Article
Microbiology
Panagiotis Papatheodorou, Selina Kindig, Adriana Badilla-Lobo, Stephan Fischer, Ebru Durgun, Tharani Thuraisingam, Alexander Witte, Shuo Song, Klaus Aktories, Esteban Chaves-Olarte, Cesar Rodriguez, Holger Barth
Summary: The intestinal pathogen Clostridioides difficile produces two large exotoxins, toxin A and toxin B, which cause clinical symptoms of C. difficile-associated diseases. Inhibiting the cellular uptake and mode of action of these toxins is a promising therapeutic strategy. The sterol regulatory element-binding protein 2 pathway and membrane cholesterol play crucial roles in the intoxication of cells by TcdA and TcdB, offering potential targets for novel antitoxin strategies.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Medicine, Research & Experimental
Chao Sun, Wei Liu, Zhiqiang Lu, Yan Li, Shengnan Liu, Zhili Tang, Ying Yan, Zhiyang Li, Hua Feng, Duo Zhang, Yun Liu, Zhong-Ze Fang, Changtao Jiang, Qiurong Ding, Jingjing Jiang, Hao Ying
Summary: The study demonstrates that TH-responsive hepatic miR-378 can modulate serum cholesterol levels by regulating both the classic and alternative bile acid synthetic pathways.
Article
Biochemistry & Molecular Biology
Man-Yu Xiao, Fang-Fang Li, Peng Xie, Yan-Shuang Qi, Jin-Bo Xie, Wen-Jing Pei, Hao-Tian Luo, Mei Guo, Yu-Long Gu, Xiang-Lan Piao
Summary: The study found that Gyp can inhibit the progression of hepatocellular carcinoma (HCC) by inhibiting cholesterol synthesis, reducing proliferation, migration, and inducing apoptosis. Gyp targets lipid metabolism and cholesterol biosynthesis, limits cholesterol production, and targets the HMGCS1 protein. Gyp suppresses cholesterol synthesis mediated by the mevalonate pathway by inhibiting the transcription factor SREBP2 and suppresses the progression of HCC.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Gastroenterology & Hepatology
Hao-Yu Liu, Ping Hu, Yanwei Li, Ming-An Sun, Huan Qu, Qiufang Zong, Haotian Gu, Xiaobo Chen, Wenbin Bao, Demin Cai
Summary: This study revealed that dietary conjugated linoleic acids (CLA) can induce hypercholesterolemia (HCL) and liver steatosis through multiple pathways, with PPAR alpha, ROR gamma, and SREBP2 being important players in the hepatic cholesterol biosynthesis programming. The small-molecule compound GW6471 was found to have a therapeutic effect for CLA-induced HCL by disrupting the physical association between PPAR alpha and SREBP2, thus affecting the expression of cholesterol biosynthesis genes.
LIVER INTERNATIONAL
(2022)
Article
Pharmacology & Pharmacy
Naiel Azzam, Rinat Bar-Shalom, Fuad Fares
Summary: Follitropin (FSH) plays a crucial role in the reproductive process in mammals, but increased FSH activity is associated with clinical conditions such as menopausal osteoporosis. A non-glycosylated single-chain FSH variant has been engineered, which has the potential to act as a Follitropin antagonist by efficiently inhibiting FSH activity at the receptor level for future clinical applications.
Article
Plant Sciences
Jutarou Fukazawa, Kazuya Mori, Hiroki Ando, Ryota Mori, Yuri Kanno, Mitsunori Seo, Yohsuke Takahashi
Summary: Jasmonic acid inhibits gibberellin (GA) levels and plant growth by decreasing GA biosynthesis gene expression and increasing GA inactivation gene expression via miR5998 and MYC2 activities.
Article
Medicine, Research & Experimental
Pelin Erkoc, Michaela Schmitt, Rebecca Ingelfinger, Iris Bischoff-Kont, Larissa Kopp, Helge B. Bode, Susanne Schiffmann, Robert Fuerst
Summary: Xcn2 exhibits significant pharmacological activity in vitro regarding inflammation and angiogenesis, inhibiting pro-inflammatory activation of endothelial cells and hindering pro-angiogenic processes in HUVECs. It also reduces viability, nitric oxide release, and iNOS expression in activated macrophages.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Medicine, Research & Experimental
Hui Zheng, Jian Wan, Yi Shan, Xi Song, Jie Jin, Qing Su, Song Chen, Xinyuan Lu, Jialin Yang, Quanmin Li, Yuping Song, Bo Li
Summary: MiR-185-5p plays an inhibitory role in hepatic gluconeogenesis by targeting G6Pase to alleviate hyperglycemia. Moreover, the antidiabetic drug metformin can suppress G6Pase by upregulating miR-185-5p expression, leading to the inhibition of hepatic glucose overproduction.
