Memantine potentiates cytarabine-induced cell death of acute leukemia correlating with inhibition of Kv1.3 potassium channels, AKT and ERK1/2 signaling

Differential Activity of Voltage- and Ca2+-Dependent Potassium Channels in Leukemic T Cell Lines: Jurkat Cells Represent an Exceptional Case

(2018) Salvador Valle-Reyes et al.   Frontiers in Physiology

Kv1.3 Channels Mark Functionally Competent CD8 + Tumor-Infiltrating Lymphocytes in Head and Neck Cancer

(2016) Ameet A. Chimote et al.   CANCER RESEARCH

Ionic immune suppression within the tumour microenvironment limits T cell effector function

(2016) Robert Eil et al.   NATURE

Immunomodulation by memantine in therapy of Alzheimer's disease is mediated through inhibition of Kv1.3 channels and T cell responsiveness

(2016) Theresa Lowinus et al.   Oncotarget

Ion Channels in Innate and Adaptive Immunity

(2015) Stefan Feske et al.   Annual Review of Immunology

Biophysical Characterization and Expression Analysis of Kv1.3 Potassium Channel in Primary Human Leukemic B Cells

(2015) Ildiko Szabo et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Voltage-Gated Ptassium Channels Kv1.3 - Potentially New Molecular Target in Cancer Diagnostics and Therapy

(2015) Andrzej Teisseyre et al.   Advances in Clinical and Experimental Medicine

Therapeutic Targeting of c-Myc in T-Cell Acute Lymphoblastic Leukemia (T-ALL)

(2015) Marie Loosveld et al.   Oncotarget

How I treat the older patient with acute myeloid leukemia

(2014) G. Ossenkoppele et al.   BLOOD

Targeting the MYC and PI3K Pathways Eliminates Leukemia-Initiating Cells in T-cell Acute Lymphoblastic Leukemia

(2014) S. Schubbert et al.   CANCER RESEARCH

NMDA-receptor antagonists block B-cell function but foster IL-10 production in BCR/CD40-activated B cells

(2014) Narasimhulu Simma et al.   Cell Communication and Signaling

Epo-induced erythroid maturation is dependent on Plcγ1 signaling

(2014) T M Schnöder et al.   CELL DEATH AND DIFFERENTIATION

Correlation between Potassium Channel Expression and Sensitivity to Drug-induced Cell Death in Tumor Cell Lines

(2014) Luigi Leanza et al.   CURRENT PHARMACEUTICAL DESIGN

Targeting proliferation of chronic lymphocytic leukemia (CLL) cells through KCa3.1 blockade

(2014) E M Grössinger et al.   LEUKEMIA

Activation and repression by oncogenic MYC shape tumour-specific gene expression profiles

(2014) Susanne Walz et al.   NATURE

A NOTCH1-driven MYC enhancer promotes T cell development, transformation and acute lymphoblastic leukemia

(2014) Daniel Herranz et al.   NATURE MEDICINE

Ion channels and anti-cancer immunity

(2014) G. Panyi et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Clofazimine, Psora-4 and PAP-1, inhibitors of the potassium channel Kv1.3, as a new and selective therapeutic strategy in chronic lymphocytic leukemia

(2013) L Leanza et al.   LEUKEMIA

A phase Ib GOELAMS study of the mTOR inhibitor RAD001 in association with chemotherapy for AML patients in first relapse

(2013) S Park et al.   LEUKEMIA

Immunosuppression byN-Methyl-d-Aspartate Receptor Antagonists Is Mediated through Inhibition of Kv1.3 and KCa3.1 Channels in T Cells

(2013) Sascha Kahlfuß et al.   MOLECULAR AND CELLULAR BIOLOGY

Activation of Ras/PI3K/ERK Pathway Induces c-Myc Stabilization to Upregulate Argininosuccinate Synthetase, Leading to Arginine Deiminase Resistance in Melanoma Cells

(2012) W.-B. Tsai et al.   CANCER RESEARCH

Targeting the Voltage-Dependent K+ Channels Kv1.3 and Kv1.5 as Tumor Biomarkers for Cancer Detection and Prevention

(2012) A. Felipe et al.   CURRENT MEDICINAL CHEMISTRY

Targeting Ion Channels in Leukemias: A New Challenge for Treatment

(2012) A. Arcangeli et al.   CURRENT MEDICINAL CHEMISTRY

Inhibitors of mitochondrial Kv1.3 channels induce Bax/Bak-independent death of cancer cells

(2012) Luigi Leanza et al.   EMBO Molecular Medicine

Treatment decisions for elderly patients with haematological malignancies: a dilemma

(2012) Frédéric Peyrade et al.   LANCET ONCOLOGY

PI3K/mTOR inhibition upregulates NOTCH-MYC signalling leading to an impaired cytotoxic response

(2012) C Shepherd et al.   LEUKEMIA

Dual mTORC1/mTORC2 inhibition diminishes Akt activation and induces Puma-dependent apoptosis in lymphoid malignancies

(2011) M. Gupta et al.   BLOOD

The ion channel network in T lymphocytes, a target for immunotherapy

(2011) Laura Conforti   CLINICAL IMMUNOLOGY

Roles of the Ras/Raf/MEK/ERK pathway in leukemia therapy

(2011) L S Steelman et al.   LEUKEMIA

Drug Combination Studies and Their Synergy Quantification Using the Chou-Talalay Method

(2010) T.-C. Chou   CANCER RESEARCH

Inhibition of MEK signaling enhances the ability of cytarabine to induce growth arrest and apoptosis of acute myelogenous leukemia cells

(2009) Chie Nishioka et al.   APOPTOSIS

High frequency of PTEN, PI3K, and AKT abnormalities in T-cell acute lymphoblastic leukemia

(2009) A. Gutierrez et al.   BLOOD

Dual Inhibition of Class IA Phosphatidylinositol 3-Kinase and Mammalian Target of Rapamycin as a New Therapeutic Option for T-Cell Acute Lymphoblastic Leukemia

(2009) F. Chiarini et al.   CANCER RESEARCH

A Phase I Study of the Mammalian Target of Rapamycin Inhibitor Sirolimus and MEC Chemotherapy in Relapsed and Refractory Acute Myelogenous Leukemia

(2009) A. E. Perl et al.   CLINICAL CANCER RESEARCH

The functional network of ion channels in T lymphocytes

(2009) Michael D. Cahalan et al.   IMMUNOLOGICAL REVIEWS

Voltage-gated potassium channels as therapeutic targets

(2009) Heike Wulff et al.   NATURE REVIEWS DRUG DISCOVERY

Pharmacodynamics of Memantine: An Update

(2008) C. Parsons et al.   Current Neuropharmacology

Myc's broad reach

(2008) M. Eilers et al.   GENES & DEVELOPMENT

Targeting survival cascades induced by activation of Ras/Raf/MEK/ERK, PI3K/PTEN/Akt/mTOR and Jak/STAT pathways for effective leukemia therapy

(2008) J A McCubrey et al.   LEUKEMIA

Mitochondrial potassium channel Kv1.3 mediates Bax-induced apoptosis in lymphocytes

(2008) I. Szabo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA