Article
Medicine, General & Internal
Ameenathul M. M. Fawzy, Arnaud Bisson, Alexandre Bodin, Julien Herbert, Gregory Y. H. Lip, Laurent Fauchier
Summary: This study investigated the association between atrial fibrillation (AF) and ventricular arrhythmias (VAs) and sudden death in hospitalized patients in France. The results showed that AF patients had significantly higher incidence and risk of VAs and cardiac arrest compared to non-AF patients. This association remained significant after adjusting for confounders, indicating a clear association between AF and VAs and sudden death.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Eric J. Hall, Soumojit Pal, Michael S. Glennon, Puneeth Shridhar, Sidney L. Satterfield, Beth Weber, Qinkun Zhang, Guy Salama, Hind Lal, Jason R. Becker
Summary: Cardiac natriuretic peptides play a crucial role in regulating cardiovascular physiology. Deficiency in either atrial natriuretic peptide (ANP) or B-type natriuretic peptide (BNP) can cause adverse effects on the structure and function of the heart. This study shows that ANP and BNP exert non-redundant functions in maintaining myocardial cGMP levels, which in turn regulate the activity of cardiomyocyte p38 mitogen-activated protein kinase (p38 MAPK) and cAMP response element-binding protein (CREB). Deficiency in cardiac natriuretic peptides increases the risk of stress-induced ventricular arrhythmias.
CARDIOVASCULAR RESEARCH
(2022)
Article
Multidisciplinary Sciences
Teresa Oliveras, Iolanda Lazaro, Ferran Rueda, German Cediel, Deepak L. Bhatt, Montserrat Fito, Francisco Madrid-Gambin, Oscar J. Pozo, William S. Harris, Cosme Garcia-Garcia, Aleix Sala-Vila, Antoni Bayes-Genis
Summary: This study found that levels of linoleic acid (LA) in serum phospholipids are associated with susceptibility to primary ventricular fibrillation (PVF). PVF patients had lower levels of LA. Each one standard deviation increase in the proportion of LA was associated with a 42% lower prevalence of PVF.
SCIENTIFIC REPORTS
(2022)
Article
Cardiac & Cardiovascular Systems
Rodrigue Garcia, Eloi Marijon, Nicole Karam, Kumar Narayanan, Frederic Anselme, Olivier Cesari, Laure Champ-Rigot, Vladimir Manenti, Raphael Martins, Etienne Puymirat, Jean Ferrieres, Francois Schiele, Tabassome Simon, Nicolas Danchin
Summary: The incidence and mortality of ventricular fibrillation (VF) among patients hospitalized for acute myocardial infarction (AMI) have significantly decreased over the past 20 years. However, VF remains associated with a 10-fold increased relative risk of in-hospital mortality, without affecting post-discharge mortality. These findings highlight the need for interventions during hospitalization to further reduce mortality in VF patients.
EUROPEAN HEART JOURNAL
(2022)
Article
Cardiac & Cardiovascular Systems
Nitin Malik, Monica Mukherjee, Katherine C. Wu, Stefan L. Zimmerman, Junzhen Zhan, Hugh Calkins, Cynthia A. James, Nisha A. Gilotra, Farooq H. Sheikh, Harikrishna Tandri, Shelby Kutty, Allison G. Hays
Summary: Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a rare and heritable myocardial disease associated with serious cardiovascular complications and early cardiac sudden death. Multimodality imaging, including echocardiography and cardiac magnetic resonance imaging, plays a crucial role in the diagnosis and evaluation of ARVC. Echocardiography is a widely available and cost-effective technique, while cardiac magnetic resonance provides more comprehensive assessment of the structure and function. However, both imaging techniques have their limitations.
CIRCULATION-CARDIOVASCULAR IMAGING
(2022)
Article
Cardiac & Cardiovascular Systems
Hilke Koenemann, Nikolaos Dagres, Jose Luis Merino, Christian Sticherling, Katja Zeppenfeld, Jacob Tfelt-Hansen, Lars Eckardt
Summary: A new guideline for the management of ventricular arrhythmias and prevention of sudden cardiac death has been published, which updates the 2015 guideline on this topic. The new recommendations cover various aspects such as public basic life support, access to defibrillators, diagnostic evaluation, management of electrical storm, genetic testing, and more.
