Review
Cardiac & Cardiovascular Systems
Siyuan Hu, Meng Yang, Shumin Huang, Senjie Zhong, Qian Zhang, Haichao Ding, Xiajun Xiong, Zhixi Hu, Yi Yang
Summary: This article summarizes the relationship between inflammation and cardiac fibrosis, discusses the regulatory role of macrophages in cardiac fibrosis, and analyzes the functional heterogeneity of macrophages from different sources.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Multidisciplinary Sciences
Mokarram Hossain, Raymond Shim, Woo-Yong Lee, Arlene H. Sharpe, Paul Kubes
Summary: Emerging evidence suggests that resident macrophages within tissues play a role in tumor growth. In this study, the authors discovered that GATA6(+) large peritoneal macrophages can invade growing metastases in the liver and promote tumor growth.
NATURE COMMUNICATIONS
(2022)
Article
Endocrinology & Metabolism
Emelie Barreby, Benedikt Strunz, Sebastian Nock, Lea Naudet, Joanne X. Shen, Helene Johansson, Isabella Soennerborg, Junjie Ma, Egon Urgard, Laura J. Pallett, Yizhou Hu, Achilleas Fardellas, Valerio Azzimato, Ana Vankova, Laura Levi, Cecilia Morgantini, Mala K. Maini, Per Stal, Stephan P. Rosshart, Jonathan M. Coquet, Greg Nowak, Erik Naeslund, Volker M. Lauschke, Ewa Ellis, Niklas K. Bjoerkstroem, Ping Chen, Myriam Aouadi
Summary: By studying patients undergoing liver transplantation, a specific population of resident liver myeloid cells that protects against metabolic impairment in obesity is identified. These cells, termed liver myeloid cells 2 (LM2), decrease in proportion during obesity but can ameliorate oxidative stress. These findings suggest that targeting resident myeloid cells could be a therapeutic approach for reducing oxidative stress in non-alcoholic fatty liver disease (NAFLD).
Article
Cardiac & Cardiovascular Systems
F. J. G. Waleczek, M. Sansonetti, K. Xiao, M. Jung, S. Mitzka, A. Dendorfer, N. Weber, F. Perbellini, T. Thum
Summary: Resident cardiac macrophages (rcMACs) exhibit plasticity and activation in response to changes in the microenvironment, which is essential for in vitro experimentation. The ex vivo model of living myocardial slices (LMS) provides a tool to investigate rcMACs response to immunomodulatory and mechanical stimulations without the interference of other cells. The study identified potential marker genes for inflammation in rcMACs and microRNAs associated with transcriptomic changes, contributing to the understanding of load-triggered cardiac inflammation.
BASIC RESEARCH IN CARDIOLOGY
(2022)
Review
Immunology
Amelia Kulle, Ajitha Thanabalasuriar, Taylor S. Cohen, Marta Szydlowska
Summary: Resident macrophages play a crucial role in tissue maintenance by defending against pathogens and regulating inflammatory tone and tissue structure. This review focuses on the developmental origin of liver and lung resident macrophages, their contribution to host defense, and the mechanisms they use to regulate tissue homeostasis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Joseph J. Sepe, Ryan T. Gardner, Matthew R. Blake, Deja M. Brooks, Melanie A. Staffenson, Courtney B. Betts, Sam Sivagnanam, William Larson, Sushil Kumar, Richard G. Bayles, Haihong Jin, Michael S. Cohen, Lisa M. Coussens, Beth A. Habecker
Summary: Circulatory neural reconstruction after myocardial infarction can alter the immune response, shifting it from inflammatory to reparative with reduced pro-inflammatory cells and increased regulatory and reparative cells.
JACC-BASIC TO TRANSLATIONAL SCIENCE
(2022)
Article
Urology & Nephrology
Anne M. Huesing, Vera C. Wulfmeyer, Svenja Gaedcke, Susanne V. Fleig, Song Rong, David DeLuca, Hermann Haller, Roland Schmitt, Sibylle von Vietinghoff
Summary: The risk of cardiovascular events increases after renal ischemia-reperfusion (IR) injury. Leukocytes play a crucial role in the growth and instability of atherosclerotic plaques. This study established a model of enhanced remote atherosclerosis after renal IR injury and investigated the underlying inflammatory mechanisms.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Article
Medicine, Research & Experimental
Kimberly A. Barker, Neelou S. Etesami, Anukul T. Shenoy, Emad I. Arafa, Carolina Lyon de Ana, Nicole M. S. Smith, Ian M. C. Martin, Wesley N. Goltry, Alexander M. S. Barron, Jeffrey L. Browning, Hasmeena Kathuria, Anna C. Belkina, Antoine Guillon, Xuemei Zhong, Nicholas A. Crossland, Matthew R. Jones, Lee J. Quinton, Joseph P. Mizgerd
Summary: The study found that lung-resident memory B cells play a crucial role in lung immunity, quickly producing antibodies after infection to help clear pathogens. These cells are elicited in mice after pneumococcal infections, are present in human lungs, and are involved in pulmonary antibacterial immunity.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Genetics & Heredity
Praveen Vasudevan, Markus Wolfien, Heiko Lemcke, Cajetan Immanuel Lang, Anna Skorska, Ralf Gaebel, Anne-Marie Galow, Dirk Koczan, Tobias Lindner, Wendy Bergmann, Brigitte Mueller-Hilke, Brigitte Vollmar, Bernd Joachim Krause, Olaf Wolkenhauer, Gustav Steinhoff, Robert David
Summary: This study compares the cellular, molecular, and functional outcomes of cardiomyocyte transplantation in wildtype and T cell- and B cell-deficient Rag2(del) mice, revealing the role of innate immune cells, especially CCR2 macrophages, in the outcome of cardiomyocyte transplantation. The results demonstrate that the improved functional outcome following cardiomyocyte transplantation is dependent on a specific CCR2 macrophage response. This highlights the importance of studying the immune response for successful clinical translation of cardiomyocyte cell therapy.
Article
Pharmacology & Pharmacy
Rong Chen, Shiqing Zhang, Fang Liu, Lin Xia, Chong Wang, Siamak Sandoghchian Shotorbani, Huaxi Xu, Subrata Chakrabarti, Tianqing Peng, Zhaoliang Su
Summary: Cardiac-resident macrophages (CRMs) have important roles in cardiac homeostasis, function, and regeneration. This study investigated the changes of CRMs during cardiac ontogeny and their contribution to cardiac regeneration. The findings reveal the dynamic subsets of CRMs during development and their ability to regulate cardiomyocyte proliferation, highlighting their potential in cardiac repair and regeneration.
ACTA PHARMACEUTICA SINICA B
(2023)
Article
Biochemistry & Molecular Biology
Samantha Muscat, Anne E. C. Nichols, Emma Gira, Alayna E. Loiselle
Summary: Macrophages play a complex role in tendon healing, with both positive and negative effects on the process. This study identified the presence of tendon-resident macrophages and T cells during both homeostasis and healing. Furthermore, it demonstrated the importance of CCR2 in modulating the tendon cell environment and promoting functional recovery during late healing.
Article
Immunology
Alan Benard, Malgorzata J. Podolska, Franziska Czubayko, Isabella Kutschick, Bettina Kloesch, Anne Jacobsen, Elisabeth Naschberger, Maximilian Brunner, Christian Krautz, Denis I. Trufa, Horia Sirbu, Roland Lang, Robert Gruetzmann, Georg F. Weber
Summary: This study reveals that specific depletion of pleural immune cells during bacterial pneumonia leads to reduced pulmonary immune response and increased mortality in mice. Pleural inflammation plays a crucial role in effective protection against bacterial airway infection.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Daile Jia, Siqin Chen, Peiyuan Bai, Chentao Luo, Jin Liu, Aijun Sun, Junbo Ge
Summary: This study reveals the importance of cardiac resident macrophages in the efficient clearance and degradation of apoptotic cardiomyocytes during myocardial infarction, which is crucial for inflammation resolution and tissue repair. The researchers identified Lgmn as a key gene involved in this process and demonstrated its functional significance through various experiments.
Review
Clinical Neurology
Taku Ito, Natsuko Kurata, Yoko Fukunaga
Summary: Tissue-resident macrophages in the cochlea play a crucial role in maintaining tissue homeostasis, immune defense, and repair. Perivascular macrophages, a unique subset associated with blood vessels, regulate blood vessel permeability and clear pigment granules in the cochlea.
FRONTIERS IN NEUROLOGY
(2022)
Review
Immunology
Irina Kologrivova, Marina Shtatolkina, Tatiana Suslova, Vyacheslav Ryabov
Summary: The burden of heart failure following myocardial infarction remains a major issue in clinical practice. The failure to resolve inflammation post-myocardial injury results in unsuccessful left ventricular remodeling and contributes to heart failure pathogenesis. The immune system's role in heart remodeling is ambiguous, with both protective and damaging effects observed.
FRONTIERS IN IMMUNOLOGY
(2021)