Article
Immunology
Ting-Ting Li, Xiao-Wei Su, Lin-Lin Chen, Wan-Nian Zhang, Jun-Ping Zhang, Yan Wang, Wei-Heng Xu
Summary: Hepatic fibrosis is a stage of chronic liver disease that can lead to cirrhosis or liver cancer. The activation of hepatic stellate cells (HSCs) is a crucial event in fibrosis development and inhibiting this activation has been shown to alleviate fibrosis. Roxarsone, an organoarsenic additive used in livestock production, has been found to inhibit HSC activation and improve liver function in a mouse model of fibrosis. These findings suggest that Roxarsone could be a potential treatment for liver fibrosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Agriculture, Multidisciplinary
Xiaolin Zhang, Zhen Dong, Yuanmiao Yang, Chaolong Liu, Jisheng Li, Wenli Sun, Yikang Zhu, Yang Shen, Zhi Wang, Muhan Lu, Hongjuan Cui
Summary: Morusinol, a compound extracted from Morus alba L., shows potential as an anticancer drug for the treatment of colorectal cancer (CRC). It inhibits cell proliferation, promotes apoptosis, and induces cytoprotective autophagy in CRC cells. Morusinol affects cholesterol metabolism and suppresses the transcription of key enzyme genes in the cholesterol biosynthesis pathway, leading to the suppression of cell proliferation and the promotion of apoptosis. It also promotes nuclear accumulation of FOXO3a, which in turn suppresses SREBF2 transcription and blocks cholesterol biosynthesis. Animal model experiments confirm the inhibitory effect of morusinol on tumor growth. These findings suggest that morusinol may be a promising candidate for CRC treatment.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Agriculture, Dairy & Animal Science
Z. Cheng, M. W. Little, C. Ferris, H. Takeda, K. L. Ingvartsen, M. A. Crowe, D. C. Wathes, GplusE Consortium
Summary: Excessive negative energy balance in early lactation is associated with increased disease risk, but nutrition can help mitigate this. The liver plays important roles in metabolism and immunity. This study compared the liver transcriptomic profiles of Holstein-Friesian cows on different diets and found different responses between primiparous and multiparous cows. Multiparous cows on a high concentrate diet had higher glucose and insulin-like growth factor-1 levels and lower urea. They also produced more milk and showed changes in gene expression related to fatty acid metabolism, cholesterol biosynthesis, and acute phase proteins. Primiparous cows on the same diet had similar gene expression changes but also showed increased expression of genes indicative of inflammation and fibrosis.
JOURNAL OF DAIRY SCIENCE
(2023)
Article
Oncology
Jian Gao, Jifen Hu, Fang Yu, Chunlin Wang, Danmei Sheng, Wuling Liu, Anling Hu, Kunling Yu, Xiao Xiao, Yi Kuang, Eldad Zacksenhaus, Babu Gajendran, Yaacov Ben-David
Summary: This study found that lovastatin inhibits the proliferation of leukemia cells by inducing G1 phase cell cycle arrest and apoptosis. It also suppresses ERK1/2 phosphorylation by downregulating FAM83A and DDIT4, and activates a subset of cholesterol biosynthesis genes, further suppressing leukemia cell growth.
Article
Agriculture, Dairy & Animal Science
Qiufang Zong, Huan Qu, Yahui Zhao, Haoyu Liu, Shenglong Wu, Shuai Wang, Wenbin Bao, Demin Cai
Summary: This study aims to investigate whether a histone deacetylase inhibitor, sodium butyrate (NaBu), can protect the porcine liver from deoxynivalenol (DON) exposure by modulating cholesterol metabolism. The results showed that NaBu effectively restored parameters associated with liver injury, cholesterol content, and key genes involved in the cholesterol biosynthesis pathway.
JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Xiaolan Bao, Xingyu Yuan, Xuexin Li, Xiaojing Liu
Summary: The study isolated IPPF from flaxseed protein, which effectively reduces serum cholesterol levels, modulates cholesterol metabolism, and has potential nutritional therapeutic value.
JOURNAL OF FOOD BIOCHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Shui-mei Sun, Zhi-fu Xie, Yang-ming Zhang, Xin-wen Zhang, Chen-dong Zhou, Jian-peng Yin, Yan-yan Yu, Shi-chao Cui, Hao-wen Jiang, Teng-teng Li, Jia Li, Fa-jun Nan, Jing-ya Li
Summary: The AMPK activator C24 shows promise in alleviating dyslipidemia by activating hepatic AMPK, reducing lipogenesis, lowering lipid levels in plasma, and protecting against hepatic dysfunction. C24 may be a potential candidate for the development of a lipid-lowering drug.
