Review
Immunology
Estefania Prochetto, Eliana Borgna, Carlos Jimenez-Cortegana, Victor Sanchez-Margalet, Gabriel Cabrera
Summary: Myeloid-derived suppressor cells (MDSCs) play a role in both pathological and non-pathological conditions, including cancer, infections, pregnancy, aging, and vaccination. Vaccination is a crucial public health measure, but the presence of MDSCs may impact vaccine efficacy.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Review
Cell Biology
Tianmiao Ma, Bernhard W. Renz, Matthias Ilmer, Dominik Koch, Yuhui Yang, Jens Werner, Alexandr V. Bazhin
Summary: Myeloid-derived suppressor cells (MDSCs) play a crucial role in the tumor microenvironment (TME) and have been linked to poor prognosis and drug resistance in cancer. Further research is needed to fully understand the definition and phenotypes of MDSCs in humans.
Article
Oncology
Mingyue Cao, Wei Huang, Yuzhu Chen, Gaoxiang Li, Nasi Liu, Youming Wu, Guiping Wang, Qian Li, Dexin Kong, Tongtong Xue, Nan Yang, Yanyong Liu
Summary: The study reveals that chronic restraint stress significantly promotes HCC growth and mobilizes MDSCs to spleen and tumor sites from bone marrow through enhancing CXCR2 and pErk1/2 expression. In addition, beta-adrenergic signaling cascade plays a crucial role in the mobilization and recruitment of MDSCs under chronic restraint stress.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Cardiac & Cardiovascular Systems
Haomin Yan, Tomohiro Kawano, Hideaki Kanki, Kumiko Nishiyama, Munehisa Shimamura, Hideki Mochizuki, Tsutomu Sasaki
Summary: In this study, prophylactic anti-Ly6G antibody administration was found to have a protective effect against ischemic stroke by reducing activated neutrophil infiltration and neutrophil extracellular trap formation in the brain parenchyma, as well as suppressing polymorphonuclear myeloid-derived suppressor cell accumulation. This study may provide a novel therapeutic approach for ischemic stroke.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Cell Biology
Karolina Okla
Summary: Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of myeloid cells that accumulate in the tumor microenvironment and play a significant role in cancer. The high abundance of MDSCs often leads to immunosuppression, tumor growth, treatment failure, and poor prognosis. Ovarian cancer, ranking fifth in cancer deaths among women, lacks effective clinical strategies for treatment. Despite the negative role of human MDSCs in ovarian cancer, this topic remains understudied. This article summarizes the research on MDSCs and explains why focusing on these cells could be a promising approach in treating ovarian cancer patients.
Article
Oncology
Jiale An, Lifeng Feng, Jiling Ren, Yafei Li, Guangru Li, Chang Liu, Yong Yao, Ye Yao, Zecheng Jiang, Yang Gao, Yang Xu, Yachen Wang, Jing Li, Jie Liu, Lei Cao, Zhi Qi, Liang Yang
Summary: Chronic stress may accumulate MDSCs via activation of beta-adrenergic signaling and IL-6/STAT3 pathway, thereby promoting breast carcinoma metastasis.
Article
Immunology
Jufeng Guo, Yingying Shen, Shufang Hu, Tao Rui, Jian Liu, Ying Yuan
Summary: Neobavaisoflavone (Neo) has been found to inhibit the expansion and suppressive function of MDSCs, leading to the inhibition of tumor growth and metastasis. Additionally, Neo enhances the efficacy of anti-PD-1 treatment. This study highlights the potential of Neo as a therapeutic strategy against cancer.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Immunology
Ina N. Eckert, Eliana Ribechini, Katja J. Jarick, Sandra Strozniak, Sarah J. Potter, Andreas Beilhack, Manfred B. Lutz
Summary: The study discovered that the adhesion of VLA-1 integrin to collagen IV plays a critical role in extending the contact time between MDSCs and T cells, which is necessary for suppression.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, General & Internal
Panpan Liu, Cong Peng, Xiang Chen, Lisha Wu, Mingzhu Yin, Jie Li, Qunshi Qin, Yehong Kuang, Wu Zhu
Summary: The study found that increased numbers of myeloid-derived suppressor cells (MDSCs) are involved in the development of psoriasis. Acitretin, a treatment for psoriasis, was shown to reduce the number of MDSCs and promote their differentiation into macrophages and dendritic cells. This effect was mediated by acitretin's regulation of glutathione synthesis and activation of extracellular signal-regulated kinase 1/2.
FRONTIERS IN MEDICINE
(2021)
Review
Oncology
Hongchao Tang, Hao Li, Zhijun Sun
Summary: Immunotherapy is a promising breakthrough in cancer treatment, with immune checkpoint blockade showing positive clinical responses in different cancer types. However, the clinical efficacy of ICB is limited in some patients due to the immunosuppressive tumor microenvironment and the role of MDSCs. A combined treatment strategy using MDSC inhibitors and ICB is being proposed to enhance the antitumor efficacy.
