Article
Veterinary Sciences
Marisa K. Ames, Shelly L. Vaden, Clarke E. Atkins, Jean-Sebastien Palerme, Catherine E. Langston, Gregory F. Grauer, Sarah Shropshire, Christina Bove, Tracy Webb
Summary: This study found that aldosterone breakthrough is common in dogs receiving RAS inhibitors for CKDp, but it is not associated with proteinuria outcome.
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2022)
Article
Urology & Nephrology
Gertjan Lugthart, Carlijn C. E. Jordans, Anne P. J. de Pagter, Dorine Bresters, Cornelia M. Jol-van der Zijde, Joell E. Bense, Roos W. G. van Rooij-Kouwenhoven, Ram N. Sukhai, Marloes Louwerens, Eiske M. Dorresteijn, Arjan C. Lankester
Summary: This study evaluated pediatric HSCT survivors and found that within ten years post-HSCT, eGFR decreased and 17% of patients developed CKD, with severe prolonged AKI being the main risk factor. Regular monitoring of eGFR, urine, and blood pressure is crucial for identifying patients at risk of CKD and providing nephroprotective interventions.
KIDNEY INTERNATIONAL
(2021)
Review
Urology & Nephrology
Rajiv Agarwal
Summary: Treatment with chlorthalidone shows potential to improve blood pressure control in patients with advanced CKD and treatment-resistant hypertension, but caution is advised, especially when patients are on loop diuretics.
CLINICAL KIDNEY JOURNAL
(2022)
Review
Pharmacology & Pharmacy
Saeed Alshahrani
Summary: Chronic kidney disease is a complex condition with various underlying causes. Current pharmacotherapeutic treatment options aim to slow disease progression and improve quality of life but cannot achieve complete cure. The first-line treatment for controlling blood pressure in chronic kidney disease is the use of renin-angiotensin-aldosterone system modulators. These modulators, including direct renin inhibitors, angiotensin-converting enzyme inhibitors, and angiotensin II receptor blockers, have different structures and mechanisms of action, leading to varying treatment outcomes. The choice of modulator depends on patient presentation, comorbidities, treatment availability and affordability, and healthcare provider expertise. Comparative studies between these modulators are currently lacking, which could provide valuable information for healthcare providers and researchers. This review compares the direct renin inhibitor (aliskiren) with angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers, aiming to identify specific areas of interest for intervention and the best possible treatment option.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Shunichiro Tsukamoto, Tatsuki Uehara, Kengo Azushima, Hiromichi Wakui, Kouichi Tamura
Summary: The incidence of heart failure and chronic kidney disease is increasing, and many patients develop both diseases. Angiotensin receptor-neprilysin inhibitor (ARNI) is a promising therapeutic candidate for both diseases. ARNI has demonstrated superior cardioprotective effects compared with renin-angiotensin system inhibitors (RAS-Is) in large clinical trials. However, it is unclear whether ARNI has long-term renoprotective effects, and it may not provide renoprotective effects beyond RAS-Is in patients with chronic kidney disease.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Editorial Material
Urology & Nephrology
Attilio Losito
Summary: This article discusses the discovery of plasma creatinine and its clearance, the controversies among different research groups, and the forgotten contributions of Giovanni Ferro-Luzzi and his advancements in nephrology.
CLINICAL KIDNEY JOURNAL
(2023)
Article
Urology & Nephrology
Sunjae Bae, JiYoon B. Ahn, Corey Joseph, Ryan Whisler, Mark A. Schnitzler, Krista L. Lentine, Bernard S. Kadosh, Dorry L. Segev, Mara A. McAdams-DeMarco
Summary: Statins appear to be well tolerated in kidney transplant recipients, but their use may be associated with a slightly higher risk of post-transplant diabetes mellitus, cataract, and rhabdomyolysis.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Review
Medicine, General & Internal
Ana Maria Garcia-Prieto, Ursula Verdalles, Marian Goicoechea
Summary: Renin-angiotensin-aldosterone system blockers have shown to be effective in treating hypertension in chronic kidney disease, but there are controversies in some subgroups such as patients with advanced chronic kidney disease or non-proteinuric nephropathies. Further research is needed to explore the benefits and potential risks in these populations.
Article
Medicine, General & Internal
Wenzhu Song, Yanfeng Liu, Lixia Qiu, Jianbo Qing, Aizhong Li, Yan Zhao, Yafeng Li, Rongshan Li, Xiaoshuang Zhou
Summary: This study aimed to construct an early warning model for chronic kidney disease (CKD) tailored to impoverished areas by employing machine learning algorithms. The results showed that machine learning algorithms performed well in classification, indicating their potential as a warning model for CKD.
