Article
Cardiac & Cardiovascular Systems
Marc P. Bonaca, Naomi M. Hamburg, Mark A. Creager
Summary: Peripheral artery disease (PAD) is a manifestation of systemic atherosclerosis with modifiable risk factors including smoking, dyslipidemia, and diabetes. Medical therapies can reduce the risk of major adverse cardiovascular events and major adverse limb events, and improve function. Diagnosis and treatment should consider the individual risk profile of the patient.
CIRCULATION RESEARCH
(2021)
Article
Medicine, General & Internal
Viviana Onofrei, Cristina Andreea Adam, Dragos Traian Marius Marcu, Maria-Magdalena Leon, Carmen Cumpat, Florin Mitu, Doina-Clementina Cojocaru
Summary: This retrospective study analyzed the clinical and therapeutic characteristics of 652 patients with peripheral artery disease (PAD) based on gender. It found that men tended to be younger, have higher BMI, and higher smoking rates, while women had a higher prevalence of hypercholesterolemia, obesity, concomitant cerebrovascular disease, and chronic kidney disease. Smoking, uric acid, and inflammatory markers were positively correlated with the number of stenotic lesions and ankle-brachial index (ABI). In the subgroup of men, the number of stenotic and thrombosed lesions positively correlated with ABI value. The presence of more than three cardiovascular risk factors and serum triglyceride levels were significantly correlated with the number of angiographically detected lesions.
Review
Biology
Lilla Horvath, Noemi Nemeth, Gergely Feher, Zsuzsanna Kives, Dora Endrei, Imre Boncz
Summary: The past decades have seen a significant increase in atherosclerotic cardiovascular diseases (CVDs), particularly in low-income and middle-income countries (LMICs). Peripheral artery disease (PAD), which is strongly age-related, is estimated to become more prevalent in the future. PAD shares risk factors with coronary and cerebrovascular diseases and is associated with significant morbidity and mortality. Despite advances in treatment, the prevalence of PAD continues to rise, and data from LMICs are scarce.
Article
Surgery
Goren Saenz-Pipaon, Susana Ravassa, Katrine L. Larsen, Esther Martinez-Aguilar, Josune Orbe, Jose A. Rodriguez, Leopoldo Fernandez-Alonso, Arantxa Gonzalez, Jose L. Martin-Ventura, Jose A. Paramo, Jes S. Lindholt, Carmen Roncal
Summary: The study aimed to determine the prognostic value of LCN2 and calprotectin in cardiovascular risk assessment for PAD patients. The results confirmed the association of these two inflammatory biomarkers with increased risks of CV death and MALE through examination of their expression in human femoral plaques and measurement of their levels in serum and plasma of PAD patients.
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
(2022)
Review
Cell Biology
Hailing Zhang, Yu Jie, Pei Wang, Yimeng Sun, Xiaoyan Wang, Yu Fan
Summary: Frailty can predict the risk of mortality in patients with lower extremity PAD, but its impact on major amputation remains unclear.
AGEING RESEARCH REVIEWS
(2022)
Article
Cardiac & Cardiovascular Systems
Sarah O'Connor, Claudia Blais, Jacinthe Leclerc, Jeremie Sylvain-Morneau, Elhadji Anassour Laouan Sidi, Denis Hamel, Laura Drudi, Nathalie Gilbert, Paul Poirier
Summary: This study aimed to document the trends of primary lower extremity amputations (LEAs) in Quebec, Canada from 2006 to 2019. The results showed a decrease in the incidence of major LEAs, but an increase in the absolute number of cases. Additionally, there was an increase in minor LEAs among younger age groups, highlighting the importance of further improving preventive care.
