4.7 Article

Maternal nutritional determinants of colostrum fatty acids in the EDEN mother-child cohort

期刊

CLINICAL NUTRITION
卷 37, 期 6, 页码 2127-2136

出版社

CHURCHILL LIVINGSTONE
DOI: 10.1016/j.clnu.2017.10.007

关键词

Maternal determinants; Colostrum PUFA; Pregnant women diet; BMI class; Cohort study

资金

  1. Foundation for Medical Research (FRM)
  2. National Agency for Research (ANR)
  3. National Institute for Research in Public Health (IRESP: TGIR cohorte sante 2008 program)
  4. French Ministry of Health (DGS)
  5. French Ministry of Research
  6. INSERM Bone and Joint Diseases National Research (PRO-A) and Human Nutrition National Research Programs
  7. Paris Sud University
  8. Nestle
  9. French National Institute for Population Health Surveillance (InVS)
  10. French National Institute for Health Education (INPES)
  11. European Union FP7 programme (FP7/2007-2013)
  12. European Union FP7 programme (HELIX)
  13. European Union FP7 programme (ESCAPE)
  14. European Union FP7 programme (ENRIECO)
  15. European Union FP7 programme (Medall projects)
  16. Diabetes National Research Program (French Association of Diabetic Patients (AFD))
  17. ANSES
  18. Mutuelle Generale de l'Education Nationale (MGEN)
  19. French National Agency for Food Security
  20. French-speaking association for the study of diabetes and metabolism (ALFEDIAM)
  21. PremUp foundation (foundation for scientific cooperation in connection with pregnancy and prematurity)
  22. Groupe Lipides Nutrition (GLN)

向作者/读者索取更多资源

Background & aims: Programming of infant development and later health may depend on early-milk polyunsaturated fatty acids (PUFA) contents, that are very variable between women for reasons not well elucidated. Indeed, a high n-6/n-3 PUFA in milk was associated with higher adiposity, arterial pressure and lower psychomotor scores in childhood. We aimed to explore the respective contribution of several maternal and perinatal factors to the variability of linoleic (LA), alpha-linolenic (ALA), arachidonic (AA), and docosahexaenoic (DHA) acid levels in early milk. Methods: Fatty acids of 934 colostrum samples from the EDEN mother-child cohort were analyzed by gas chromatography. The dietary intakes during the last trimester of pregnancy were estimated using a quantitative food frequency questionnaire. Relationship between milk PUFA and dietary fatty acids, and other maternal or pregnancy variables were analyzed by multiple linear regression. Results: The means (+/- SD) of colostrum LA, ALA, AA and DHA levels were, respectively, 9.85 +/- 1.85, 0.65 +/- 0.22, 0.86 +/- 0.16, and 0.64 +/- 0.19% of total fatty acids. Obese mothers colostrum contained the highest level of LA and AA and the lowest level of ALA and DHA. Colostrum LA, AA and DHA levels were higher in primiparous women. Mother's age was positively associated with colostrum AA and DHA. Dietary n-6 PUFA were associated with higher LA and lower DHA levels in colostrum, while dietary n-3 PUFA were related to higher LA and lower AA levels. Contrary to what was observed for DHA, AA level in colostrum was not related to its dietary intake. High dietary AA/DHA and total n-6/n-3 ratios were critical for the content of DHA in colostrum lipids. Conclusions: Our study brings new insights in the understanding of the main maternal factors involved in PUFA levels variability in early milk. These data are important to consider for dietary counseling for women prior to and during pregnancy. (C) 2017 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.

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