Review
Cardiac & Cardiovascular Systems
Cicely Anne Dye, Erica Engelstein, Sean Swearingen, Jeanine Murphy, Timothy Larsen, Annabelle Santos Volgman
Summary: Arrhythmias and sudden cardiac death with sexual activity are rare, but recent studies suggest that these events are occurring in younger individuals, with a higher proportion of female decedents than previously described. Open dialogue between the cardiovascular team and the cardiac patient is necessary to provide education and reassurance for safe sexual activity participation.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Philippe Chevalier, Adrien Moreau, Francis Bessiere, Sylvain Richard, Mohamed Chahine, Gilles Millat, Elodie Morel, Franck Paganelli, Nathalie Lesavre, Leslie Placide, Francois Montestruc, Benedicte Ankou, Rosa Donate Puertas, Babken Asatryan, Antoine Deliniere
Summary: The presence of GJA1 gene variants increases the risk of ventricular fibrillation (VF) in ST-elevation myocardial infarction (STEMI) patients. Beta-blocker intake, atrial fibrillation, and left ventricular ejection fraction >50% decrease the risk of primary VF (PVF). Three novel GJA1 variants were identified, and in vitro studies showed that these variants cause changes in Cx43 localization and cellular communication.
Article
Cardiac & Cardiovascular Systems
Grigorios Giamouzis, Apostolos Dimos, Andrew Xanthopoulos, John Skoularigis, Filippos Triposkiadis
Summary: The research discusses the association between LVH and SCD, emphasizing the need to consider additional variables to improve SCD risk prediction, including LV geometry.
HEART FAILURE REVIEWS
(2022)
Article
Cardiac & Cardiovascular Systems
Deborah Foltran, Celine Guilbeau-Frugier, Nathan Marimpouy, Maxime Beneyto, Miloud Cherbi, Vanina Bongard, Philippe Maury
Summary: This study investigates the correlations between COVID waves and malignant ventricular arrhythmias, and finds no significant association between the two. Furthermore, the incidence of malignant ventricular arrhythmias tends to decrease after the onset of vaccination.
Review
Medicine, General & Internal
Giulia Brunetti, Alberto Cipriani, Martina Perazzolo Marra, Manuel De Lazzari, Barbara Bauce, Chiara Calore, Ilaria Rigato, Francesca Graziano, Riccardo Vio, Domenico Corrado, Alessandro Zorzi
Summary: Premature ventricular beats (PVBs) are not uncommon in athletes, and the risk depends on whether there is an underlying myocardial substrate that predisposes to sudden cardiac death. The standard diagnostic work-up for athletes with PVBs includes family and personal history, ECG, 24-hour ambulatory ECG, exercise testing, and echocardiography. Echocardiography has limited sensitivity in detecting non-ischemic left ventricular scars, which can be revealed through more in-depth studies, such as CMR imaging. The morphology, complexity, and exercise inducibility of PVBs can help estimate the likelihood of underlying heart disease. CMR imaging may be indicated even when echocardiography is normal.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Sumeet S. Chugh, Kyndaron Reinier, Audrey Uy-Evanado, Harpriya S. Chugh, David Elashoff, Christopher Young, Angelo Salvucci, Jonathan Jui
Summary: This study successfully developed a novel algorithm for predicting sudden cardiac arrest with ventricular fibrillation/ventricular tachycardia, with good discrimination in training and validation datasets, potentially enhancing primary prevention efforts.
