Cell–Cell Mechanical Communication in Cancer

Mechanical cell competition

(2018) Catarina Brás-Pereira et al.   CURRENT OPINION IN CELL BIOLOGY

Intermediate filaments control collective migration by restricting traction forces and sustaining cell–cell contacts

(2018) Chiara De Pascalis et al.   JOURNAL OF CELL BIOLOGY

Cell contraction induces long-ranged stress stiffening in the extracellular matrix

(2018) Yu Long Han et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanical interactions among followers determine the emergence of leaders in migrating epithelial cell collectives

(2018) Medhavi Vishwakarma et al.   Nature Communications

Tight junctions negatively regulate mechanical forces applied to adherens junctions in vertebrate epithelial tissue

(2017) Guillaume Hatte et al.   JOURNAL OF CELL SCIENCE

Activation of ROCK and MLCK tunes regional stress fiber formation and mechanics via preferential myosin light chain phosphorylation

(2017) Elena Kassianidou et al.   MOLECULAR BIOLOGY OF THE CELL

Integrin-mediated traction force enhances paxillin molecular associations and adhesion dynamics that increase the invasiveness of tumor cells into a three-dimensional extracellular matrix

(2017) Armen H. Mekhdjian et al.   MOLECULAR BIOLOGY OF THE CELL

The desmoplakin–intermediate filament linkage regulates cell mechanics

(2017) Joshua A. Broussard et al.   MOLECULAR BIOLOGY OF THE CELL

Mechanical stretch triggers rapid epithelial cell division through Piezo1

(2017) S. A. Gudipaty et al.   NATURE

A mechanically active heterotypic E-cadherin/N-cadherin adhesion enables fibroblasts to drive cancer cell invasion

(2017) Anna Labernadie et al.   NATURE CELL BIOLOGY

The role of desmosomes in carcinogenesis

(2017) Guangxin Zhou et al.   OncoTargets and Therapy

Starved epithelial cells uptake extracellular matrix for survival

(2017) Taru Muranen et al.   Nature Communications

Cancer cell-secreted IGF2 instigates fibroblasts and bone marrow-derived vascular progenitor cells to promote cancer progression

(2017) Wen Wen Xu et al.   Nature Communications

Cancer-associated fibroblasts induce metalloprotease-independent cancer cell invasion of the basement membrane

(2017) Alexandros Glentis et al.   Nature Communications

Measurement of dynamic cell-induced 3D displacement fields in vitro for traction force optical coherence microscopy

(2017) Jeffrey A. Mulligan et al.   Biomedical Optics Express

Mechanotransduction of matrix stiffness in regulation of focal adhesion size and number: reciprocal regulation of caveolin-1 and β1 integrin

(2017) Yi-Chun Yeh et al.   Scientific Reports

Cancer-associated fibroblasts support vascular growth through mechanical force

(2017) Mary Kathryn Sewell-Loftin et al.   Scientific Reports

Strain Stiffening of Fibrillar Collagen during Individual and Collective Cell Migration Identified by AFM Nanoindentation

(2016) Sjoerd van Helvert et al.   ACS Applied Materials & Interfaces

Galectin-1 knockdown in carcinoma-associated fibroblasts inhibits migration and invasion of human MDA-MB-231 breast cancer cells by modulating MMP-9 expression

(2016) Xue Zhu et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Cell Competition and Its Role in the Regulation of Cell Fitness from Development to Cancer

(2016) Aida Di Gregorio et al.   DEVELOPMENTAL CELL

Force transmission in epithelial tissues

(2016) Claudia G. Vasquez et al.   DEVELOPMENTAL DYNAMICS

Nanoscale architecture of cadherin-based cell adhesions

(2016) Cristina Bertocchi et al.   NATURE CELL BIOLOGY

Oriented collagen fibers direct tumor cell intravasation

(2016) Weijing Han et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fibrous nonlinear elasticity enables positive mechanical feedback between cells and ECMs

(2016) Matthew S. Hall et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Matrix stiffening promotes a tumor vasculature phenotype

(2016) Francois Bordeleau et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Collective cell durotaxis emerges from long-range intercellular force transmission

(2016) R. Sunyer et al.   SCIENCE

Mechanical cell competition kills cells via induction of lethal p53 levels

(2016) Laura Wagstaff et al.   Nature Communications

Regulation of matrix metalloproteinases (MMPs) expression and secretion in MDA-MB-231 breast cancer cells by LIM and SH3 protein 1 (LASP1)

(2016) Marcel Endres et al.   Oncotarget

Comparative mechanisms of cancer cell migration through 3D matrix and physiological microtracks

(2015) Shawn P. Carey et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Stiffening and unfolding of early deposited-fibronectin increase proangiogenic factor secretion by breast cancer-associated stromal cells

(2015) Karin Wang et al.   BIOMATERIALS

Remodeling of extracellular matrix by normal and tumor-associated fibroblasts promotes cervical cancer progression

