Article
Geriatrics & Gerontology
Wonjeong Jeong, Jong Youn Moon, Jae-Hyun Kim
Summary: This study examined the association between absolute and relative hand grip strength (HGS) and the risk of all-cause mortality among middle-aged and old-aged people in South Korea. The findings showed that both absolute and relative HGS were inversely associated with the risk of all-cause mortality, indicating that higher HGS is associated with a lower risk of mortality.
Article
Cell Biology
Xue Liang, Chao Qiang Jiang, Wei Sen Zhang, Feng Zhu, Ya Li Jin, Kar Keung Cheng, Tai Hing Lam, Lin Xu
Summary: In older Chinese individuals, lower scores of relative grip strength and timed up and go test were associated with increased glycemia and incident type 2 diabetes mellitus, particularly in those with overweight/obesity. This suggests that assessing physical function may play a vital role in preventing diabetes.
Article
Medicine, Research & Experimental
Sunmin Park, Heng Yuan, Ting Zhang, Xuangao Wu, Shao Kai Huang, Song Mee Cho
Summary: Silk peptide intake may prevent age-related muscle mass and strength decline in middle-aged female rats by maintaining higher serum amino acid levels, reducing inflammation and insulin resistance, and modulating gut microbiota.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Geriatrics & Gerontology
Alexandra J. Mayhew, Hon Y. So, Jinhui Ma, Marla K. Beauchamp, Lauren E. Griffith, Ayse Kuspinar, Justin J. Lang, Parminder Raina
Summary: This study aims to establish normative values for commonly used physical performance-based tests in Canadians aged 45-85 years. Through testing of 25,470 participants without disability or mobility limitation, percentile values for grip strength, gait speed, timed up and go, single-leg balance, and five-repetition chair rise tests were determined for different age and sex groups. These normative values are valuable for clinicians and researchers to identify individuals with low physical performance among peers of the same age and sex.
Article
Nutrition & Dietetics
Hyeonmok Kim, Sun Hee Beom, Tae Ho Kim, Beom-Jun Kim
Summary: This study explored the relationship between water intake and hand grip strength in older adults, finding that the correlation between water intake and hand grip strength may not be significant, potentially influenced by other factors such as age, body size, and resistance exercise.
Article
Nutrition & Dietetics
Tingyu Lu, Weisen Zhang, Chaoqiang Jiang, Yali Jin, Tong Zhu, Feng Zhu, Lin Xu
Summary: Older people with high salt intake have lower grip strength and higher TUGT scores, suggesting that avoiding high-salt diets may play a role in preserving muscle strength and physical function in the elderly. This association was found to be significant in women, but not in men. The study highlights the importance of salt intake in maintaining muscle health and physical performance in older individuals.
Article
Nutrition & Dietetics
Shunming Zhang, Yeqing Gu, Sabina Rayamajhi, Amrish Thapa, Ge Meng, Qing Zhang, Li Liu, Hongmei Wu, Tingjing Zhang, Xuena Wang, Jun Dong, Xiaoxi Zheng, Zhixia Cao, Xu Zhang, Xinrong Dong, Shaomei Sun, Xing Wang, Ming Zhou, Qiyu Jia, Kun Song, Jian Huang, Junsheng Huo, Bing Zhang, Gangqiang Ding, Lu Qi, Kaijun Niu
Summary: Higher intake of ultra-processed foods is associated with faster decline in grip strength among middle-aged and older Chinese adults.
EUROPEAN JOURNAL OF NUTRITION
(2022)
Article
Multidisciplinary Sciences
Ki Young Son, Dong Wook Shin, Ji Eun Lee, Sang Hyuck Kim, Jae Moon Yun, Belong Cho
Summary: This study examines the association between the Timed Up and Go (TUG) test and disability incidence using national disability registration data in Korea. The results show a significantly higher disability incidence in participants with abnormal TUG results compared to those with normal results. Subgroup analysis also reveals an increased disability incidence in participants without cognitive impairment, obesity, or cardiovascular disease. This study provides important insights into the relationship between mobility and disability.
