期刊
COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES
卷 64, 期 -, 页码 47-52出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.cimid.2019.01.009
关键词
Sepsis; Inflammasome; Autophagy; Rapamycin
资金
- Shanghai Science of Technology Commission [18490712700]
- SJTU translational medicine cross fund [ZH2018ZDA37]
- Science and Technology Commission of Sichuan Province [2017JZ0010]
- Med-X [YG2016MS69]
- State Key Laboratory of Dairy Biotechnology [SKLDB2017-005]
Sepsis is a life-threatening condition that may develop to multiple organ failure and septic shock. Autophagy is considered to play an important role in the regulation of inflammation. The present study aims to investigate the protective role of mTORC1 inhibitor, rapamycin, on septic death using cecal ligation and puncture (CLP) mice model. Here, results showed that pretreatment with rapamycin reduced the pyroptosis of peritoneal macrophages stimulated by cecal contents and the release of inflammatory factors such as interleukin-1 beta (IL-1 beta), tumor necrosis factor-alpha (TNF-alpha); In septic mice, rapamycin treatment decreased the activation of inflammasome in lung, and alleviated the pathological injuries in lung, liver and spleen tissues during acute stage of sepsis. Treatment of rapamycin rescued animals from septic death significantly. Our results indicated that activation of autophagy is a potential strategy to regulate the excessive inflammation in acute stage of sepsis.
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