(2015) Alexandra Fullár et al.   BMC CANCER

ZO-1 controls endothelial adherens junctions, cell–cell tension, angiogenesis, and barrier formation

(2015) Olga Tornavaca et al.   JOURNAL OF CELL BIOLOGY

A molecular mechanotransduction pathway regulates collective migration of epithelial cells

(2015) Tamal Das et al.   NATURE CELL BIOLOGY

Control of cell–cell forces and collective cell dynamics by the intercellular adhesome

(2015) Elsa Bazellières et al.   NATURE CELL BIOLOGY

Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver

(2015) Bruno Costa-Silva et al.   NATURE CELL BIOLOGY

Testing the differential adhesion hypothesis across the epithelial−mesenchymal transition

(2015) Steve Pawlizak et al.   NEW JOURNAL OF PHYSICS

Dynamic tensile forces drive collective cell migration through three-dimensional extracellular matrices

(2015) Nikolce Gjorevski et al.   Scientific Reports

Tumor cell secretion of soluble factor(s) for specific immunosuppression

(2015) Arihiro Kano   Scientific Reports

3D Collagen Alignment Limits Protrusions to Enhance Breast Cancer Cell Persistence

(2014) Kristin M. Riching et al.   BIOPHYSICAL JOURNAL

Long-Range Force Transmission in Fibrous Matrices Enabled by Tension-Driven Alignment of Fibers

(2014) Hailong Wang et al.   BIOPHYSICAL JOURNAL

Physical and mechanical regulation of macrophage phenotype and function

(2014) Frances Y. McWhorter et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Cell competition: how to eliminate your neighbours

(2014) M. Amoyel et al.   DEVELOPMENT

Cellular contractility and extracellular matrix stiffness regulate matrix metalloproteinase activity in pancreatic cancer cells

(2014) Amanda Haage et al.   FASEB JOURNAL

Actin dynamics modulate mechanosensitive immobilization of E-cadherin at adherens junctions

(2014) W. Engl et al.   NATURE CELL BIOLOGY

Interplay of RhoA and mechanical forces in collective cell migration driven by leader cells

(2014) M. Reffay et al.   NATURE CELL BIOLOGY

Extracellular matrix stiffness and composition jointly regulate the induction of malignant phenotypes in mammary epithelium

(2014) Ovijit Chaudhuri et al.   NATURE MATERIALS

Extracellular Matrix Density Regulates the Rate of Neovessel Growth and Branching in Sprouting Angiogenesis

(2014) Lowell T. Edgar et al.   PLoS One

A mechanical-biochemical feedback loop regulates remodeling in the actin cytoskeleton

(2014) Matthew R. Stachowiak et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Desmosomes: Regulators of Cellular Signaling and Adhesion in Epidermal Health and Disease

(2014) J. L. Johnson et al.   Cold Spring Harbor Perspectives in Medicine

Mechanical Cell-Matrix Feedback Explains Pairwise and Collective Endothelial Cell Behavior In Vitro

(2014) René F. M. van Oers et al.   PLoS Computational Biology

Mapping the dynamics of force transduction at cell–cell junctions of epithelial clusters

(2014) Mei Rosa Ng et al.   eLife

Mechanosensitive systems at the cadherin-F-actin interface

(2013) S. Huveneers et al.   JOURNAL OF CELL SCIENCE

Mechanotransduction at focal adhesions: from physiology to cancer development

(2013) Jihye Seong et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Mechanotransduction and YAP-dependent matrix remodelling is required for the generation and maintenance of cancer-associated fibroblasts

(2013) Fernando Calvo et al.   NATURE CELL BIOLOGY

Rapid disorganization of mechanically interacting systems of mammary acini

(2013) Q. Shi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gap junctional communication promotes apoptosis in a connexin-type-dependent manner

(2013) P Kameritsch et al.   Cell Death & Disease

Large Oncosomes in Human Prostate Cancer Tissues and in the Circulation of Mice with Metastatic Disease

(2012) Dolores Di Vizio et al.   AMERICAN JOURNAL OF PATHOLOGY

Effects of mechanical forces and stretch on intercellular gap junction coupling

(2012) Aida Salameh et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Force Fluctuations within Focal Adhesions Mediate ECM-Rigidity Sensing to Guide Directed Cell Migration

(2012) Sergey V. Plotnikov et al.   CELL

E-cadherin plays an essential role in collective directional migration of large epithelial sheets

(2012) Li Li et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

United we stand – integrating the actin cytoskeleton and cell–matrix adhesions in cellular mechanotransduction

(2012) Ulrich S. Schwarz et al.   JOURNAL OF CELL SCIENCE

Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET

(2012) Héctor Peinado et al.   NATURE MEDICINE

Lysyl oxidase enzymatic function increases stiffness to drive colorectal cancer progression through FAK