Article
Engineering, Biomedical
Joao Elison da Rosa Tavares, Martin Ullrich, Nils Roth, Felix Kluge, Bjoern M. Eskofier, Heiko Gassner, Jochen Klucken, Till Gladow, Franz Marxreiter, Cristiano Andre da Costa, Rodrigo da Rosa Righi, Jorge Luis Victoria Barbosa
Summary: Inertial measurement units (IMU) are used diagnostically in the movement analysis of Parkinson's disease (PD) patients. We developed and evaluated a novel algorithmic pipeline called unsupervised TUG (uTUG) for automatic detection and decomposition of TUG tests into their subphases.
BIOMEDICAL SIGNAL PROCESSING AND CONTROL
(2023)
Article
Geriatrics & Gerontology
Laetitia Lengele, N. A. Grande de Franca, Y. Rolland, S. Guyonnet, P. de Souto Barreto
Summary: Dietary patterns were found to have varying associations with body composition and physical performance based on age and sex. Men tended to have less healthy food intake across all age groups. Diets high in sugary foods, fast foods, and processed meat were linked to higher fat mass and lower strength in the study participants.
JOURNAL OF NUTRITION HEALTH & AGING
(2023)
Article
Nutrition & Dietetics
Yun-Jung Bae, Xiang-Shun Cui, Seung-Ho Shin
Summary: This study investigated the relationship between omega-3 fatty acid intake and sarcopenia in elderly Koreans. The results showed that elderly females with inadequate intake of EPA and DHA had lower grip strength and lower protein intake compared to those with adequate intake. Sufficient intake of EPA and DHA was found to be crucial in mitigating a reduction in grip strength and improving nutrient intake quality among elderly females.
Article
Nutrition & Dietetics
Keita Suzuki, Hiromasa Tsujiguchi, Akinori Hara, Sakae Miyagi, Thao Thi Thu Nguyen, Yasuhiro Kambayashi, Yukari Shimizu, Fumihiko Suzuki, Chie Takazawa, Masaharu Nakamura, Hirohito Tsuboi, Takayuki Kannon, Atsushi Tajima, Hiroyuki Nakamura
Summary: This study investigated the relationship between calcium intake and bone strength in older Japanese populations. The findings showed a positive correlation between calcium intake and bone strength in males, but no correlation in females. Additionally, grip strength was positively correlated with bone strength in females.
Article
Medicine, General & Internal
Won Bin Kim, Jun-Bean Park, Yong-Jin Kim
Summary: Reduced handgrip strength is associated with increased risk for cardiovascular disease and mortality. This study in the middle-aged Korean population showed that handgrip strength is a significant predictor of 10-year CVD risk, especially in women. Advanced age was inversely associated with handgrip strength in both sexes.
AMERICAN JOURNAL OF THE MEDICAL SCIENCES
(2021)
Article
Environmental Sciences
Kai Hong Xie, Xiao Han, Wei Jun Zheng, Su Fang Zhuang
Summary: This study evaluates the association between lower grip strength and mortality hazard. The findings suggest that elevated grip strength is correlated with lower mortality up to a certain threshold. The study also identifies sex-specific grip strength thresholds for middle-aged and older Chinese adults, below which grip strength is inversely associated with mortality hazard.
BIOMEDICAL AND ENVIRONMENTAL SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Laurie E. Davies, Adam Todd, David R. Sinclair, Louise Robinson, Andrew Kingston
Summary: Using Newcastle 85+ Study data and mixed-effects modelling, the association between polypharmacy and difficulty taking medications was investigated among 85-year-olds living at home. The study found that disability, visual impairment, and cognitive impairment were significant predictors, suggesting that these factors play a more important role than the number of medications prescribed.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Article
Nutrition & Dietetics
Nuno M. P. Mendonca, Linda M. Hengeveld, Nancy Presse, Helena Canhao, Eleanor Simonsick, Stephen B. Kritchevsky, Samaneh Farsijani, Pierrette Gaudreau, Carol Jagger, Marjolein Visser
Summary: This study aimed to investigate the relationship between protein intake and grip strength, as well as the interaction between protein intake and physical activity, in relation to the rate of grip strength decline in older adults. The findings showed no evidence to support the hypothesis that higher protein intake, alone or in combination with higher physical activity, slowed the rate of grip strength decline in older adults.