CANCER BIOLOGY & MEDICINE
(2021)
Article
Medicine, Research & Experimental
Genyu Liu, Qingyang Wang, Lijiao Deng, Xiaofeng Huang, Guang Yang, Qianqian Cheng, Tingting Guo, Lu Guo, Chunxiao Niu, Xiqin Yang, Jie Dong, Jiyan Zhang
Summary: Research has found that hepatic RACK1 deficiency can protect mice from fulminant hepatitis (FH). RACK1-deficient livers accumulate myeloid-derived suppressor cells (MDSCs) under steady-state conditions, which inhibit the production of inflammatory cytokines and enhance the activation of the IKK/NF-kappa B pathway. The interaction between RACK1 and HDAC1 regulates the acetylation of Cxcl1 and S100a9, further affecting the accumulation of MDSCs and their protective effects. During FH induction, phosphorylation of RACK1 enhances its binding to E2T, promoting its ubiquitination and degradation, and increasing the expression of CXCL1/S100A9 and accumulation of MDSCs.
Review
Immunology
Jiaojiao Huang, Yue Zhao, Kexin Zhao, Kai Yin, Shengjun Wang
Summary: This review focuses on how MDSCs survive and function in high levels of ROS, and summarizes immunotherapy targeting ROS in MDSCs. The distinctive role of ROS in MDSCs will inspire us to widely apply the blocked oxidative stress strategy in targeting MDSC therapy to future clinical therapeutics.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jae-young Lee, Hyun-Jung Sohn, Chang-Hyun Kim, Tai-Gyu Kim, Hyun Soo Lee
Summary: This study confirmed the immunosuppressive effect of human cord blood MDSCs on corneal allograft models. Local and systemic MDSC administration inhibited the maturation of dendritic cells and the differentiation of Th1 cells, while reducing the infiltration of inflammatory cells and angiogenesis. The results suggest that CB-MDSCs have therapeutic potential for preventing corneal allograft rejection.
Article
Medicine, General & Internal
Bo Peng, Yulin Luo, Quan Zhuang, Junhui Li, Pengpeng Zhang, Min Yang, Yu Zhang, Gangcheng Kong, Ke Cheng, Yingzi Ming
Summary: In kidney transplant recipients (KTRs) with pneumonia, the frequency of myeloid-derived suppressor cells (MDSCs) and granulocytic-MDSCs (G-MDSCs) is persistently increased. G-MDSCs are correlated with the severity of pneumonia and can serve as an indicator for assessing pneumonia severity.
FRONTIERS IN MEDICINE
(2022)
Article
Immunology
Jiali Ni, Xiaoying Li, Xiaodi Tu, Haiyan Zhu, Shiqi Wang, Yayi Hou, Huan Dou
Summary: This study found that Halofuginone (HF), a traditional Chinese medicine, could alleviate the progression of lupus mice by targeting and promoting the apoptosis of myeloid-derived suppressor cells (MDSCs) through B lymphoid tyrosine kinase (Blk). This indicates the potential of HF as an immunotherapeutic agent for the treatment of systemic lupus erythematosus (SLE).
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Geriatrics & Gerontology
Cristina Sanfilippo, Paola Castrogiovanni, Manlio Vinciguerra, Rosa Imbesi, Martina Ulivieri, Francesco Fazio, Kaj Blennow, Henrik Zetterberg, Michelino Di Rosa
Summary: This study found that high levels of CHI3L1 and CHI3L2 in the brains of AD patients are associated with inflammatory transcriptomic signatures. High CHI3L1 and CHI3L2 expression is associated with inflammatory features, while low expression is associated with neuronal activation. Gene ontology analysis revealed immune response as a main biological process based on the common genes regulated by the two chitinases.
