Article
Multidisciplinary Sciences
Michal Largman-Chalamish, Asaf Wasserman, Adi Silberman, Tal Levinson, Omri Ritter, Shlomo Berliner, David Zeltser, Itzhak Shapira, Ori Rogowski, Shani Shenhar-Tsarfaty
Summary: This study utilized estimated C-reactive protein velocity (eCRPv) to differentiate between acute viral and bacterial infections. By dividing the admission CRP level by time from symptom onset, eCRPv can provide a rapid and accurate differentiation, especially for patients with high CRP values.
Article
Pediatrics
Maria Hartiala, Elina Lahti, Laura Toivonen, Matti Waris, Olli Ruuskanen, Ville Peltola
Summary: A study analyzed blood samples from children hospitalized with pneumonia and found that 6 of them had rhinovirus (RV) infection, among which 4 had bacterial infections. RV-positive pneumonia differs from pneumonia caused by other viruses and requires further investigation.
FRONTIERS IN PEDIATRICS
(2023)
Review
Immunology
Iole Macchia, Valentina La Sorsa, Francesca Urbani, Sonia Moretti, Caterina Antonucci, Claudia Afferni, Giovanna Schiavoni
Summary: Eosinophils are important in allergic asthma and parasitic infections, but they also participate in the immune response against respiratory viruses. In the context of COVID-19, eosinophils can serve as potential biomarkers for diagnosis, prognosis, and severity prediction. This review provides an overview of the role of eosinophils in various respiratory viral infections and discusses their utility as prognostic/predictive immune biomarkers in emerging respiratory viral diseases, particularly COVID-19.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Bernt Hjertner, Claudia Lutzelschwab, Elise Schieck, Benjamin Nzau, Sonal Henson, Marie Sjolund, Caroline Fossum, Ulf Magnusson
Summary: This study evaluated the potential of genes considered biomarkers in humans to differentially diagnose bacterial from viral infections in pigs. Utilizing these genes, infected pigs could be effectively distinguished from healthy pigs.
Article
Infectious Diseases
Samuel Rhedin, Annika Eklundh, Malin Ryd-Rinder, Ville Peltola, Matti Waris, Jesper Gantelius, Magnus Lindh, Maria Andersson, Giulia Gaudenzi, Andreas Martensson, Pontus Naucler, Tobias Alfven
Summary: The study aimed to assess the differences in blood MxA levels between children with viral and bacterial lower respiratory tract infection (LRTI). The results showed that children with viral LRTI had higher MxA levels, especially in the subgroup of children with pneumonia diagnosis, MxA accurately discriminated between viral and bacterial aetiology.
CLINICAL MICROBIOLOGY AND INFECTION
(2022)
Article
Infectious Diseases
Matthaeus Metz, Guido A. Gualdoni, Heide-Maria Winkler, Alexandra-Maria Warenits, Johannes Stoeckl, Heinz Burgmann, Stefan Winkler, Zoe Anne Oesterreicher
Summary: In this prospective exploratory study, we measured monocyte MxA expression in 61 adults with different viral, bacterial, and co-infections. We found that monocyte MxA expression was significantly higher in virus-infected patients compared to bacterial infections. This study confirms the diagnostic value of MxA in differentiating viral and bacterial infections and suggests its usefulness as a biomarker in immunocompromised patients.
Article
Virology
Dhiviya Vedagiri, Divya Gupta, Anurag Mishra, Gayathri Krishna, Meenakshi Bhaskar, Vishal Sah, Anirban Basu, Debasis Nayak, Manjula Kalia, Mohanan Valiya Veettil, Krishnan Harinivas Harshan
Summary: RLRs play a crucial role in sensing viral RNA and activating type I IFNs. This study reveals a novel mechanism of Snail transcriptional regulation during RNA viral infections, indicating its role in antiviral response. Snail regulates the RLR pathway and enhances antiviral functions, offering insights into potential coregulation of innate antiviral pathways by RLRs.
JOURNAL OF VIROLOGY
(2021)
Review
Cell Biology
Ana Rita Ferreira, Mariana Marques, Bruno Ramos, Jonathan C. Kagan, Daniela Ribeiro
Summary: Peroxisomes, essential subcellular organelles, play crucial roles in lipid and reactive oxygen species metabolism, and have recently been recognized as key players in viral infections. They are involved in both cellular antiviral response and proviral functions. Targeting peroxisome-related mechanisms may represent a promising strategy for the development of novel antiviral approaches in the future.
TRENDS IN CELL BIOLOGY
(2022)
Article
Immunology
Robert S. Wallis, Anne O'Garra, Alan Sher, Andreas Wack
Summary: This Perspective reflects on the historical development of host-directed immunotherapeutic interventions for viral and bacterial infections, and discusses their application to current approaches to therapy of SARS-CoV-2 and Mycobacterium tuberculosis infections.
NATURE REVIEWS IMMUNOLOGY
(2023)
Article
Medicine, Research & Experimental
Faisal Mahmood, Ruixian Xu, Maher Un Nisa Awan, Yuzhu Song, Qinqin Han, Xueshan Xia, Jinyang Zhang
Summary: The role of PDIA3 in catalyzing disulphide bonds, acting as a chaperone, and its association with cancer, cellular stress, and viral infections is highlighted. Inhibitors targeting PDIA3 show potential in interfering with viral infections, suggesting a promising avenue for future research in combating viral diseases.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Pediatrics
Samuel Rhedin, Kristina Elfving, Anna Berggren
Summary: Distinguishing between viral and bacterial infections in febrile children remains challenging and there is a need for more accurate diagnostic tools. Recent studies have focused on host-pathogen interactions to identify pathogen-specific biomarkers as potential future diagnostic tools. Promising novel biomarkers are in development, but well-designed randomized controlled trials are necessary to evaluate their safety and effectiveness in guiding clinical decisions.