CANADIAN JOURNAL OF CARDIOLOGY
(2023)
Article
Medicine, General & Internal
Karsten Keller, Volker H. Schmitt, Lukas Martin Alois Hobohm, Christoph Brochhausen, Thomas Muenzel, Christine Espinola-Klein
Summary: The COVID-19 pandemic led to a 13.2% reduction in hospitalizations of PAD patients, as well as decreased total numbers of revascularization and amputation treatments in 2020 compared to the pre-pandemic year 2019. The case fatality rate and major adverse cardiovascular and cerebrovascular events rate were slightly higher during the pandemic year 2020.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Eddie L. Hackler, Naomi M. Hamburg, Khendi T. White Solaru
Summary: Peripheral artery disease disproportionately affects Black Americans and they are less likely to be diagnosed and treated promptly, leading to grim consequences. The review discusses the risk factors of the disease and how they differentially affect certain groups, providing a resource of available recommendations for clinical management.
CIRCULATION RESEARCH
(2021)
Review
Surgery
Joanne G. Abi-Jaoude, Ahmed A. Naiem, Thomas Edwards, Marie-Amelie Lukaszewski, Daniel Obrand, Oren K. Steinmetz, Jason P. Bayne, Kent S. MacKenzie, Heather L. Gill, Elie Girsowicz
Summary: This review evaluated the impact of comorbid depression on adverse outcomes in patients with peripheral arterial disease. The results showed that depressed patients were more likely to be women, diabetic, have a history of smoking, and have chronic limb threatening ischaemia. Depressed patients had a 20% increased risk of major adverse limb events, but no increased risk of death or major adverse cardiovascular events. Analysis of other comorbidities and demographic variables did not demonstrate a significant contribution to the risk of major adverse limb events.
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
(2022)
Article
Medicine, General & Internal
Karsten Keller, Volker H. Schmitt, Markus Vosseler, Christoph Brochhausen, Thomas Munzel, Lukas Hobohm, Christine Espinola-Klein
Summary: The study revealed that patients with PAD and DM had a more severe cardiovascular risk profile and higher rates of in-hospital mortality, major adverse cardiovascular and cerebrovascular events, and amputation surgeries.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Surgery
Jean Jacob-Brassard, Mohammed Al-Omran, Therese A. Stukel, Muhammad Mamdani, Douglas S. Lee, Charles de Mestral
Summary: The study aimed to quantify the regional variation in revascularization and amputation rates for peripheral artery disease (PAD). A repeated cross-sectional analysis of Ontarians aged 40 years and older between 2002 and 2019 was conducted. The results showed significant regional differences in demographics, comorbidities, and rates of revascularization and amputation for PAD.
JOURNAL OF VASCULAR SURGERY
(2023)
Review
Medicine, General & Internal
Agastya D. Belur, Aangi J. Shah, Salim S. Virani, Mounica Vorla, Dinesh K. Kalra
Summary: Atherosclerosis is a disease that causes plaque formation and significantly impacts the global rates of cardiovascular diseases. Peripheral artery disease is a common condition that leads to loss of mobility and amputation. This paper reviews the role of lipid-lowering therapies in lower extremity atherosclerotic peripheral artery disease.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Endocrinology & Metabolism
Ioannis G. Lempesis, Dimitrios Varrias, Marios Sagris, Robert R. Attaran, Elissa S. Altin, Christos Bakoyiannis, Leonidas Palaiodimos, Maria Dalamaga, Damianos G. Kokkinidis
Summary: The association between obesity and peripheral artery disease (PAD) is controversial, but recent evidence suggests a potential protective effect of higher body mass index on PAD-related complications and mortality. Possible mechanisms include genetic background, adipose tissue dysfunction, and body fat distribution.
CURRENT OBESITY REPORTS
(2023)
Article
Surgery
Francois-Xavier Lapebie, Victor Aboyans, Philippe Lacroix, Joel Constans, Carine Boulon, Emmanuel Messas, Jean Ferrieres, Vanina Bongard, Alessandra Bura-Riviere
Summary: In France, only about 30% of hospitalized patients with LEAD were eligible for low dose rivaroxaban plus aspirin regimen, with others being ineligible for various reasons. Eligible and ineligible patients had higher risk of ischemic events compared to participants in the trials.
