Article
Hematology
Yifan Pang, Ananth Charya, Michael B. Keller, Arlene Sirajuddin, Yi-Ping Fu, Noa G. Holtzman, Steven Z. Pavletic, Sean Agbor-Enoh
Summary: This study adapted the 2019 International Society for Heart and Lung Transplantation criteria to define novel phenotypes of pulmonary chronic graft-versus-host disease (PcGVHD) and compared its performance with the NIH criteria in identifying high-risk PcGVHD patients. The adapted criteria were found to be effective in identifying high-risk PcGVHD patients that were missed by the NIH criteria.
Article
Infectious Diseases
Hugo Testaert, Margaux Bouet, Florent Valour, Anne Gigandon, Marie -Edith Lafon, Francois Philit, Agathe Senechal, Jean-Sebastien Casalegno, Elodie Blanchard, Jerome Le Pavec, Florence Ader
Summary: This study analysed the impact of antimicrobial treatments on functional outcomes in adult lung transplant recipients with RSV-confirmed infection. It was found that 28.8% of recipients developed new allograft dysfunction at 3 months post-infection. Ribavirin treatment and azithromycin prophylaxis did not prevent decline in lung function.
CLINICAL MICROBIOLOGY AND INFECTION
(2021)
Article
Medicine, Research & Experimental
Aaditya Khatri, Jamie L. . Todd, Fran L. . Kelly, Andrew Nagler, Zhicheng Ji, Vaibhav Jain, Simon G. Gregory, Kent J. Weinhold, Scott M. Palmer
Summary: Chronic lung allograft dysfunction (CLAD), characterized by decline in pulmonary function and bronchiolitis obliterans, lacks approved therapies. Single-cell RNA-Seq and spatial transcriptomic analysis identified the important role of JAK-STAT signaling in airway epithelial cells in CLAD. Activation of JAK-STAT signaling leads to upregulation of MHC-I in airway basal cells, resulting in cytotoxic T cell-mediated basal cell death. This study provides mechanistic insight and potential therapeutic strategy for CLAD.
Review
Medicine, Research & Experimental
Aparna C. Swaminathan, Jamie L. Todd, Scott M. Palmer
Summary: Lung transplantation has substantially increased in volume in recent decades, with advances being made in understanding and treating post-transplant complications like CLAD. Ongoing studies are exploring novel approaches to improve long-term outcomes for lung transplant recipients.
ANNUAL REVIEW OF MEDICINE, VOL 72, 2021
(2021)
Review
Respiratory System
Sara Assadiasl, Mohammad Hossein Nicknam
Summary: Post-transplant care and patients' survival in lung transplantation need improvement, and cytokine monitoring pre- and post-transplant could be used for prevention and early diagnosis of inflammatory events, providing new therapeutic options to enhance lung allograft survival.
Article
Cardiac & Cardiovascular Systems
Siddhartha G. Kapnadak, Eric D. Morrell, Travis Hee Wai, Christopher H. Goss, Pali D. Shah, Christian A. Merlo, Ramsey R. Hachem, Kathleen J. Ramos
Summary: This study investigated the practices of azithromycin use among lung transplant providers internationally. The results showed significant variations in indications, timing, and dosing of azithromycin, with even inconsistencies within the same center. Most providers initiated azithromycin after the occurrence of risk factors and/or events related to chronic lung allograft dysfunction (CLAD).
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2022)
Review
Immunology
Barbara N. Porto
Summary: The virome refers to the viral component of the microbiome, including all viruses that inhabit the human body. Despite previous limitations in accurately characterizing viruses, recent advancements in methods such as deep sequencing and metagenomics have allowed for a better understanding of the diverse viral species present in the human body.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Medicine, General & Internal
Trieu-Nghi Hoang-Thi, Guillaume Chassagnon, Thong Hua-Huy, Veronique Boussaud, Anh-Tuan Dinh-Xuan, Marie-Pierre Revel
Summary: Quantitative imaging methods play a key role in early identification and prognostic estimation of CLAD, with the need for novel approaches to predict, understand, and identify CLAD in its early stages. However, there are limitations to be addressed in quantitative imaging for evaluating CLAD.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Respiratory System
Jesper M. Magnusson, Petrea Ericson, Sara Tengvall, Marit Stockfelt, Bettina Brundin, Anders Linden, Gerdt C. Riise
Summary: This pilot study revealed a significant increase in extracellular IL-26 protein concentration in BAL samples from patients with BOS, but not in samples from patients with AR. Macrophages and lymphocytes were identified as cellular sources of IL-26 protein in BAL cells obtained from BOS patients.