FRONTIERS IN MEDICINE
(2023)
Article
Medicine, General & Internal
Yuri Battaglia, Francesca Bulighin, Luigi Zerbinati, Nicola Vitturi, Giacomo Marchi, Gianni Carraro
Summary: Fabry disease is a rare genetic disorder caused by a deficiency in the a-galactosidase A enzyme, leading to the accumulation of globotriaosylceramide in various organs, including the kidneys. Nephropathy is a major complication that can progress to end-stage renal disease. SGLT2 inhibitors have recently been approved as innovative drugs for treating chronic kidney disease, and this study aims to evaluate the effect of Dapagliflozin on FD patients with CKD stages 1-3.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Urology & Nephrology
Hiddo L. Heerspink, Niels Jongs, Patrick Schloemer, Dustin J. Little, Meike Brinker, Christoph Tasto, Martin Karpefors, David C. Wheeler, George Bakris, Vlado Perkovic, Richard Nkulikiyinka, Jerome Rossert, Samvel B. Gasparyan
Summary: This study developed and validated a new method for measuring kidney disease progression, which combines clinical importance with composite endpoint components. The method could improve the statistical power of clinical trials.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Peripheral Vascular Disease
Chi D. Chu, Neil R. Powe, Charles E. McCulloch, Tanushree Banerjee, Deidra C. Crews, Rajiv Saran, Jennifer Bragg-Gresham, Hal Morgenstern, Meda E. Pavkov, Sharon H. Saydah, Delphine S. Tuot
Summary: This study observed a slight increase in the prevalence of albuminuria >= 300 mg/g among US adults with hypertension from 2001 to 2018, but no significant changes in the proportion receiving ACE inhibitor/ARB treatment. In the period from 2013 to 2018, the utilization of ACE inhibitor/ARB in adults with diabetes and albuminuria >= 300 mg/g was 55.3%, while it was 33.4% in those without diabetes.
Review
Cell Biology
Mengsi Hu, Qianhui Wang, Bing Liu, Qiqi Ma, Tingwei Zhang, Tongtong Huang, Zhimei Lv, Rong Wang
Summary: Chronic kidney disease (CKD) and cancer have a complex relationship, which may be associated with chronic inflammation, accumulation of carcinogenic compounds, and impaired DNA repair. Understanding this field can be helpful for both nephrologists and oncologists in clinical practice.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Medicine, General & Internal
Kaixi Chang, Yupei Li, Zheng Qin, Zhuyun Zhang, Liya Wang, Qinbo Yang, Baihai Su
Summary: This study aimed to quantify the relationship between alpha-Klotho and urinary albumin-to-creatinine ratio (ACR). The results showed a negative correlation between alpha-Klotho and ACR and revealed a nonlinear relationship between them. The study suggests that alpha-Klotho has potential as a serum marker and prophylactic or therapeutic agent.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Pharmacology & Pharmacy
Joshua Solomon, Maria Carolina Festa, Yiannis S. Chatzizisis, Ratna Samanta, Rita S. Suri, Thomas A. Mavrakanas
Summary: Diabetes leads to an increasing burden of cardiovascular and renal diseases globally, driving the search for new hypoglycemic agents that provide cardiac and renal protective effects. Sodium-glucose co-transporter 2 (SGLT-2) inhibitors, originally developed as hypoglycemic agents, have shown efficacy and safety in patients with chronic kidney disease (CKD) due to their complex mechanisms of action. This review focuses on the pharmacology and pathophysiology of SGLT-2 inhibitors in CKD patients, as well as their cardiovascular and renal effects in this population.
PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Neurosciences
Ayman G. Elnahry, Zainab B. Asal, Noreen Shaikh, Kate Dennett, Mai N. Abd Elmohsen, Gehad A. Elnahry, Azza Shehab, Michal Vytopil, Leila Ghaffari, Geetha K. Athappilly, David J. Ramsey
Summary: This report describes two cases of optic nerve pathology after COVID-19 vaccination and discusses the management implications for post-vaccination central nervous system (CNS) inflammation. The cases involve a 69-year-old woman and a 32-year-old woman who experienced optic nerve issues after receiving the Pfizer-BioNTech and AstraZeneca-Oxford vaccines, respectively. Both patients showed improvement and recovery following treatment.
INTERNATIONAL JOURNAL OF NEUROSCIENCE
(2023)
Article
Genetics & Heredity
James T. Kwan, David J. Ramsey
Summary: This study presents a semi-automated method of image alignment to monitor the progression of inherited retinal degenerations. The results show the case of a 22-year-old woman with inherited retinal degeneration, including the findings from fundus examination and multimodal imaging. The study highlights the utility of image registration and alignment in monitoring disease progression in IRDs.