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
(2021)
Article
Health Care Sciences & Services
Mohammad Mahdi Kasiri, Martina Mittlboek, Giurgiana-Aura Giurgea, Norbert Fortner, Philip Lirk, Wolf Eilenberg, Bernd Gollackner, Christoph Neumayer
Summary: The COVID-19 pandemic had a negative impact on the treatment of patients with peripheral artery disease (PAD), leading to increased emergency admissions and limb amputations, even after the peak of the pandemic.
Article
Cardiac & Cardiovascular Systems
Natalie Arnold, Iris M. Hermanns, Andreas Schulz, Omar Hahad, Volker H. Schmitt, Marina Panova-Noeva, Juergen H. Prochaska, Harald Binder, Norbert Pfeiffer, Manfred Beutel, Karl J. Lackner, Thomas Muenzel, Philipp S. Wild
Summary: This study investigates the predictive ability of direct plasma renin and aldosterone concentrations as well as their ratio (aldosterone-to-renin, ARR) for incident hypertension in the general population. The study finds that ARR has a stronger predictive value for incident hypertension than renin or aldosterone alone, especially in obese subjects.
CARDIOVASCULAR RESEARCH
(2023)
Article
Psychology, Clinical
Danieelle Otten, Mareike Ernst, Antonia M. Werner, Ana N. Tibubos, Iris Reiner, Elmar Braehler, Joerg Wiltink, Matthias Michal, Markus Nagler, Philipp S. Wild, Thomas Muenzel, Jochem Koenig, Karl J. Lackner, Norbert Peiffer, Manfred E. Beutel
Summary: This study aimed to predict the occurrence of chronic diseases based on baseline depressive symptoms and to examine the sex-dependent effects. The results showed that baseline depressive symptoms predicted cardiovascular disease, chronic obstructive lung disease, diabetes, and migraine in both men and women, but not cancer. Additional adjustments for metabolic and lifestyle risk factors increased the risk of chronic obstructive lung disease and migraine for each point of depressive symptoms. There were trends suggesting a relevance of depressive symptoms for cardiovascular disease in men and for diabetes in women.
PSYCHOLOGICAL MEDICINE
(2023)
Review
Cardiac & Cardiovascular Systems
Thomas Muenzel, Omar Hahad, Andreas Daiber, Philip J. Landrigan
Summary: Healthy soil is essential for human health as it supports the growth of crops, provides food, and sustains populations. However, soil pollution poses a great threat to human health, reducing soil's ability to yield food and resulting in contamination and disease. It also causes water pollution and contributes to air, water, and soil pollution, leading to millions of deaths each year.
CARDIOVASCULAR RESEARCH
(2023)
Article
Ophthalmology
Achim Fiess, Michael S. Urschitz, Markus Nagler, Stefan Nickels, Susanne Marx-Gross, Thomas Muenzel, Philipp S. Wild, Manfred E. Beutel, Karl J. Lackner, Norbert Pfeiffer, Alexander K. Schuster
Summary: This study aimed to analyze the long-term effect of low birth weight on corneal aberrations in adulthood. The results indicated that low birth weight is associated with increased spherical aberration, which may affect optical image quality and visual function.
JOURNAL OF OPTOMETRY
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Thomas Muenzel, Tommaso Gori
CARDIOVASCULAR RESEARCH
(2023)
Article
Respiratory System
Karsten Keller, Volker H. Schmitt, Mir A. Ostad, Thomas Muenzel, Lukas Hobohm, Christine Espinola-Klein
Summary: Pulmonary embolism is a life-threatening acute disease. Risk stratification of hospitalized patients with PE is crucial. The performance of Mansoor's Self-Report Tool for Cardiovascular Risk Assessment in predicting adverse in-hospital events was evaluated.
CLINICAL RESPIRATORY JOURNAL
(2023)
Editorial Material
Medicine, General & Internal
John F. Keaney, Thomas Muenzel
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Hematology
Karsten Keller, Seyed Hamed Rastguye Haghi, Omar Hahad, Irene Schmidtmann, Sourangsu Chowdhury, Jos Lelieveld, Thomas Muenzel, Lukas Hobohm
Summary: There is a growing body of evidence suggesting that air pollution is associated with an increased risk of cardiovascular diseases. However, there is limited data on the impact of long-term air pollution exposure on ischemic stroke mortality.
