Article
Chemistry, Organic
Xiaoqin Ning, Yongke Chen, Fangdong Hu, Ying Xia
Summary: This study presents the palladium-catalyzed cross-coupling reactions of cyclobutanone-derived N-sulfonylhydrazones with aryl or benzyl halides, demonstrating that the metal carbene process and beta-hydride elimination can occur smoothly in strained ring systems to yield structurally diverse products. The preliminary success in asymmetric carbene coupling reactions in strained ring systems offers a promising route for the synthesis of enantioenriched four-membered-ring molecules.
Article
Chemistry, Physical
Shidheshwar B. Ankade, Pragnya Paramita Samal, Vineeta Soni, Rajesh G. Gonnade, Sailaja Krishnamurty, Benudhar Punji
Summary: The intramolecular oxidative cyclization of indoles via nickel-catalyzed C(sp(2))-H/C(sp(3))-H and C(sp(2))-H/C(sp(2))-H couplings provides access to biologically relevant five- and six-membered substituted cyclopentaindolones, carbazolones, and indenoindolones in high yields. The mechanism involves a Ni(II)/Ni(III) pathway without the participation of a carbon-based radical.
Article
Chemistry, Physical
Jiangjie Zhang, Jinni Shen, Dongmiao Li, Jinlin Long, Xiaochen Gao, Wenhui Feng, Shiying Zhang, Zizhong Zhang, Xuxu Wang, Weimin Yang
Summary: Metal-decorated oxide semiconductors are efficient photocatalysts for nonoxidative coupling of methane, but the detailed mechanism remains unknown. In this study, a series of noble metal-decorated oxides were investigated for methane coupling. It was found that the active sites for H abstraction and C-C coupling of CH4 were spatially separated. Noble metals, especially Ag, significantly decreased the energy barrier and promoted C-C coupling, leading to high CH4 conversion and selectivity. This work provides molecular-level insight into the CH4 coupling mechanism on metal-decorated photocatalysts.
Article
Chemistry, Multidisciplinary
Alexander Purtsas, Marco Rosenkranz, Evgenia Dmitrieva, Olga Kataeva, Hans-Joachim Knoelker
Summary: In this paper, the oxygenation and amination reactions of tertiary arylamines are described. The key steps of these coupling reactions involve iron-catalyzed oxidative C-O or C-N bond formation, which typically provide the desired products in high yields and with excellent regioselectivity. These transformations are carried out using hexadecafluorophthalocyanine-iron(II) (FePcF16) as catalyst, with the presence of an acid or base additive, and only require ambient air as the oxidant.
CHEMISTRY-A EUROPEAN JOURNAL
(2022)
Article
Chemistry, Multidisciplinary
Michael W. Milbauer, Jeff W. Kampf, Melanie S. Sanford
Summary: In this study, we successfully isolated a cyclometalated nickel(IV) complex that is similar to a key intermediate proposed in aminoquinoline-directed C-H functionalization catalysis. The complex undergoes bond-forming reaction under mild conditions and demonstrates the importance of LX-type ligands in stabilizing these nickel(IV) species.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Chemistry, Organic
Xinyu Chen, Hongqiang Liu, Hui Gao, Pinhua Li, Tao Miao, Hongji Li
Summary: An electrochemical cross-dehydrogenative coupling of indoles with xanthenes has been achieved at room temperature without the need for any catalyst or external oxidant, yielding moderate amounts of indole derivatives. Mechanistic experiments suggest a possible involvement of a radical pathway in this reaction system.
JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Organic
Le-Cheng Wang, Nai-Xian Sun, Chang-Sheng Wang, Kai Guo, Xiao-Feng Wu
Summary: The direct concurrent installation of amide and ester groups across olefin motifs is a powerful and promising functionalization tool in organic chemistry. Here, a ligand-free cobalt-catalyzed four-component radical relay carbonylative difunctionalization of ethylene for the synthesis of 4-oxobutanoates has been developed, providing a highly atom-economical approach for the production of valuable C4 building blocks.
Article
Chemistry, Organic
Yang Liao, Yi Zhou, Zhen Zhang, Junzhen Fan, Feng Liu, Zhangjie Shi
Summary: The study presents a new Pd-catalyzed intramolecular oxidative coupling method for constructing C-C bonds between inert C-H bonds. This chemistry has the capability to build fused cyclic structures from linear substrates and synthesize privileged cyclic scaffolds.
