Article
Cardiac & Cardiovascular Systems
Koshiro Kanaoka, Yoshitaka Iwanaga, Michikazu Nakai, Yuichi Nishioka, Tomoya Myojin, Shinichiro Kubo, Katsuki Okada, Tsunenari Soeda, Tatsuya Noda, Yasushi Sakata, Yoshihiro Miyamoto, Yoshihiko Saito, Tomoaki Imamura
Summary: This study aimed to investigate the variations in care quality for patients with acute coronary syndrome (ACS) and its association with mortality at both hospital and patient levels. The analysis of a nationwide database revealed substantial variations in ACS care. High adherence to quality indicators was associated with significant survival gains at both levels, indicating the effectiveness of a multi-level approach in improving survival for this population.
CANADIAN JOURNAL OF CARDIOLOGY
(2023)
Article
Medicine, General & Internal
Marcelo Cerullo, Kelly Yang, Karen E. Joynt Maddox, Ryan C. McDevitt, James W. Roberts, Anaeze C. Offodile
Summary: This study aimed to explore the impact of private equity acquisition of short-term acute care hospitals on healthcare access, patient outcomes, and spending. The results showed that PE acquisition had limited association with patient outcomes, but was moderately associated with improved mortality among Medicare beneficiaries hospitalized with acute myocardial infarction.
Article
Cardiac & Cardiovascular Systems
Heba Kamel, Mohamed Saber Hafez, Islam Bastawy
Summary: Telemedicine utilizing video conferencing can enhance medication adherence and healthy lifestyle compliance in STEMI patients following primary PCI, without significant impact on short-term MACE. Patients expressed high satisfaction with this virtual care approach.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Emergency Medicine
Jun Ke, Yiwei Chen, Xiaoping Wang, Zhiyong Wu, Qiongyao Zhang, Yangpeng Lian, Feng Chen
Summary: The study aims to identify risk factors for in-hospital mortality in patients with acute coronary syndrome (ACS) and evaluate the performance of traditional regression and machine learning prediction models. The results showed that age, NSTEMI, Killip III, Killip IV, and certain biomarkers were independent predictors of in-hospital mortality. Logistic regression, gradient boosting decision tree (GBDT), random forest, and support vector machine (SVM) models were developed and showed good predictive performance. Monitoring changes in specific biomarkers may improve clinical outcomes for ACS patients.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2022)
Article
Computer Science, Interdisciplinary Applications
Joshua Emakhu, Leslie Monplaisir, Celestine Aguwa, Suzan Arslanturk, Sara Masoud, Hashem Nassereddine, Mohamed S. Hamam, Joseph B. Miller
Summary: This study developed an ensemble learning-driven framework as a diagnostic support tool to prevent misdiagnosis of acute coronary syndrome (ACS) in emergency medicine. The framework successfully classified patients with ACS or non-ACS etiologies of their symptoms with high sensitivity and performance evaluation metrics. The study identified significant risk factors contributing to ACS and emphasized the potential of early identification using the proposed model.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2022)
Article
Medicine, General & Internal
Rishi K. Wadhera, Karen E. Joynt Maddox, Nihar R. Desai, Bruce E. Landon, Muthiah Vaduganathan, Lauren G. Gilstrap, Changyu Shen, Robert W. Yeh
Summary: The Hospital Readmissions Reduction Program (HRRP) has penalized hospitals with higher 30-day readmission rates more than $3 billion. A study comparing hospital performance on readmission and EDAC measures found only moderate agreement in rankings. Using the EDAC measure instead of the readmission measure could change penalty status for a significant number of hospitals.
