Editorial Material
Immunology
Athanasios Sachinidis, Alexandros Garyfallos
Summary: A recently published study has provided strong evidence that EBV is a trigger for multiple sclerosis. The involvement of age-associated B cells in EBV-triggered autoimmunity is highlighted, as they contribute to the pathogenesis of autoimmune diseases through various functions, such as autoantibody production and germinal center formation. Targeting these B cells and eliminating EBV may be potential treatments for autoimmunity.
IMMUNOLOGIC RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Isobel C. Mouat, Erin Goldberg, Marc S. Horwitz
Summary: Age-associated B cells (ABCs) are a unique population of B cells that are associated with age, infection, and autoimmune diseases. The exact impact of ABCs on diseases remains unclear.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Ana Merino-Vico, Jan Piet van Hamburg, Sander W. Tas
Summary: This review discusses the role of B cells and potential therapeutic targets in anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV), including B cell specific receptors and downstream signaling molecules.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Sandra Hocevar, Viola Puddinu, Laetitia Haeni, Alke Petri-Fink, Julia Wagner, Montserrat Alvarez, Martin James David Clift, Carole Bourquin
Summary: This study found that polymer-coated gold nanoparticles mainly interact with a subpopulation of B cells called age-associated B cells. However, they do not affect the percentages of other B cell populations or immune responses. These findings suggest that gold nanoparticles may be a safe tool for targeted therapy.
Article
Multidisciplinary Sciences
Juan Carlos Yam-Puc, Zhaleh C. Hosseini, Emily Horner, Pehuen Pereyra Gerber, Nonantzin Beristain-Covarrubias, Robert Hughes, Aleksei Lulla, Maria Rust, Rebecca Boston, Magda Ali, Katrin Fischer, Edward Simmons-Rosello, Martin O'Reilly, Harry H. Robson, Lucy Booth, Lakmini Kahanawita, Andrea Correa-Noguera, David Favara, Lourdes Ceron-Gutierrez, Baerbel Keller, Andrew Craxton, Georgina S. F. Anderson, Xiao-Ming Sun, Anne Elmer, Caroline Saunders, Areti Bermperi, Sherly Jose, Nathalie E. Kingston, Thomas Mulroney, Lucia P. G. A. Pinon, Michael Chapman, Sofia E. Grigoriadou, Marion R. MacFarlane, Anne Willis, Kiran Patil, Sarah Spencer, Emily S. Staples, Klaus Warnatz, Matthew Buckland, Florian Hollfelder, Marko Hyvonen, Rainer Doffinger, Christine J. Parkinson, Sara Lear, Nicholas Matheson, James E. D. Thaventhiran
Summary: The research shows that age-associated B cells (ABC) remain transcriptionally similar in individuals with reduced immune cell function. Higher pre-vaccine levels of ABC are associated with poor vaccine response. ABCs from different conditions have common transcriptional profiles and can be categorized based on their expression of immune genes.
NATURE COMMUNICATIONS
(2023)
Article
Immunology
Natalin J. Valeff, Maria S. Ventimiglia, Marcos Dibo, Udo R. Markert, Federico Jensen
Summary: B1 B cells, a distinct subpopulation of B cells, have been controversial in their role during pregnancy. This study revealed an expanded and proliferative splenic B1 B cell population in mice during pregnancy, accompanied by an immunoregulatory phenotype, suggesting their critical role in the intricate process of pregnancy tolerance.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Robert W. Maul, Michelle D. Catalina, Varsha Kumar, Prathyusha Bachali, Amrie C. Grammer, Shu Wang, William Yang, Sarfaraz Hasni, Rachel Ettinger, Peter E. Lipsky, Patricia J. Gearhart
Summary: A distinct population of B cells marked by elevated CD11c expression was identified in patients with systemic lupus erythematosus (SLE), exhibiting unique characteristics in gene expression and IgH repertoire composition. These CD11c(hi) B cells showed similarities with some germinal center transcripts but distinct from conventional B cell subsets, suggesting a potential role in autoimmune responses. The findings suggest a potential link between defects in negative selection in germinal centers and the development of autoimmune diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Pharmacology & Pharmacy
N. J. Carruthers, C. Guo, R. Gill, P. M. Stemmer, A. J. Rosenspire
Summary: Epidemiological studies have found a correlation between exposure to mercury and autoimmune disease, however, the mechanism is still unknown. This report focuses on how mercury intoxication affects phosphorylation of B cell proteins in antigen-non stimulated mouse splenic B cells. It was found that the effects were pleotropic and the B cell signaling pathway appeared to be most affected, possibly leading to systemic autoimmunity.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
Edd Ricker, Michela Manni, Danny Flores-Castro, Daniel Jenkins, Sanjay Gupta, Juan Rivera-Correa, Wenzhao Meng, Aaron M. Rosenfeld, Tania Pannellini, Mahesh Bachu, Yurii Chinenov, Peter K. Sculco, Rolf Jessberger, Eline T. Luning Prak, Alessandra B. Pernis
Summary: This study demonstrates that age-associated B cells (ABC) play a crucial role in sex-specific autoimmune diseases, particularly in the development of lupus-like syndrome in females. The absence of certain guanine exchange factors in double-knock-out (DKO) mice leads to the accumulation of ABCs, which differentiate into pathogenic effector B cell populations with pro-inflammatory function. The upregulation of Tlr7 in DKO males further enhances the dissemination and pathogenicity of ABCs, resulting in severe pulmonary inflammation and early mortality.
