期刊
CHEMISTRY AND PHYSICS OF LIPIDS
卷 218, 期 -, 页码 34-39出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.chemphyslip.2018.11.006
关键词
Detergent-resistant membranes; Lipid domains; Lipid phases; Lipid rafts; Membrane rafts; Microdomains; Nanodomains
资金
- Spanish Ministry of Economy [FEDER MINECO BFU 2015-66306-P]
- Basque Government [IT849-13]
The membrane raft hypothesis, proposed in 1997 by Simons and Ikonen, has played a paradoxical role in the history of biomembrane research. While it has generated a large amount of investigations, thus helping to increase our understanding of membranes, the object that gives name to the hypothesis, i.e. the raft itself, has been and still is an object of controversy, in which its very reality is often questioned. In this contribution I review the history of the hypothesis and its reception by membrane biologists, and summarize some of the valuable physico-chemical results that have been obtained while testing the raft hypothesis. To save a useful concept from its many misuses I propose that the expression (transient) nanodomains be employed instead of rafts.
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