Article
Medicine, General & Internal
Xuelian Gao, Rui Wang, Zhonghua Sun, Hongkai Zhang, Kairui Bo, Xiaofei Xue, Junjie Yang, Lei Xu
Summary: This study found that the CTP-FFR model has promising value in improving the diagnostic accuracy of CCTA in detecting coronary ischemia. The feasibility of using CTP-FFR to detect coronary artery ischemia in patients with suspected CAD was proven.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Sebastian Gassenmaier, Ilias Tsiflikas, Simon Greulich, Jens Kuebler, Florian Hagen, Konstantin Nikolaou, Andreas M. Niess, Christof Burgstahler, Patrick Krumm
Summary: This study evaluated computed tomography fractional flow reserve (FFRCT) values in distal coronary segments of marathon runners, finding a significant occurrence of false-positive values. This phenomenon was commonly observed in participants without anatomical coronary artery stenosis, partially attributable to small distal vessel diameters.
EUROPEAN RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Shi-hai Zhao, Wei-feng Guo, Zhi-feng Yao, Shan Yang, Hong Yun, Yin-yin Chen, Tong-tong Han, Xiao-yue Zhou, Cai-xia Fu, Meng-su Zeng, Chen-guang Li, Cui-zhen Pan, Hang Jin
Summary: In this study, a fully automated pixel-wise post-processing framework was used to evaluate quantitative cardiovascular magnetic resonance myocardial perfusion imaging (CMR-MPI). The study aimed to assess the additional value of coronary magnetic resonance angiography (CMRA) in the diagnostic performance of fully automated pixel-wise quantitative CMR-MPI for detecting hemodynamically significant coronary artery disease (CAD). The results showed that the fully automated pixel-wise quantitative CMR-MPI can accurately detect hemodynamically significant CAD, but the integration of CMRA did not provide significantly additive value.
EUROPEAN RADIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Gilles Rioufol, Francois Derimay, Francois Roubille, Thibault Perret, Pascal Motreff, Denis Angoulvant, Yves Cottin, Ludovic Meunier, Laura Cetran, Guillaume Cayla, Brahim Harbaoui, Jean-Yves Wiedemann, Eric Van Belle, Christophe Pouillot, Nathalie Noirclerc, Jean-Francois Morelle, Francois-Xavier Soto, Christophe Caussin, Bernard Bertrand, Thierry Lefevre, Patrick Dupouy, Pierre-Francois Lesault, Franck Albert, Olivier Barthelemy, Rene Koning, Laurent Leborgne, Pierre Barnay, Philippe Chapon, Sebastien Armero, Antoine Lafont, Christophe Piot, Camille Amaz, Bernadette Vaz, Lakhdar Benyahya, Yvonne Varillon, Michel Ovize, Nathan Mewton, Gerard Finet
Summary: The FUTURE trial investigated whether a treatment strategy based on FFR was superior to a traditional strategy in the treatment of multivessel CAD, and found no significant difference in rates of major adverse cardiac events or death at 1-year follow-up between the two groups.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Toshimitsu Tsugu, Kaoru Tanaka, Yuji Nagatomo, Dries Belsack, Hannes Devos, Nico Buls, Bernard Cosyns, Jean-Francois Argacha, Michel De Maeseneer, Johan De Mey
Summary: This study found that in vessels with no apparent CAD, vessel length was the most influential factor on FFRCT, followed by the bifurcation angle.
EUROPEAN RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Mihaly Karolyi, Alexander Gotschy, Malgorzata Polacin, Sven Plein, Ingo Paetsch, Cosima Jahnke, Michael Frick, Rolf Gebker, Hatem Alkadhi, Sebastian Kozerke, Robert Manka
Summary: This study aimed to test the accuracy of 3D cardiac magnetic resonance stress perfusion in the elderly population compared to reference standard fractional flow reserve (FFR). The results showed that 3D CMR perfusion has excellent diagnostic accuracy for the detection of hemodynamically relevant coronary stenosis, independent of patient age.
