Article
Virology
Maxim Cherneha, Johannes Korth, Meike Kaulfuss, Mirko Trilling, Marek Widera, Hana Rohn, Sebastian Dolff, Nina Babel, Andre Hoerning, Andreas Kribben, Oliver Witzke
Summary: Reactivations of BK polyoma virus and human cytomegalovirus can cause complications in renal transplant recipients. The phosphorylation of P70S6k in peripheral lymphocytes is associated with BKPyV reactivations and, to a lesser extent, with HCMV infections in these recipients, independent of immunosuppressive drug levels.
Article
Oncology
Corinna Kosnopfel, Simone Wendlinger, Heike Niessner, Johannes Siewert, Tobias Sinnberg, Angelika Hofmann, Jonas Wohlfarth, David Schrama, Marion Berthold, Claudia Siedel, Birgit Sauer, Aarthi Jayanthan, Georg Lenz, Sandra E. Dunn, Bastian Schilling, Birgit Schittek
Summary: Inhibition of p90 ribosomal S6 kinases (RSK) has demonstrated anti-tumor effects in malignant melanoma with hyperactivated MAPK signaling, regardless of the genetic subgroups. RSK inhibition not only suppresses tumor cell growth and survival, but also promotes tumor cell differentiation and immunogenicity, leading to enhanced T-cell activation and melanoma cell killing.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Xiaoyue Ji, Junhong Chen, Chaoying You, Jing Sun, Xiulong Xu
Summary: Leflunomide controls obesity in part by activating AMPK and inducing lipophagy.
Article
Biochemistry & Molecular Biology
Ayako Aihara, Takumi Iwawaki, Natsuki Abe-Fukasawa, Keiichiro Otsuka, Koichiro Saruhashi, Takumi Mikashima, Taito Nishino, Henrik Dohlman
Summary: This study identified a novel small molecule, GA-017, that promotes cell proliferation in 3D culture conditions and enhances the growth of spheroids and organoids. GA-017 inhibits the activity of large tumor suppressor kinase 1/2, key effectors of the Hippo signaling pathway, and facilitates the growth of spheroids and organoids by stabilizing and translocating specific proteins into the cell nucleus.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Cell Biology
Alison J. May, Aaron J. Mattingly, Eliza A. Gaylord, Nathan Griffin, Sonia Sudiwala, Noel Cruz-Pacheco, Elaine Emmerson, Seayar Mohabbat, Sara Nathan, Hanan Sinada, Isabelle M. A. Lombaert, Sarah M. Knox
Summary: Neuronal-epithelial cross-talk drives acinar specification through NRG1-ERBB3-mTORC2 signaling. NRG1-ERBB3 regulates the cellular programs of lineage progression, secretion, and polarization through the mTORC2 signaling pathway. This mechanism plays a crucial role in the formation of functional acini.
DEVELOPMENTAL CELL
(2022)
Article
Multidisciplinary Sciences
Yuhan Yan, Chao Chen, Zhiguo Li, Jing Zhang, Narin Park, Cheng-Kui Qu
Summary: A continuous supply of exogenous arginine is crucial for the maintenance and function of normal hematopoietic stem cells (HSCs), but the L-arginine transporter CAT3 is dispensable for normal hematopoiesis and leukemogenesis.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Eric B. Wright, Shinji Fukuda, Mingzong Li, Yu Li, George A. O'Doherty, Deborah A. Lannigan
Summary: The study identified a natural product, SL0101, that binds specifically to RSK1/2 by inducing conformational rearrangement, but not to RSK3/4 due to a single amino acid difference. Kinetic analysis revealed that regions outside of the N-terminal kinase domain also contribute to stable inhibitor binding towards RSK2. Additionally, a modification on SL0101 was discovered to form a highly stable inhibitor complex with RSK2, suggesting potential for identifying RSK2-specific inhibitors.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Hui Ma, Jiayan Cui, Zehui Liu, Wenqing Fang, Sisi Lu, Shuying Cao, Yuanyuan Zhang, Ji-An Chen, Lixue Lu, Qiong Xie, Yonghui Wang, Ying Huang, Kongfei Li, Hongyan Tong, Jin Huang, Weiqiang Lu
Summary: This study demonstrates that induction of degradation of FLT3-ITD protein by DHODH blockade may offer a promising therapeutic strategy for AML patients harboring FLT3-ITD mutation.
