Article
Oncology
Purab Pal, Alec Millner, Svetlana E. Semina, Rosemary J. Huggins, Logan Running, Diana S. Aga, Debra A. Tonetti, Rachel Schiff, Geoffrey L. Greene, G. Ekin Atilla-Gokcumen, Jonna Frasor
Summary: Endocrine therapy resistance is a critical problem in estrogen receptor-positive breast cancer. This study investigated how alterations in sphingolipids promote cell survival in ET-resistant breast cancer. Through targeted sphingolipidomics analysis, the researchers found that tamoxifen-resistant cells have lower levels of ceramides compared to their sensitive counterparts. They also identified that CERK inhibition induces ceramide-mediated cell death in tamoxifen-resistant cells. These findings suggest that ET-resistant breast cancer cells rely on CERK activity to maintain lower ceramide levels, making CERK a potential therapeutic target.
Article
Plant Sciences
Jing Zhao, Xin-Chen Tian, Jia-Qi Zhang, Tan-Tan Li, Sen Qiao, Shu-Long Jiang
Summary: This study investigated the pharmacological effects and mechanisms of action of Tribulus terrestris extract on breast cancer using network pharmacology analysis and in vivo experiments. The results demonstrated that Tribulus terrestris extract had therapeutic effects on breast cancer and modulated the sphingolipid metabolism signaling pathways.
Article
Food Science & Technology
Philippe Guerre, Caroline Gilleron, Maria Matard-Mann, Pi Nyvall Collen
Summary: Fumonisins have significant effects on sphingolipids in the heart and gizzard of chickens, but no significant effects were observed in breast muscle. There are significant differences in sphingolipid composition between the heart and gizzard.
Article
Biochemistry & Molecular Biology
Aiping Bai, Jacek Bielawski, Alicja Bielawska, Yusuf A. Hannun
Summary: This study describes the synthesis and evaluation of erythro-enantiomers in comparison with threo-enantiomers of B13, revealing that erythro-enantiomers are more effective in inhibiting the growth of MCF7 cells. The results also indicate that erythro-enantiomers are more cell permeable and capable of hydrolysis and phosphorylation in cells. Moreover, the study shows the de-acylation and re-acylation of the amino group of the aromatic alcohol from the full set of B13 isomers within the cells.
BIOORGANIC & MEDICINAL CHEMISTRY
(2021)
Article
Multidisciplinary Sciences
Zeynep Itah, Shanzah Chaudhry, Sithara Raju Ponny, Ozkan Aydemir, Alexandra Lee, Julie Cavanagh-Kyros, Cathy Tournier, William J. Muller, Roger J. Davis
Summary: The HER2(+) subtype of human breast cancer is associated with the malignant transformation of luminal ductal cells of the mammary epithelium. Loss of function mutations and deletions of the MAP2K4 and MAP2K7genes that encode direct activators of the JUN NH2-terminal kinase (JNK) were found in tumor DNA sequence analysis. In vitro and in vivo studies demonstrated that JNK pathway deficiency promotes HER2(+)-driven breast cancer.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Biochemistry & Molecular Biology
Xuewei Zhang, Wataru Sakamoto, Daniel Canals, Masumi Ishibashi, Masaya Matsuda, Kentaro Nishida, Masafumi Toyoshima, Shogo Shigeta, Makoto Taniguchi, Can E. Senkal, Toshiro Okazaki, Nobuo Yaegashi, Yusuf A. Hannun, Takeshi Nabe, Kazuyuki Kitatani
Summary: Regulation of sphingolipid metabolism has a significant impact on cellular homeostasis and cancer progression. Dysregulation of ceramide-centered metabolism is associated with metastatic potential in ovarian cancer cells. Specifically, the CerS2-C-24:1-ceramide axis, possibly counteracted by neutral ceramidase, plays a key role in limiting cell motility and metastatic potential.
Review
Urology & Nephrology
Yelena Drexler, Judith Molina, Alla Mitrofanova, Alessia Fornoni, Sandra Merscher
Summary: Recent studies have shown that sphingolipids and sphingolipid metabolites play important roles in the pathogenesis and progression of kidney diseases by influencing the intracellular sphingolipid composition of renal cells and the integrity of the glomerular filtration barrier. The sphingolipid metabolite S1P plays a crucial role in renal cells, and aberrant S1P signaling contributes to the pathogenesis and progression of kidney diseases.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yayun Gu, Huanyao Gao, Huan Zhang, August John, Xiujuan Zhu, Suganti Shivaram, Jia Yu, Richard M. Weinshilboum, Liewei Wang
Summary: The TRAF4-SMURF2 complex is identified as a potential mechanism for maintaining HER2 signaling in HER2-positive breast cancer cells during Trastuzumab treatment. Knockdown of TRAF4 reduces HER2 stability and improves Trastuzumab sensitivity.