NATURE COMMUNICATIONS
(2021)
Review
Immunology
Jonas Bystrom, Taher E. Taher, Sian M. Henson, David J. Gould, Rizgar A. Mageed
Summary: This review examines the changing metabolic requirements of Th17 cells and B cells at different stages of their development and activation, and discusses their association with diseases. The study of immune cell metabolism can reveal novel therapeutic targets for treating diseases.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Borja Hernandez-Breijo, Chamaida Plasencia-Rodriguez, Victoria Navarro-Compan, Carlota Garcia-Hoz, Israel Nieto-Ganan, Cristina Sobrino, Javier Bachiller-Corral, Mariana Diaz-Almiron, Ana Martinez-Feito, Teresa Jurado, Paloma Lapuente-Suanzes, Gema Bonilla, Cristina Pijoan-Moratalla, Garbine Roy, Monica Vazquez-Diaz, Alejandro Balsa, Luisa M. Villar, Dora Pascual-Salcedo, Eulalia Rodriguez-Martin
Summary: The study focused on analyzing the changes in PBMC of RA patients treated with TNFi, finding that a reduction in naive B-cell percentage was associated with achieving REM in patients who received concomitant therapy with MTX. No association was found for patients who did not receive concomitant MTX.
FRONTIERS IN MEDICINE
(2021)
Review
Immunology
Zhen-yu Li, Ming-Long Cai, Yi Qin, Zhu Chen
Summary: Age/autoimmunity-associated B cells (ABCs) are a unique B cell subpopulation with distinct transcriptional and cell surface characteristics. They rely on TLR7 or TLR9 and T cell-derived cytokines for differentiation and their aberrant expansion is associated with systemic autoimmune diseases. Recent studies have shown a pathogenic role of increased ABCs in rheumatoid arthritis (RA), suggesting that targeting specific B cell subsets could be a promising treatment strategy for inflammatory arthritis.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Xuan Sun, Benjamin Cao, Marina Naval-Sanchez, Tony Pham, Yu Bo Yang Sun, Brenda Williams, Shen Y. Heazlewood, Nikita Deshpande, Jinhua Li, Felix Kraus, James Rae, Quan Nguyen, Hamed Yari, Jan Schroder, Chad K. Heazlewood, Madeline Fulton, Jessica Hatwell-Humble, Kaustav Das Gupta, Ronan Kapetanovic, Xiaoli Chen, Matthew J. Sweet, Robert G. Parton, Michael T. Ryan, Jose M. Polo, Christian M. Nefzger, Susan K. Nilsson
Summary: Nicotinamide riboside treatment can restore metabolic capacity of hematopoietic stem cells through various ways and shift aged HSC function, metabolism, and molecular characteristics towards a youthful state.
NATURE COMMUNICATIONS
(2021)
Article
Rheumatology
Corrie M. Wortel, Sophie I. E. Liem, Nina M. van Leeuwen, Maaike Boonstra, Cynthia M. Fehres, Lauran Stoeger, Tom W. J. Huizinga, Rene E. M. Toes, Jeska De Vries-Bouwstra, Hans U. Scherer
Summary: This study investigates the autoreactive B cell responses in ATA-positive and ACA-positive SSc patients. The results show that ATA-positive patients exhibit a more active B cell response, which is associated with the presence and severity of ILD. This may explain the differential responsiveness to B cell depleting therapy.