Review
Pathology
Junpeng Xu, Qingge Jia, Yan Zhang, Yuan Yuan, Tianqi Xu, Kangjie Yu, Jia Chai, Kaijing Wang, Ligang Chen, Tian Xiao, Mingyang Li
Summary: RSK4 is a Ser/Thr protein kinase that regulates cell survival and proliferation in various types of cancer. Its role as a tumor suppressor gene or an oncogene is controversial, and specific inhibitors for RSK4 have not been found.
PATHOLOGY RESEARCH AND PRACTICE
(2021)
Review
Cardiac & Cardiovascular Systems
Muna Suleiman, Afnan Al Najjar, Zain Z. Zakaria, Rashid Ahmed, Huseyin C. Yalcin, Hesham M. Korashy, Shahab Uddin, Sadaf Riaz, Nabeel Abdulrahman, Fatima Mraiche
Summary: Targeted therapy, such as TKIs, has been approved for managing cancer, but TKI-induced cardiotoxicity limits their use. Investigating potential cardioprotective techniques to combine with TKIs has become necessary.
JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH
(2023)
Article
Dentistry, Oral Surgery & Medicine
Ali Esmaeili, Solmaz Dini, Azadeh Pourveiseh, Abolghasem Esmaeili
Summary: This study investigated the expression profile of TrkA, TrkB, TrkC, and p75NTR neurotrophin receptors in SHED cells before and after differentiation into neural-like cells. The results showed significant differences in the expression levels of these receptors, indicating their crucial roles in the differentiation of SHED cells into neuron cells. The findings suggest that derived cells from SHED cells could be an ideal source for tissue engineering due to their neurogenic potential and accessibility.
ARCHIVES OF ORAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Fabian Arechavaleta-Velasco, Pablo Dominguez-Lopez, Ernesto Acosta-Jimenez, Laura Diaz-Cueto
Summary: RSK4 promoter methylation is increased in malignant ovarian tumors, but this does not regulate its expression in ovarian cancer. Reactivation of RSK4 only reduces cell proliferation in the endometrioid histological subtype.
MOLECULAR BIOLOGY REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Hansol Lee, Yun-Jin Hwang, Jung-Hyun Park, Du-Hyong Cho
Summary: This study investigates the effect of valproic acid (VPA) on vascular smooth muscle cell (VSMC) proliferation and its mechanism. The results show that VPA decreases cell proliferation through PP2A-mediated inhibition of p-p70S6K-Thr(389). This suggests that VPA could be used in the treatment and prevention of atherosclerosis and in-stent restenosis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Engineering, Biomedical
Ge Li, Bao Zhang, Jia-hui Sun, Li-yang Shi, Meng-yao Huang, Li-jun Huang, Zi-jing Lin, Qiong-yu Lin, Bi-qin Lai, Yuan-huan Ma, Bin Jiang, Ying Ding, Hong-bo Zhang, Miao-xin Li, Ping Zhu, Ya-qiong Wang, Xiang Zeng, Yuan-shan Zeng
Summary: By engineering TrkC-modified neural network tissue in a 3D scaffold, tissue repair for spinal cord injury was improved, leading to enhanced motor function recovery in rats.