RESPIRATORY RESEARCH
(2022)
Article
Cell Biology
Laura Bergantini, Miriana d'Alessandro, Elda De Vita, Felice Perillo, Antonella Fossi, Luca Luzzi, Piero Paladini, Anna Perrone, Paola Rottoli, Piersante Sestini, Elena Bargagli, David Bennett
Summary: In acute rejection (AR) and chronic lung allograft dysfunction, the balance between immune cells is different, with a predominance of Th17 cells subtypes and depletion of Tregs observed in AR patients. Understanding the balance between regulatory and effector cells can effectively discriminate patients' immunological status.
Article
Cardiac & Cardiovascular Systems
Wai Wong, Brandy Johnson, Pi Chun Cheng, Maureen B. Josephson, Katsuhide Maeda, Robert A. Berg, Steven M. Kawut, Michael O. Harhay, Samuel B. Goldfarb, Nadir Yehya, Adam S. Himebauch
Summary: This study aimed to investigate the impact of grade 3 PGD within 48 or 72 hours on CLAD-free survival following pediatric lung transplantation. The study found that the occurrence of grade 3 PGD within 48 or 72 hours was associated with shorter CLAD-free survival, and gender may be a modifier of this association.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2023)
Article
Respiratory System
Micheal C. McInnis, Jin Ma, Gauri Rani Karur, Christian Houbois, Liran Levy, Jan Havlin, Eyal Fuchs, Jussi Tikkanen, Chung-Wai Chow, Ella Huszti, Tereza Martinu
Summary: In this study, a machine learning computed tomography (CT) lung texture analysis tool was used for phenotyping and prognostication of chronic lung allograft dysfunction (CLAD) in lung transplant recipients. The results showed that machine learning could effectively distinguish different CLAD phenotypes, and the associated parameters were able to predict the risk of graft failure.
EUROPEAN RESPIRATORY JOURNAL
(2022)
Review
Medicine, General & Internal
Christophe Pison, Adrien Tissot, Eric Bernasconi, Pierre-Joseph Royer, Antoine Roux, Angela Koutsokera, Benjamin Coiffard, Benjamin Renaud-Picard, Jerome Le Pavec, Pierre Mordant, Xavier Demant, Thomas Villeneuve, Jean-Francois Mornex, Simona Nemska, Nelly Frossard, Olivier Brugiere, Valerie J. Siroux, Benjamin Marsland, Aurore Foureau, Karine Botturi, Eugenie Durand, Johann Pellet, Richard Danger, Charles Auffray, Sophie Brouard, Laurent Nicod, Antoine Magnan
Summary: SysCLAD is a research aiming to predict chronic lung allograft dysfunction (CLAD), which involves investigating various factors including clinical data, assessment of airway microbiota, air pollution studies, activation of immune cells, secretion of matrix metalloproteinase-9 by T cells, subpopulations of T and B cells, genome polymorphisms, blood transcriptome, plasma proteome studies, and MSK1 expression to develop predictors of CLAD.
FRONTIERS IN MEDICINE
(2023)
Article
Medicine, General & Internal
Jesper Romhild Davidsen, Christian B. Laursen, Mikkel Hojlund, Thomas Kromann Lund, Klaus Nielsen Jeschke, Martin Iversen, Anna Kalhauge, Elisabeth Bendstrup, Jorn Carlsen, Michael Perch, Daniel Pilsgaard Henriksen, Hans Henrik Lawaetz Schultz
Summary: This study found that pleural thickening identified by lung ultrasound may serve as a potential surrogate marker to distinguish restrictive allograft syndrome (RAS) from bronchiolitis obliterans syndrome (BOS) in chronic lung allograft dysfunction (CLAD) patients after lung transplant. This discovery provides a new method for clinical diagnosis of CLAD patients post lung transplant.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Critical Care Medicine
Jarrod E. Dalton, Carli J. Lehr, Paul R. Gunsalus, Lyla Mourany, Maryam Valapour
Summary: This study examined the performance of models predicting waitlist and posttransplant survival in lung transplant allocation. The results showed that different models had similar performance in predicting waitlist and posttransplant survival, and using alternative modeling strategies and contemporary cohorts did not improve the models' performance in determining access to lung transplant.