(2012) A-M Baker et al.   ONCOGENE

Cellular Traction Stresses Increase with Increasing Metastatic Potential

(2012) Casey M. Kraning-Rush et al.   PLoS One

Dynamic Regulation of Myosin Light Chain Phosphorylation by Rho-kinase

(2012) Takako Kaneko-Kawano et al.   PLoS One

Basic and Therapeutic Aspects of Angiogenesis

(2011) Michael Potente et al.   CELL

Remodeling and homeostasis of the extracellular matrix: implications for fibrotic diseases and cancer

(2011) T. R. Cox et al.   Disease Models & Mechanisms

The Matrisome:In SilicoDefinition andIn VivoCharacterization by Proteomics of Normal and Tumor Extracellular Matrices

(2011) Alexandra Naba et al.   MOLECULAR & CELLULAR PROTEOMICS

Collective cell guidance by cooperative intercellular forces

(2011) Dhananjay T. Tambe et al.   NATURE MATERIALS

Cell-ECM traction force modulates endogenous tension at cell-cell contacts

(2011) V. Maruthamuthu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Productive tension: force-sensing and homeostasis of cell–cell junctions

(2011) Guillermo A. Gomez et al.   TRENDS IN CELL BIOLOGY

Plithotaxis and emergent dynamics in collective cellular migration

(2011) Xavier Trepat et al.   TRENDS IN CELL BIOLOGY

Matrix Metalloproteinases: Regulators of the Tumor Microenvironment

(2010) Kai Kessenbrock et al.   CELL

Mesenchymal cells stimulate capillary morphogenesis via distinct proteolytic mechanisms

(2010) Cyrus M. Ghajar et al.   EXPERIMENTAL CELL RESEARCH

Roles of matrix metalloproteinases in cancer progression and their pharmacological targeting

(2010) Chrisostomi Gialeli et al.   FEBS Journal

Matrix stiffness modulates proliferation, chemotherapeutic response, and dormancy in hepatocellular carcinoma cells

(2010) Jörg Schrader et al.   HEPATOLOGY

Integration of contractile forces during tissue invagination

(2010) Adam C. Martin et al.   JOURNAL OF CELL BIOLOGY

Vinculin potentiates E-cadherin mechanosensing and is recruited to actin-anchored sites within adherens junctions in a myosin II–dependent manner

(2010) Quint le Duc et al.   JOURNAL OF CELL BIOLOGY

Intercellular mechanotransduction during multicellular morphodynamics

(2010) J. H. Kim et al.   Journal of the Royal Society Interface

Cell adhesion: integrating cytoskeletal dynamics and cellular tension

(2010) J. Thomas Parsons et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Mechanical Rigidity of the Extracellular Matrix Regulates the Structure, Motility, and Proliferation of Glioma Cells

(2009) T. A. Ulrich et al.   CANCER RESEARCH

Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling

(2009) Kandice R. Levental et al.   CELL

Proteinases involved in matrix turnover during cartilage and bone breakdown

(2009) Tim E. Cawston et al.   CELL AND TISSUE RESEARCH

Cellular Receptors of Extracellular Matrix Molecules

(2009) Jyrki Heino et al.   CURRENT PHARMACEUTICAL DESIGN

Matrix density-induced mechanoregulation of breast cell phenotype, signaling and gene expression through a FAK–ERK linkage

(2009) P P Provenzano et al.   ONCOGENE

Non-Linear Elasticity of Extracellular Matrices Enables Contractile Cells to Communicate Local Position and Orientation

(2009) Jessamine P. Winer et al.   PLoS One

Clustering of  5 1 integrins determines adhesion strength whereas  v 3 and talin enable mechanotransduction

(2009) P. Roca-Cusachs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transglutaminase 2 cross-linking of matrix proteins: biological significance and medical applications

(2008) R. J. Collighan et al.   AMINO ACIDS

Contact Guidance Mediated Three-Dimensional Cell Migration is Regulated by Rho/ROCK-Dependent Matrix Reorganization

(2008) Paolo P. Provenzano et al.   BIOPHYSICAL JOURNAL

Cell-Cell Mechanical Communication through Compliant Substrates

(2008) Cynthia A. Reinhart-King et al.   BIOPHYSICAL JOURNAL

Collagen density promotes mammary tumor initiation and progression

(2008) Paolo P Provenzano et al.   BMC Medicine

Extracellular Matrix Rigidity Promotes Invadopodia Activity

(2008) Nelson R. Alexander et al.   CURRENT BIOLOGY

Cadherin switching

(2008) M. J. Wheelock et al.   JOURNAL OF CELL SCIENCE

Secretion of active membrane type 1 matrix metalloproteinase (MMP-14) into extracellular space in microvesicular exosomes

(2008) Juha Hakulinen et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Pulsed contractions of an actin–myosin network drive apical constriction

(2008) Adam C. Martin et al.   NATURE

Macrophage polarization in tumour progression

(2008) Antonio Sica et al.   SEMINARS IN CANCER BIOLOGY