BIOACTIVE MATERIALS
(2021)
Article
Dermatology
Xiong Cai, Qingyuan Fan, Gi Soo Kang, Kelsey Grolig, Xiaoyan Shen, Eric M. Billings, Gustavo Pacheco-Rodriguez, Thomas N. Darling, Joel Moss
Summary: The study suggests that rapamycin may reduce the size of TSC tumors by decreasing TSC2(-/-) cell volume, altering the cell cycle, and reprogramming TSC2-null cells.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Article
Chemistry, Medicinal
Aya Hasan Al-Shammari, Yusuke Masuo, Ken-ichi Fujita, Yuka Yoshikawa, Noritaka Nakamichi, Yutaro Kubota, Yasutsuna Sasaki, Yukio Kato
JOURNAL OF PHARMACEUTICAL SCIENCES
(2019)
Article
Chemistry, Medicinal
Noritaka Nakamichi, Shunsuke Nakao, Yusuke Masuo, Ayaka Koike, Naoto Matsumura, Misa Nishiyama, Aya Hasan Al-Shammari, Hirotaka Sekiguchi, Keita Sutoh, Koji Usumi, Yukio Kato
JOURNAL OF MEDICINAL FOOD
(2019)
Article
Chemistry, Medicinal
Takumi Kawanishi, Hiroshi Arakawa, Yusuke Masuo, Noritaka Nakamichi, Yukio Kato
JOURNAL OF PHARMACEUTICAL SCIENCES
(2019)
Review
Pharmacology & Pharmacy
Noritaka Nakamichi, Yusuke Masuo, Yukio Kato
YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN
(2019)
Editorial Material
Pharmacology & Pharmacy
Noritaka Nakamichi, Takeshi Takarada
YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN
(2019)
Article
Pharmacology & Pharmacy
Noritaka Nakamichi, Yuta Matsumoto, Takumi Kawanishi, Takahiro Ishimoto, Yusuke Masuo, Masato Horikawa, Yukio Kato
BIOLOGICAL & PHARMACEUTICAL BULLETIN
(2019)
Article
Chemistry, Multidisciplinary
Naoto Hashimoto, Noritaka Nakamichi, Hikari Nanmo, Kei-ichi Kimura, Yusuke Masuo, Yasuyuki Sakai, Alfred H. Schinkel, Shinichi Sato, Tomoyoshi Soga, Yukio Kato
PHARMACEUTICAL RESEARCH
(2019)
Article
Biochemistry & Molecular Biology
Noritaka Nakamichi, Shunsuke Nakao, Misa Nishiyama, Yuka Takeda, Takahiro Ishimoto, Yusuke Masuo, Satoshi Matsumoto, Makoto Suzuki, Yukio Kato
Summary: Oral administration of ergothioneine can enhance object recognition memory in mice by promoting neuronal maturation and increasing the expression of the synaptic formation marker synapsin I.
CURRENT MOLECULAR PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Misa Nishiyama, Noritaka Nakamichi, Tomoyuki Yoshimura, Yusuke Masuo, Tomoe Komori, Takahiro Ishimoto, Jun-ichi Matsuo, Yukio Kato
NEUROCHEMICAL RESEARCH
(2020)
Review
Biochemistry & Molecular Biology
Takahiro Ishimoto, Yukio Kato
Summary: Ergothioneine (ERGO), a natural antioxidant derived from food, has been found to enter brain cells through a specific transporter and play a role in brain function. Oral administration of ERGO has antidepressant effects and improves memory function. ERGO also protects against stress and neuronal injury. In vitro studies suggest that ERGO benefits brain function through antioxidative activity and promotion of neurogenesis and neuronal maturation.
Article
Pharmacology & Pharmacy
Aya Hasan Alshammari, Yusuke Masuo, Shotaro Yoshino, Reiya Yamashita, Takahiro Ishimoto, Ken-ichi Fujita, Yukio Kato
Summary: This study used an in vivo knockdown approach to investigate the role of BCRP in the disposition of regorafenib. The results showed that BCRP plays a key role in the disposition of the active metabolite M-5. Knockdown of hepatic Bcrp led to increased concentrations of M-5 in plasma and liver, and decreased biliary excretion.