Review
Biochemistry & Molecular Biology
Jaya M. Thomas, Tara Sudhadevi, Prathima Basa, Alison W. Ha, Viswanathan Natarajan, Anantha Harijith
Summary: This article discusses the role of sphingolipid signaling in hyperoxia-induced lung injury and Bronchopulmonary dysplasia (BPD). The study found that sphingolipids such as ceramides and sphingosine 1-phosphate (S1P) are elevated in premature infants developing BPD, and treatment with a specific inhibitor can protect against BPD and improve lung function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Oncology
Serenella M. Pupa, Francesca Ligorio, Valeria Cancila, Alma Franceschini, Claudio Tripodo, Claudio Vernieri, Lorenzo Castagnoli
Summary: Breast cancer is a group of different tumors, with altered HER2 expression defining a particularly aggressive subtype. Understanding HER2 biology and the mechanisms underlying aggressiveness and drug susceptibility is crucial. Breast cancer stem cells play a significant role in tumor growth, aggressiveness, metastasis, and treatment resistance.
Review
Cell Biology
MelissaR Pitman, Martin K. Oehler, Stuart M. Pitson
Summary: Ovarian cancer is a deadly gynaecological malignancy commonly diagnosed at an advanced stage, making treatment challenging. Novel strategies for early detection and therapeutics are urgently needed to improve patient survival, with the sphingolipid pathway showing promise as a potential therapeutic target against chemotherapy-resistant disease.
CELLULAR SIGNALLING
(2021)
Article
Oncology
Arnaldo Marin, Abdullah Al Mamun, Hima Patel, Hiroaki Akamatsu, Dan Ye, Dhivya R. Sudhan, Lisa Eli, Katherine Marcelain, Benjamin P. Brown, Jens Meiler, Carlos L. Arteaga, Ariella B. Hanker
Summary: This study reveals the driver function of acquired HER2 mutations in resistance to HER2 tyrosine kinase inhibitors, and provides a potential treatment strategy to overcome this resistance.
Review
Biochemistry & Molecular Biology
Long Hoa Chung, Da Liu, Xin Tracy Liu, Yanfei Qi
Summary: Sphingolipids play essential roles in constructing cellular membranes and regulating cellular functions, with ceramide and sphingomyelin as key components; Ceramide transfer protein (CERT) controls the balance of these two substances within cells, crucial for cancer cell survival and functioning.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Li-Teng Ong, Wee Chyan Lee, Shijun Ma, Gokce Oguz, Zhitong Niu, Yi Bao, Mubaraka Yusuf, Puay Leng Lee, Jian Yuan Goh, Panpan Wang, Kylie Su Mei Yong, Qingfeng Chen, Wenyu Wang, Adaikalavan Ramasamy, Dave S. B. Hoon, Henrik J. Ditzel, Ern Yu Tan, Soo Chin Lee, Qiang Yu
Summary: In this study, we discovered that IF‑β is highly expressed in HER2(+) breast cancer and inhibits the malignant characteristics of cancer cells by regulating the AKT signaling pathway and XBP1 activation.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biochemistry & Molecular Biology
Yun Ling, Gehao Liang, Qun Lin, Xiaolin Fang, Qing Luo, Yinghuan Cen, Maryam Mehrpour, Ahmed Hamai, Zihao Liu, Yu Shi, Juanmei Li, Wanyi Lin, Shijie Jia, Wenqian Yang, Qiang Liu, Erwei Song, Jun Li, Chang Gong
Summary: The study identified a circRNA circCDYL2 that is overexpressed in HER2(+) breast cancer patients resistant to trastuzumab, playing a critical role in maintaining HER2 signaling and contributing to trastuzumab resistance. High levels of circCDYL2 were associated with rapid recurrence and shorter survival in HER2(+) breast cancer patients, suggesting circCDYL2 as a potential biomarker for trastuzumab resistance.