Article
Infectious Diseases
Konstantina Iliopoulou, Panagiotis Koufargyris, Sarantia Doulou, Elisavet Tasouli, Sokratis Katopodis, Stavroula-Porphyria Chachali, Georgios Schinas, Charalampos Karachalios, Myrto Astriti, Paraskevi Katsaounou, George Chrysos, Theodoros Seferlis, Effrosyni Dimopoulou, Myrto Kollia, Garyphalia Poulakou, Styliani Gerakari, Ilias C. Papanikolaou, Haralampos Milionis, George N. Dalekos, Vasiliki Tzavara, Theano Kontopoulou, Evangelos J. Giamarellos-Bourboulis
Summary: The study aimed to assess the performance of a blood assay combining measurements of MxA and CRP to differentiate viral from bacterial respiratory infections. The results demonstrated that calculating the probability for bacterial infection using MxA and CRP can efficiently discriminate between different types of infections.
INFECTIOUS DISEASES AND THERAPY
(2023)
Article
Immunology
Ni An, Qinghua Ge, Huihan Shao, Quanjie Li, Fei Guo, Chen Liang, Xiaoyu Li, Dongrong Yi, Long Yang, Shan Cen
Summary: SAMHD1 plays a crucial role in inhibiting flaviviruses infection by targeting lipid bio-metabolic pathway in an IFN-mediated manner. Through down-regulating genes related to lipid bio-metabolic pathway, SAMHD1 impairs lipid droplets formation and inhibits viral replication, highlighting the importance of lipid metabolism in antiviral defense.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Zerina Rahic, Emanuele Buratti, Sara Cappelli
Summary: TDP-43, a RNA-binding protein, is involved in neurological disorders and recent studies have shown its potential important role in viral entry, replication and latency.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Microbiology
Ruut Piri, Mohamed Yahya, Lauri Ivaska, Laura Toivonen, Johanna Lempainen, Kirsi Nuolivirta, Lav Tripathi, Matti Waris, Ville Peltola
Summary: A biomarker called MxA showed moderate accuracy in differentiating viral infections from bacterial infections in children. It can help reduce antibiotic overuse and improve diagnostic accuracy, especially when combined with biomarkers for bacterial infections.
MICROBIOLOGY SPECTRUM
(2022)
Article
Immunology
Elena V. Navolotskaya, Vladimir B. Sadovnikov, Dmitry V. Zitichenko, Valery M. Lipkin, Vladimir P. Zav'yalov
INTERNATIONAL IMMUNOPHARMACOLOGY
(2017)
Article
Toxicology
Elena V. Navolotskaya, Vladimir B. Sadovnikov, Valery M. Lipkin, Vladimir P. Zav'yalov
TOXICOLOGY IN VITRO
(2018)
Article
Multidisciplinary Sciences
Sergey Ryazantsev, Vladimir Tischenko, Christopher Nguyen, Vyacheslav Abramov, Vladimir Zav'yalov
Review
Microbiology
Anton Zavialov, Galina Zav'yalova, Timo Korpela, Vladimir Zav'yalov
FEMS MICROBIOLOGY REVIEWS
(2007)
Article
Biochemistry & Molecular Biology
AV Zavialvo, VM Tischenko, LJ Fooks, BO Brandsdal, J Åqvist, VP Zav'Yalov, S MacIntyre, SD Knight
BIOCHEMICAL JOURNAL
(2005)
Article
Biochemistry & Molecular Biology
VM Tischenko, GA Zav'yalova, OP Bliznyukov, VP Zav'yalov
MOLECULAR IMMUNOLOGY
(2004)
Article
Immunology
VM Tischenko, GA Zav'yalova, VP Zav'yalov
IMMUNOLOGY LETTERS
(2003)
Article
Immunology
VM Tischenko, VP Zav'yalov
IMMUNOLOGY LETTERS
(2003)
Article
Biochemistry & Molecular Biology
RV Chertkova, ZK Abdullaev, DA Dolgikh, VP Zav'yalov, MP Kirpichnikov
RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY
(2003)
Article
Immunology
VM Tischenko, VP Zav'yalov
IMMUNOLOGY LETTERS
(2002)
Article
Biochemistry & Molecular Biology
AV Zavialov, J Kersley, T Korpela, VP Zav'yalov, S MacIntyre, SD Knight
MOLECULAR MICROBIOLOGY
(2002)
Article
Biochemistry & Molecular Biology
EV Navolotskaya, TA Zargarova, NV Malkova, SB Krasnova, VP Zav'yalov, VM Lipkin
Article
Biochemistry & Molecular Biology
EV Navolotskaya, NV Malkova, TA Zargarova, TN Lepikhova, VP Zav'yalov, VM Lipkin
Article
Biochemistry & Molecular Biology
EV Navolotskaya, AA Kolobov, EA Kampe-Nemm, TA Zargarova, NV Malkova, SB Krasnova, YA Kovalitskaya, VP Zav'yalov, VM Lipkin
BIOCHEMISTRY-MOSCOW
(2003)