Article
Chemistry, Multidisciplinary
Xiang-Ting Min, Ding-Wei Ji, Yu-Qing Guan, Shi-Yu Guo, Yan-Cheng Hu, Boshun Wan, Qing-An Chen
Summary: Transition metal catalyzed decarbonylation offers a unique synthetic strategy for new chemical bond formation. The study developed a visible light induced rhodium catalysis for decarbonylative coupling of imides with alkynes under ambient conditions, revealing the rhodium complex serves as both the catalytic center and photosensitizer. This visible light promoted catalytic decarbonylation strategy opens up new opportunities for re-evaluating old transformations with ligand dissociation as a rate-determining step.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Multidisciplinary
Youxiang Jin, Lian-Feng Fan, Elvis Wang Hei Ng, Lu Yu, Hajime Hirao, Liu-Zhu Gong
Summary: The selective functionalization of C(sp(3))-H bonds is an important approach for streamlining synthetic routes. In this study, an atom transfer radical coupling (ATRC) strategy was adopted to achieve the asymmetric functionalization of hydrocarbons, resulting in the formation of valuable chiral lactones with high efficiency and excellent enantioselectivity.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Review
Chemistry, Organic
Rasmi P. Bhaskaran, Kalinga H. Nayak, Mariswamy K. Sreelekha, Beneesh P. Babu
Summary: Transition metal-catalysed C-H functionalization reactions using copper catalysts have become an efficient and green method for constructing carbon-carbon and carbon-heteroatom bonds. Intramolecular dehydrogenative coupling reactions offer a direct route to complex polycyclic scaffolds. This review focuses on the development and applications of copper-based intramolecular dehydrogenative coupling reactions.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Maorui Wang, Chengqian Zhang, Chenggang Ci, Huanfeng Jiang, Pierre. H. Dixneuf, Min Zhang
Summary: Despite the challenges, we have successfully developed a room temperature approach for the direct construction of alpha-hydroxyalkyl cyclic amines through the strategy of electroreductive alpha-hydroxyalkylation. This method offers a broad substrate scope, simplicity in operation, high chemoselectivity, and does not require pressurized H2 gas or transition metal catalysts. The activation of reactants by the zinc ion generated from anode oxidation plays a crucial role in this transformation. This strategy, combined with substrate activation by Lewis acids, is expected to lead to the development of more useful transformations.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Multidisciplinary
Jingjie Yang, Zhuofan Gui, Yuli He, Shaolin Zhu
Summary: An attractive approach for selective functionalization of remote C-H bonds is the metal/hydride shift/cross-coupling reaction sequence. In this study, an unprecedented aryl-to-vinyl 1,4-nickel/hydride shift reaction is reported, which selectively traps migratory alkenylnickel species generated in situ by various coupling partners to access trisubstituted alkenes with excellent regio- and stereoselectivity. Unlike previously reported ipso-aryl coupling reactions, this strategy provides remote alkenyl C-H functionalized products with high yield and excellent chemo-, regio-, and E/Z-selectivity.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Review
Chemistry, Multidisciplinary
Jianbin Li, Chia-Yu Huang, Chao-Jun Li
Summary: This review summarises recently developed strategies for achieving C-C cross-couplings between an inert aliphatic C-H bond and another C-H bond through different C(sp3)-H functionalisation tactics.
TRENDS IN CHEMISTRY
(2022)
Review
Chemistry, Multidisciplinary
Xueyuan Wang, Nengchao Luo, Feng Wang
Summary: This comprehensive review summarizes recent advances in photocatalytic methane conversion, with a focus on methane C-C bond coupling. Methods for methane C-H bond activation and radical manipulation for selective C-C bond coupling are discussed in detail. This review provides valuable guidance for future research on photocatalytic methane C-C coupling.
CHINESE JOURNAL OF CHEMISTRY
(2022)
Article
Nanoscience & Nanotechnology
Sangita Kumari, Ajay Chouhan, Om P. Sharma, Sherif Abdulkader Tawfik, Kevin Tran, Michelle J. S. Spencer, Suresh K. Bhargava, Sumeet Walia, Anjan Ray, Om P. Khatri
Summary: By synthesizing oxygenated WS2 nanosheets through strong acid-mediated oxidation and ultrasound-assisted exfoliation, and functionalizing them with organosilanes, a significant enhancement in lubrication properties was achieved in mineral lube base oil.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Review
Environmental Sciences
Ragini Singh, Akhela Umapathi, Gaurang Patel, Chayan Patra, Uzma Malik, Suresh K. Bhargava, Hemant Kumar Daima
Summary: Nanozymes are nanomaterials that have enzyme-like properties and unique physical and chemical characteristics. They have shown great potential in environmental monitoring and remediation of pollutants, including heavy metals and organic compounds. However, their inherent toxicity needs to be evaluated and monitored to ensure their safe use.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Chemistry, Physical
Luqman H. Hashim, Ahmed Halilu, Yahaya Balarabe Umar, Mohd Rafie Bin Johan, Mohamed Kheireddine Aroua, Paramita Koley, Suresh K. Bhargava
Summary: This study focuses on the design and synthesis of highly active bifunctional catalysts for the conversion of furfural to furfuryl acetate. The catalysts with lower lattice strain exhibited higher catalytic activity.