EUROPEAN RADIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Fay M. A. Nous, Tobias Geisler, Mariusz B. P. Kruk, Hatem Alkadhi, Kakuya Kitagawa, Rozemarijn Vliegenthart, Michaela M. Hell, Jorg Hausleiter, Patricia K. Nguyen, Ricardo P. J. Budde, Konstantin Nikolaou, Cezary Kepka, Robert Manka, Hajime Sakuma, Sachin B. Malik, Adriaan Coenen, Felix Zijlstra, Ernst Klotz, Pim van der Harst, Christoph Artzner, Admir Dedic, Francesca Pugliese, Fabian Bamberg, Koen Nieman
Summary: In this multicenter study, the combination of dynamic stress CT myocardial perfusion imaging (CT-MPI) with coronary CT angiography (CTA) showed incremental diagnostic value for the identification of hemodynamically significant coronary artery disease.
JACC-CARDIOVASCULAR IMAGING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Liu Yang, Peng Peng Xu, U. Joseph Schoepf, Christian Tesche, Balakrishnan Pillai, Rock H. Savage, Chun Xiang Tang, Fan Zhou, Hao Dong Wei, Zhong Qiang Luo, Qing Gen Wang, Chang Sheng Zhou, Meng Jie Lu, Guang Ming Lu, Long Jiang Zhang
Summary: Fractional flow reserve and plaque progression assessed by serial coronary CT angiography predicted the risk of future major adverse cardiovascular events (MACE), demonstrating better accuracy compared to traditional assessment markers.
EUROPEAN RADIOLOGY
(2021)
Article
Health Care Sciences & Services
Chien-Boon Jong, Tsui-Shan Lu, Patrick Yan-Tyng Liu, Jeng-Wei Chen, Ching-Chang Huang, Hsien-Li Kao
Summary: In patients with chronic kidney disease, functional ischemia in coronary artery stenosis is associated with poor clinical outcomes despite coronary revascularization.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Xin Liu, Xukai Mo, Heye Zhang, Guang Yang, Changzheng Shi, William Kongtou Hau
Summary: DL-FFRCT can reduce the need for diagnostic coronary angiography when identifying patients suitable for coronary intervention, and a low MACE rate was found in a 2-year follow-up investigation.
EUROPEAN RADIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Carlos Collet, Nils P. Johnson, Takuya Mizukami, William F. Fearon, Colin Berry, Jeroen Sonck, Damien Collison, Bon-Kwon Koo, Nicolas Meneveau, Shiv Kumar Agarwal, Barry Uretsky, Abdul Hakeem, Joon-Hyung Doh, Bruno R. Da Costa, Keith G. Oldroyd, Jonathon A. Leipsic, Umberto Morbiducci, Charles Taylor, Brian Ko, Pim A. L. Tonino, Divaka Perera, Toshiro Shinke, Claudio Chiastra, Andrei C. Sposito, Antonio Maria Leone, Olivier Muller, Stephane Fournier, Hitoshi Matsuo, Julien Adjedj, Nicolas Amabile, Zsolt Piroth, Fernando Alfonso, Fernando Rivero, Jung-Min Ahn, Gabor G. Toth, Abdul Ihdayhid, Nick E. J. West, Tetsuya Amano, Eric Wyffels, Daniel Munhoz, Marta Belmonte, Hirofumi Ohashi, Koshiro Sakai, Emanuele Gallinoro, Emanuele Barbato, Thomas Engstrom, Javier Escaned, Ziad A. Ali, Morton J. Kern, Nico H. J. Pijls, Peter Jueni, Bernard De Bruyne
Summary: This study found that the post-PCI FFR of the left anterior descending (LAD) artery was lower than that of non-LAD arteries, highlighting the importance of interpreting post-PCI FFR on a vessel-specific basis. Although a higher post-PCI FFR was associated with improved prognosis, its predictive capacity for events differed between the LAD and non-LAD arteries, being poor in the LAD and moderate in the non-LAD vessels.