ANNALS OF INTERNAL MEDICINE
(2021)
Article
Medicine, General & Internal
Gjin Ndrepepa, Franz-Josef Neumann, Maurizio Menichelli, Stefan Holdenrieder, Gert Richardt, Katharina Mayer, Salvatore Cassese, Erion Xhepa, Sebastian Kufner, Jens Wiebe, Michael Joner, Thorsten Kessler, Karl Ludwig Laugwitz, Heribert Schunkert, Adnan Kastrati
Summary: In patients with acute coronary syndrome, in-hospital hemoglobin drop was associated with a higher risk of one-year mortality, even in the absence of overt bleeding.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Medicine, General & Internal
Michael Klompas, Meghan A. Baker, Chanu Rhee, Robert Tucker, Karen Fiumara, Diane Griesbach, Carin Bennett-Rizzo, Hojjat Salmasian, Rui Wang, Noah Wheeler, Glen R. Gallagher, Andrew S. Lang, Timelia Fink, Stephanie Baez, Sandra Smole, Larry Madoff, Eric Goralnick, Andrew Resnick, Madelyn Pearson, Kathryn Britton, Julia Sinclair, Charles A. Morris
Summary: This study described a large cluster of SARS-CoV-2 infections in an acute care hospital, identifying potential transmission factors such as high viral loads and nebulization. Whole-genome sequencing confirmed infections in staff members despite wearing masks and eye protection.
ANNALS OF INTERNAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Takayuki Idaka, Hajime Iwasa, Seiji Yasumura
Summary: Japan's healthcare system provides inpatient care inefficiently, with a low number of physicians per hospital bed and a long average length of stay. This study investigated the associations of acute medical care with hospital-level factors, such as transfer and acceptance rates, and the mediation effect of length of stay. The findings suggest that enhanced transfer function, reduced acceptance function, and a large number of patients per physician for acute episodes are associated with increased medical service fees per day.
Article
Medicine, General & Internal
Orlanda Q. M. Goh, Xiaohui Xin, Wan Tin Lim, Michelle W. J. Tan, Juliana Y. L. Kan, Hartini Bte Osman, Wanyi Kee, Tse Yean Teo, Wee Boon Tan, Mei Ling Kang, Nicholas Graves
Summary: During COVID-19, Singapore implemented new models of care to treat patients with acute, low-severity medical conditions, which helped lower bed occupancy rates and alleviate pressure on acute hospitals.
Article
Cardiac & Cardiovascular Systems
Alberto Cordero, Belen Alvarez-Alvarez, David Escribano, Jose Ma Garcia-Acuna, Belen Cid-Alvarez, Moises Rodriguez-Manero, M. Amparo Quintanilla, Rosa Agra-Bermejo, Pilar Zuazola, Jose R. Gonzalez-Juanatey
Summary: Elevated remnant cholesterol is commonly found in ACS patients and is negatively correlated with age and positively correlated with body mass index. Remnant cholesterol is not associated with higher risk of in-hospital mortality, but it is associated with higher long-term risk of mortality and heart failure.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Manan Pareek, Kristian H. Kragholm, Anna Meta Dyrvig Kristensen, Muthiah Vaduganathan, Jannik L. Pallisgaard, Christina Byrne, Tor Biering-Sorensen, Christina Ji-Young Lee, Anders Nissen Bonde, Martin Bodtker Mortensen, Michael Maeng, Emil L. Fosbol, Lars Kober, Niels Thue Olsen, Gunnar H. Gislason, Deepak L. Bhatt, Christian Torp-Pedersen
Summary: The study found that individuals suspected of acute coronary syndrome who had consecutively elevated high-sensitivity troponin concentrations had the highest risk of death, while those with consecutively normal hsTnT concentrations had very low mortality rates, regardless of changes between measurements.
EUROPEAN HEART JOURNAL
(2023)
Article
Peripheral Vascular Disease
Jing Wen Yong, Yue Yan Xing, Meng Ge Zhou, Na Yang, Yong Chen Hao, Jing Liu, Jun Liu, Dong Zhao, Yu Jie Zhou, Zhi Jian Wang
Summary: A study in China found wide regional variations in in-hospital mortality among ACS patients, some of which could be explained by differences in patient characteristics, while other factors remain unexplained.