ACTA PHARMACOLOGICA SINICA
(2021)
Article
Biochemistry & Molecular Biology
Md Reyad-ul Ferdous, Mohnad Abdallae, Mengjiao Yang, Li Xiaoling, Yongfeng Song
Summary: Obesity leads to various diseases and plants can provide effective drugs to treat these diseases. This study focuses on the effect of Berberine on mitochondrial UCP1 gene expression and adipocyte content reduction. Results showed that Berberine can up-regulate UCP1 gene expression and reduce fat droplets in adipocytes.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Public, Environmental & Occupational Health
Bingjie He, Zhengyang Li, Lu Xu, Lili Liu, Shengfeng Wang, Siyan Zhan, Yongfeng Song
Summary: The study found that limb lengths are inversely associated with the risk of diabetes. Specifically, upper arm length was more significantly related to diabetes in females, while knee height was more significantly related to diabetes in males. Additionally, the associations between upper arm length and knee height with diabetes risk were more significant among underweight individuals.
PUBLIC HEALTH NUTRITION
(2023)
Article
Health Care Sciences & Services
Hang Sun, Lu Xu, Lili Liu, Siyan Zhan, Shengfeng Wang, Yongfeng Song
Summary: Limited studies have explored the predictive efficiency of prediabetes based on two definitions for diabetes among Chinese middle-aged and older populations with prediabetes. This study found that neither definition of prediabetes is robust for predicting diabetes development in Chinese middle-aged and older populations.
JOURNAL OF GENERAL INTERNAL MEDICINE
(2023)
Article
Engineering, Multidisciplinary
Yafei Wu, Guijun Qin, Guixia Wang, Libin Liu, Bing Chen, Qingbo Guan, Zhongshang Yuan, Xu Hou, Ling Gao, Chao Xu, Haiqing Zhang, Xu Zhang, Qiu Li, Yongfeng Song, Fei Jing, Shizhan Ma, Shanshan Shao, Meng Zhao, Qingling Guo, Nanwei Tong, Hongyan Zhao, Xiaomin Xie, Chao Liu, Zhongyan Shan, Zhifeng Cheng, Xuefeng Yu, Shulin Chen, Tao Yang, Yangang Wang, Dongmei Li, Zhaoli Yan, Lixin Guo, Qiuhe Ji, Wenjuan Wang, Jiajun Zhao
Summary: The aim of this study was to explore the associations of moderate-to-vigorous-intensity physical activity (MVPA) time and sedentary (SED) time with a history of cardiovascular disease (CVD) and multifactorial control status among type 2 diabetes mellitus (T2DM) patients in China. The study found that higher MVPA time was associated with lower odds of CVD risk, regardless of SED time, among patients with T2DM. Rating: 8/10.
Review
Endocrinology & Metabolism
L. Zhuo, Z. Wang, Y. Yang, Z. Liu, S. Wang, Y. Song
Summary: Isolated maternal hypothyroxinaemia (IMH) is associated with some adverse obstetric outcomes, but not with other outcomes such as placenta previa and gestational hypertension. There is currently insufficient evidence to support the use of levothyroxine treatment during pregnancy to reduce adverse maternal outcomes and disability in offspring.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2023)
Article
Health Care Sciences & Services
Jing Du, Shizhan Ma, Li Fang, Meng Zhao, Zhongshang Yuan, Yiping Cheng, Jiajun Zhao, Xiude Fan, Qingling Guo, Zhongming Wu
Summary: This study found a correlation between muscle distribution and nonalcoholic fatty liver disease (NAFLD). Higher muscle mass in the lower limbs, extremities, and trunk was associated with a lower risk of NAFLD. Furthermore, a decrease in muscle mass in the lower limbs and trunk was linked to increased severity of NAFLD.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Review
Cell Biology
Yashuang Yang, Quanshu Wang, Ling Gao, Sijin Liu, Jiajun Zhao, Guoliang Liu, Shuping Zhang
Summary: Many indicators, including RDW and iron metabolism, are sensitive to various risk factors and are associated with pathological alterations and disease onset. Increased RDW indicates various conditions such as iron deficiency anemia and chronic inflammation. Understanding the factors affecting RDW, such as disordered iron metabolism and oxidative stress, can be valuable in diagnosing and monitoring pathological conditions.