JACC-CARDIOVASCULAR INTERVENTIONS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Masahiro Hoshino, Seokhun Yang, Tomoyo Sugiyama, Jinlong Zhang, Yoshihisa Kanaji, Rikuta Hamaya, Masao Yamaguchi, Masahiro Hada, Tomoki Horie, Kai Nogami, Hiroki Ueno, Toru Misawa, Taishi Yonetsu, Doyeon Hwang, Joo Myung Lee, Eun-Seok Shin, Joon-Hyung Doh, Chang-Wook Nam, Bon-Kwon Koo, Tetsuo Sasano, Tsunekazu Kakuta
Summary: This study found that the prevalence of coronary microvascular dysfunction (CMD) in patients with intermediate epicardial stenosis is about one-third. CMD was significantly associated with greater lumen volume, fibrofatty and necrotic component volume, and epicardial fat volume.
EUROPEAN RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Elia von Felten, Dominik C. Benz, Georgios Benetos, Jessica Baehler, Dimitri Patriki, Georgios P. Rampidis, Andreas A. Giannopoulos, Adam Bakula, Christoph Graeni, Aju P. Pazhenkottil, Catherine Gebhard, Tobias A. Fuchs, Philipp A. Kaufmann, Ronny R. Buechel
Summary: Assessing regional quantitative myocardial flow measures through N-13-ammonia PET myocardial perfusion imaging can predict adverse cardiac outcomes and all-cause death in patients with suspected coronary artery disease.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Article
Medicine, General & Internal
Povilas Budrys, Aaron Peace, Arvydas Baranauskas, Giedrius Davidavicius
Summary: This study compared the effectiveness of FFR and IVUS PCI optimization strategies for long coronary lesions. The results showed that the FFR optimization strategy resulted in poorer functional PCI outcomes and larger myocardial ischemia burden compared to the IVUS optimization strategy. However, this difference did not have a statistically significant impact on clinical outcomes.
Article
Radiology, Nuclear Medicine & Medical Imaging
Alexis Poitrasson-Riviere, Jonathan B. Moody, Jennifer M. Renaud, Tomoe Hagio, Liliana Arida-Moody, Christopher J. Buckley, Mouaz H. Al-Mallah, Brahmajee K. Nallamothu, Richard L. Weinberg, Edward P. Ficaro, Venkatesh L. Murthy
Summary: This study combines MFR and relative perfusion quantification to create an integrated MFR (iMFR) for distinguishing obstructive epicardial coronary artery disease (CAD) from microvascular dysfunction. The results show that iMFR can serve as a powerful predictor for diagnosing obstructive stenosis, and the absence of transient ischemic dilation (TID) can help rule out obstructive and high-risk CAD.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Cardiac & Cardiovascular Systems
Alessandro Candreva, Mattia Pagnoni, Maurizio Lodi Rizzini, Takuya Mizukami, Emanuele Gallinoro, Valentina Mazzi, Diego Gallo, David Meier, Toshiro Shinke, Jean-Paul Aben, Sakura Nagumo, Jeroen Sonck, Daniel Munhoz, Stephane Fournier, Emanuele Barbato, Ward Heggermont, Stephane Cook, Claudio Chiastra, Umberto Morbiducci, Bernard De Bruyne, Oliver Muller, Carlos Collet
Summary: This study used 3D quantitative coronary angiography to analyze wall shear stress and found that TSVI had a stronger predictive capacity for identifying lesions culprit for future myocardial infarction compared to traditional indicators.
Editorial Material
Cardiac & Cardiovascular Systems
Ioannis Skalidis, Stephane Fournier, Emmanouil Skalidis, Niccolo Maurizi
EUROPEAN HEART JOURNAL
(2023)
Correction
Cardiac & Cardiovascular Systems
Mattia Pagnoni, David Meier, Adrian Luca, Stephane Fournier, Farhang Aminfar, Pascale Gentil, Christelle Haddad, Giulia Domenichini, Mathieu Le Bloa, Claudia Herrera-Siklody, Stephane Cook, Jean-Jacques Goy, Christan Roguelov, Gregoire Girod, Vladimir Rubimbura, Marion Dupre, Eric Eeckhout, Etienne Pruvot, Olivier Muller, Patrizio Pascale
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Ioannis Skalidis, David Meier, Bernard De Bruyne, Carlos Collet, Jeroen Sonck, Thabo Mahendiran, David Rotzinger, Salah Dine Qanadli, Eric Eeckhout, Olivier Muller, Stephane Fournier
Summary: Noninvasive methods of estimating invasively measured fractional flow reserve (FFRinvasive) are actively being explored, aiming to avoid invasive procedures and drugs. This study evaluates the diagnostic performance of coronary angiography-derived FFR (FFRangio) in NSTEMI patients, demonstrating its sensitivity, specificity, and accuracy. FFRangio can precisely estimate FFRinvasive in NSTEMI patients and guide treatment decisions for coronary artery lesions without invasive procedures or drugs.
CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS
(2023)
Article
Cardiac & Cardiovascular Systems
Matthieu Dietz, Christel H. Kamani, Gilles Allenbach, Vladimir Rubimbura, Stephane Fournier, Vincent Dunet, Giorgio Treglia, Marie Nicod Lalonde, Niklaus Schaefer, Eric Eeckhout, Olivier Muller, John O. Prior
Summary: Using low-dose silicon photomultipliers (SiPM) technology with Rb-82 cardiac PET/CT, impaired global stress MBF, global MFR, and regional MFC were found to be powerful predictors of major adverse cardiovascular events (MACE), outperforming traditional risk factors. However, only reduced global stress MBF independently predicted MACE.
JOURNAL OF NUCLEAR CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Fabienne Foster-Witassek, Hans Rickli, Marco Roffi, Giovanni Pedrazzini, Franz Eberli, Amir Fassa, Raban Jeger, Stephane Fournier, Paul Erne, Dragana Radovanovic
Summary: This study aimed to analyze changes in pre-hospital delay over time in women and men with ST-elevation myocardial infarction (STEMI) in Switzerland. The study found that the pre-hospital delay decreased significantly for both sexes between 2002 and 2019, with a greater decrease observed in women. After adjustment for patient characteristics, the delay in 2019 was nearly the same for women and men.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Roxane de La Harpe, Christian W. Thorball, Claire Redin, Stephane Fournier, Olivier Mueller, Davide Strambo, Patrik Michel, Peter Vollenweider, Pedro Marques-Vidal, Jacques Fellay, Julien Vaucher
Summary: This study aimed to determine whether using polygenic risk scores improves the prediction of atherosclerotic cardiovascular disease risk when combined with clinical scores. The results showed that combining a polygenic risk score with clinical risk scores significantly improved risk reclassification for patients with intermediate risk for cardiovascular disease.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Thabo Mahendiran, Dorina Thanou, Ortal Senouf, David Meier, Nicolas Dayer, Fahrang Aminfar, Denise Auberson, Omar Raita, Pascal Frossard, Mattia Pagnoni, Stephane Cook, Bernard De Bruyne, Olivier Muller, Emmanuel Abbe, Stephane Fournier
Summary: This study compared the ability of humans, angiographic parameters, and deep learning to predict the lesion responsible for future myocardial infarction. The results showed that deep learning outperformed other parameters and human visual assessment in predicting future culprit lesions.
Article
Cardiac & Cardiovascular Systems
Marco Durig, Diego Arroyo, Marc Bedossa, Philippe Commeau, Stephane Fournier, Olivier Mueller, Paul Barragan, Herve Le Breton, Serban Puricel, Stephane Cook
Summary: This study provides data on patients presenting with acute coronary syndrome due to unprotected left main coronary artery (ULMCA) occlusion. The study found that ULMCA occlusion has a high short-term mortality rate, with 15% of patients dying in the cath lab and 42% dying in hospital. Patients who survived the index hospitalization had similar mortality rates as other st elevation myocardial infarction patients.
CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS
(2023)
Article
Cardiac & Cardiovascular Systems
Giuseppe Tarantini, Gilbert Tang, Luca Nai Fovino, Daniel Blackman, Nicolas M. Van Mieghem, Won-Keun Kim, Nicole Karam, Pedro Carrilho-Ferreira, Stephane Fournier, Jerzy Pregowski, Chiara Fraccaro, Flavien Vincent, Rui Campante Teles, Darren Mylotte, Ivan Wong, Gintautas Bieliauskas, Martin Czerny, Nikolaos Bonaros, Alessandro Parolari, Darius Dudek, Didier Tchetche, Helene Eltchaninoff, Ole De Backer, Giulio Stefanini, Lars Sondergaard
Summary: Significant coronary artery disease (CAD) is common in patients with severe aortic stenosis undergoing transcatheter aortic valve implantation (TAVI), and the management of these two conditions is crucial, especially in younger and lower-risk patients. However, the preprocedural diagnostic evaluation and treatment indications for significant CAD in TAVI candidates are still debated. In this clinical consensus statement, experts aim to review the available evidence and propose a rationale for diagnostic evaluation and indications for percutaneous revascularisation of CAD in TAVI patients, as well as addressing other concerns related to TAVI.
Article
Cardiac & Cardiovascular Systems
Thabo Mahendiran, Andre Hoepli, Fabienne Foster-Witassek, Hans Rickli, Marco Roffi, Franz Eberli, Giovanni Pedrazzini, Raban Jeger, Dragana Radovanovic, Stephane Fournier
Summary: We evaluated 20-year trends in modifiable cardiovascular risk factors in young adults with acute coronary syndromes in Switzerland. Young ACS patients in Switzerland exhibited a high prevalence of risk factors, with obesity and smoking being major concerns. These findings highlight the need for public health initiatives targeting young adults in Switzerland.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Simon Oestreicher, Agnese Vella, Olivier Muller, Matthias Kirsch, Eric Eeckhout, Stephane Fournier, Pierre Monney, Olivier Roux, Christan Roguelov, Philippe Zhang, Paul Abraham, Clemence Ferlay, Panagiotis Antiochos, Henri Lu
Summary: The prevalence of carotid artery stenosis (CAS) in patients undergoing transcatheter aortic valve implantation (TAVI) is not well-documented. This study aimed to investigate the impact of CAS, especially severe or bilateral CAS, on the prognosis after TAVI. The results showed that while CAS as a whole did not predict neurovascular complications, bilateral CAS was associated with an increased risk of stroke after TAVI.
JOURNAL OF INVASIVE CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Emanuele Gallinoro, Dario Tino Bertolone, Estefania Fernandez-Peregrina, Pasquale Paolisso, Konstantinos Bermpeis, Giuseppe Esposito, Andrea Gomez-Lopez, Alessandro Candreva, Niya Mileva, Marta Belmonte, Takuya Mizukami, Stephane Fournier, Marc Vanderheyden, Eric Wyffels, Jozef Bartunek, Jeroen Sonck, Emanuele Barbato, Carlos Collet, Bernard De Bruyne
Summary: This study aimed to assess the reproducibility of bolus and continuous thermodilution in assessing coronary microvascular function. The results showed that continuous thermodilution demonstrated significantly less variability on repeated measurements than bolus thermodilution, indicating its higher reliability in evaluating coronary microvascular function.
Article
Cardiac & Cardiovascular Systems
Vladimir Rubimbura, Nils Johnson, Marcel van't Veer, Julien Adjedj, Stephane Fournier, Marion Dupre, Bernard De Bruyne, Eric Eeckhout, Olivier Muller
Summary: This study compared the distal pressure to aortic pressure ratio (Pd/Pa) measurements of a jailed wire and a free-floating wire in bifurcation treatment. The results showed that the Pd/Pa value of the jailed wire was reliable compared to the inserted wire after stent implantation.
JOURNAL OF INVASIVE CARDIOLOGY
(2022)
Article
Medicine, General & Internal
Lauriane Gilgien-Denereaz, Julian Jakob, Kali Tal, Baris Gencer, David Carballo, Lorenz Raber, Roland Klingenberg, Christian M. Matter, Isabella Sudano, Thomas F. Luscher, Stephan Windecker, Olivier Muller, Stephane Fournier, Nicolas Rodondi, Francois Mach, Reto Auer, David Nanchen
Summary: This study compared systematic and opportunistic smoking cessation counseling for patients with acute coronary syndromes, and found that systematic counseling did not increase 5-year smoking cessation rates or decrease cardiovascular event recurrence.
SWISS MEDICAL WEEKLY
(2022)