JACC-CLINICAL ELECTROPHYSIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Julia Cadrin-Tourigny, Laurens P. Bosman, Anna Nozza, Weijia Wang, Rafik Tadros, Aditya Bhonsale, Mimount Bourfiss, Annik Fortier, Oyvind H. Lie, Ardan M. Saguner, Anneli Svensson, Antoine Andorin, Crystal Tichnell, Brittney Murray, Katja Zeppenfeld, Maarten P. van den Berg, Folkert W. Asselbergs, Arthur A. M. Wilde, Andrew D. Krahn, Mario Talajic, Lena Rivard, Stephen Chelko, Stefan L. Zimmerman, Ihab R. Kamel, Jane E. Crosson, Daniel P. Judge, Sing-Chien Yap, Jeroen F. van der Heijden, Harikrishna Tandri, Jan D. H. Jongbloed, Marie-Claude Guertin, J. Peter van Tintelen, Pyotr G. Platonov, Firat Duru, Kristina H. Haugaa, Paul Khairy, Richard N. W. Hauer, Hugh Calkins, Anneline S. J. M. te Riele, Cynthia A. James
Summary: We developed a prediction model for incident VA/SCD in ARVC patients using readily available clinical parameters, which accurately distinguished patients with and without events and showed superior clinical benefit compared to current ICD placement algorithms.
EUROPEAN HEART JOURNAL
(2022)
Review
Cardiac & Cardiovascular Systems
Alexandra Butters, Clare Arnott, Joanna Sweeting, Bo Gregers Winkel, Christopher Semsarian, Jodie Ingles
Summary: The overall incidence of sudden cardiac death is considerably lower among women than men, with different characteristics observed in female victims. Research suggests that these gender disparities may be due to a lack of sufficient female representation in clinical trials, a lack of sex-disaggregated evidence, and inadequate attention to sudden cardiac death in women.
CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Vincenzo Russo, Andrea Antonio Papa, Anna Rago, Carmine Ciardiello, Anna Maria Martino, Alessandra Stazi, Paolo Golino, Leonardo Calo, Gerardo Nigro
Summary: The study aimed to evaluate the prognostic value of programmed ventricular stimulation in DM1 patients with conduction system disease. The results showed that the inducibility of ventricular tachyarrhythmias has limited value in arrhythmic risk stratification among DM1 patients.
Article
Cardiac & Cardiovascular Systems
Flemming Javier Olsen, Caroline Lokke Bjerregaard, Kristoffer Grundtvig Skaarup, Mats Christian Hojbjerg Lassen, Niklas Dyrby Johansen, Daniel Modin, Gorm Boje Jensen, Peter Schnohr, Peter Sogaard, Gunnar Gislason, Jesper Hastrup Svendsen, Rasmus Mogelvang, Tor Biering-Sorensen
Summary: Different event timing modalities have an impact on myocardial work indices, with visual assessment yielding lower global work index (GWI) values compared with Doppler-based methods.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2023)
Article
Infectious Diseases
Christian Ronn, Pradeesh Sivapalan, Josefin Eklof, Peter Kamstrup, Tor Biering-Sorensen, Barbara Bonnesen, Zitta Barrella Harboe, Andrea Browatzki, Jakob Lyngby Kjaergaard, Christian Niels Meyer, Torben Tranborg Jensen, Sofie Lock Johansson, Elisabeth Bendstrup, Charlotte Suppli Ulrik, Jens-Ulrik Staehr Jensen
Summary: This study aimed to determine the relationship between cumulative inhaled corticosteroid (ICS) doses and the risk of hospitalization for pneumonia in patients with chronic obstructive pulmonary disease (COPD). The results showed a positive correlation between ICS dose and the risk of hospitalization for pneumonia. Therefore, it is recommended to use the lowest possible dose of ICS in the treatment of COPD and only for patients who truly need it.
CLINICAL MICROBIOLOGY AND INFECTION
(2023)
Article
Cardiac & Cardiovascular Systems
Manan Pareek, Kristian H. Kragholm, Anna Meta Dyrvig Kristensen, Muthiah Vaduganathan, Jannik L. Pallisgaard, Christina Byrne, Tor Biering-Sorensen, Christina Ji-Young Lee, Anders Nissen Bonde, Martin Bodtker Mortensen, Michael Maeng, Emil L. Fosbol, Lars Kober, Niels Thue Olsen, Gunnar H. Gislason, Deepak L. Bhatt, Christian Torp-Pedersen
Summary: The study found that individuals suspected of acute coronary syndrome who had consecutively elevated high-sensitivity troponin concentrations had the highest risk of death, while those with consecutively normal hsTnT concentrations had very low mortality rates, regardless of changes between measurements.
EUROPEAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Emilie K. Frimodt-Moller, Elsayed Z. Soliman, Jorge R. Kizer, Eric Vittinghoff, Bruce M. Psaty, Tor Biering-Sorensen, John S. Gottdiener, Gregory M. Marcus
Summary: Cardiac conduction disease can lead to serious complications, but there are no established prevention strategies. A study found that older age, male sex, higher BMI, hypertension, and coronary heart disease were associated with a higher prevalence of conduction disease, while White race and more physical activity were associated with a lower prevalence. More physical activity was also associated with a reduced risk of incident conduction disease.
EUROPEAN HEART JOURNAL
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Giovanni Benfari, Kristoffer Grundtvig Skaarup, Niklas Dyrby Johansen, Gorm Jensen, Peter Schnohr, Rasmus Mogelvang, Stefano Nistri, Tor Biering-Sorensen
JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY
(2023)
Article
Cardiac & Cardiovascular Systems
Niklas Dyrby Johansen, Muthiah Vaduganathan, Ankeet S. Bhatt, Simin Gharib Lee, Daniel Modin, Brian L. Claggett, Erica L. Dueger, Sandrine Samson, Matthew M. Loiacono, Lars Kober, Scott D. Solomon, Pradeesh Sivapalan, Jens Ulrik Staehr Jensen, Palle Valentiner-Branth, Tyra Grove Krause, Tor Biering-Sorensen
Summary: The NUDGE-FLU trial aims to investigate the effectiveness of digitally delivered behavioral nudges in increasing influenza vaccination uptake among older adults. It has randomized 964,870 Danish citizens aged 65 years and above to receive either no nudge or one of 9 electronic letters leveraging different behavioral science strategies. The trial will provide important insights into effective communication strategies to maximize vaccination uptake among high-risk groups.
AMERICAN HEART JOURNAL
(2023)
Article
Infectious Diseases
Molly D. Kaagaard, Luan Oliveira Matos, Marliton V. P. Evangelista, Alma Wegener, Anna Engell Holm, Lasse S. Vestergaard, Suiane C. N. Do Valle, Odilson M. Silvestre, Marcus Vinicius Guimaraes Lacerda, Rodrigo Medeiros de Souza, Flavia Barreto dos Santos, Tor Biering-Sorensen, Philip Brainin
Summary: This study systematically assessed the frequency of pleural effusion in patients with dengue infection and found that 1/3 of the patients presented with pleural effusion, and the frequency increased with severity and younger age. Lung ultrasound was found to be the best method for detecting pleural effusion.
BMC INFECTIOUS DISEASES
(2023)
Article
Cardiac & Cardiovascular Systems
Andreas Ruhvald Madsen, Kristoffer Grundtvig Skaarup, Allan Zeeberg Iversen, Peter Godsk Jorgensen, Philip Ruessell Pedersson, Tor Biering-Sorensen
Summary: Echocardiographic measures of left atrial (LA) structure and function are important predictors of atrial fibrillation (AF) following acute coronary syndrome (ACS).
Article
Cardiac & Cardiovascular Systems
Daniel Modin, Niklas Dyrby Johansen, Muthiah Vaduganathan, Ankeet S. Bhatt, Simin Gharib Lee, Brian L. Claggett, Erica L. Dueger, Sandrine I. Samson, Matthew M. Loiacono, Lars Kober, Scott D. Solomon, Pradeesh Sivapalan, Jens Ulrik Staehr Jensen, Cyril Jean-Marie Martel, Palle Valentiner-Branth, Tyra Grove Krause, Tor Biering-Sorensen
Summary: Digital behavioral nudges, such as electronic letters, emphasizing the potential cardiovascular benefits of influenza vaccination and using a reminder letter strategy, were found to be effective in increasing influenza vaccine uptake among older adults both with and without cardiovascular disease.