OPHTHALMIC GENETICS
(2023)
Article
Ophthalmology
Yi Ling Dai, David J. Ramsey, Geetha K. Athappilly, Susan M. Tucker
Summary: ONSF leads to rapid improvement in papilledema and steady recovery in VF in appropriately selected patients.
ORBIT-THE INTERNATIONAL JOURNAL ON ORBITAL DISORDERS-OCULOPLASTIC AND LACRIMAL SURGERY
(2023)
Article
Biochemistry & Molecular Biology
Michael R. R. Duggan, Lauren Butler, Zhongsheng Peng, Gulzar N. N. Daya, Abhay Moghekar, Yang An, Stephen R. R. Rapp, Kathleen M. M. Hayden, Aladdin H. H. Shadyab, Ginny Natale, Longjian Liu, Linda Snetselaar, Ruin Moaddel, Casey M. M. Rebholz, Kevin Sullivan, Christie M. M. Ballantyne, Susan M. M. Resnick, Luigi Ferrucci, Keenan A. A. Walker
Summary: Dysregulation of the immune system and inflammatory dietary patterns may increase the risk for cognitive decline. Proteomic assays of plasma samples identified a group of proteins linked to future cognitive impairment, as well as associations with dementia risk and biomarkers of Alzheimer's disease and neurodegeneration.
MOLECULAR PSYCHIATRY
(2023)
Article
Health Care Sciences & Services
Rachel Munzar, Joseph A. A. Anaya, Claudia Lasalle, Shiyoung Roh, David J. J. Ramsey
Summary: The study aims to evaluate the effectiveness and financial implications of employing a telehealth physician extender program in re-engaging lost-to-follow-up patients with diabetic retinopathy (DR). Randomized patients were assigned to a recall intervention or standard operating procedure (SOP), and the intervention group demonstrated higher rates of appointment scheduling and adherence. The use of a telehealth physician extender improves patient re-engagement at a reasonable cost.
TELEMEDICINE AND E-HEALTH
(2023)
Letter
Cardiac & Cardiovascular Systems
Salim S. S. Virani, David J. J. Ramsey, Dax Westerman, Mark K. K. Kuebeler, Liang Chen, Julia M. M. Akeroyd, Glenn T. T. Gobbel, Christie M. M. Ballantyne, Laura A. A. Petersen, Alexander Turchin, Michael E. E. Matheny
Letter
Cardiac & Cardiovascular Systems
Yiyi Zhang, Jacqueline S. Dron, Brandon K. Bellows, Amit V. Khera, Junxiu Liu, Pallavi P. Balte, Elizabeth C. Oelsner, Sami Samir Amr, Matthew S. Lebo, Anna Nagy, Gina M. Peloso, Pradeep Natarajan, Jerome I. Rotter, Cristen Willer, Eric Boerwinkle, Christie M. Ballantyne, Pamela L. Lutsey, Myriam Fornage, Donald M. Lloyd-Jones, Lifang Hou, Bruce M. Psaty, Joshua C. Bis, James S. Floyd, Ramachandran S. Vasan, Nancy L. Heard-Costa, April P. Carson, Michael E. Hall, Stephen S. Rich, Xiuqing Guo, Dhruv S. Kazi, Sarah D. de Ferranti, Andrew E. Moran
Article
Cardiac & Cardiovascular Systems
Nicolas Girerd, Daniel Levy, Kevin Duarte, Joao Pedro Ferreira, Christie Ballantyne, Timothy Collier, Anne Pizard, Jens Bjoerkman, Javed Butler, Andrew Clark, John G. Cleland, Christian Delles, Javier Diez, Arantxa Gonzalez, Mark Hazebroek, Jennifer Ho, Anne-Cecile Huby, Shih-Jen Hwang, Roberto Latini, Beatrice Mariottoni, Alexandre Mebazaa, Pierpaolo Pellicori, Naveed Sattar, Peter Sever, Jan A. Staessen, Job Verdonschot, Stephane Heymans, Patrick Rossignol, Faiez Zannad
Summary: This study identified protein biomarkers associated with new-onset heart failure in three independent cohorts. The inclusion of these biomarkers in addition to clinical risk factors improved the prediction of heart failure risk. The B-type natriuretic peptide and N-terminal pro-B-type natriuretic peptide were found to be particularly relevant in predicting heart failure.
