期刊
WORLD JOURNAL OF STEM CELLS
卷 7, 期 2, 页码 495-501出版社
BAISHIDENG PUBLISHING GROUP INC
DOI: 10.4252/wjsc.v7.i2.495
关键词
Stem cell niche; Epidermal stem cells; Integrins; Type IV collagen; MiR135b
资金
- Korea Healthcare Technology R and D Project by Ministry for Health, Welfare and Family Affairs, South Korea [A103017, HN10C0001]
Within the epidermis and dermis of the skin, cells secrete and are surrounded by the extracellular matrix (ECM), which provides structural and biochemical support. The ECM of the epidermis is the basement membrane, and collagen and other dermal components constitute the ECM of the dermis. There is significant variation in the composition of the ECM of the epidermis and dermis, which can affect cell to cell and cell to ECM interactions. These interactions, in turn, can influence biological responses, aging, and wound healing; abnormal ECM signaling likely contributes to skin diseases. Thus, strategies for manipulating cell-ECM interactions are critical for treating wounds and a variety of skin diseases. Many of these strategies focus on epidermal stem cells, which reside in a unique niche in which the ECM is the most important component; interactions between the ECM and epidermal stem cells play a major role in regulating stem cell fate. As they constitute a major portion of the ECM, it is likely that integrins and type IV collagens are important in stem cell regulation and maintenance. In this review, we highlight recent research-including our previous work-exploring the role that the ECM and its associated components play in shaping the epidermal stem cell niche.
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