Article
Infectious Diseases
Ricard Ferrer, Jose Garnacho-Montero, Pedro Rascado, Sofia Contreras, Luisa Canton-Bulnes, Patricia Barral, Ines del Cerro, Xavier Badia
Summary: This study investigated the use of resources associated with the clinical management of carbapenem-resistant Gram-negative bacteria (CRGN) infections. It found that CRGN infections consume a significant amount of healthcare resources, with length of hospital stay being the main driver of total costs.
ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA
(2023)
Article
Critical Care Medicine
G. Moreno, M. Ruiz-Botella, I Martin-Loeches, J. Gomez Alvarez, M. Jimenez Herrera, M. Bodi, F. Armestar, A. Marques Parra, A. Estella, S. Trefler, R. Jorge Garcia, J. Murcia Paya, P. Vidal Cortes, E. Diaz, R. Ferrer, A. Albaya-Moreno, L. Socias-Crespi, J. M. Bonell Goytisolo, S. Sancho Chinesta, A. Loza, L. Forcelledo Espina, J. C. Pozo Laderas, M. DeAlba-Aparicio, L. Sanchez Montori, I Vallverdu Perapoch, V Hidalgo, V Fraile Gutierrez, A. M. Casamitjana Ortega, F. Martin Serrano, M. Nieto, M. Blasco Cortes, J. Marin-Corral, J. Sole-Violan, A. Rodriguez
Summary: This study aimed to determine the association between corticosteroid use and ICU mortality in both the whole population and pre-specified clinical phenotypes. The results showed that corticosteroids were not associated with ICU mortality in the overall population, but they may have a protective effect in patients with the highest inflammatory levels.
MEDICINA INTENSIVA
(2023)
Editorial Material
Infectious Diseases
Antoni Torres, Ricard Ferrer, Jorge Mestre-Ferrandiz, Jose Maria Eiros
ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA
(2023)
Article
Respiratory System
Jordi Riera, Enric Barbeta, Adrian Tormos, Ricard Mellado-Artigas, Adrian Ceccato, Anna Motos, Laia Fernandez-Barat, Ricard Ferrer, Dario Garcia-Gasulla, Oscar Penuelas, Jose Angel Lorente, Rosario Menendez, Oriol Roca, Andrea Palomeque, Carlos Ferrando, Jordi Sole-Violan, Mariana Novo, Maria Victoria Boado, Luis Tamayo, Angel Estella, Cristobal Galban, Josep Trenado, Arturo Huerta, Ana Loza, Luciano Aguilera, Jose Luis Garcia Garmendia, Carme Barbera, Victor Gumucio, Lorenzo Socias, Nieves Franco, Luis Jorge Valdivia, Pablo Vidal, Victor Sagredo, Angela Leonor Ruiz-Garcia, Ignacio Martinez Varela, Juan Lopez, Juan Carlos Pozo, Maite Nieto, Jose M. Gomez, Aaron Blandino, Manuel Valledor, Elena Bustamante-Munguira, Angel Sanchez-Miralles, Yhivian Penasco, Jose Barberan, Alejandro Ubeda, Rosario Amaya-Villar, Maria Cruz Martin, Ruth Jorge, Jesus Caballero, Judith Marin, Jose Manuel Anon, Fernando Suarez Sipmann, Guillermo M. Albaiceta, Alvaro Castellanos-Ortega, Berta Adell-Serrano, Mercedes Catalan, Amalia Martinez de la Gandara, Pilar Ricart, Cristina Carbajales, Alejandro Rodriguez, Emili Diaz, Mari C. de la Torre, Elena Gallego, Luisa Canton-Bulnes, Nieves Carbonell, Jessica Gonzalez, David de Gonzalo-Calvo, Ferran Barbe, Antoni Torres
Summary: The study investigated the association between intubation timing and hospital mortality in critically ill COVID-19 patients. Delayed intubation was found to be associated with a higher risk of mortality, while early intubation reduced mortality. The use of early intubation decreased as the pandemic progressed.