BRITISH JOURNAL OF NUTRITION
(2023)
Article
Nutrition & Dietetics
Antoneta Granic, Rachel Cooper, Richard M. Dodds, Susan J. Hillman, Avan A. Sayer, Sian M. Robinson
Summary: Milk is a potential source of nutrients that may benefit skeletal muscle health. However, there is currently a lack of evidence linking milk intake with declines in muscle strength. More research is needed to explore the relationship between milk consumption and muscle health.
BRITISH JOURNAL OF NUTRITION
(2023)
Article
Public, Environmental & Occupational Health
Alvaro Carvalho, Ana Rita Henriques, Paula Queiros, Joana Rodrigues, Nuno Mendonca, Ana Maria Rodrigues, Helena Canhao, Germano de Sousa, Francisco Antunes, Miguel Guimaraes
Summary: This study aimed to evaluate the antibody responses to SARS-CoV-2 and its dynamics during 9 months in COVID-19 patients. The results showed a lasting anti-S IgG antibody response after 9 months in the majority of patients. Factors such as age and symptomatic disease were found to be associated with different concentrations of IgG antibodies. Overall, this study provides important insights into the immune response to SARS-CoV-2 and has implications for preventive strategies and public health policies.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Geriatrics & Gerontology
Li-Tang Tsai, Eleanor Boyle, Sussi F. Buhl, Gry Kock, Jan C. Brond, Marjolein Visser, Nuno Mendonca, Eric J. Shiroma, Paolo Caserotti
Summary: The objective of this study was to examine the association between physical activity, sedentary behavior, and appetite among community-dwelling older adults. Data from three cohort studies were analyzed, and accelerometers were used to measure activity. Results showed that higher total activity and light-intensity physical activity were associated with increased appetite, while sedentary behavior was associated with decreased appetite. However, no association was found when wrist-worn accelerometers were used. This study highlights the importance of interpreting accelerometer data from different body locations carefully and considering concurrent health outcomes.
GERIATRICS & GERONTOLOGY INTERNATIONAL
(2023)
Article
Geriatrics & Gerontology
Milly A. van der Ploeg, Rosalinde K. E. Poortvliet, Jonathan M. K. Bogaerts, Veerle M. G. T. H. van der Klei, Ngaire Kerse, Anna Rolleston, Ruth Teh, Louise Robinson, Carol Jagger, Yasumichi Arai, Ryo Shikimoto, Yukiko Abe, Jeanet W. Blom, Yvonne M. Drewes, Jacobijn Gussekloo, TULIPS Consortium
Summary: This study aimed to investigate whether the association between LDL-C and mortality in the very old is modified by a composite fitness score. The study found that there is an inverse association between LDL-C and 5-year mortality risk, which is most pronounced in participants with a low-composite fitness scores. These findings suggest that the relationship between LDL-C and mortality may be influenced by overall fitness in very old individuals.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Geriatrics & Gerontology
Marjolein Visser, Nuno Mendonca, Christina Avgerinou, Sibel Cavdar, Tommy Cederholm, Alfonso J. Cruz-Jentoft, Eva Kiesswetter, Hanna M. Siebentritt, Cornel Sieber, Gabriel Torbahn, Dorothee Volkert
Summary: This article describes a protocol for developing a Core Outcome Set (COS) for nutritional intervention studies in older adults with malnutrition. The COS will be developed through a scoping review, a Delphi survey, and consensus meetings. This COS will help standardize outcome measurement and improve the quality of research in this field.
Article
Geriatrics & Gerontology
Miles D. Witham, Antoneta Granic, Satomi Miwa, Joao F. Passos, Gavin D. Richardson, Avan A. Sayer
Summary: Cellular senescence is a fundamental biological mechanism contributing to aging and age-related diseases. It can be induced by various mechanisms, not just replication and telomere attrition. Senescent cells secrete inflammatory mediators that drive chronic inflammation and can convert other cells to the senescent state. Research in animal models suggests that preventing or reversing senescence may be a potential strategy against aging and age-related diseases, with interventions including exercise, nutrition, and senolytics/senostatic drugs. However, it is crucial to measure outcomes reflecting improved healthy life expectancy in clinical studies to gain trust from clinicians, patients, and the public.