Article
Biochemistry & Molecular Biology
Jacek Marzec, Abu Z. Dayem Ullah, Stefano Pirro, Emanuela Gadaleta, Tatjana Crnogorac-Jurcevic, Nicholas R. Lemoine, Hemant M. Kocher, Claude Chelala
NUCLEIC ACIDS RESEARCH
(2018)
Article
Cardiac & Cardiovascular Systems
Ayman Samman Tahhan, Muhammad Hammadah, Mohamad Raad, Zakaria Almwaqqat, Ayman Alkhoder, Pratik B. Sandesara, Heval Mohamed-Kelli, Salim S. Hayek, Jeong Hwan Kim, Wesley T. O'Neal, Matthew L. Topel, Aubrey J. Grant, Nabil Sabbak, Robert E. Heinl, Mohamad Mazen Gafeer, Malik Obideen, Belal Kaseer, Nasser Abdelhadi, Yi-An Ko, Chang Liu, Iraj Hesaroieh, Ernestine A. Mahar, Viola Vaccarino, Edmund K. Waller, Arshed A. Quyyumi
CIRCULATION RESEARCH
(2018)
Article
Cardiac & Cardiovascular Systems
Salim S. Hayek, Jasmin Divers, Mohamad Raad, Jianzhao Xu, Donald W. Bowden, Melissa Tracy, Jochen Reiser, Barry I. Freedman
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2018)
Article
Clinical Neurology
Sally El-Sitt, Jihane Soueid, Jamal Al Ali, Joelle Makoukji, Nadine J. Makhoul, Hayat Harati, Rose-Mary Boustany
FRONTIERS IN NEUROLOGY
(2019)
Review
Cardiac & Cardiovascular Systems
Aneesha Thobani, Devinder S. Dhindsa, Benjamin D. DeMoss, Mohamad Raad, Pratik B. Sandesara, Laurence S. Sperling, Jefferson T. Baer
AMERICAN JOURNAL OF CARDIOLOGY
(2019)
Article
Medicine, General & Internal
Salim S. Hayek, David E. Leaf, Ayman Samman Tahhan, Mohamad Raad, Shreyak Sharma, Sushrut S. Waikar, Sanja Sever, Alex Camacho, Xuexiang Wang, Ranadheer R. Dande, Nasrien E. Ibrahim, Rebecca M. Baron, Mehmet M. Altintas, Changli Wei, David Sheikh-Hamad, Jenny S-C Pan, Michael W. Holliday, James L. Januzzi, Steven D. Weisbord, Arshed A. Quyyumi, Jochen Reiser
NEW ENGLAND JOURNAL OF MEDICINE
(2020)
Article
Cardiac & Cardiovascular Systems
Mohamad Raad, Ahmed AlBadri, Janet Wei, Puja K. Mehta, Jenna Maughan, Adit Gadh, Louise Thomson, Dean P. Jones, Arshed A. Quyyumi, Carl J. Pepine, C. Noel Bairey Merz
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2020)
Review
Cardiac & Cardiovascular Systems
Ayman Samman Tahhan, Muthiah Vaduganathan, Stephen J. Greene, Alaaeddin Alrohaibani, Mohamed Raad, Mazen Gafeer, Roxana Mehran, Gregg C. Fonarow, Pamela S. Douglas, Deepak L. Bhatt, Javed Butler
Article
Cardiac & Cardiovascular Systems
Mohamad Raad, Mohammed Dabbagh, Sarah Gorgis, Jerry Yan, Omar Chehab, Carina Dagher, Khaled Jamoor, Inaya Hajj Hussein, Bernard Cook, Meredith Van Harn, Gurjit Singh, James McCord, Sachin Parikh
AMERICAN JOURNAL OF CARDIOLOGY
(2020)
Review
Cardiac & Cardiovascular Systems
Waddah Maskoun, Mohamad Raad, Arfaat Khan, Ramy Mando, Mohamed Homsi
Article
Cardiac & Cardiovascular Systems
Jin-Sin Koh, Olivia Y. Hung, Parham Eshtehardi, Arnav Kumar, Rani Rabah, Mohamad Raad, Sonali Kumar, Sundeep Chaudhry, Sonu Gupta, Hossein Hosseini, Emmanouil Brilakis, Michel Corban, Nabil Sabbak, Grady Murphy Burnett, Chang Liu, Puja K. Mehta, Arshed A. Quyyumi, Habib Samady
CIRCULATION-CARDIOVASCULAR INTERVENTIONS
(2020)
Article
Cardiac & Cardiovascular Systems
Mohamad Raad, Sarah Gorgis, Chelsea Abshire, Monica Yost, Mohammed F. Dabbagh, Omar Chehab, Lindsey Aurora, Sati Patel, Paul Nona, Jerry Yan, Gurjit Singh, John Syrjamaki, Scott Kaatz, Sachin Parikh
Summary: This study aimed to describe and validate the COVID-19 Risk Index (CRI) in a cohort of hospitalized patients with COVID-19. The CRI is a disease-specific tool that assesses the risk for mechanical ventilation or death, with variables like age, chronic obstructive pulmonary disease, chronic kidney disease, and initial D-dimer levels being independently associated with adverse outcomes.
JOURNAL OF THROMBOSIS AND THROMBOLYSIS
(2022)
Article
Cardiac & Cardiovascular Systems
Waddah Maskoun, Mohamad Raad, Yong-Mei Cha, Mahmoud Houmsse, Amjad Abualsuod, Fatima Ezzeddine, Justin Pieper, Khaled Jamoor, Cristina Tita, John Miller
Summary: In patients after orthotopic heart transplant, implantation of ICD as secondary prevention and in patients with higher baseline LVEF can lead to beneficial outcomes. Resynchronization therapy also shows benefits.
JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Mohamad Raad, Sarah Gorgis, Mohammed Dabbagh, Omar Chehab, Sachin Parikh, Gurjit Singh
Summary: The study assessed the association of new right heart strain patterns on presenting 12-lead electrocardiogram (RHS-ECG) with outcomes in hospitalized COVID-19 patients. Findings of RHS-ECG were significantly associated with adverse outcomes, mortality, and the need for mechanical ventilation in patients. Special attention should be given to patients with new signs of RHS on presenting ECG.
JACC-CLINICAL ELECTROPHYSIOLOGY
(2021)
Meeting Abstract
Cardiac & Cardiovascular Systems
Mohamad Raad, Sachin Parikh, Gurjit Singh