DRUG METABOLISM AND PHARMACOKINETICS
(2023)
Article
Pharmacology & Pharmacy
Waleed Elsayed Ahmed Ellawatty, Yusuke Masuo, Ken-ichi Fujita, Erina Yamazaki, Hiroo Ishida, Hiroshi Arakawa, Noritaka Nakamichi, Ramadan Abdelwahed, Yasutsuna Sasaki, Yukio Kato
DRUG METABOLISM AND DISPOSITION
(2018)
Article
Cell Biology
Ke Mi, Lizhong Zeng, Yang Chen, Jingya Ning, Siyuan Zhang, Peilin Zhao, Shuanying Yang
Summary: In this study, the researchers explored the role of DHX38 in NSCLC and its underlying molecular mechanism. They found that DHX38 was overexpressed in NSCLC and patients with high DHX38 expression had poor prognosis. DHX38 promoted cell proliferation, migration, and invasion in NSCLC and activated the MAPK pathway. The researchers also identified G3BP1 as a target protein that interacted with DHX38 and showed that DHX38 regulated the expression of G3BP1. Silencing G3BP1 reversed the effects of DHX38 overexpression on tumor cell proliferation, migration, and invasion and inhibited the MAPK pathway activation.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Tiina A. Jokela, Mark A. Dane, Rebecca L. Smith, Kaylyn L. Devlin, Sundus Shalabi, Jennifer C. Lopez, Masaru Miyano, Martha R. Stampfer, James E. Korkola, Joe W. Gray, Laura M. Heiser, Mark A. Labarge
Summary: Microenvironment signals have a significant impact on cell fate and tissue homeostasis. Understanding how different microenvironment factors regulate cellular phenotype has been challenging. In this study, a high-throughput microenvironment microarray was used to identify factors that support the proliferation and maintenance of primary human mammary luminal epithelial cells. Multiple factors that modulate luminal cell number were identified and their effects were confirmed using RNA sequencing and cell-based functional studies. Hepatocyte growth factor (HGF) was found to be robust to individual variation and played a role in expanding luminal cells. Our approach demonstrates the power of high-dimensional cell-based approaches in dissecting microenvironmental signals.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Chao He, Yongfeng Ding, Yan Yang, Gang Che, Fei Teng, Haohao Wang, Jing Zhang, Donghui Zhou, Yanyan Chen, Zhan Zhou, Haiyong Wang, Lisong Teng
Summary: This study categorized gastric cancer patients into three stemness subtypes, each demonstrating distinct prognoses, components of tumor microenvironment (TME) infiltration, and varying sensitivity or resistance to treatment. A stemness risk model was constructed to predict treatment response and prognosis.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Haile Zhao, Lijuan Feng, Rui Cheng, Man Wu, Xiaozhou Bai, Lifei Fan, Yaping Liu
Summary: miR-29c-3p is overexpressed in benign and malignant ovarian carcinoma and is associated with poor prognosis. Its overexpression modulates tumorigenesis in ovarian cancer cells, including epithelial-mesenchymal transition, proliferation, migration, and invasion, through the regulation of DNMT3A, TET1, and HBP1. miR-29c-3p may serve as a potential biomarker for clinical diagnosis or co-diagnosis of ovarian carcinoma.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Haiyan Zhao, Fangfang Bi, Mengyuan Li, Yuhan Diao, Chen Zhang
Summary: This study confirmed the tumor suppressor effect of RNF180 on ovarian cancer, elucidated the mechanism of the molecule network related to RNF180 and IPO4 in ovarian cancer, and identified a new therapeutic target for ovarian cancer.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Chu Chen, Guanhua Xu, Jiajia Chen, Chunshuai Wu, Jinlong Zhang, Jiawei Jiang, Hongxiang Hong, Zhiming Cui
Summary: This study investigated the role of transcription factor FoxO1 in facet joint osteoarthritis (FJOA) and found that FoxO1 deletion led to severe osteoarthritic changes. Transcriptome sequencing and bioinformatics analysis identified differentially expressed genes (DEGs) and potential key contributors to FJOA. Additionally, over-expression of certain genes and inhibition of others were shown to counteract the impairments caused by FoxO1 deletion in chondrocyte migration and extracellular matrix synthesis. These findings help unravel the molecular mechanisms underlying FJOA and open up promising therapeutic avenues for its treatment.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Wen Deng, Ru Chen, Situ Xiong, Jianqiang Nie, Hailang Yang, Ming Jiang, Bing Hu, Xiaoqiang Liu, Bin Fu
