Article
Environmental Studies
Arman Hazrathosseini, Ali Moradi Afrapoli
Summary: The weaknesses of conventional simulations and the increasing capabilities offered by technological trends have driven the surface mining industry towards Mining 4.0. The Digital Twin concept, with its focus on real-time data exchange and cognitive decision-making, is seen as the key to the mines of the future. This research provides a comprehensive review of simulation applications in surface mining, dissects the concept of twinning, unveils an exemplary architecture for Digital Twin in surface mines, and explores the challenges and opportunities of this disruptive technology.
Article
Polymer Science
Mohd Sameer, Yaseera Arif, Anjlina Aqil, Arif Nadaf, Km Rafiya, Nazeer Hasan, Prashant Kesharwani, Farhan Jalees Ahmad
Summary: Carbon nanodots (CNDs) have been extensively explored in the industry of carbon nanomaterials due to their potential applications in biomedicine, including therapy, imaging, and drug delivery. CNDs offer advantages such as better biocompatibility, lower toxicity, and environment-friendly properties. Moreover, their photophysical and chemical properties can be altered, making them more desirable for enhanced biocompatibility and targeting potency.
EUROPEAN POLYMER JOURNAL
(2023)
Editorial Material
Medicine, Research & Experimental
Carlos J. Pirola, Silvia Sookoian
Summary: MicroRNAs (miRNAs) are crucial regulators of gene expression and cell biology, existing as stable molecules in various body fluids. Circulating miRNAs have potential applications in diagnosing liver pathologies, and some miRNAs may act in similar biological processes, making the miRNA regulatory networks more complex than expected.
Article
Chemistry, Multidisciplinary
A. H. Lotfallah, J. J. Andreu, R. M. Hathout, D. H. Kassem, S. S. Ibrahim, B. Altava, E. Garcia-Verdugo, S. V. Luis
Summary: Nanovesicles based on tripodal amphiphilic pseudopeptides were developed as carriers for p-coumaric acid (p-CA) delivery. The nanovesicles obtained through thin film hydration and ethanol injection methods showed positive Z-potential values. The ethanol injection method resulted in smaller particle sizes and better polydispersity index. In vitro release experiments demonstrated interesting results under different external stimuli. The loaded pseudopeptide nanovesicles exhibited enhanced cytotoxicity against brain cancer cells, and the observed biological activity was associated with an enhanced permeability and retention effect.
MATERIALS TODAY CHEMISTRY
(2023)
Article
Pharmacology & Pharmacy
Manali Jadhav, Rajendra Prasad, Mayuri Gandhi, Rohit Srivastava
Summary: The use of biodegradable nanoparticles as drug carriers has gained attention worldwide. In this study, erythrocyte-derived nanovesicles were extracted from mouse blood and loaded with doxorubicin for targeted cancer chemotherapy. The surface markers on these nanovesicles were identified using mass spectrometry, which could potentially be used for targeting cancer cells. The uniform particle size distribution was confirmed through dynamic light scattering measurements. Cell viability and confocal microscopy studies showed effective cancer cell killing by these drug-loaded nanocarriers.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Agriculture, Multidisciplinary
Xin Lu, Qing Han, Jiachen Chen, Tingyu Wu, Yirui Cheng, Fan Li, Weiliang Xia
Summary: Extracellular vesicles (EVs) released from cells have shown robust efficacy in drug delivery compared with traditional synthetic carriers. However, the clinical application of EVs as drug carriers is limited due to high production cost and complex purification process. Plant-derived nanovesicles with exosome-like morphology and similar delivery effects could be a new option for drug delivery. Celery exosome-like nanovesicles (CELNs), as a drug carrier, have higher cellular uptake efficiency and better tolerance as biotherapeutic roles verified in mice models. Encapsulating doxorubicin (DOX) into CELNs to construct engineered CELNs (CELNs-DOX) has proved to be more efficient in treating tumors than conventional synthetic carriers like liposome both in vitro and in vivo. This study proposes the emerging role of CELNs as a new-generation drug delivery carrier with distinct advantages.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Review
Pharmacology & Pharmacy
Yurong Lai
Summary: Since 2016, significant progress has been made in confirming the usefulness of coproporphyrins I and III (CP-I and CP-III) as biomarkers for assessing organic anion transporting polypeptide (OATP) functions. CP-I exhibits selectivity toward OATP1B activity and shows sensitivity to a broad range of OATP1B inhibitors. Monitoring CP-I levels in clinical studies can aid in early assessment of drug-drug interaction risks and understanding the dose-response of investigational drugs to OATP inhibitions.