EUROPEAN RESPIRATORY JOURNAL
(2023)
Review
Critical Care Medicine
Pedro Povoa, Luis Coelho, Felipe Dal-Pizzol, Ricard Ferrer, Angela Huttner, Andrew Conway Morris, Vandack Nobre, Paula Ramirez, Anahita Rouze, Jorge Salluh, Mervyn Singer, Daniel A. Sweeney, Antoni Torres, Grant Waterer, Andre C. Kalil
Summary: Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. Biomarkers can be used as indicators for infection, dysregulated host response, treatment response, and can aid in prognosticating patient risk. Over 250 biomarkers have been identified and evaluated, but none can accurately differentiate between sepsis and sepsis-like syndrome.
INTENSIVE CARE MEDICINE
(2023)
Article
Immunology
Patricia Montiel Villalonga, Itziar Martinez-Alpuente, Mario Fernandez-Ruiz, Oscar Len, Marta Bodro, Ibai Los-Arcos, Jose Moya, Braulio de la Calle, Manuela Cid-Cumplido, Gerard Sanchez-Etayo, Ana Avila, Gabriel Moreno-Gonzalez, Elisabeth Coll, Beatriz Dominguez-Gil
Summary: This nationwide prospective study explored the utilization of non-lung organs from deceased donors with a positive SARS-CoV-2 PCR test. The results supported the safety of this policy, as the transplant recipients did not get infected with the virus and showed no symptoms of COVID-19 prior to transplantation.
TRANSPLANT INFECTIOUS DISEASE
(2023)
Article
Microbiology
Marta Palau, Estela Munoz, Nieves Larrosa, Xavier Gomis, Ester Marquez, Oscar Len, Benito Almirante, Joan Gavalda
Summary: Biofilm-producing microorganisms are medically crucial and cause 80% of human infections. This study evaluated the efficacy of hyperthermia in preventing biofilm formation in vitro and in a rabbit model. The results showed that hyperthermia can effectively prevent biofilm formation under specific temperature and time conditions.
MICROBIOLOGY SPECTRUM
(2023)
Article
Transplantation
Cristina Perez-Cameo, Isabel Oriol, Mayli Lung, Laura Llado, Cristina Dopazo, Xavier Nuvials, Ibai Los-Arcos, Nuria Sabe, Lluis Castells, Oscar Len
Summary: This study investigated whether prophylactic use of norfloxacin increased the risk of multidrug-resistant bacterial infections in the early posttransplant period. The results showed that liver transplant recipients who received prophylactic norfloxacin had a higher risk of multidrug-resistant bacterial infections during the first month after transplant.
EXPERIMENTAL AND CLINICAL TRANSPLANTATION
(2023)
Article
Cardiac & Cardiovascular Systems
Rosa Vila-Olives, Aitor Uribarri, Maria Martinez-Martinez, Eduard Argudo, Camilo Bonilla, Luis Chiscano, Lorena Herrador, Alejandra Gabaldon, Irene Buera, Maria Vidal, Ana De la Iglesia, Maria Angeles Diaz, Elena Lopez, Marta A. Font, Jose A. Barrabes, Jordi Riera, Ignacio Ferreira-Gonzalez, Ricard Ferrer
Summary: Two cases of myocarditis after COVID-19 mRNA vaccines were presented, and both patients required support with V-A ECMO. Treatment included peripheral V-A ECMO, left ventricular unloading, and high-dose corticosteroids. Both cases achieved significant recovery and were discharged successfully.