THROMBOSIS RESEARCH
(2023)
Article
Hematology
Karsten Keller, Claudia Kohring, Ioannis T. Farmakis, Luca Valerio, Stefano Barco, Joerg Baetzing, Manas K. Akmatov, Stavros Konstantinides, Thomas Muenzel, Lukas Hobohm, Jakob Holstiege
Summary: Recent studies have found a clear association between venous thromboembolism (VTE) and arterial thromboembolism (ATE). This study aimed to evaluate the long-term risk of ATE in VTE patients compared to controls without VTE. The results showed that VTE events were independently associated with an increased occurrence of ATE events during the follow-up period.
THROMBOSIS RESEARCH
(2023)
Review
Cell Biology
Sanela Rajlic, Hendrik Treede, Thomas Muenzel, Andreas Daiber, Georg Daniel Duerr
Summary: Previous studies have shown that oxidative stress plays an important role in the development of cardiovascular disease (CVD) in diabetic patients with high blood sugar. CVD is still the leading cause of premature death in the western world. Therefore, it is crucial to recognize diabetes mellitus-associated oxidative stress and subsequent inflammation as early as possible to initiate appropriate treatment before the occurrence of cardiovascular complications such as hypertension or coronary artery disease (CAD). This review provides an overview of methods for quantifying reactive oxygen and nitrogen species (RONS) production, which originate from different cellular mechanisms in separate cellular compartments, in order to facilitate early detection and effective treatment of these patients and their cardiovascular sequelae.
Article
Cardiac & Cardiovascular Systems
Majid Ahoopai, Martin Geyer, Alexander R. Tamm, Theresa Goessler, Martin Oberhoffer, Franz Masseli, Thomas Muenzel, Ralph Stephan von Bardeleben
Summary: Minimalist approaches in TAVR have shown positive impacts on in-hospital stay and patient safety. In this study, we present a simple piggyback technique to simplify the management of transradial secondary access in transfemoral TAVR.
ECHOCARDIOGRAPHY-A JOURNAL OF CARDIOVASCULAR ULTRASOUND AND ALLIED TECHNIQUES
(2023)
Article
Virology
Volker H. Schmitt, Lukas Hobohm, Ingo Sagoschen, Visvakanth Sivanathan, Omar Hahad, Christine Espinola-Klein, Thomas Muenzel, Karsten Keller
Summary: A study in Germany found that diabetes mellitus (DM) has a significant impact on the clinical outcome of patients with COVID-19 infection. Compared to non-diabetic patients, COVID-19 patients with DM are more likely to develop pneumonia, acute respiratory distress syndrome, require intensive care, and have a higher mortality rate.
Article
Cardiac & Cardiovascular Systems
Omar Hahad, Donya A. Gilan, Julian Chalabi, Sadeer Al-Kindi, Alexander K. Schuster, Felix Wicke, Matthias Buettner, Oliver Tuescher, Karl J. Lackner, Peter R. Galle, Stavros Konstantinides, Andreas Daiber, Philipp S. Wild, Thomas Muenzel
Summary: This study aims to investigate the association between social disadvantage and cardiovascular burden and mortality. The findings suggest that low socioeconomic status is associated with increased risk of cardiovascular disease and mortality, with education and occupation being stronger predictors compared to household net income.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Sebastian Goebel, Arthur Wingerter, Juergen H. Prochaska, Andreas Schulz, Marie A. Neu, Nicole Henninger, Claudia Spix, Manfred Beutel, Karl Lackner, Thomas Muenzel, Carolyn S. Lam, Hiltrud Merzenich, Joerg Faber, Philipp S. Wild
Summary: The CVSS study found that the prevalence of different stages of heart failure in childhood cancer survivors is higher than the general population, but varies significantly based on tumor history. Systolic dysfunction is primarily associated with tumor entities, while diastolic dysfunction is associated with a higher burden of cardiovascular risk factors in childhood cancer survivors.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