Letter
Cardiac & Cardiovascular Systems
Mats C. Hojbjerg Lassen, Daniel Modin, Kristoffer Grundtvig Skaarup, Niklas Dyrby Johansen, Brian Claggett, Scott D. Solomon, Michael Fralick, Jens Ulrik Staehr Jensen, Pradeesh Sivapalan, Muthiah Vaduganathan, Manan Pareek, Morten Schou, Tyra Grove Krause, Anders Hviid, Lars Kober, Christian Torp-Pedersen, Gunnar Gislason, Tor Biering-Sorensen
Article
Cardiac & Cardiovascular Systems
Kristoffer Grundtvig Skaarup, Daniel Modin, Lene Nielsen, Jens Ulrik Staehr Jensen, Tor Biering-Sorensen
Summary: The link between influenza infection and cardiovascular morbidity has been established for almost a century. This review explores the cardiovascular complications associated with influenza and the possible mechanisms behind this relationship. The most common complications include cardiovascular death, myocardial infarction, and heart failure hospitalization. Proposed mechanisms include direct cardiac infection, endothelial dysfunction, hypoxemia, and systemic inflammatory responses. The significance of each mechanism and whether influenza directly or indirectly causes cardiovascular events remains uncertain.
EUROPEAN HEART JOURNAL SUPPLEMENTS
(2023)
Article
Cardiac & Cardiovascular Systems
Kristoffer Grundtvig Skaarup, Mats Christian Hojbjerg Lassen, Niklas Dyrby Johansen, Morten Sengelov, Flemming Javier Olsen, Gorm Boje Jensen, Peter Schnohr, Amil Shah, Brian Lee Claggett, Scott D. Solomon, Rasmus Mogelvang, Tor Biering-Sorensen
Summary: This study investigates the link between myocardial deformation phenotyping using longitudinal and circumferential strain and the risk of heart failure (HF) and cardiovascular death (CD). It found that decreased global longitudinal strain (GLS) and augmented global circumferential strain (GCS) are early markers of ventricular disease process. The associations between GCS and HF/CD differ depending on the left ventricular ejection fraction (LVEF), with higher GCS associated with increased risk in participants with normal LVEF and decreased risk in participants with abnormal LVEF.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2023)
Article
Cardiac & Cardiovascular Systems
Tor Biering-Sorensen, Maja Cikes, Mats C. H. Lassen, Brian Claggett, Masatoshi Minamisawa, Angela B. S. Santos, Elisabeth Pieske-Kraigher, Amil M. Shah, Michael R. Zile, John J. McMurray, Scott D. Solomon, Susan Cheng
Summary: This study aimed to investigate whether regional differences in impaired myocardial function contribute to the greater mechanical dysfunction seen in HFPEF compared to HHD.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2023)
Article
Cardiac & Cardiovascular Systems
Liv Borum Schops, Morten Sengelov, Daniel Modin, Peter Godsk Jorgensen, Niels Eske Bruun, Thomas Fritz-Hansen, Gunnar Gislason, Emil Wolsk, Morten Schou, Tor Biering-Sorensen
Summary: This study aims to identify clinical and echocardiographic parameters associated with improvement in systolic function in outpatients with heart failure with reduced ejection fraction (HFrEF), in order to improve targeted treatment and outcomes. The results showed that improvement in systolic function was significantly associated with various echocardiographic parameters as well as heart failure etiology and comorbidities. Furthermore, greater improvement in systolic function was associated with lower mortality risk.
Article
Cardiac & Cardiovascular Systems
Flemming Javier Olsen, Kristoffer Grundtvig Skaarup, Mats Christian Hojbjerg Lassen, Niklas Dyrby Johansen, Gorm Boje Jensen, Peter Schnohr, Jacob Louis Marott, Peter Sogaard, Gunnar Gislason, Jesper Hastrup Svendsen, Rasmus Mogelvang, John Moene Aalen, Otto Armin Smiseth, Espen Wattenberg Remme, Tor Biering-Sorensen
Summary: This study evaluates the prognostic value of myocardial work indices in the general population. The results indicate that hypertension modifies the association between myocardial work indices and heart failure/cardiovascular death. All work indices are associated with outcome in normotensive participants, whereas only global work efficiency (GWE) predicts outcome in hypertensive participants. Furthermore, GWE improves risk prediction in the hypertensive population.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2023)