Summary: This study demonstrates that circFSCN1 is upregulated in bladder cancer and associated with cancer-specific survival. CircFSCN1 promotes tumor progression and epithelial-mesenchymal transition in bladder cancer through enhancing MDM2-mediated silencing of p53 by sponging miR-145-5p.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Jun Wu, Weibin Hu, Wenhui Yang, Yihao Long, Kaizhao Chen, Fugui Li, Xiaodong Ma, Xun Li
Summary: Cholesterol biosynthesis and metabolism play critical roles in tumor development and microenvironmental conditions. Squalene Epoxidase (SQLE), the second rate-limiting enzyme in cholesterol synthesis, is found to be uniquely expressed in various cancers, and its expression level is closely associated with tumor mutation burden and microsatellite instability. SQLE expression is negatively correlated with immune cell infiltration. Inhibition of SQLE alters the immune response in the tumor microenvironment. Furthermore, protein metabolism and translation are identified as main binding factors with SQLE.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Zhihong Zhang, Mingyue Li, Yi Tai, Yue Xing, Hongxiang Zuo, Xuejun Jin, Juan Ma
Summary: ZNF70 plays an important role in colitis-associated colorectal cancer (CAC) by regulating macrophages IL-1 beta secretion to promote HCT116 proliferation. It may serve as a promising target for treating CAC.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Zenghong Wu, Gangping Li, Weijun Wang, Kun Zhang, Mengke Fan, Yu Jin, Rong Lin
Summary: This study comprehensively explored the role of immune checkpoints and tumor microenvironment in gastric cancer patients based on genomic data. It constructed an ICIs signature and ICI score to evaluate patient prognosis and heterogeneity.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Yantong Wan, Jieshu Zhou, Panpan Zhang, Xuemei Lin, Hao Li
Summary: This study found that Rac1 plays a role in astrocyte activation and attenuates chronic inflammatory pain by blocking the phosphorylation of NLRP3 inflammasome and NF-kappa B.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Zhen Wang, Diankun She, Lei Liu, Xianming Hua, Hao Zhu, Lingfeng Yu, Han Wang, Yan Zhu, Gentao Fan, Yicun Wang, Meng Xu, Guangxin Zhou
Summary: Circular RNAs (circRNAs) are non-coding RNAs that play a role in the regulation of various cancers, including osteosarcoma (OS). This study identified circSATB2 as a highly expressed circRNA in OS tissues and cell lines, and demonstrated its involvement in promoting OS proliferation and migration. Mechanistically, circSATB2 was found to regulate the progression of OS by sponging miR-661 and FUS to regulate ZNFX1 mRNA. These findings suggest that circSATB2 could serve as a prognostic marker and therapeutic target for osteosarcoma.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Kenichi Ogata, Masafumi Moriyama, Tatsuya Kawado, Hiroki Yoshioka, Aiko Yano, Mayu Matsumura-Kawashima, Seiji Nakamura, Shintaro Kawano
Summary: This study found that extracellular vesicles released by induced pluripotent stem cells can reduce inflammatory cell infiltration, increase saliva volume, and decrease the production of antibodies associated with Sjogren's syndrome in a mouse model. The let-7 family in these vesicles may suppress the expression of TLR4 and NF-kappa B, which leads to the inhibition of pro-inflammatory cytokine production through the MAPK pathway.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Mikayla R. Erdelsky, Sarah A. Groves, Charmi Shah, Samantha B. Delios, M. Bibiana Umana, Donald H. Maurice
Summary: Recent evidence suggests that cAMP signaling within the primary cilium plays a crucial role in promoting adipogenic differentiation of 3T3-L1 preadipocytes. In this study, the researchers identified the specific cAMP phosphodiesterases expressed by these cells and found that inhibition of PDE4 promotes FFAR4-mediated adipogenesis. This work could potentially lead to the discovery of more targeted therapeutic approaches for controlling adipogenesis and differentiation of other stem cells.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Chun-Hui Liu, Jun-Jie Zhang, Qian-Jin Zhang, Yang Dong, Zhen-Duo Shi, Si-Hao Hong, Hou-Guang He, Wei Wu, Cong-Hui Han, Lin Hao
Summary: Bladder cancer, the most common malignant tumor in the urinary system, is associated with significantly up-regulated expression of P3H4, which is regulated by METTL3 and plays a crucial role in the proliferation, metastasis, and EMT progression of bladder cancer. Targeting this METTL3-P3H4 pathway may serve as a potential therapeutic strategy for bladder cancer.
CELLULAR SIGNALLING
(2024)