DRUG METABOLISM AND DISPOSITION
(2023)
Article
Economics
Marcos Dantas, Luiz Leo
Summary: The article discusses the economic-political transformations in the organization of football in the past 20 to 30 years, where non-profit sports clubs have now become profit-oriented companies under the control of mediatic-financial capital. The article suggests a theoretical approach that combines Debord's concept of spectacle with categories from the Political Economy of Information and Communication. It concludes by emphasizing that while football still evokes emotions for millions of people, it should be understood and regulated as an important economic sector in the capital accumulation process.
Review
Oncology
Simon Deycmar, Bruno Gomes, Jehad Charo, Maurizio Ceppi, J. Mark Cline
Summary: The complexity of cancer immunotherapy (CIT) requires reliable preclinical models. Non-human primates (NHPs) share similarities with humans and have the potential to bridge the gap between preclinical models and human patients. This review presents the current knowledge of NHP immunology, naturally-occurring cancers in NHPs, and TBM trials investigating CIT.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Review
Pharmacology & Pharmacy
Ana Ortega, Olga Martinez-Arroyo, Maria J. Forner, Raquel Cortes
Summary: Exosomes, as nanometer-sized lipid-bilayer-enclosed extracellular vesicles, have shown promising potential as drug delivery vehicles with features like stability, biocompatibility, and low immunogenicity. They have been utilized for gene therapy and treating autoimmune diseases due to their ability to regulate immune signaling and inflammation.
Article
Medicine, Research & Experimental
Fahimeh Nojoki, Bahman Ebrahimi-Hosseinzadeh, Ashrafalsadat Hatamian-Zarmi, Fariba Khodagholi, Khadijeh Khezri
Summary: In this study, chitosan-Transfersulin (CTI) nanovesicles were prepared and characterized as an effective intranasal drug delivery system for the treatment of memory disorders. The results showed that CTI nanovesicles had appropriate particle size, polydispersity index, and drug loading, and could stably release insulin with neuroprotective effects in the brain.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Pharmacology & Pharmacy
Hiroyuki Takita, Daniel Scotcher, Xiaoyan Chu, Ka Lai Yee, Kayode Ogungbenro, Aleksandra Galetin
Summary: This study investigated the mechanism behind the altered baseline of Coproporphyrin I (CPI) in patients with chronic kidney disease (CKD). A physiologically-based pharmacokinetic (PBPK) model was used to evaluate CKD-related factors such as hepatic uptake, renal clearance, and endogenous synthesis. The results showed that the changes in CPI in CKD patients were mainly attributed to alterations in these factors.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Chemistry, Multidisciplinary
Lu Liu, Wei Li, Le Yang, Zi-tao Guo, Hao Xue, Ning-jie Xie, Xiao-yan Chen
Summary: Almonertinib, a novel EGFR tyrosine kinase inhibitor, is metabolized by CYP3A, with the major active metabolite being N-desmethyl almonertinib (HAS-719). Co-administration with itraconazole increased almonertinib levels but reduced HAS-719 levels, while rifampicin decreased levels of both almonertinib and HAS-719. Further metabolism of HAS-719 may contribute to its altered pharmacokinetics when combined with rifampicin.
ACTA PHARMACOLOGICA SINICA
(2022)
Article
Multidisciplinary Sciences
Rodrigo B. Aires, Alexandre A. de S. M. Soares, Ana Paula M. Gomides, Andre M. Nicola, Andrea Teixeira-Carvalho, Dayde Lane M. da Silva, Eliana T. de Gois, Flavia D. Xavier, Francielle P. Martins, Gabriela P. J. Santos, Heidi Luise Schulte, Isabelle S. Luz, Laila S. Espindola, Laurence R. do Amaral, Liza F. Felicori, Luciana A. Naves, Maira R. M. de Carvalho, Matheus de S. Gomes, Otavio T. Nobrega, Patricia Albuquerque, Wagner Fontes, Ciro M. Gomes, Patricia S. Kurizky, Cleandro P. Albuquerque, Olindo A. Martins-Filho, Licia Maria H. da Mota
Summary: Thromboelastometry parameters are useful in differentiating the coagulation profile between severe and non-severe COVID-19 patients, which is important for therapeutic intervention.
Article
Pharmacology & Pharmacy
Sheng Feng, Qingyan Bo, Hugh A. Coleman, Jean Eric Charoin, Mingfen Zhu, Jim Xiao, Yuyan Jin
Summary: Coproporphyrins (CP-I and CP-III) in plasma show potential as endogenous markers for evaluating liver OATP1B activity, with impact of altered renal clearance on these measurements being explored for the first time in this study.
JOURNAL OF CLINICAL PHARMACOLOGY
(2021)