期刊
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
卷 13, 期 11, 页码 1633-1640出版社
AMER SOC NEPHROLOGY
DOI: 10.2215/CJN.04910418
关键词
interventional nephrology; kidney biopsy; kidney failure; risk factors; ultrasonography; kidney pathology; blood transfusion; female; adult; prospective studies; multivariable analysis; Blood Urea Nitrogen; Confidence Intervals; Platelet Count; Angiography; Acute Kidney Injury; biopsy; Tomography; X-Ray Computed; Hematoma; hospitalization; Hemoglobins; Cohort Studies
资金
- National Institutes of Health (NIH) [K24DK090203]
- NIH [T32DK007276, K23DK097201, R01DK113191, T32DK007757, K23DK107908]
- Robert E. Leet and Clara Guthrie Patterson Trust Mentored Clinical Research Award
- American Heart Association [18CDA34060118]
- National Institute of Diabetes and Digestive and Kidney Diseases [UG3-DK114866]
Background and objectives Patients are informed of the risk of kidney biopsy-related complications using data from nonhospitalized patients, which may underestimate the risk for hospitalized patients. We evaluated the rate and risk factors of kidney biopsy-related complications in hospitalized patients with acute kidney disease (AKD) to better estimate the risk in this population. Design, setting, participants, & measurements We used data from the Yale biopsy cohort to evaluate rates of kidney biopsy-related complications including adjudicated procedure-related bleeding requiring blood transfusions or angiographic interventions, medium- or large-sized hematomas, reimaging after biopsy including abdominal ultrasonography or computed tomography, and death in hospitalized patients with AKD (including AKI). We evaluated univariable and multivariable association of risk factors with transfusions. We compared rates of complications between hospitalized and nonhospitalized patients. Results Between 2015 and 2017, 159 hospitalized patients underwent a kidney biopsy for AKD evaluation, of which 80 (51%) had stage 1 AKI, 42 (27%) had stage 2 (or higher) AKI, and 27 (17%) had AKD (without AKI). Of these, 12 (8%; 95% confidence interval [95% CI], 5% to 15%) required a transfusion, three (2%; 95% CI, 1% to 5%) required an intervention, 11 (7%; 95% CI, 4% to 12%) had hematoma, and 31 (20%; 95% CI, 14% to 26%) required reimaging after biopsy. Of the four (3%; 95% CI, 1% to 6%) deaths during hospitalization, none were related to the biopsy. Female sex, lower platelet count, and higher BUN were associated with postbiopsy transfusions on univariable and multivariable analyses. Trainee as proceduralist and larger needle gauge were associated with transfusions in univariable, but not multivariable, analysis. Nonhospitalized patients had lower rates of transfusion than hospitalized patients, although the latter also had lower prebiopsy hemoglobin and greater surveillance after biopsy. ConclusionsHospitalized patients experience higher risk of postbiopsy complications than previously reported and several factors, such as lower platelet count, female sex, and higher BUN, are associated with this risk.
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