CELL BIOLOGY INTERNATIONAL
(2023)
Article
Cell Biology
Xiude Fan, Junming Han, Enfa Zhao, Jiansong Fang, Dawei Wang, Yiping Cheng, Yingzhou Shi, Zhen Wang, Zhenyu Yao, Peng Lu, Tianbao Liu, Qihang Li, Kyle L. Poulsen, Zhongshang Yuan, Yongfeng Song, Jiajun Zhao
Summary: Breakthrough SARS-CoV-2 infections of vaccinated individuals are increasing the risk of hospitalization and death. It is crucial to identify modifiable risk factors and initiate early interventions.
Article
Gastroenterology & Hepatology
Jing Wu, Xiude Fan, Yongfeng Song
Summary: This study investigated the causal effect between total testosterone (TT), bioavailable testosterone (BAT), sex hormone binding globulin (SHBG) in female and primary biliary cholangitis (PBC) using public GWAS summary data. The results revealed a positive association between genetically predicted BAT in female and PBC, and a negative association between SHBG in female and PBC.
DIGESTIVE AND LIVER DISEASE
(2023)
Article
Immunology
Yunyun Xu, Xu Hou, Honglin Guo, Zhenyu Yao, Xiude Fan, Chao Xu, Guimei Li, Yanzhou Wang, Yan Sun, Ling Gao, Yongfeng Song, Jiajun Zhao
Summary: Patients with Prader-Willi syndrome (PWS) show hyper-inflammatory state in their peripheral immune cells, characterized by increased CD16(+) monocytes. These monocytes transmit chemokine and cytokine signaling to drive inflammatory process in other cell types. This study provides insights into the characteristics of peripheral immune cells in PWS at the single cell level and suggests potential targets for immunotherapy in the future.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Oncology
Chao Xu, Zhao He, Yongfeng Song, Shanshan Shao, Guang Yang, Jiajun Zhao
Summary: It has been traditionally believed that pituitary hormones act on their cognate receptors in classical target glands to carry out their various functions. However, recent studies have revealed that multiple types of pituitary hormone receptors are widely expressed in non-classical target organs. This article summarizes the additional biological functions of pituitary hormones (thyroid-stimulating hormone, follicle-stimulating hormone, luteinizing hormone, adrenocorticotrophic hormone, and prolactin) when they act on non-classical organs, defining them as part of an atypical pituitary hormone-target tissue axis. This novel concept provides insight into the mechanisms behind metabolic diseases and offers potential novel therapeutic targets.
FRONTIERS OF MEDICINE
(2023)
Article
Cell Biology
Ruizhi Zheng, Yu Xu, Mian Li., Zhengnan Gao, Guixia. Wang, Xinguo Hou, Li Chen, Yanan Huo, Guijun Qin, Li Yan, Qin Wan, Tianshu Zeng, Lulu Chen, Lixin Shi, Ruying Hu, Xulei Tang, Qing Su, Xuefeng Yu, Yingfen Qin, Gang Chen, Xuejiang Gu, Feixia Shen, Zuojie Luo, Yuhong Chen, Yinfei Zhang, Chao Liu, Youmin Wang, Shengli Wu, Tao Yang, Qiang Li, Yiming Mu, Jiajun Zhao, Chunyan Hu, Xiaojing Jia, Min Xu, Tiange Wang, Zhiyun Zhao, Shuangyuan Wang, Hong Lin, Guang Ning, Weiqing Wang, Jieli Lu, Yufang Bi
Summary: By analyzing 12 variables related to body fat, glycemic measures, pancreatic b cell function, insulin resistance, blood lipids, and liver enzymes, the study examined the cluster characteristics of prediabetes and their associations with the development of diabetes and its complications. Significant differences in the risks of diabetes and its complications were observed among different clusters. Prediabetes in cluster 4, characterized by obesity and insulin resistance, had a higher risk of cardiovascular diseases compared to other clusters. This subcategorization has the potential to develop more precise strategies for targeted prediabetes prevention and treatment.
CELL REPORTS MEDICINE
(2023)
Article
Medicine, Research & Experimental
Wei Zhang, Jing Du, Hang Dong, Yiping Cheng, Fang Zhong, Zinuo Yuan, Yingchun Dong, Rong Wang, Shumin Mu, Jiajun Zhao, Wenxia Han, Xiude Fan
Summary: This study investigated the relationship between obesity, metabolic abnormalities, and hospitalizations related to diabetic kidney disease (DKD). The findings showed that both metabolic abnormalities and obesity were independently associated with increased readmission risk and hospitalization costs for DKD.
ARCHIVES OF MEDICAL RESEARCH
(2023)