CATALYSIS SCIENCE & TECHNOLOGY
(2023)
Article
Electrochemistry
Lizhi Qian, Jinliang Li, Gongxu Lan, Yuan Wang, Sufeng Cao, Lu Bai, Runguo Zheng, Zhiyuan Wang, Suresh K. Bhargava, Hongyu Sun, Hamidreza Arandiyan, Yanguo Liu
Summary: Transition metal oxide (TMO)-based anodes attract attention for lithium storage due to their high capacity, easy synthesis, and improved battery safety. The electrochemical performance of TMO anodes can be significantly improved through configurational entropy optimization. For example, a high-entropy oxide (FeCoNiCrCu)(3)O-4 with low potential and high capacity is synthesized. In both half-cell and full-cell configurations, the (FeCoNiCrCu)(3)O-4 electrode shows excellent performance with high specific capacity and low discharge voltage.
Article
Chemistry, Inorganic & Nuclear
Robert Gericke, Martin A. Bennett, Steven H. Priver, Suresh K. Bhargava
Summary: A series of mono and double bridged heterobimetallic d(8)-d(10) complexes with a [MM'](3+) core (M = Ni, Pt; M' = Cu, Ag, Au) were synthesized. The compounds have short metal-metal separations and metallophilic bonding interactions. Analysis using DFT showed the bonding trends between the metals.
INORGANIC CHEMISTRY
(2023)
Review
Chemistry, Physical
Hamidreza Arandiyan, Putla Sudarsanam, Suresh K. Bhargava, Adam F. Lee, Karen Wilson
Summary: Biomass is a renewable energy source that is being increasingly utilized due to concerns about climate change caused by fossil fuel consumption. Waste biomass-derived fuels and chemicals offer a solution to reduce reliance on fossil fuels and achieve "Net Zero 2050 CO2 emissions" with environmental, health, and economic benefits. This review focuses on the use of perovskite oxide catalysts for biomass valorization, discussing their structure-reactivity relationships in various reactions. The study highlights the prospects and challenges for the broader application of perovskite oxide catalysts in biomass valorization.
Article
Geochemistry & Geophysics
Md Khairul Islam, Michael Somerville, Mark I. Pownceby, James Tardio, Nawshad Haque, Suresh Bhargava
Summary: Printed circuit boards (PCBs) from antiquated electronic goods were processed through pyrometallurgical route to separate alloy and slag phases. The addition of B2O3 flux, along with CaO and SiO2, decreased the melting temperature and improved the recovery of valuable metals at 1350°C smelting temperature. A fluxing strategy for smelting e-waste PCBs containing high Al2O3 was proposed based on the experimental findings of this research.
Review
Immunology
K. Swetha, Niranjan G. Kotla, Lakshmi Tunki, Arya Jayaraj, Suresh K. Bhargava, Haitao Hu, Srinivasa Reddy Bonam, Rajendra Kurapati
Summary: Lipid nanoparticles (LNPs) are an advanced technology for efficient in vivo delivery of exogenous mRNA, especially for COVID-19 vaccines. LNPs consist of four different lipids: ionizable lipids, helper or neutral lipids, cholesterol, and lipids attached to polyethylene glycol (PEG). This review presents recent advances and insights in LNPs design, composition, and properties, with a focus on COVID-19 vaccine development. The role of ionizable lipids in mRNA vaccines and the use of LNPs as effective delivery vehicles for vaccination, genome editing, and protein replacement therapy are discussed.