Article
Biochemistry & Molecular Biology
Lucia Longhitano, Sebastiano Giallongo, Laura Orlando, Giuseppe Broggi, Antonio Longo, Andrea Russo, Rosario Caltabiano, Cesarina Giallongo, Ignazio Barbagallo, Michelino Di Rosa, Rosario Giuffrida, Rosalba Parenti, Giovanni Li Volti, Nunzio Vicario, Daniele Tibullo
Summary: This study aimed to investigate the role of lactate in uveal melanoma (UM) cells. The results showed that lactate could inhibit cell proliferation and migration, and switch cell metabolism towards oxidative phosphorylation. It was also found that an increase in lactate transporters MCT4 and HCAR1 was associated with a spindle-shape histological type in UM. These findings suggest that lactate metabolism may serve as a prognostic marker of UM progression and a potential therapeutic target.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Romina Pallisco, Giacomo Lazzarino, Gabriele Bilotta, Francesca Marroni, Renata Mangione, Miriam Wissam Saab, Maria Violetta Brundo, Alessandra Pittala, Giuseppe Caruso, Elena Capoccia, Giuseppe Lazzarino, Barbara Tavazzi, Pasquale Bilotta, Angela Maria Amorini
Summary: Despite advances in assisted reproductive technology (ART), the success rate of human embryo implantation remains low. The current method of evaluating embryo quality based on morphology alone is not very predictive. Previous studies have suggested that analyzing metabolites in human embryo culture media may help in selecting embryos for implantation. In this study, the presence of certain compounds released by cell metabolism, including purines, pyrimidines, nitrite, and nitrate, were analyzed in the culture media of 66 human embryos. It was found that embryos with low grades had higher levels of these compounds, and embryos from unsuccessful pregnancies released higher concentrations compared to successful ones. These findings indicate that analyzing metabolites in human embryo culture media could be a useful tool for selecting embryos for implantation and potentially increasing the overall success rate of ART.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Andrea Duminuco, Salvatore Scarso, Alessandra Cupri, Nunziatina Laura Parrinello, Loredana Villari, Grazia Scuderi, Giuliana Giunta, Salvatore Leotta, Giulio Antonio Milone, Giulia Giuffrida, Giuseppe Alberto Palumbo, Giuseppe Milone
Summary: Ruxolitinib, a JAK1/2 inhibitor, has revolutionized the treatment of myelofibrosis by improving symptoms but also increasing the risk of immunosuppression-related infections. Limited information is available regarding parasitic infections, particularly leishmaniasis.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biology
Daniela Cambria, Lucia Longhitano, Enrico La Spina, Sebastiano Giallongo, Laura Orlando, Rosario Giuffrida, Daniele Tibullo, Paolo Fontana, Ignazio Barbagallo, Vincenzo Giuseppe Nicoletti, Giovanni Li Volti, Vittorio Del Fabro, Anna Rita Daniela Coda, Arcangelo Liso, Giuseppe Alberto Palumbo
Summary: Chronic myeloid leukemia (CML) is a myeloproliferative disorder characterized by the presence of Philadelphia chromosome/translocation t(9;22) and increased granulocyte proliferation. In this study, the role of the IGFBP-6/SHH/TLR4 axis in the response to tyrosine kinase inhibitors (TKi) in CML was investigated. The results showed that co-culture and Dasatinib exposure induced inflammation and modulated the expression of TLR4 in stromal and cancer cells. IGFBP-6 and sonic hedgehog (SHH) were found to be involved in the resistance mechanisms induced by the modulation of TLR-4, suggesting that they could be potential therapeutic targets.
Article
Cell Biology
Alessandro Barbato, Cesarina Giallongo, Sebastiano Giallongo, Alessandra Romano, Grazia Scandura, Saoca Concetta, Tatiana Zuppelli, Marco Lolicato, Giacomo Lazzarino, Nunziatina Parrinello, Vittorio Del Fabro, Paolo Fontana, M'hammed Aguennoz, Giovanni Li Volti, Giuseppe A. A. Palumbo, Francesco Di Raimondo, Daniele Tibullo
Summary: Metabolic changes and adaptation to the tumor microenvironment are important characteristics of multiple myeloma. This study found that mesenchymal stromal cells in multiple myeloma have higher glycolysis and lactate production compared to healthy cells. The high lactate concentration was found to affect the metabolism of tumor cells and make them less responsive to proteasome inhibitors.
CELL PROLIFERATION
(2023)
Article
Biochemistry & Molecular Biology
Maria Denaro, Elisa Ferro, Giuseppe Barrano, Salvatore Meli, Mariangela Busacca, Damiano Corallo, Alessia Capici, Alessandra Zisa, Luana Cucuzza, Sandra Gradante, Marialuisa Occhipinti, Paola Santalucia, Raffaele Elia, Angelo Aliquo, Daniele Tibullo, Carmelo Fidone, Vincenzo Bramanti
Summary: The study found that the trend of SARS-CoV-2 variants in Ragusa area is comparable to the Sicily region based on genomic sequencing and immune monitoring of 600 samples. Although no correlation was found between variants and clinical symptoms, antibody levels were positively correlated with an increase in the number of symptoms. Furthermore, SARS-CoV-2 infection induced a significantly higher enhancement in antibody titers compared to vaccine administration. Therefore, the evaluation of anti-N IgG levels could be used as an early marker to identify asymptomatic individuals in the post-pandemic period.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Elena Maria Scalisi, Roberta Pecoraro, Antonio Salvaggio, Fabiano Capparucci, Cosimo Gianluca Fortuna, Massimo Zimbone, Giuliana Impellizzeri, Maria Violetta Brundo
Summary: This article evaluated the potential toxic effects of titanium dioxide nanoparticles (TiO2-NPs) on embryonic development and the male reproductive system using zebrafish as a model organism. The results showed that TiO2-NPs did not interfere with embryonic development, but caused morphological changes in the male reproductive organs. Immunofluorescence investigation showed increased levels of oxidative stress biomarkers and sex hormone binding globulin (SHBG), which were confirmed by qRT-PCR results. The gene responsible for the conversion of testosterone to dihydrotestosterone also showed increased expression, suggesting an androgenic effect of TiO2-NPs.