CIRCULATION-HEART FAILURE
(2023)
Article
Endocrinology & Metabolism
Suzanne V. Arnold, James A. de Lemos, Luke Zheng, Robert S. Rosenson, Christie M. Ballantyne, Shushama Alam, Deepak L. Bhatt, Christopher P. Cannon, Mikhail Kosiborod, GOULD Investigators
Summary: The study aimed to examine the improvement in the use of optimal medical therapy (OMT) for patients with atherosclerotic cardiovascular disease (ASCVD) and diabetes. The study found that the use of secondary prevention in US patients with ASCVD and diabetes was suboptimal, with minimal improvement over time.
DIABETES OBESITY & METABOLISM
(2023)
Article
Pharmacology & Pharmacy
Paul M. Ridker, Lei Lei, Kausik K. Ray, Christie M. Ballantyne, Gary Bradwin, Nader Rifai
Summary: Bempedoic acid (BA) reduces hsCRP and LDL-C levels in patients with atherosclerotic disease and/or familial hypercholesterolemia. It also shows potential anti-inflammatory effects and has similar lipid-lowering and inflammation-inhibiting properties to statin therapy.
JOURNAL OF CLINICAL LIPIDOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Lena Mathews, Xiao Hu, Ning Ding, Junichi Ishigami, Mahmoud Al Rifai, Ron C. C. Hoogeveen, Josef Coresh, Christie M. M. Ballantyne, Elizabeth Selvin, Kunihiro Matsushita
Summary: A study on 9205 participants from the ARIC study found that higher levels of GDF15 protein were associated with bleeding events and improved the prediction of bleeding risk in individuals without cardiovascular disease.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Marina Cuchel, Paul C. Lee, Lisa C. Hudgins, P. Barton Duell, Zahid Ahmad, Seth J. Baum, MacRae F. Linton, Sarah D. de Ferranti, Christie M. Ballantyne, John A. Larry, Linda C. Hemphill, Iris Kindt, Samuel S. Gidding, Seth S. Martin, Patrick M. Moriarty, Paul P. Thompson, James A. Underberg, John R. Guyton, Rolf L. Andersen, David J. Whellan, Irwin Benuck, John P. Kane, Kelly Myers, William Howard, David Staszak, Allison Jamison, Mary C. Card, Mafalda Bourbon, Joana R. Chora, Daniel J. Rader, Joshua W. Knowles, Katherine Wilemon, Mary P. McGowan
Summary: This study investigated the diagnosis and treatment of HoFH in the United States and found a low diagnosis rate and low treatment rate, highlighting the need for enhanced screening and treatment to reduce the burden of the disease.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Brian Olshansky, Deepak L. L. Bhatt, Michael Miller, Ph. Gabriel Steg, Eliot A. A. Brinton, Terry A. A. Jacobson, Steven B. B. Ketchum, Ralph T. T. Doyle Jr, Rebecca A. A. Juliano, Lixia Jiao, Peter R. R. Kowey, James A. A. Reiffel, Jean-Claude Tardif, Christie M. M. Ballantyne, Mina K. K. Chung
Summary: In the REDUCE-IT study, icosapent ethyl (IPE) reduced cardiovascular events but was associated with increased atrial fibrillation/atrial flutter (AF) hospitalization. The study analyzed the relationships between IPE and outcomes in patients with or without prior AF and with or without in-study AF hospitalization. Overall, in-study AF hospitalization rates were higher in patients with prior AF, especially in those randomized to IPE. Serious bleeding rates also trended higher in these patients. However, patients with prior AF or in-study AF hospitalization showed consistent risk reductions in cardiovascular events with IPE.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Ophthalmology
F. Sema Akkan Aydogmus, Oluchukwu Onwuka, Jackson Saddemi, Claudia C. Lasalle, David J. Ramsey
Summary: This study compared visual and anatomical outcomes for patients with sequential neovascular age-related macular degeneration (nAMD), both at diagnosis and one year after treatment. Results showed that second eyes had better visual acuity and smaller pigment epithelial detachment (PED) heights at diagnosis and at one year after treatment compared to first eyes. This may be due to earlier diagnosis enabled by monitoring.
Article
Cardiac & Cardiovascular Systems
Austin Deets, Parag H. Joshi, Alvin Chandra, Kavisha Singh, Amit Khera, Salim S. Virani, Christie M. Ballantyne, James D. Otvos, Robin P. F. Dullaart, Eke G. Gruppen, Margery A. Connelly, Colby Ayers, Ann Marie Navar, Ambarish Pandey, John T. Wilkins, Anand Rohatgi
Summary: This study aimed to assess the association between levels of specific size-based HDL subspecies and atherosclerotic cardiovascular disease, and investigate their role in risk prediction.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)