Review
Engineering, Biomedical
N. P. Navya, Sunil Mehla, Amrin Begum, Harit K. Chaturvedi, Ruchika Ojha, Christian Hartinger, Magdalena Plebanski, Suresh K. Bhargava
Summary: Nanomaterials that mimic natural enzymes in the human body are known as nanozymes and have diagnostic, imaging, and therapeutic capabilities. Smart nanozymes exploit the tumor microenvironment to provide effective cancer therapy. This review focuses on the design and synthesis of nanozymes for cancer therapy, including understanding the tumor microenvironment and surface chemistry for site-specific therapy.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Engineering, Chemical
P. Sudhakar, Alka Kumari, Sazal Kundu, Vivek Ravi Sankar, Prathap Kumar Thella, Kalpit Shah, Suresh K. Bhargava
Summary: In this study, antisolvent crystallization of L-aspartic acid (L-ASP) was optimized using response surface methodology (RSM) and a focused beam reflectance measurement (FBRM) tool. Important process parameters such as storage temperature, stirrer velocity, storage time, and solvent ratio were identified to significantly improve the yield and quality of the product, while chord length distribution (CLD) data was obtained through FBRM. The results showed that 2-propanol was a more effective antisolvent than methanol for L-ASP crystallization. Temperature was found to have a critical effect on crystal formation, with crystals forming between 298.15 and 303.15 K. ANOVA results confirmed the significant impact of all studied variables on the yield and CLD. The optimum crystallization conditions were determined as 18 h, stirrer velocity of 200 rpm, distilled water-formic acid/IPA ratio of 1:3 (v/v), and storage temperature of 298.15 K. A quadratic response surface model satisfactorily described the crystallization of L-ASP with an R2 of 0.99 and a deviation of 1.2%.
CHEMICAL ENGINEERING RESEARCH & DESIGN
(2023)
Article
Chemistry, Multidisciplinary
Gongxu Lan, Huilin Fan, Yuan Wang, Hamidreza Arandiyan, Suresh K. Bhargava, Zongping Shao, Hongyu Sun, Yanguo Liu
Summary: The surface atomic arrangement and defective structures of electrocatalysts play a crucial role in determining their catalytic activity and selectivity. In this study, alpha-Fe2O3 nanosheets with surface oxygen vacancies were synthesized and their oxygen vacancy concentration was varied to study their oxygen reduction reaction (ORR) performance. The results showed that increasing the oxygen vacancy concentration improved the ORR activity up to a certain point, but further increase deteriorated the crystalline quality and affected the performance.
NEW JOURNAL OF CHEMISTRY
(2023)
Review
Chemistry, Physical
Pengcheng Mao, Hamidreza Arandiyan, Sajjad S. Mofarah, Pramod Koshy, Cristina Pozo-Gonzalo, Runguo Zheng, Zhiyuan Wang, Yuan Wang, Suresh K. Bhargava, Hongyu Sun, Zongping Shao, Yanguo Liu
Summary: Rechargeable sodium-air batteries have gained extensive attention and developed rapidly in recent years for electrochemical energy storage applications due to their low costs, abundance of precursor resources, and high energy density. However, challenges such as poor charge-discharge reversibility at the cathode and the formation of sodium dendrites at the anode still need to be addressed. Therefore, designing efficient and stable air cathode materials is crucial for the development and practical application of sodium-air batteries.
Review
Chemistry, Multidisciplinary
Uzma Malik, Roxanne Hubesch, Paramita Koley, Maciej Mazur, Sunil Mehla, Sai Kishore Butti, Milan Brandt, P. R. Selvakannan, Suresh Bhargava
Summary: Combining additive manufacturing with photocatalytic and plasmonic functionalities has promising applications in next-generation SERS. Laser powder bed fusion is a mature technique for manufacturing metallic structures, allowing the printing of complex internal structures. This feature article elaborates on the grafting of plasmonic and semiconductor nanoparticles on LPBF manufactured metallic substrates, showcasing the potential for tailoring substrate properties.
CHEMICAL COMMUNICATIONS
(2023)
Article
Materials Science, Multidisciplinary
Sunil Mehla, Sivacarendran Balendhran, Suresh K. Bhargava
Summary: This study investigates the impact of variations in the morphology of sunflower mimic metasurfaces on their plasmonic activity using experimental studies and finite difference time domain (FDTD) simulations. The study found that light polarization and morphological features such as dendrite shape, aspect ratio, and packing density play an important role in the distribution of enhanced electric field and plasmonic hot spots.
JOURNAL OF MATERIALS CHEMISTRY C
(2023)
Article
Thermodynamics
Ramesh Tangirala, Anoosha Borra, Bankupalli Satyavathi, Prathap Kumar Thella, K. Padmaja, Madapusi P. Srinivasan, Rajarathinam Parthasarathy, Suresh Bhargava
Summary: Crystallization experiments can provide insights into growth kinetic parameters through seeded or unseeded processes, aiding in the design of optimal crystallizers and control of crystal size distribution.
JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
(2022)