标题
Bromodomain Drug Discovery – the Past, the Present, and the Future
作者
关键词
-
出版物
CHEMICAL RECORD
Volume 18, Issue 12, Pages 1808-1817
出版商
Wiley
发表日期
2018-10-06
DOI
10.1002/tcr.201800074
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Benzoisoquinolinediones as Potent and Selective Inhibitors of BRPF2 and TAF1/TAF1L Bromodomains
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- Structural basis of PROTAC cooperative recognition for selective protein degradation
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- BET bromodomain inhibitors and agonists of the beta-2 adrenergic receptor identified in screens for compounds that inhibit DUX4 expression in FSHD muscle cells
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- Discovery of a PCAF Bromodomain Chemical Probe
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- Abstract 14: A switch in metabolic phenotype in vemurafenib-resistant melanoma cells to increased amino acid dependence serves as an alternate mechanism for survival
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- BRD4 Regulates Breast Cancer Dissemination through Jagged1/Notch1 Signaling
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- Overexpression of bromodomain factor 3 inTrypanosoma cruzi(TcBDF3) affects differentiation of the parasite and protects it against bromodomain inhibitors
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- Haploinsufficiency of BAZ1B contributes to Williams syndrome through transcriptional dysregulation of neurodevelopmental pathways
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- Pharmacological Inhibition of Bromodomain Proteins Suppresses Retinal Inflammatory Disease and Downregulates Retinal Th17 Cells
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- Structure-Based Design of an in Vivo Active Selective BRD9 Inhibitor
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- BET Bromodomain Inhibition Promotes Anti-tumor Immunity by Suppressing PD-L1 Expression
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- The SMARCA2/4 ATPase Domain Surpasses the Bromodomain as a Drug Target in SWI/SNF-Mutant Cancers: Insights from cDNA Rescue and PFI-3 Inhibitor Studies
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- A Plasmodium Falciparum Bromodomain Protein Regulates Invasion Gene Expression
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- ATAD2 Overexpression Identifies Colorectal Cancer Patients with Poor Prognosis and Drives Proliferation of Cancer Cells
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- Suppression of BRD4 inhibits human hepatocellular carcinoma by repressing MYC and enhancing BIM expression
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- Bromodomain Proteins Contribute to Maintenance of Bloodstream Form Stage Identity in the African Trypanosome
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- The bromodomain protein inhibitor I-BET151 suppresses expression of inflammatory genes and matrix degrading enzymes in rheumatoid arthritis synovial fibroblasts
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- BET bromodomain proteins are required for glioblastoma cell proliferation
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- The Epigenetic Regulator I-BET151 Induces BIM-Dependent Apoptosis and Cell Cycle Arrest of Human Melanoma Cells
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- BET and HDAC inhibitors induce similar genes and biological effects and synergize to kill in Myc-induced murine lymphoma
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- BET bromodomain-targeting compounds reactivate HIV from latency via a Tat-independent mechanism
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- BET bromodomain inhibition suppresses TH17-mediated pathology
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- BET Protein Function Is Required for Inflammation: Brd2 Genetic Disruption and BET Inhibitor JQ1 Impair Mouse Macrophage Inflammatory Responses
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- BET acetyl-lysine binding proteins control pathological cardiac hypertrophy
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- Targeting MYCN in Neuroblastoma by BET Bromodomain Inhibition
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- ChromoHub: a data hub for navigators of chromatin-mediated signalling
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- BET bromodomain inhibition targets both c-Myc and IL7R in high-risk acute lymphoblastic leukemia
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- Small-Molecule Inhibition of BRDT for Male Contraception
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- BET bromodomain inhibition as a novel strategy for reactivation of HIV-1
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- Sensitivity of human lung adenocarcinoma cell lines to targeted inhibition of BET epigenetic signaling proteins
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- BET Bromodomain Inhibition as a Therapeutic Strategy to Target c-Myc
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- Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia
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- Targeting MYC dependence in cancer by inhibiting BET bromodomains
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- Global histone acetylation levels: Prognostic relevance in patients with renal cell carcinoma
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- Selective inhibition of BET bromodomains
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- Regulation of Cellular Metabolism by Protein Lysine Acetylation
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- ATAD2 Is a Novel Cofactor for MYC, Overexpressed and Amplified in Aggressive Tumors
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- Regulation of Aurora B Expression by the Bromodomain Protein Brd4
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- A complex t(1;22;11)(q44;q13;q23) translocation causingMLL-p300fusion gene in therapy-related acute myeloid leukemia
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