Article
Cardiac & Cardiovascular Systems
Chieh-Ju Chao, Anusha Shanbhag, Chia-Chun Chiang, Marlene E. Girardo, Amith R. Seri, Muhammad U. Khalid, Corbin Rayfield, Michael P. O'Shea, Olubadewa Fatunde, F. David Fortuin
Summary: This study found that baseline thrombocytopenia in patients with acute coronary syndrome is associated with increased all-cause mortality and bleeding events. With the severity of thrombocytopenia increasing, the all-cause mortality also increases.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Yihong Sun, Lin Feng, Xian Li, Zhe Wang, Runlin Gao, Yangfeng Wu
Summary: In ACS patients on DAPT, advancing age, impaired renal function, thrombolytic treatment, and severe comorbidities were independently associated with a higher risk of in-hospital major bleeding.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Ziping Li, Pengfei Yang, A. Geru, Haonan Sun, Hangkuan Liu, Xiwen Song, Zhengyang Jin, Linjie Li, Yongchen Hao, Yongle Li, Jing Liu, Dong Zhao, Xin Zhou, Qing Yang
Summary: Early guideline-directed medical therapy (GDMT) reduces the risk of major bleeds, ischemic events, and in-hospital mortality in ST-elevation myocardial infarction (STEMI) patients treated with percutaneous coronary intervention (PCI).
CARDIOVASCULAR DRUGS AND THERAPY
(2023)
Review
Cardiac & Cardiovascular Systems
Muhammad Shahzeb Khan, Aymen Ahmed, Stephen J. Greene, Mona Fiuzat, Michelle M. Kittleson, Javed Butler, George L. Bakris, Gregg C. Fonarow
Summary: Heart failure and end-stage kidney disease often coexist and worsen each other's prognosis. Patients on dialysis are at high risk, but they have been excluded from major clinical trials on heart failure, resulting in a lack of data and reliance on observational evidence. In clinical practice, heart failure treatment is often reduced or discontinued in patients with end-stage kidney disease undergoing dialysis due to safety concerns. This review discusses the available evidence, challenges, and future directions for optimizing heart failure management in these high-risk patients.
JOURNAL OF CARDIAC FAILURE
(2023)
Article
Health Care Sciences & Services
Yuwei Su, Zhengying Liu, Jie Chang, Qiuju Deng, Yuyang Zhang, Jing Liu, Ying Long
Summary: Using taxi GPS traces provides a more accurate method to estimate historical health care accessibility compared to conventional methods, and can accurately identify areas with low or high accessibility to health care facilities.
INTERNATIONAL JOURNAL OF HEALTH POLICY AND MANAGEMENT
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Yaling Han
EUROPEAN HEART JOURNAL
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Gregg C. Fonarow, Harriette G. C. Van Spall, James L. Januzzi
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Muhammad Shariq Usman, Tariq Jamal Siddiqi, Stefan D. Anker, George L. Bakris, Deepak L. Bhatt, Gerasimos Filippatos, Gregg C. Fonarow, Stephen J. Greene, James L. Januzzi, Muhammad Shahzeb Khan, Mikhail N. Kosiborod, Darren K. McGuire, Ileana L. Pina, Julio Rosenstock, Muthiah Vaduganathan, Subodh Verma, Shelley Zieroth, Javed Butler
Summary: SGLT2 inhibitors can reduce the risk of heart failure events and cardiovascular death in patients with type 2 diabetes, heart failure, and chronic kidney disease, and the effects are consistent in patients with different combinations of these diseases.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Gregg C. Fonarow, Stephen J. Greene
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Jie Chang, Qiuju Deng, Piaopiao Hu, Moning Guo, Feng Lu, Yuwei Su, Jiayi Sun, Yue Qi, Ying Long, Jing Liu
Summary: Little is known about the geographic variation in acute myocardial infarction (AMI) mortality and its association with changes in health care accessibility in Beijing. This study found that an increase in township-level health care accessibility was associated with a decrease in AMI mortality. Targeted improvement of health care accessibility in areas with high AMI mortality may help reduce AMI burden and improve its geographic inequality in megacities.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Josephine Harrington, Jie-Lena Sun, Gregg C. Fonarow, Stephen B. Heitner, Punag H. Divanji, Gary Binder, Larry A. Allen, Brooke Alhanti, Clyde W. Yancy, Nancy M. Albert, Adam D. DeVore, G. Michael Felker, Stephen J. Greene
