal regulators is stage-specific during embryogenesis.
DEVELOPMENTAL CELL
(2023)
Article
Cell Biology
Hannah F. Fung, Dominique C. Bergmann
Summary: Cell size has significant effects on biological function, such as biosynthetic capacity, metabolism, and nutrient uptake. Maintaining cell size within a specific range is crucial and is regulated by size control mechanisms. While the physiological consequences of cell size are well-known, its developmental consequences, especially its impact on developmental transitions, are less understood. This review compares systems where cell size is linked to developmental transitions, with a focus on examples from plants. The review concludes by suggesting that cell size can serve as a simple readout of complex inputs, allowing for flexible decisions during plant development.
EUROPEAN JOURNAL OF CELL BIOLOGY
(2023)
Article
Plant Sciences
Rui Lu, Mengting Pi, Zhongchi Liu, Chunying Kang
Summary: The FveYUC4 gene is crucial for leaf and flower morphogenesis in woodland strawberry, as it provides auxin hormone at the proper time and in the right tissues, affecting the width of leaf blade, the number and shape of floral organs, and the size of fruits.
Article
Cell Biology
Eva-Sophie Wallner, Liam Dolan, Dominique C. Bergmann
Summary: Cell polarity and asymmetric cell divisions generate cellular diversity. In the Arabidopsis stomatal lineage, two polarity domains (BASL and OPL) are segregated to larger and smaller daughter cells, respectively, to regulate cell fate. The localization and function of OPLs are independent of other stomatal polarity genes and signaling components.
DEVELOPMENTAL CELL
(2023)
Article
Plant Sciences
Zhongchi Liu, Tong Liang, Chunying Kang
Summary: Strawberries are popular fruits that provide vitamins, fibers, and antioxidants. Recent advances in genome sequencing and CRISPR-mediated genome editing have improved the understanding of strawberry growth and development. This review focuses on fruit quality traits such as aroma, sweetness, color, firmness, and shape, and highlights the use of genomic data for marker-assisted breeding and precise gene editing. These advances will benefit strawberries, providing tastier, longer-lasting, healthier, and more beautiful fruit to consumers.
Article
Multidisciplinary Sciences
Andrew Muroyama, Yan Gong, Kensington S. Hartman, Dominique C. Bergmann
Summary: Asymmetric cell divisions play a crucial role in determining cell fates in different kingdoms. While animal cells rely on polarity-cytoskeleton interactions, little is known about the mechanisms segregating fate determinants during asymmetric divisions in plants. This study uncovers a mechanism in Arabidopsis leaf epidermis that ensures unequal inheritance of a fate-enforcing polarity domain. The polarity domain limits division orientations by depleting stable microtubules in a specific cortical region, and disruption of this mechanism results in aberrant division planes and cell identity defects.
Article
Multidisciplinary Sciences
Yan Gong, Renee Dale, Hannah F. Fung, Gabriel O. Amador, Margot E. Smit, Dominique C. Bergmann
Summary: This study reveals that stem cells of the Arabidopsis stomatal lineage transition from asymmetric self-renewing divisions to commitment and terminal differentiation triggered by crossing a critical cell size threshold. Computational simulation and genetic manipulations demonstrate that this cell size-mediated transition allows flexible control of stem cell proliferation.