Article
Public, Environmental & Occupational Health
David G. Lopes, Nuno Mendonca, Ana Rita Henriques, Jaime Branco, Helena Canhao, Ana M. Rodrigues
Summary: This study examines the health trajectories of Portuguese older adults over a 10-year period and identifies associated sociodemographic, lifestyle factors and multimorbidity status. The findings show that physical disability increased and health-related quality of life declined with advancing age. Women had worse health at baseline but exhibited similar rates of change compared to men. Higher education and regular exercise were associated with better health outcomes, while multimorbidity and excess weight were associated with worse outcomes. This research provides valuable insights for resource allocation, healthcare improvement, and public health policymaking in Portugal.
Article
Radiology, Nuclear Medicine & Medical Imaging
Matthew G. Birkbeck, Linda Heskamp, Ian S. Schofield, Julie Hall, Avan A. Sayer, Roger G. Whittaker, Andrew M. Blamire
Summary: This study used phase contrast MU MRI to measure the contraction and relaxation times of the anterior compartment in a group of healthy adults. The results showed that age and sex have a significant effect on the contraction and relaxation times. Females had significantly longer contraction times than males.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Geriatrics & Gerontology
Mo Osman, Miles D. Witham, Avan A. Sayer, Rachel Cooper
Summary: The study aimed to evaluate the impact of different SARC-F cut-points for identifying muscle weakness in an older clinical population. A total of 159 men and 311 women aged 56-98 completed the SARC-F questionnaire and had their maximum grip strength measured. Cut-points of ≥4, 3, and 2 were applied to SARC-F and tested for agreement with muscle weakness.
EUROPEAN GERIATRIC MEDICINE
(2023)
Article
Geriatrics & Gerontology
Leena Habiballa, Adam Hruby, Antoneta Granic, Richard M. Dodds, Susan J. Hillman, Diana Jurk, Joao F. Passos, Avan A. Sayer
Summary: This study aimed to determine the feasibility of characterizing cellular senescence in skeletal muscle and explore sex-specific associations between markers of cellular senescence, muscle morphology, and physical function. The findings showed weak associations between most senescence markers and morphological characteristics with age in men, while they were stronger but non-significant in women. Additionally, associations between senescence markers, morphology, and physical function were stronger in women but also non-significant.
Article
Geriatrics & Gerontology
Thomas A. Stubbs, William J. Doherty, Andrew Chaplin, Sarah Langford, Mike R. Reed, Avan A. Sayer, Miles D. Witham, Antony K. Sorial
Summary: This study assessed the ability of pre-fracture mobility to predict post-operative outcomes in hip fracture patients. Patients with worse mobility had higher mortality, longer length of hospital stay, higher likelihood of living in a care home, and higher likelihood of complications. Including mobility assessment in risk scores can improve casemix adjustment and prognostication following hip fracture.
EUROPEAN GERIATRIC MEDICINE
(2023)
Article
Rheumatology
David G. Lopes, Daniela Costa, Eduardo B. Cruz, Nuno Mendonca, Ana Rita Henriques, Jaime Branco, Helena Canhao, Ana M. Rodrigues
Summary: This study analyzed the impact of long-term physical activity on physical function and health-related quality of life in patients with hip and knee osteoarthritis. The results showed that frequent and very frequent physical activity were associated with improved physical function and health-related quality of life over time. These findings emphasize the importance of maintaining regular physical activity to optimize quality of life and physical function.
ARTHRITIS RESEARCH & THERAPY
(2023)
Review
Medicine, Research & Experimental
Antoneta Granic, Karen Suetterlin, Tea Shavlakadze, Miranda D. Grounds, Avan A. Sayer
Summary: This article evaluates the classic hallmarks of ageing and the novel hallmarks associated with skeletal muscle ageing and sarcopenia. The interconnections between these hallmarks are discussed, and their clinical relevance and translational potential are considered.