Article
Multidisciplinary Sciences
Luis Felipe Reyes, Alejandro Rodriguez, Yuli V. Fuentes, Sara Duque, Esteban Garcia-Gallo, Alirio Bastidas, Cristian C. Serrano-Mayorga, Elsa D. Ibanez-Prada, Gerard Moreno, Paula C. Ramirez-Valbuena, Gustavo Ospina-Tascon, Glenn Hernandez, Edwin Silva, Ana Maria Diaz, Manuel Jibaja, Magdalena Vera-Alarcon, Emili Diaz, Maria Bodi, Jordi Sole-Violan, Ricard Ferrer, Antonio Albaya-Moreno, Lorenzo Socias, William Figueroa, Jose L. Lozano-Villanueva, Fabio Varon-Vega, Angel Estella, Ana Loza-Vazquez, Ruth Jorge-Garcia, Isabel Sancho, Manu Shankar-Hari, Ignacio Martin-Loeches
Summary: Around one-third of patients diagnosed with COVID-19 develop a severe illness that requires ICU admission. Severe COVID-19 patients admitted to the ICU frequently develop ventilator-associated lower respiratory tract infections (VA-LRTI). This multicentre study analyzed the clinical characteristics, factors associated with VA-LRTI, and its impact on clinical outcomes in severe COVID-19 patients. The study found that VA-LRTI is common in ICU-admitted patients with severe COVID-19 and is associated with worse clinical outcomes.
SCIENTIFIC REPORTS
(2023)
Article
Medicine, General & Internal
Peter Pickkers, Derek C. Angus, Jacques Arend, Rinaldo Bellomo, Erik van den Berg, Juliane Bernholz, Morten Bestle, Kristine Broglio, Jan Carlsen, Christopher J. Doig, Ricard Ferrer, Michael Joannidis, Bruno Francois, Kent Doi, John A. Kellum, Pierre-Francois Laterre, Kathleen Liu, Ravindra L. Mehta, Patrick T. Murray, Marlies Ostermann, Ville Pettila, Sharon Richards, Paul Young, Alexander Zarbock, Anne Louise Kjolbye
Summary: This study investigates the efficacy of alkaline phosphatase (ALP) in patients with sepsis-associated acute kidney injury (AKI). A phase 2 trial showed that a recombinant human ALP compound, ilofotase alfa, significantly improved renal function and reduced all-cause mortality within 28 days. A phase 3 trial is currently ongoing to confirm these findings.
Article
Respiratory System
C. Cilloniz, A. Motos, J. M. Pericas, T. G. Castaneda, A. Gabarrus, R. Ferrere, D. Garcia-Gasulla, O. Penuelas, D. de Gonzalo-Calvo, L. Fernandez-Barat, F. Barbe, A. Torres
Review
Medicine, General & Internal
Francisco Javier Candel, Miguel Salavert, Angel Estella, Miquel Ferrer, Ricard Ferrer, Julio Javier Gamazo, Carolina Garcia-Vidal, Juan Gonzalez del Castillo, Victor Jose Gonzalez-Ramallo, Federico Gordo, Manuel Miron-Rubio, Javier Perez-Pallares, Cristina Pitart, Jose Luis del Pozo, Paula Ramirez, Pedro Rascado, Soledad Reyes, Patricia Ruiz-Garbajosa, Borja Suberviola, Pablo Vidal, Rafael Zaragoza
Summary: Nosocomial pneumonia and ventilator-associated pneumonia are significant global health problems, causing high morbidity and mortality rates. This scientific manuscript reviews important aspects of the management of these infectious respiratory syndromes, providing updates on etiological perspectives, diagnostic techniques, treatment options, and preventive strategies.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Geriatrics & Gerontology
Marco Falcone, Michael Bauer, Ricard Ferrer, Gaetan Gavazzi, Juan Gonzalez del Castillo, Alberto Pilotto, Philipp Schuetz
Summary: The optimal treatment of infections in the elderly population is challenging due to less specific clinical symptoms and signs. Elderly patients have a weaker immune response to infection and may be at risk of both over- and undertreatment. The use of biomarkers, particularly procalcitonin (PCT), has shown potential in assessing the risk of septic complications and guiding antibiotic treatment decisions in elderly patients.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2023)
Article
Microbiology
Ricard Ferrer, Juan Gonzalez del Castillo, Maria Martinez-Martinez, Erika P. Plata-Menchaca, M. Nieves Larrosa
Summary: This study aimed to identify the common barriers causing delays in initial management, microbiological diagnosis, and appropriate empirical antimicrobial treatment in sepsis. A cross-sectional survey was conducted, and valid surveys were collected from healthcare personnel in various hospital areas. The study found significant barriers in Spanish hospitals that hinder adequate management processes in sepsis.
REVISTA ESPANOLA DE QUIMIOTERAPIA
(2023)