Review
Medicine, General & Internal
Andrea Duminuco, Antonella Nardo, Gaetano Giuffrida, Salvatore Leotta, Uros Markovic, Cesarina Giallongo, Daniele Tibullo, Alessandra Romano, Francesco Di Raimondo, Giuseppe A. Palumbo
Summary: Among myeloproliferative diseases, myelofibrosis has a highly variable prognosis, and several prognostic models have been proposed to categorize patients effectively, such as IPSS, DIPSS, and MYSEC-PM. Recently, new models like MIPSS-70, GIPSS, and RR6 have been developed and validated using new diagnostic techniques and the use of JAK inhibitor drugs. The new frontier of artificial intelligence may enable the creation of models that provide an overall survival perspective for each patient.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Engineering, Marine
Roberta Pecoraro, Santi Concetto Pavone, Elena Maria Scalisi, Sara Ignoto, Carmen Sica, Stefania Indelicato, Fabiano Capparucci, Carmelo Iaria, Antonio Salvaggio, Gino Sorbello, Loreto Di Donato, Maria Violetta Brundo
Summary: 5G technology aims to provide high data rates and low latency. To ensure wide coverage, a large number of repeaters are needed due to the decreased ability of high frequency electromagnetic waves to propagate in free space. However, a study showed that exposure to 27 GHz electromagnetic fields had no significant effects on the embryonic development of zebrafish.
JOURNAL OF MARINE SCIENCE AND ENGINEERING
(2023)
Article
Biochemistry & Molecular Biology
Lucia Longhitano, Alfio Distefano, Angela Maria Amorini, Laura Orlando, Sebastiano Giallongo, Daniele Tibullo, Giuseppe Lazzarino, Anna Nicolosi, Amer M. Alanazi, Concetta Saoca, Vincenzo Macaione, M'hammed Aguennouz, Federico Salomone, Emanuela Tropea, Ignazio Alberto Barbagallo, Giovanni Li Volti, Giacomo Lazzarino
Summary: This study aimed to investigate the effects of lipoic acid on lipotoxicity and mitochondrial dynamics in an in vitro model of liver steatosis. The results showed that lipoic acid treatment reduced lipotoxicity and improved mitochondrial functions, suggesting its potential as a pharmacological tool for NAFLD treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Agriculture, Dairy & Animal Science
Martina Contino, Greta Ferruggia, Stefania Indelicato, Roberta Pecoraro, Elena Maria Scalisi, Antonio Salvaggio, Maria Violetta Brundo
Summary: This study evaluated the lethal and sublethal effects of amino-modified polystyrene nanoplastics on Artemia salina. The results showed that while no lethal impact was observed, the nanoparticles caused gut and body size malformations, as well as increased apoptosis and oxidative stress at higher concentrations and smaller particle sizes.
Review
Biochemistry & Molecular Biology
Sebastiano Giallongo, Francesco Costa, Lucia Longhitano, Cesarina Giallongo, Jessica Ferrigno, Emanuela Tropea, Nunzio Vicario, Giovanni Li Volti, Rosalba Parenti, Ignazio Barbagallo, Vincenzo Bramanti, Daniele Tibullo
Summary: Tumor onset and progression are closely associated with the metabolic rewiring driven by the Warburg effect. Accumulation of fumarate, due to the loss of function of fumarate hydratase (FH), not only participates in the metabolic rewiring of cancer cells, but also plays a crucial role in chromatin architecture reorganization. Moreover, FH has the ability to recruit DNA double strand breaks, which affects the DNA repair pathway and mutational state of cells.
Article
Environmental Sciences
Martina Contino, Greta Ferruggia, Stefania Indelicato, Roberta Pecoraro, Elena Maria Scalisi, Antonio Salvaggio, Maria Violetta Brundo
Summary: Continuous discharge of wastes and pollutants into water ecosystems requires constant monitoring of the risks they pose. The release of nano-scale fragments from larger plastic artifacts has raised concerns about their potential impact on the reproductive processes of aquatic organisms. Research using Mytilus galloprovincialis has shown that exposure to 50 nm amino-modified polystyrene nanoplastics can cause structural and metabolic damage to sperm, affecting their quality and fertilizing capacity. Importantly, the negative impact is dependent on the size and concentration of the nanoplastics.