Summary: This study investigated the clinical profile and healthcare costs of US patients with heart failure who do not meet the threshold for advanced therapies. The majority of these patients have severely reduced ejection fraction (≤30%) and face increased risk of death and heart failure hospitalization despite receiving guideline-directed medical therapy.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Hubert B. Haywood, Gregg C. Fonarow, Muhammad Shahzeb Khan, Michael E. Nassif, Javed Butler, Stephen J. Greene
JACC-HEART FAILURE
(2023)
Article
Health Care Sciences & Services
Boshu Ru, Xi Tan, Yu Liu, Kartik Kannapur, Dheepan Ramanan, Garin Kessler, Dominik Lautsch, Gregg Fonarow
Summary: This study aimed to compare different machine learning prediction models and feature construction methods to predict readmissions and worsening heart failure events (WHFEs) in patients with heart failure with reduced ejection fraction (HFrEF). The results showed that the XGBoost model with the frequency of clinical codes as features had the best discriminative ability for predicting these events.
JMIR FORMATIVE RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Neil Keshvani, Vinayak Subramanian, Christopher A. Wrobel, Nicole Solomon, Brooke Alhanti, Stephen J. Greene, Adam D. DeVore, Clyde W. Yancy, Larry A. Allen, Gregg C. Fonarow, Ambarish Pandey
Summary: This study aimed to investigate the referral and participation rates in cardiac rehabilitation (CR) among patients with heart failure with reduced ejection fraction and evaluate the impact on survival and readmission. The results showed that referral rates have increased from 2010 to 2020, but only one in four patients were referred to CR. The participation rate in CR was low. Patients referred to CR had a lower risk of 1-year death compared to those not referred.
CIRCULATION-HEART FAILURE
(2023)
Article
Endocrinology & Metabolism
Deshan Yuan, Na Xu, Ying Song, Zheng Zhang, Jingjing Xu, Zhenyu Liu, Xiaofang Tang, Yaling Han, Yan Chen, Yongzhen Zhang, Pei Zhu, Xiaogang Guo, Zhifang Wang, Ru Liu, Qingsheng Wang, Yi Yao, Yingqing Feng, Xueyan Zhao, Jinqing Yuan
Summary: This study aimed to examine the relationship between free fatty acids (FFAs) and cardiovascular risk in patients with coronary artery disease (CAD). The results showed that elevated FFA levels were associated with increased risks of all-cause death, cardiac death, and MACE. Combining the evaluation of FFAs with other traditional risk factors could help identify high-risk individuals who may require closer monitoring and aggressive treatment.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Cardiac & Cardiovascular Systems
Anping Cai, Congyi Zheng, Jiayuan Qiu, Gregg C. Fonarow, Gregory Y. H. Lip, Yingqing Feng, Zengwu Wang
Summary: The burden of heart failure (HF) in China is expected to increase due to population ageing. However, there is limited knowledge about the prevalence of HF stages in China. Therefore, this study aimed to evaluate the prevalence of HF stages in the general Chinese population and the specific prevalence by age, sex, and urbanity. The study found that both pre-clinical and clinical HF burdens are high in China and vary by age, sex, and urbanity.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Arnaud D. Kaze, Gregg C. Fonarow, Justin B. Echouffo-Tcheugui
Summary: In a large cohort of adults with type 2 diabetes, the study found a significant association between cardiac autonomic neuropathy (CAN) and the risk of silent myocardial infarction (SMI). Low heart rate variability was significantly associated with an increased risk of incident SMI. Participants with CAN had a 1.9-fold greater risk of SMI.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)