Article
Immunology
Kartik Bhamidipati, John L. Silberstein, Yashaar Chaichian, Matthew C. Baker, Tobias Lanz, Amin Zia, Yusuf S. Rasheed, Jennifer R. Cochran, William H. Robinson
Summary: SLE patients exhibit upregulated CD52 expression, which correlates with disease activity. CD52 functions as a homeostatic protein on B cells by inhibiting BCR signaling, and is cleaved from the cell surface upon antigen engagement.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Horticulture
Manoj Kulkarni, Swati Phalke
SCIENTIA HORTICULTURAE
(2009)
Article
Multidisciplinary Sciences
Swati Popat Phalke, Yafei Huang, Kira Rubtsova, Andrew Getahun, Deming Sun, Richard L. Reinhardt, Rebecca L. O'Brien, Willi K. Born
Article
Critical Care Medicine
Swati Phalke, Katja Aviszus, Kira Rubtsova, Anatoly Rubtsov, Briana Barkes, Linda Powers, Brenda Warner, James L. Crooks, John W. Kappler, Evans R. Fernandez-Perez, Lisa A. Maier, Nabeel Hamzeh, Philippa Marrack
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2020)
Article
Cell Biology
Ling Ma, Swati Phalke, Caroline Stevigny, Florence Souard, David Vermijlen
Review
Immunology
Swati Phalke, Juan Rivera-Correa, Daniel Jenkins, Danny Flores Castro, Evgenia Giannopoulou, Alessandra B. Pernis
Summary: Age-associated B cells (ABCs) play critical roles in the pathogenesis of autoimmune disorders, aging-associated diseases, and infections. They exhibit a distinctive phenotype and express T-bet and CD11c markers, hence known as CD11c(+)T-bet(+) B cells. The formation of ABCs is promoted by specific combinations of innate and adaptive signals.
IMMUNOLOGICAL REVIEWS
(2022)
Article
Rheumatology
Zhu Chen, Danny Flores Castro, Sanjay Gupta, Swati Phalke, Michela Manni, Juan Rivera-Correa, Rolf Jessberger, Habib Zaghouani, Eugenia Giannopoulou, Tania Pannellini, Alessandra B. Pernis
Summary: The study revealed that IL-13R alpha 1 plays a crucial role in controlling the generation and differentiation of ABCs. Deficiency of IL-13R alpha 1 reduced the accumulation of ABCs, differentiation into plasmablasts, and autoantibody production, leading to prolonged survival and delayed tissue inflammation.
ARTHRITIS & RHEUMATOLOGY
(2022)
Article
Orthopedics
Daniel Jenkins, Swati Phalke, Richard Bell, Samantha Lessard, Sanjay Gupta, Mark Youssef, Kathleen Tam, Allina Nocon, Juan Rivera-Correa, Timothy Wright, Thomas Sculco, Miguel Otero, Alessandra B. Pernis, Peter Sculco
Summary: Dissatisfaction after total knee arthroplasty (TKA) occurs in nearly 20% of patients, but the biological mechanisms contributing to postoperative complications requiring revision surgery are poorly understood. This pilot study found significant differences in immunoglobulin and antiphospholipid antibody levels in synovial fluid between patients with arthrofibrosis and instability. The findings suggest that intra-articular T-B cell interactions may contribute to fibrous tissue growth in arthrofibrotic patients.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Rebecca L. O'Brien, Jennifer Matsuda, M. Kemal Aydintug, Niyun Jin, Swati Phalke, Willi K. Born
Summary: Previous studies have shown inconsistent results regarding the role of gamma delta T cells in the development of type 1 diabetes. This study focused on NOD mice and found that NOD V γ4+ γδ T cells inhibit diabetes development, while NOD V γ1+ cells promote it. Additionally, changes in the abundance of other T cell types were observed in NOD mice deficient in specific gamma delta T cell subsets.
Article
Multidisciplinary Sciences
Rosa J. Chen, Anika Nabila, Swati Phalke, Danny Flores Castro, Judit Gal Toth, Paul Bergin, Jeroen Bastiaans, Heidi Stuhlmann, Alessandra B. Pernis, Miklos Toth
Summary: This study reveals that 5HT1AR deficit leads to immune abnormalities in the maternal system, which in turn affects the in utero environment and results in sex-biased outcomes.